ライフサイエンスコーパス: valency

1 eved with excellent control over the desired valency.

2 cy being better detected than those of lower valency.

3 observed at a frequency dependent on display valency.

4 ter size with high surface area and thiolate valency.

5 termediates are resolved is sensitive to ion valency.

6 nvolving specific biointeractions at tunable valency.

7 pe on engagement of surface integrins at low valency.

8 rpolarizing shift and decreased the apparent valency.

9 reated with MHC-peptide oligomers of varying valency.

10 of the nanoassemblies is related to the dye valency.

11 through changes in scaffold concentration or valency.

12 e show here that Fe doping influences the Ni valency.

13 ty, and receptor clustering, which modulates valency.

14 gree of Cu-O hybridization and, thus, the Cu valency.

15 at they are examples of proton-coupled mixed valency.

16 of the putative sugar ligand with identical valency.

17 bs involved in these two different states of valency.

18 election through the manipulation of display valency.

19 noids" for silicon clusters with unsaturated valencies.

20 The sum of the effective valencies, 1.14 +/- 0.12, demonstrates that the electrog

21 ted, dual-ligand liposomes with equal ligand valencies achieved enhanced binding and selectivity for

22 ynamics of the clusters are modulated by the valencies and affinities of the interacting species.

23 An examination of the valencies and charges of the hydrogen-bonding groups sug

24 13 modularly assembled ligands with defined valencies and distances between ligand modules was synth

25 s, when designed to have well-defined ligand valencies and spacings, can effectively inhibit IAV infe

26 e were evaluated to understand the effect of valency and avidity on delivery.

27 We investigate the nature of valency and bonding in the highly unusual O(2)PR(3) "pho

28 a-electrolyte interface as a function of ion valency and concentration using subnanometer oscillation

29 functional ligand presentations in terms of valency and density, most of the reported multivalent ca

30 were constructed to facilitate both display valency and formats, based on various phage coat protein

31 skeleton, whereas ICAM-1 clustering enhances valency and further promotes ligand-dependent LFA-1 acti

32 ificantly affecting diffusion, including the valency and ionic radius, are discussed.

33 role of the H4 tail varied depending on the valency and ionic strength, suggesting that electrostati

34 By tuning the valency and linker length, we designed polyvalent inhibi

35 quantitative information about the residual valency and orientation of surface-bound molecules is mi

36 ate in a directional manner, with controlled valency and recognition motifs.

37 ivalent approach to determine optimal ligand valency and spacing that can be subsequently optimized f

38 mimetics with systematically varied mannose valency and spacing.

39 ctionalization allow a strict control of the valency and spatial orientation of the recognition motif

40 ent surface densities to evaluate how glycan valency and spatial separation affect the preferential b

41 4,5-trisphosphate receptor suggests that the valency and specificity of ankyrin binding is achieved b

42 Both the change in valency and the release rate of the molecules are strong

43 The ability to control independently the valency and the spacing between ligands would be valuabl

44 fashion to satisfy the complexation [2 + 2] valency and thereby give stable two-dimensional supramol

45 e familiar chemical concepts of "bonds" and "valency" and review two distinct but related strategies

46 nalyses provided the associated bond orders, valencies, and natural population analysis charges.

47 ther impacted by factors such as Ab epitope, valency, and affinity.

48 its molecular characteristics such as size, valency, and affinity.

49 at were varied include scaffold shape, size, valency, and density of binding elements.

50 cells enhanced ligand binding affinity, not valency, and did not alter cell-surface clustering as de

51 4E10 combining sites that differed in size, valency, and flexibility.

52 ltimeric complexes with defined composition, valency, and geometry.

53 the influence of polymeric backbone length, valency, and hapten presentation on binding to anti-DNP

54 is strongly dependent on ion concentration, valency, and size.

55 ng the number of defects, that is, the shell valency, and their positions, is a key success factor fo

56 gnition elements to introduce the concept of valency, and through anisotropic interactions resulting

57 s into the role of water in stabilizing high-valency anions and how these ions can pattern the struct

58 he natural water oxidation system; the mixed valencies (AOS = 3.7); and the lowest charge transfer re

59 with high affinity but likely with different valencies based on their binding orientation.

60 We differentiated between affinity- and valency-based modes of activation by TM domain mutations

61 sensitivity than NPs with targets of higher valency being better detected than those of lower valenc

62 primary determinant of TLR9 signaling is not valency but endosomal location and demonstrates a strict

63 We revisited the issue of TCR valency by examining complexes isolated from primary alp

64 finity conformation of LFA-1, for increasing valency by recruiting LFA-1 to the immunological synapse

65 s) can be replicated in the absence of mixed-valency by the introduction of electronic asymmetry.

66 We demonstrate how the residual valency can be adjusted to one or two biotin binding sit

67 Our findings indicate that glycan valency can set thresholds for cross-linking by lectins.

68 nd other mean-field theories fail for higher valency cations where ion-ion correlation effects may be

69 phase-separated liquids that concentrate low valency client proteins.

70 how structural parameters such as the size, valency, conformation, self-assembling behaviour of the

71 may reduce racial disparities in IPD, higher valency conjugate vaccines and strategies to directly ad

72 18% with a transition from single to double valency, consistent with a doubling of the molecular bri

73 The pseudopolyrotaxane exhibited a valency-corrected 10-fold enhancement over native lactos

74 copolymers displayed 10-20-fold increases in valency-corrected affinities compared to the correspondi

75 e the effects of target concentration, phage valency, degree of background binding and other laborato

76 rying effective site pair affinities and RNA valency demonstrate that interactions between multivalen

77 Thus, the valency dependence of the response of CD8 T cells to sol

78 n live cells decreased GFP fluorescence in a valency-dependent manner, indicating that the RNA aptame

79 We find that mannose spacing and valency dictate whether glycopeptides engage GRFT in a f

80 Different valencies did not significantly affect antitumor efficac

81 ortrait painted by these results is that ion valency differentially affects steps in the folding proc

82 channel that can conduct cations of multiple valencies down the electrochemical gradient.

83 mum in gene delivery as a function of ligand valency, due to saturation of receptor binding and inter

84 The increased valency enhances the apparent affinity of 2G12 for Man(4

85 e consider up to four DNA loci and different valencies for diffusing molecular factors.

86 Cr(VI) is the most toxic valency form of Cr, but its toxicity targets and the cel

87 work is consistent with a two-electron mixed valency formulation for the [L(Delta)Zn] species.

88 the alpha-GalNAc epitope and cross-link low valency glycoconjugates, only SBA showed a tendency to f

89 pectra and electrochemical data support a Co valency greater than 3 for both Co-Pi samples when catal

90 Models of different stoichiometry and valency have been proposed based on cellular experiments

91 ging from 1:10 to 1:1 to hemoglobin, are the valency hybrid intermediates alpha3+beta2+ and alpha2+be

92 tained with a hemoxometer indicated that the valency hybrids were measured as MetHb and the values of

93 itrosothiols, methaemoglobin and its related valency hybrids.

94 ic affinity for ligand, but not the receptor valency, i.e., clustering.

95 Surprisingly, anti-NP antibodies of lower valency, IgA (n = 4) and IgG (n = 2), were also found to

96 Z0) was highest in Kir2.2 channels while the valencies in Kir2.1 and Kir2.3 channels were not signifi

97 observation of Robin-Day Class II/III mixed valency in a MOF.

98 We explored the role of antigen valency in B cell receptor (BCR) activation and rearrang

99 To determine the role of ligand valency in M6P/IGF-II receptor-mediated endocytosis, we

100 rameters in the biradical complexes to mixed valency in the corresponding quinone-semiquinone radical

101 s were observed for compounds with identical valencies, indicating that the spatial distribution of t

102 Thus, Ag valency influences B cell responses by modulating the st

103 mply explained by the interception of a high-valency iron-oxo species.

104 onstrate that an increase of the interaction valency leads to a precipitous decline in the dissociati

105 iffuse double layer as an ion with effective valency < 6.

106 nition domain specificity, presentation, and valency make distinct contributions to the specific effe

107 This work shows that high-valency metal-oxo species can be used to create reductio

108 functional theory suggested that non-3d high-valency metals such as tungsten can modulate 3d metal ox

109 s tetramer behaved as an ideal model for the valency mode of regulation, because it exhibited signifi

110 se-designed SAv constructs having controlled valencies (mono-, di-, trivalent in terms of biotin-bind

111 Since Abeta aggregates possess the multiple valencies of an FAED motif (20th to 23rd amino acid resi

112 rogenase has been proposed to have metal-ion valencies of either Mo(4+)6Fe(2+)Fe(3+) (derived from me

113 tent with decreasing affinity and functional valencies of the multivalent analogues upon sequential b

114 IgE and challenged with Pen a 1 (IgE epitope valency of >/=8), although measurable responses were ach

115 Importantly, differences in the functional valency of a triantennary analog for concanavalin A and

116 tage (g(V)) curve and increased the apparent valency of activation.

117 number of points of attachment (that is, the valency of attachment).

118 t TAM depletion constructs by increasing the valency of both the M2pep targeting and KLA drug domains

119 on, both in vitro and in vivo, driven by the valency of constituent proteins.

120 In all these NCs the valency of Cu in the lattice stays always close to +1, w

121 el was built to explore how the affinity and valency of dual-ligand liposomes affect the binding and

122 By altering length and valency of epitope-bearing synthetic peptides, we examin

123 h dissipation monitoring, while the residual valency of immobilized SAv is quantified using spectrosc

124 physical studies to determine the oligomeric valency of membrane-associated env.

125 ions; and product topology determined by the valency of monomeric units.

126 concentration would be expected to alter the valency of NuMA toward MTs; the "density" of NuMA-MT cro

127 lergen-specific IgE, as well as the dose and valency of Pen a 1.

128 to four bioO variants designed to reduce the valency of repressor binding from 2 to 1 have been perfo

129 ays always close to +1, while the average -1 valency of S in covellite gradually evolves to -2 with i

130 expected trends due to net charge on Fe and valency of S, and both exhibit a splayed configuration w

131 fluence the average orientation and residual valency of SAv on a biotinylated surface.

132 ils were employed to mimic the physiological valency of selectins and selectin ligands.

133 The effective valency of spermine block (Z0) was highest in Kir2.2 cha

134 mmunofluorescent approaches to determine the valency of TCRgammadelta heterodimers and CD3gammaepsilo

135 ost can be qualitatively correlated with the valency of the adsorbate, and this is the key to underst

136 Rather, it appears that the valency of the antibody is the critical factor determini

137 d reversibly about tenfold by decreasing the valency of the bathing external cation (La3+ < Ca2+ < Na

138 orresponding F(AB) fragments showed that the valency of the binding protein had no influence on the v

139 Epitope valency of the e-antigen was also studied, using a sandw

140 We show here that the valency of the entering Sn ions dictates the structure a

141 l alterations influence the receptor-binding valency of the FimH adhesin via distal effects on the co

142 phase transition are directly related to the valency of the interacting species.

143 mostly independent of the ionic strength and valency of the ions.

144 ype A erythrocytes increases with increasing valency of the isolectin.

145 resent study indicates that the location and valency of the M6P moieties and the right oligosaccharid

146 erent maxima and midpoints, depending on the valency of the soluble oligomer used.

147 olume transition, whose sign depended on the valency of the solvent.

148 The valency of the system (i.e., the number of molecules bou

149 physical techniques to assess the oligomeric valency of virion-associated Env prior to fusion activat

150 portional to the number of binding epitopes (valency) of each carbohydrate.

151 r to fully characterize the effect of GalNAc valency, oligonucleotide length, flexibility and chemica

152 igand cross-linker spacer length, and ligand valency on polyplex cell surface binding, internalizatio

153 opportunity to examine the effect of lectin valency on the association constants of these GS-I isole

154 In this study, we analyzed the effects of Ag valency on the signaling and Ag-targeting functions of t

155 These bsAbs varied in valency or in the presence or absence of an Fc domain.

156 different sialic acid compounds of different valency or number of sialic acid moieties per molecule t

157 come countries, introduce PCVs and as higher valency PCVs are used.

158 We measured the effects of introducing high-valency PCVs on the incidence of invasive pneumococcal d

159 or the effects after introduction of higher valency PCVs.

160 omagnetic coupling promoted by organic mixed-valency provides keen insight into the ability of single

161 Single-particle tracking with defined-valency quantum dots confirmed that HA has significant m

162 resented to other T cells, clouding the true valency requirement for activation.

163 Valency requirements for B cell activation upon antigen

164 Tuning the QD surface mannose valency reveals that DC-SIGN binds more efficiently to d

165 Furthermore, studies with ligands of varying valency show that kindlins primarily increase cellular a

166 ss with rich information on Li distribution, valency, spin states, and crystal field.

167 ctroscopically that NO reacts with all three valency states of cobalamin and that NO's inhibition of

168 om temperature and for ca. 1:1 mol:mol mixed valencies, the bimolecular ET rate constants (assuming a

169 is not absolute, and factors that include Ag valency, the availability of T help, and polyclonal B ce

170 nges in integrin ligand-binding affinity and valency through inside-out signaling.

171 a1-integrin-Arg-Gly-Asp-peptide affinity and valency, thus implicating Ld domains in modulation of in

172 Using bispecific antibodies of different valencies to cell surface antigens including MET and EGF

173 f a semiclassical three-state model of mixed valency to complexes of the type [Ru(3)(mu(3)-O)(OAc)(6)

174 Increasing M2pep valency to four, however, resulted in a reduction in bot

175 which is perfectly matched in both size and valency to the target toxin, provides a convenient route

176 how that larger DNP(16)-dendrimers of higher valency trigger degranulation by cross-linking IgE-recep

177 lustering and the stop signal, whereas LFA-1 valency up-regulation occurs normally.

178 en evaluating the potential impact of higher valency vaccines on overall disease burden and associate

179 ing surveillance and development of expanded valency vaccines.

180 stimated for the serotypes covered by higher valency vaccines.

181 assessing the potential benefit of different valency vaccines.

182 Thus electrostatic selection by valency was computed self-consistently, and selection by

183 The apparent valency was decreased for all mutations.

184 The extent of valency was determined directly by measuring the visible

185 o sufficient quantity of input antigens, and valency was not a major factor for potency or breadth of

186 To obtain targets of different size and valency, we attached the Tag peptide to BSA (M(w)= 65000

187 onductivity is determined to be ligand mixed-valency, which is characterized using a suite of spectro

188 P3 secondary structure is independent of ion valency while the rate at which the respective intermedi

189 eats shows incremental gains with increasing valency, while the background binding to genomic DNA is

190 The method allows for high valency within many different kinds of interacting molec

191 e values of V(c) and E(m) to the mean charge valency (z(x)) of intracellular membrane-impermeant anio

192 ant solute content (X-i) and its mean charge valency (zX), while in contrast, the set point of Em was