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1 in the biosynthesis of the azoxy antibiotic valanimycin.
3 experiments suggest that the role of VlmL in valanimycin biosynthesis is to produce seryl-tRNA, which
4 lor SerRS, is hypothesized to play a role in valanimycin biosynthesis, because the vlmL gene resides
7 evealed that the VlmA protein encoded by the valanimycin biosynthetic gene cluster catalyzes the tran
9 ons led to the cloning and sequencing of the valanimycin biosynthetic gene cluster, which was found t
13 t the conversion of valanimycin hydrate into valanimycin by S. viridifaciens requires both the vlmJ a
15 on experiments defined the boundaries of the valanimycin gene cluster, which appears to contain 14 ge
16 s the isolation and structure elucidation of valanimycin hydrate from vlmJ and vlmK mutants of S. vir
17 al studies have shown that the conversion of valanimycin hydrate into valanimycin by S. viridifaciens
18 ent phosphorylation of the hydroxyl group of valanimycin hydrate prior to VlmK-catalyzed dehydration.
21 cursor incorporation experiments showed that valanimycin is derived from l-valine and l-serine via th
27 plified by PCR from a genomic library of the valanimycin-producing organism, Streptomyces viridifacie
29 iridifaciens DNA was isolated that conferred valanimycin production upon Strepto-myces lividans TK24.
30 an amino acid decar-boxylase gene (vlmD), a valanimycin resistance gene (vlmF ), at least two regula
31 volved in the biosynthesis of the antibiotic valanimycin was discovered in a Streptomyces strain.
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