ライフサイエンスコーパス: valine residue

1 sine and the transfer of a methyl group to l-valine residue.

2 d inversion of the alpha-stereocenter at the valine residue.

3 ic protein with an unusually high content of valine residues.

4 chain of the hemoglobin (Hb) tetramer has 17 valine residues.

5 gauche(-) side-chain rotamer for one of the valine residues.

6 When the central valine residues 6, 7, and 8 of gramicidin A (gA) are shi

7 ich negatively affect protease activity, and valine residues 785 and 787, which negatively affect deu

8 predicted phosphorylation site Asp-52 with a valine residue abolished phosphorylation of the PhoP pro

9 nt revertants were found to have changed the valine residue at position 155 back to the wild- type ph

10 Thus, neither the cPPT nor the valine residue at position 165 of integrase is essential

11 reover, mutagenesis analyses revealed that a valine residue at position 264 in the rat p75 neurotroph

12 s support a model by which the presence of a valine residue at position 437 of mGR induces a conforma

13 milar to those of valine A3, suggesting that valine residues at both A3 and B12 contribute to the ins

14 ighly stable trimeric coiled coil by placing valine residues at each a position and leucine residues

15 sive loss of lysine, cysteine, arginine, and valine residues compared to native ANT.

16 Substitution of two valine residues corresponding to amino acids 95 and 96 (

17 four leucine residues (a position) and three valine residues (d position) were replaced by the unnatu

18 r populations for threonine, isoleucine, and valine residues, determined from measurements of 3J(Cgam

19 cted, a WT mutant lacking the two C-terminal valine residues does not.

20 The key glutamate and flanking valine residues energetically couple to conserved prolin

21 se the beta-strand propensity of the central valine residue even further.

22 that AMD analogues derivatized at N-methyl-L-valine residues (fifth amino acid residue in the cyclic

23 ult in the nonconservative substitution of a valine residue for a phylogenetically conserved aspartic

24 des, only those containing phenylalanine and valine residues form fibrils.

25 tation of Cys-69 of PKCiota to isoleucine or valine, residues frequently found at this position in ot

26 A C-terminal valine residue functioned in ER export and interacted wi

27 selective set of the isoleucine, leucine or valine residues (ILV) with alanine in a large ILV cluste

28 e and other data suggest that the mischarged valine residue in IleRS.Val-tRNAIle is, most likely, pos

29 By contrast, mutation of the equivalent valine residue in the delta subunit impairs channel gati

30 ate that the modifications of the N-methyl-L-valine residues in the AMD molecule do affect the DNA bi

31 Replacing the valine residues in the cyclic octadepsipeptide with lysi

32 Two valine residues in the middle of the peptide were substi

33 We tested the effect of converting other non-valine residues in this region to valine.

34 sition 165 that were bulkier than the native valine residue inhibited glucose transport activity, whe

35 The leucine and valine residues insert into the binding groove while the

36 CHO cells is dependent on the presence of a valine residue located at the carboxyl terminus of the p

37 ituting a highly conserved methionine with a valine residue (M55V).

38 consistent with the hypothesis that smaller valine residues may allow the heme to regain planarity i

39 ine, isoleucine, leucine, lysine, serine, or valine residues of the coat protein.

40 The two carboxyl-terminal valine residues of WT are replaced by 5 (GCRLY) or 4 (AT

41 indicate that the optical configurations of valine residues on the PCS backbone affect chiral resolu

42 beta-hairpin (230-245) with an intercalating valine residue plays a role in promoter opening.

43 harged domain in the vicinity of proline and valine residues, (PPRKKRTVV), characteristic of a nuclea

44 Mutation of the terminal valine residue resulted in markedly reduced association

45 sion and processing, whereas substitution of valine residues resulted in hypofusogenic F proteins des

46 t pro TGF alpha mutants lacking the terminal valine residues showed greatly reduced maturation to the

47 clusters defined by isoleucine, leucine, and valine residues suggests that branch aliphatic side-chai

48 Only mutation of the H-helix valine residue V228 to leucine prevented phosphorylation

49 ed to those of NP1-4, all of which present a valine residue [valine 24 (NP2 and NP3) or valine 25 (NP

50 In this work, a valine residue was introduced at position 64 (H64V varia

51 The analogues in which N-methyl-L-valine residues were replaced with L- and D-forms of N-m

52 approximately 500 nM), by replacing the two valine residues with tert-leucine and the C-terminal pro

53 s result from replacement of five isoleucine/valine residues with threonine, one leucine with glutami

54 ting GDP release, is mediated by a conserved valine residue within this sensor, whereas binding of GT