1 Valosin containing protein (VCP) mutations also lead to
2 ovel PTPN22 substrates (Vav, CD3epsilon, and
valosin containing protein) and two known substrates of
3 Here, we report that p97, a
valosin-
containing protein (also called VCP), plays an e
4 FTD with mutations in progranulin (n = 36),
valosin-
containing protein (n = 5), charged multivesicul
5 The 97-kDa
valosin-
containing protein (p97-VCP) belongs to the AAA
6 The 97-kDa
valosin-
containing protein (p97-VCP) plays a role in a w
7 ER-associated degradation (ERAD), including
valosin-
containing protein (VCP) and Hrd1.
8 We identify here
valosin-
containing protein (VCP) as a novel substrate of
9 ns followed by proteomic analysis identified
valosin-
containing protein (VCP) as an Akt-binding prote
10 Our proteomic analysis identifies
valosin-
containing protein (VCP) as an mtHtt-binding pro
11 family member known to interact with the p97/
valosin-
containing protein (VCP) ATPase.
12 The 97 kDa
valosin-
containing protein (VCP) belongs to a highly con
13 The 97-kDa molecular chaperone
valosin-
containing protein (VCP) belongs to a highly con
14 Mutations in
valosin-
containing protein (VCP) cause a rare, autosomal
15 Missense mutations of
valosin-
containing protein (VCP) cause an autosomal domi
16 Mutations in
valosin-
containing protein (VCP) cause inclusion body my
17 Mutations in
valosin-
containing protein (VCP) cause inclusion body my
18 dentified a p.R191Q amino acid change in the
valosin-
containing protein (VCP) gene in an Italian fami
19 nerative disorder caused by mutations in the
valosin-
containing protein (VCP) gene.
20 nerative disorder caused by mutations in the
valosin-
containing protein (VCP) gene.
21 Valosin-
containing protein (VCP) is a highly expressed m
22 p97/
valosin-
containing protein (VCP) is a type II ATPase ass
23 Mutations in the gene encoding
valosin-
containing protein (VCP) lead to multisystem pro
24 Valosin-
containing protein (VCP) mutations cause inclusi
25 ical inhibition of either the AAA ATPase p97/
valosin-
containing protein (VCP) or the proteasome resul
26 the membrane by the p97 ATPase [also called
valosin-
containing protein (VCP) or, in yeast, Cdc48].
27 The
valosin-
containing protein (VCP) participates in signali
28 p97/
valosin-
containing protein (VCP) physically interacts wi
29 ciated with various cellular activities) p97/
valosin-
containing protein (VCP) subsequently dislodges
30 We observed that both WRNp and
valosin-
containing protein (VCP) were present in the nuc
31 Among the protein targets,
valosin-
containing protein (VCP), a homolog of the SNARE
32 Here, we show that mutation or inhibition of
Valosin-
Containing Protein (VCP), a ubiquitin-dependent
33 Here, we examined the function of
Valosin-
containing protein (VCP), a ubiquitin-selective
34 We identify
valosin-
containing protein (VCP), an AAA (ATPases associ
35 Here, we identify the ATPase p97/
valosin-
containing protein (VCP), an enzyme with segrega
36 and the ubiquitin-binding protein dislocase,
valosin-
containing protein (VCP), may act in concert dur
37 we discovered that EPSTI1 interacts with the
valosin-
containing protein (VCP), resulting in the degra
38 y or by depletion or pathogenic mutations in
valosin-
containing protein (VCP), the human ortholog of
39 p97/
valosin-
containing protein (VCP), which is involved in m
40 mitochondrial quality control (MQC) requires
valosin-
containing protein (VCP)-dependent Mitofusin/Mar
41 rings resembling the eukaryotic complex p97/
valosin-
containing protein (VCP).
42 defined reactions mediated by the AAA-ATPase
valosin-
containing protein (VCP)/p97 and augmented by th
43 sitional endoplasmic reticulum ATPase (TERA)/
valosin-
containing protein (VCP)/p97 directly binds to m
44 Presumably,
valosin-
containing protein (VCP)/p97 extracts misfolded
45 Valosin-
containing protein (VCP)/p97 is an AAA ATPase mo
46 We further show that
valosin-
containing protein (VCP)/p97 is involved in UV l
47 Binding to the AAA adenosine triphosphatase
valosin-
containing protein (VCP)/p97 is the only known b
48 Here, we report that
valosin-
containing protein (VCP)/p97 promotes the degrad
49 Here we demonstrate that
valosin-
containing protein (VCP)/p97 segregase functions
50 oteins in the media, such as mutant SOD1 and
valosin-
containing protein (VCP)/p97.
51 y in Wld(S) requires the N16-binding protein
valosin-
containing protein (VCP)/TER94.
52 six missense mutations in the gene encoding
valosin-
containing protein (VCP, a member of the AAA-ATP
53 Valosin-
containing protein (VCP/p97) ATPase (a.k.a. Cdc4
54 in- and proteasome-binding factors Rad23 and
valosin-
containing protein (VCP/p97), findings that supp
55 nerative disorder caused by mutations in the
valosin-
containing protein (VCP7) gene.
56 Valosin-
containing protein (VCP; p97; cdc48 in yeast) is
57 Our data identify two molecules,
valosin-
containing protein and apoptosis-linked gene-2 (
58 tudy, we show that interactions of Atx3 with
valosin-
containing protein and hHR23B are dynamic and mo
59 membranes, a process known to be mediated by
valosin-
containing protein and necessary for ER-associat
60 er functional convergence, ubiquilin 2, p62,
valosin-
containing protein and optineurin are all linked
61 d by C1orf124 requires its interactions with
valosin-
containing protein and PCNA.
62 The AAA-ATPase p97/
valosin-
containing protein associates with both CaR and
63 The cytosolic p97/
valosin-
containing protein is an essential ATPase for de
64 Valosin-
containing protein is recruited to Insig-1 throu
65 llowing receptor engagement, suggesting that
valosin-
containing protein may target the ubiquitinated
66 VCIP135 (
valosin-
containing protein p97/p47 complex-interacting p
67 he members of this family, the hexameric p97/
valosin-
containing protein p97/VCP, is essential for the
68 C1orf124 also binds to the AAA-ATPase
valosin-
containing protein via its SHP domain, and cellu
69 h a variety of cellular activities) p97/VCP (
valosin-
containing protein) cause a dominantly inherited
70 ant disorder caused by mutations in the VCP (
valosin-
containing protein) gene.
71 The AAA ATPase p97 (also called
valosin-
containing protein) participates in the retro-tr
72 verse cellular activities), also called VCP (
valosin-
containing protein), is an important therapeutic
73 ant disorder caused by mutations in p97/VCP (
valosin-
containing protein).
74 p97, also known as
valosin-
containing protein, is a versatile participant i
75 tion of growth factor receptors and p97 VCP (
valosin-
containing protein, termed Cdc48 in Saccharomyce
76 usly identified putative molecular chaperon,
valosin-
containing protein, undergoes tyrosine phosphory
77 roteome revealed that a 9-kDa protein, small
valosin-
containing protein-interacting protein (SVIP), i
78 Valosin-
containing protein-like ATPase of Thermoplasma a
79 to the Hrd1-mediated ubiquitination and the
valosin-
containing protein-mediated extraction pathway.
80 NMR titration experiments confirmed a
valosin-
containing protein/p97 interaction motif and ide
81 Valosin-
containing protein/p97 is an ATP-driven protein
82 ormally after PR39 treatment, and binding of
valosin-
containing proteins is not impaired.