ライフサイエンスコーパス: vanilloid receptor

1 sts the existence of distinct classes of the vanilloid receptor ().

2 that also expressed substance P and the VR1 vanilloid receptor.

3 stances is a recent acquisition of mammalian vanilloid receptors.

4 ing they do not arise from the activation of vanilloid receptors.

5 data provide strong evidence for subtypes of vanilloid receptors.

6 xpression of the heat and capsaicin receptor vanilloid receptor 1 (TRPV1 or VR1) was changed in recta

7 l)thiourea (IBTU), a novel antagonist of the vanilloid receptor 1 (TRPV1 or VR1).

8 ., capsaicin, a transient receptor potential vanilloid receptor 1 (TRPV1) agonist] stimuli and becaus

9 Vanilloid receptor 1 (TRPV1) has been proposed to be the

10 Vanilloid receptor 1 (TRPV1) is activated by chemical li

11 The three-dimensional structure of the vanilloid receptor 1 (TRPV1) was recently determined by

12 IX, XII, and XIV and cytosolic CA II and the vanilloid receptor 1 (TRPV1) were expressed in duodenum

13 ermined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel activated

14 Vanilloid receptor 1 (TRPV1), a membrane-associated cati

15 Vanilloid receptor 1 (TRPV1), a nonspecific cation chann

16 We investigated the hypothesis that vanilloid receptor 1 (TRPV1), a transducer of noxious he

17 In particular, the Vanilloid Receptor 1 (TRPV1), besides being involved in

18 es the neuronal transient receptor potential vanilloid receptor 1 (TRPV1), expressed on sensory C-fib

19 ensitization of transient receptor potential vanilloid receptor 1 (TRPV1), which is gated by capsaici

20 Transient receptor potential vanilloid receptor 1 (TRPV1)-mediated release of neuroac

21 vity of the bronchopulmonary C-fibres to the vanilloid receptor 1 (VR1) agonist capsaicin was depende

22 Expression of the heat-sensitive vanilloid receptor 1 (VR1) and sensitivity to capsaicin

23 ely 3 s acid treatment was not affected by a vanilloid receptor 1 (VR1) antagonist, capsazepine (10 m

24 ous studies demonstrate an important role of vanilloid receptor 1 (VR1) in inflammation and injury-in

25 Vanilloid receptor 1 (VR1) is expressed by sensory neuro

26 Vanilloid Receptor 1 (VR1), a member of the TRP family o

27 Because primary afferents that express vanilloid receptor 1 (VR1), a receptor for noxious heat,

28 The CP receptor, vanilloid receptor 1 (VR1), has been shown to be highly

29 identifying " peptide-rich" neurons; or the vanilloid receptor 1 (VR1), identifying neurons activate

30 minals of cranial visceral afferents express vanilloid receptor 1 (VR1), little is known about their

31 d immunofluorescence labelling revealed that vanilloid receptor 1 (VR1)-containing afferent nerve fib

32 Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective

33 In horizontal brainstem slices, we used the vanilloid receptor 1 agonist capsaicin (CAP; 100 nm) to

34 2+ transients were completely blocked by the vanilloid receptor 1 antagonist capsazepine (100 microm)

35 Vanilloid receptor 1 belongs to the transient receptor p

36 unofluorescence labeling showed a diminished vanilloid receptor 1 immunoreactivity in dorsal root gan

37 tion channel subfamily V member 1 (TRPV1) or vanilloid receptor 1 is a nonselective cation channel th

38 ctivation of endoplasmic reticulum-localized vanilloid receptor 1 triggered store operated calcium en

39 against proteinase-activated receptor 2 and vanilloid receptor 1, a marker for primary nociceptive n

40 t receptor potential vanilloid 1 (TRPV1), or vanilloid receptor 1, is the founding member of the vani

41 The vanilloid receptor-1 (TRPV1 or VR1) is a member of the t

42 tent agonist of transient receptor potential vanilloid receptor-1 (TRPV1), abolished DD responses and

43 in Sprague-Dawley rats, and in wild-type and vanilloid receptor-1 (VR-1) knockout mice.

44 The vanilloid receptor-1 (VR1 or TRPV1) is a member of the t

45 The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound,

46 The vanilloid receptor-1 (VR1) is a ligand-gated, non-select

47 the activation of afferent central terminal vanilloid receptor-1 (VR1) receptors and P2X receptors.

48 The capsaicin receptor, vanilloid receptor-1 (VR1), is an important cation chann

49 Vanilloid receptor-1 (VR1, also known as TRPV1) is a the

50 minor role for transient receptor potential vanilloid receptor-1 as mediators of cutaneous acid-indu

51 spective TRPV1 (transient receptor potential vanilloid receptor-1) and TrkA receptors on nociceptor s

52 Vr1, stretch-inactivated channel (SIC), and vanilloid receptor 5' splice variant (VR.5'sv) have been

53 Here, we report the isolation of a vanilloid receptor 5'-splice variant (VR.5'sv) which dif

54 lose, glucose, caffeine, denatonium, and the vanilloid receptor activator capsaicin all stimulated se

55 antagonist SR141716A but not mimicked by the vanilloid receptor agonist capsaicin.

56 molecular characterization of the capsaicin (vanilloid) receptor, an excitatory ion channel expressed

57 nmyelinated nerve fibers expressing both the vanilloid receptor and purinergic receptors.

58 The competitive vanilloid receptor antagonist capsazepine inhibited [(3)

59 atively impermeant CA inhibitor benzolamide, vanilloid receptor antagonist capsazepine, or sodium-hyd

60 ese responses were also not inhibited by the vanilloid receptor antagonist, capsazepine, suggesting t

61 show that the engagement of the cannabinoid/vanilloid receptors augments the number and immune suppr

62 We conclude that certain MCs possess vanilloid receptors, but only the C-type that functions

63 enhance the piperine current by altering the vanilloid receptor/channel complex or increasing the len

64 and cytokines) and relevant receptors (e.g., vanilloid receptor channels and proteinase-activated, ca

65 nit involved in the formation of heteromeric vanilloid receptor channels.

66 al for temperature sensing in heat-activated vanilloid receptor channels.

67 ed calcium-induced calcium release in either vanilloid receptor-expressing neurons or heterologous ex

68 The analysis of vanilloid receptor gene knockout mice confirms the invol

69 ) transiently or stably expressing the human vanilloid receptor hVR1.

70 Thus, (+/-)-epibatidine may inhibit the vanilloid receptor in a manner that is not dependent upo

71 Furthermore, NADA potently activates native vanilloid receptors in neurons from rat dorsal root gang

72 tor pharmacology in the PNS, the function of vanilloid receptors in the brain has remained elusive.

73 The transient receptor potential TRPV1 or vanilloid receptor is a nonselective ligand-gated channe

74 es of pyridinylpiperazine ureas (3) as TRPV1 vanilloid receptor ligands.

75 The presence of P2X1 receptors and vanilloid receptor like 1 protein on somatostatin-contai

76 The vanilloid receptor-like 1 protein (VRL-1, also called TR

77 peptide (CGRP) and substance P; the related vanilloid receptor-like protein (VRL) 2; glial markers S

78 r of the vanilloid receptor/TRP gene family, vanilloid receptor-like protein 3 (VRL3, also known as T

79 annel with mechanosensitive properties and a vanilloid receptor-like protein that is responsive to hi

80 The distribution of vanilloid receptor like1 immunoreactivity (VRL1-IR) in t

81 In this context, the recent cloning of the vanilloid receptor may be a useful target for drug disco

82 of their possible relation to the sensitized vanilloid receptor mechanism unique to nociceptors.

83 g resiniferatoxin (RTX) act through specific vanilloid receptors on sensory neurons.

84 elicits buming pain by activating specific (vanilloid) receptors on sensory nerve endings.

85 f the rapid advances in our understanding of vanilloid-receptor pharmacology in the PNS, the function

86 These neurons contain two vanilloid receptor pools, one in the plasma membrane and

87 between the endoplasmic reticulum-localized vanilloid receptor regulated stores and thapsigargin-sen

88 f ion channels, we cloned cDNAs encoding the vanilloid receptor-related osmotically activated channel

89 The TRPV4 ion channel, previously named vanilloid receptor-related osmotically activated channel

90 ge- and time-dependent properties of the rat vanilloid receptor (rVR1) stably expressed in human embr

91 us oocytes heterologously expressing the rat vanilloid receptor (rVR1).

92 chanism by which such ligands could modulate vanilloid receptor signaling.

93 ously found that a Drosophila protein in the vanilloid receptor subfamily (TRPV) channel subunit, Nan

94 ly (transient receptor potential superfamily-vanilloid receptor subfamily) of channel genes have been

95 Vanilloid receptor subtype 1 (VR1) is a ligand-gated cha

96 The recently cloned vanilloid receptor subtype 1 (VR1) is a ligand-gated cha

97 capsaicin stimulates muscle metabosensitive vanilloid receptor subtype 1 (VR1), inducing a neurally

98 cloned capsaicin receptor, also known as the vanilloid receptor subtype 1 (VR1), is a heat-gated ion

99 enes neighboring CTNS (human ortholog of rat vanilloid receptor subtype 1 gene, CARKL, TIP-1, P2X5, a

100 s positive for the nociceptive neuron marker vanilloid receptor subtype 1, the small peptidergic neur

101 expression, including downregulation of the vanilloid receptor subtype 1.

102 Vanilloid receptor subtype-1 (VR1) is a nonselective cat

103 Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and fou

104 provide further support for the existence of vanilloid receptor subtypes on DRG neurons with distinct

105 n channel but it may represent an additional vanilloid receptor subunit involved in the formation of

106 response by identifying a domain of the rat vanilloid receptor that confers sensitivity to capsaicin

107 For example, the vanilloid receptor transient receptor potential 3 (TRPV3

108 emperature-sensitive cationic channels (e.g. vanilloid receptor TRP channels) constitute the underlyi

109 Here we identify a member of the vanilloid receptor/TRP gene family, vanilloid receptor-l

110 The vanilloid receptor TRPV1 (formerly VR1) has been implica

111 The vanilloid receptor TRPV1 (transient receptor potential v

112 The opposite effects of PIP2 on the vanilloid receptor TRPV1 and TRPM8 also implies that the

113 Vanilloid receptor TRPV1 is a cation channel that can be

114 Phosphorylation-dependent modulation of the vanilloid receptor TRPV1 is one of the key mechanisms me

115 mice but not in transient receptor potential vanilloid receptor TRPV1(-/-) mice.

116 s AEA; however, CP acts by engagement of the vanilloid receptor TRPV1, causing local production of AE

117 The vanilloid receptor TRPV1, previously known as VR1, has b

118 ied the recovery from desensitization of the vanilloid receptor TRPV1.

119 n embryonic kidney 293T cells expressing the vanilloid receptor (TRPV1) or a purinergic receptor (P2X

120 Most nociceptive neurons express the vanilloid receptor, TRPV1, a nonselective cation channel

121 was attributable to stimulation of neuronal vanilloid receptor, TRPV1, because blockers of this chan

122 The vanilloid receptor TRPV2 is involved in detection of nox

123 expressing a calcium-permeable ion channel, vanilloid receptor type 1 (the capsaicin receptor), and

124 Vanilloid receptor type 1 (TRPV1) is a ligand-gated nons

125 This study investigated the contribution of vanilloid receptor type 1 (VR-1) containing fibers to SC

126 The vanilloid receptor type 1 (VR1) is a heat-activated iono

127 This effect was sensitive to vanilloid receptor (VR) antagonists.

128 The responses of vanilloid receptor (VR) channels to changing membrane po

129 ctivity relations, suggestive of independent vanilloid receptor (VR) subtypes.

130 Native and cloned vanilloid receptor (VR)-mediated currents exhibited outw

131 edge of the distribution and function of the vanilloid receptor (VR-1 or TRPV1) in the CNS lacks the

132 nals in the rat spinal cord that express the vanilloid receptor VR1 are from small and medium dorsal

133 The vanilloid receptor VR1 has attracted great interest as a

134 The cloned vanilloid receptor VR1 has attracted recent attention as

135 The vanilloid receptor VR1 is a nonselective cation channel

136 The vanilloid receptor VR1 is a polymodal nociceptor sensiti

137 The vanilloid receptor VR1 provides one exception.

138 ately 2%) IB4-positive neurons expressed the vanilloid receptor VR1, a heat-sensitive receptor expres

139 ns colocalized with immunoreactivity for the vanilloid receptor VR1, another protein associated prima

140 Its molecular target, the vanilloid receptor VR1, was recently cloned and confirme

141 to function as an endogenous agonist at the vanilloid receptor VR1.

142 The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by

143 Activation of vanilloid receptor (VR1) by protein kinase C (PKC) was i

144 The cloned vanilloid receptor (VR1) is a cation channel that is als

145 The vanilloid receptor (VR1) is a nonselective cation channe

146 The recently cloned vanilloid receptor (VR1) is postulated to account for he

147 nociceptive neurons expressing the wild-type vanilloid receptor (VR1) were investigated.

148 f proteins and is a homolog of the capsaicin/vanilloid receptor (VR1, or TRPV1).

149 family V, member 1 (TRPV1; also known as the vanilloid receptor, VR1) in nociceptive neurons of the d

150 The recently cloned rat vanilloid receptor, VR1, can be activated by capsaicin,

151 The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific i

152 Capsaicin or vanilloid receptors (VRs) participate in the sensation o

153 h non-CB1, SR141716A-sensitive site, the VR1 vanilloid receptor, was tested by administering SR141716