ライフサイエンスコーパス: variable region

1 -specific responses (targeting V1, V2, or V3 variable regions).

2 c antibodies with specificity for the unique variable region.

3 the length and amino acid composition of the variable region.

4 ous phosphorylation sites within the PACSIN2-variable region.

5 nce changes accumulated throughout the MG192 variable region.

6 ngineering new functions into the antibody's variable region.

7 ymphoma immunoglobulin heavy- or light-chain variable regions.

8 ogically active forms of cagA with longer 3' variable regions.

9 luenza infection but generally target highly variable regions.

10 permutation, both in their CDR and framework-variable regions.

11 and also immunodominant epitopes located in variable regions.

12 ghout the protein and not just in the highly variable regions.

13 into the Env trimer fold as well as more the variable regions.

14 f sequence coverage of both the constant and variable regions.

15 tated by a relatively few amino acids within variable regions.

16 despite ongoing somatic hypermutation of Ig variable regions.

17 of conserved regions interweaved with highly variable regions.

18 cells expresses a unique set of IgH and IgL variable regions.

19 that harbored substitutions and deletions in variable region 1 (V1), V2, and V4 of Env.

20 plasma IgG against the HIV-1 envelope (Env) variable region 1 and 2 inversely correlated with risk,

21 oduces reads spanning 16S ribosomal RNA gene variable regions 1 and 2 ( approximately 360 bp) with a

22 d directly with antibodies to HIV-1 envelope variable regions 1 and 2 (V1-V2).

23 Variable regions 1 and 2 (V1/V2) of human immunodeficien

24 ction risk: the binding of IgG antibodies to variable regions 1 and 2 (V1V2) of HIV-1 envelope protei

25 s capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the HIV-1 envelope, b

26 tralization by monoclonal antibodies against variable regions 1 and 2 (V1V2), suggesting that SIV and

27 the T cell antigen receptor (TCR) beta-chain variable region 11 (TRBV11-2) were 'preferentially' acti

28 y the expression of an invariant alpha-chain variable region 14-alpha-chain joining region 18 (V(alph

29 17, as well as with mucosal IgG to the gp120 variable region 2 (V2) and the expression of 12 genes, t

30 immune pressure in the HIV-1 envelope (Env) variable region 2 (V2) focused on residue 169, which is

31 -chain variable region 9 and the delta-chain variable region 2 (Vgamma9Vdelta2 T cells) are the predo

32 Arabidopsis CESA7 reveals four cysteines in variable region 2 (VR2) and two cysteines at the carboxy

33 onstrate that vaccine-induced HIV-1 envelope variable region 2 and constant region 1 antibodies syner

34 om the sequence of the vaccine insert in Env variable region 2 positions 169 and 181, which were impl

35 d protection identified HIV-1 envelope (Env) variable region 2-binding antibodies as inversely correl

36 evidence, the antiviral mechanisms by which variable region 2-specific antibodies may have contribut

37 receptor (TCR) incorporating TCRdelta-chain variable-region-2 [Vdelta2((+))], which are activated by

38 lative microscopy, we found that gamma-chain variable region 5 (V(gamma)5) TCRs expressed by epiderma

39 ragine-linked glycosylation sites (PNGSs) in variable region 5 (V5) than did paired ibalizumab-suscep

40 oop D and two glycosylation sites located in variable region 5 of Env allows Env-binding to, and acti

41 reared Amblyomma americanum using PCR of the variable region 5 of the 16S rRNA gene followed by semic

42 aracterized by high-throughput sequencing of variable regions 7-9 of prokaryotic 16S ribosomal DNA.

43 xpressing the TCR containing the gamma-chain variable region 9 and the delta-chain variable region 2

44 ptor binding domain (RBD) extends beyond the variable regions A and B (VRA and VRB, respectively), to

45 ric between GALV and KoRV-B established that variable regions A and B of the surface unit of the enve

46 results suggest that outside of structurally variable regions, admixture does not substantially disru

47 g these loci, and highlight that copy number variable regions allow for the creation of novel genes t

48 lonal IgG(1) antibodies which share over 90% variable-region amino acid sequence identity and recogni

49 In contrast, Met oxidation in the variable region and CH3 domain had no detectable impact

50 reaction amplification of the 16S rRNA V4-V5 variable region and deep sequencing using the Illumina M

51 ulated by PACSIN1 phosphorylation within the variable region and is required for AMPAR endocytosis.

52 itopes on spikes, including the proximity of variable regions and a high density of glycans.

53 rimer pairs in conserved regions that border variable regions and could differentiate between serotyp

54 These antibodies express identical variable regions and display the same specificity.

55 comparing monoclonal IgA1 that had different variable regions and mesangial deposition patterns indic

56 Env also contains variable regions and protein surfaces occluded within th

57 binding epitopes on the therapeutic antibody variable region, and featured inhibitory and neutralizin

58 ptide sequences are attributable to antibody variable regions, and are potentially indicative of dise

59 tein that undergoes antigenic variation at 7 variable regions, and variants are selected by immune pr

60 nal status of the immunoglobulin heavy-chain variable region are important in clinical management of

61 ncoded elements in the T cell receptor (TCR) variable regions are evolutionarily conserved to only re

62 fidence peptide spectral matches of antibody variable regions are obtained by searching a reference d

63 The atp1 gene is flanked by very variable regions, as deduced from four completely sequen

64 Furthermore, our data show that some variable regions associated with either chain can remain

65 served central core region with structurally variable regions at the amino- and carboxyl termini, tha

66 ir major viral protein 3 contains loops with variable regions at their apexes conferring capsid surfa

67 8 weeks of infection, sequences within mgpB variable region B were replaced by novel sequences gener

68 ressing an SEA-nonresponsive T-cell receptor variable region beta chain are nonresponsive to SEA in m

69 n within the well-known activation T-loop, a variable region between protein kinase catalytic subdoma

70 These antigen-binding variable regions can interfere with protein function or

71 , antibodies that were bioengineered to have variable regions capable of binding to neurons or oligod

72 king of conserved stereotypic features of Ig variable regions characteristic of U-CLL indicate circul

73 w often gene segments are chosen to complete variable region coding exons remain elusive.

74 The MG192 variable region consisted of 11 discrete subvariable reg

75 Identical variable regions consistently neutralized virus more pot

76 Protochordate variable region-containing chitin-binding proteins (VCBP

77 Each variable region contains three antigen-contacting comple

78 cificity, challenging the paradigm that only variable regions contribute to antigen binding.

79 selection and/or mutability of the antibody variable region contributed significantly to observed de

80 N-linked glycosylation and sequence-variable regions cover the pre-fusion closed spike; we u

81 rminus of Bacillus subtilis FtsZ (C-terminal variable region (CTV)) are both necessary and sufficient

82 omologous inoculation of the PF2-containing, variable region-deleted YU2 gp120 trimers (DeltaV123/PF2

83 Analysis of previously reported genomic variable regions demonstrated that these regions were li

84 llama single-domain VHH (camelid heavy-chain variable region derived from heavy-chain-only antibody)

85 In this study the gp120 variable-region determinants were mapped for eight rhesu

86 ce exposure of amino-acid side-chains in the variable region directly from the antibody sequence.

87 activate the mutational machinery at Ig gene variable regions during SHM.

88 N-glycosylation sites in the immunoglobulin variable regions during somatic hypermutation.

89 e nucleotide substitutions in immunoglobulin variable regions during somatic hypermutation.

90 mposition undergo stepwise rearrangements of variable region-encoding gene segments.

91 or genes for the heavy chain and light chain variable region-encoding genes were determined by using

92 In developing B cells, IgH variable-region exon assembly is ordered with D to J(H)

93 T cell antigen receptor delta (Tcrd) variable region exons are assembled by RAG-initiated V(D

94 Ig heavy-chain variable region exons are assembled developmentally from

95 Antigen receptor variable region exons are assembled during lymphocyte de

96 T cell receptor (TCR) variable region exons are assembled from germline V, (D)

97 Immunoglobulin heavy chain (IgH) variable region exons are assembled from V(H), D and J(H

98 Ig heavy chain (IgH) variable region exons are assembled from V, D, and J gen

99 noglobulin heavy (IgH) and light (IgL) chain variable region exons from germline gene segments to gen

100 V, D, J segments (that can be assembled into variable region exons that encode bnAb precursors), have

101 in progenitor B (pro-B) cells assembles Igh variable region exons upstream of mu constant region (Cm

102 n sites: one present on the heavy chain (HC) variable region (Fab) and the other present on the conse

103 une-challenged chicken single-chain antibody variable-region fragment (scFv) libraries targeting the

104 Molecular characterization of the Ig variable region from 320 sequences expressed by germ cel

105 ire sequencing of PB and CSF IgG heavy chain variable regions from MS patients.

106 showed previously that deletion of the three variable regions from the E2 receptor-binding domain (De

107 t immunotoxins containing mouse single-chain variable regions fused with a Pseudomonas toxin.

108 A variable region fusion strategy was used to generate an

109 An empirical model relating variable region (Fv) charge and hydrophobicity to cyno n

110 identified by their coexpression of the TCR variable regions gamma4 and delta4.

111 mined the role of immunoglobulin heavy-chain variable region gene (IGHV) mutation status and genetic

112 Use of immunoglobulin heavy-chain variable region gene families 1 (IGHV1) and 5 (IGHV5) wa

113 ed lymphomas use a restricted immunoglobulin variable region gene repertoire.

114 tools for determining the complete set of Ig variable region gene segment alleles carried by an indiv

115 is required for assembly of antigen receptor variable region gene segments by V(D)J recombination.

116 We reasoned the introduced human variable region gene segments would function indistingui

117 minal center (GC) disruption experiments and variable region gene sequencing.

118 IgM(+) B cells had Ig variable region gene usage similar to IgG but with fewer

119 respective of the immunoglobulin heavy-chain variable-region gene (IGHV) mutational status.

120 Ig and T-cell receptor (TCR) variable-region gene exons are assembled from component

121 We suggest that each TCR variable-region gene product engages each type of MHC th

122 eep repertoire sequencing of IgG heavy chain variable region genes (IgG-VH) in paired cerebrospinal f

123 o present mutated immunoglobulin heavy chain variable region genes (IGHVs), being the most frequently

124 olated used different heavy- and light-chain variable region genes and carried high levels of somatic

125 ibodies do not differ in their repertoire of variable region genes and in most of the molecular featu

126 ly that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan

127 body discovery process, and the selected IgG variable region genes were successfully humanised and re

128 ion status of the immunoglobulin heavy-chain variable region genes.

129 lower numbers of somatic mutations in their variable region genes.

130 ed to anticipate its maneuvers, the antibody variable-region genes pursue the virus in futility.

131 acing 6 Mb of mouse Ig heavy and kappa light variable region germ-line gene segments with their human

132 this aim, we characterized the repertoire of variable region germline genes of lambda LC preferential

133 server predicts the structure of an antibody variable region given the amino-acid sequences of the re

134 Here, we investigated the effect of N-linked variable-region glycosylation for BCR interaction with c

135 ions shared with closely related species and variable regions harboring genes that are unique to F. g

136 of 1 or higher and unmutated immunoglobulin variable region heavy chain (IgVH).

137 present a new method that identifies highly variable regions (HVRs), and then maps each HVR to a com

138 s revealed that the mcr-1 was located on the Variable Region I of IncX4 plasmids in 11 E. coli isolat

139 ng IgG1- and IgG3-mediated phagocytosis with variable region-identical mAbs using mouse macrophages d

140 ated (M-CLL) immunoglobulin gene heavy-chain variable region (IGHV) displays different states of aner

141 -70 expression or immunoglobulin heavy chain variable region (IGHV) status is uncertain.

142 s more evident in immunoglobulin heavy chain variable region (IGHV)-mutated, CD38(-) or early Rai-sta

143 al abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene mutation status, and zeta-as

144 e from a specific antibody gene, heavy-chain variable region IGHV1-69, after limited affinity maturat

145 lood and spleen revealed that immunoglobulin variable region (IgV) gene unmutated CLL derives from un

146 estigate the frequency of use of light-chain variable region (IGVL) genes among patients with systemi

147 N type III repeat (FNIII13), and one from FN variable region (IIICS), which when tethered to a surfac

148 avoid the vague alignments rooted in highly variable regions, improving remote homologue identificat

149 ff, although the ST and antigenic flaA short variable region in combination were stable over a number

150 n a transcription terminator into an Ig gene variable region in DT40 chicken B cell line.

151 previously characterised, common copy number variable regions in 6 independent cohorts (n = 24,237) u

152 ation allowed an analysis of the role of TCR variable regions in determining T cell lineage choice an

153 nt increase in the frequencies of SHM in Igh variable regions in Peyer's patch cells, and of double-s

154 even though the unstructured, thus generally variable regions in proteins are often flanked by very c

155 olving targeted amplification of one or more variable regions in the 16S rRNA gene.

156 frequency in nsp2, which is one of the most variable regions in the PRRSV genome, than MLV.

157 This variable region includes the reactive center loop, which

158 n serpin1 gene and four in serpin28 encode a variable region including the reactive site loop.

159 ntibody sequences for the entire heavy chain variable region, including framework, CDR1, and CDR2 mut

160 D-J gene combinations of the B-cell receptor variable region; increased frequency of variable regions

161 frequencies and spectra of mutations in the variable region, indicating that loss of Pol iota did no

162 Partitioning the human immunoglobulin variable region into variable (V), diversity (D), and jo

163 ccumulation of somatic mutations in antibody variable regions is critical for antibody affinity matur

164 ove predicted human T-cell epitopes, and the variable regions joined to human constant regions to gen

165 chimeric antigen receptors with the antibody variable regions kill MUC1(+) target cells, express acti

166 The highly variable regions lead to vague alignments in threading a

167 he PSG1 structure is composed of a single Ig variable region-like N-terminal domain and three Ig cons

168 basic segment, but not the N- and C-terminal variable regions, masks the effect of this determinant.

169 ination score and immunoglobulin heavy chain variable region mutation status were independent markers

170 ination score and immunoglobulin heavy chain variable region mutation status were independent prognos

171 ognostic markers (immunoglobulin heavy chain variable-region mutation status, CD38 or ZAP-70 cytogene

172 nd OS showed that immunoglobulin heavy chain variable region mutational status was significant for bo

173 independently of immunoglobulin heavy chain variable region mutational status, CD38, and ZAP-70 expr

174 A strand that is complementary to the target variable region of 16S rRNA of M. aeruginosa.

175 t the strategic placement of a glycan in the variable region of a monoclonal antibody can substantial

176 ug composed of a single-chain version of the variable region of an anti-alphaIIbbeta3 mAb fused to a

177 ship among chlamydial strains is linked to a variable region of chlamydial genomes, termed the plasti

178 s into exons that encode the antigen-binding variable region of Ig heavy (H) and light (L) chains.

179 The highly variable region of MG192 was amplified by PCR from M. ge

180 ghly conserved binding site found within the variable region of nearly all antibody Fab arms.

181 ere designed for the nested run to amplify a variable region of the 23S-5S intergenic spacer (IGS) of

182 ctive site was identified in the light chain variable region of the antibody.

183 uly tumor-specific cell-surface product, the variable region of the B-cell receptor (BCR), otherwise

184 We used 454-based sequencing of a variable region of the bacterial 16S ribosomal RNA gene

185 X encodes a glycosyltransferase located in a variable region of the enterococcal polysaccharide antig

186 e somatic hypermutation (SHM) pattern of the variable region of the immunoglobulin heavy gene (IgH-VH

187 attachment to the conserved portions of the variable region of the kappa and lambda light chains.

188 ER were determined to be located only on the variable region of the light chain.

189 The variable region of the MG192 gene was PCR amplified, sub

190 Point mutations were introduced into the variable region of the murine mAb to remove predicted hu

191 Deep sequencing at a highly variable region of the P. vivax merozoite surface protei

192 luded high-throughput sequencing of the CDR3 variable region of the T cell receptor beta-chain and an

193 ition activity in planta, and the C-terminal variable region of VgrG2 governs this specificity for Td

194 irst time, that every Leu/Ile residue in the variable regions of a monoclonal antibody that could not

195 The major variable regions of all the IncX4 plasmids were fully ch

196 re single-domain antibodies derived from the variable regions of Camelidae atypical immunoglobulins.

197 These amino acids are present in the variable regions of distantly related species such as sh

198 d heteroduplex tracking assays targeting the variable regions of env and single-genome amplification

199 r and immunity proteins are contained in two variable regions of GA3 loci, GA3 T6SSs of the species B

200 detergent does not involve the V1, V2, or V3 variable regions of gp120.

201 Variable regions of Ig chains provide the antigen recogn

202 Possibly the variable regions of Ig genes have evolved for low nucleo

203 y selected from a naive library derived from variable regions of llama heavy chain-only antibodies, a

204 all level of selective constraint within the variable regions of mammalian proteins allows the metabo

205 polymerase chain reaction (RT-PCR) amplified variable regions of mouse immunoglobulin genes using a s

206 umvented the lack of antibodies specific for variable regions of mouse TCRalpha chains and the need f

207 reflect accurate genetic distances in highly variable regions of rRNA genes than do traditional multi

208 ddition, we have cloned and expressed the Ig variable regions of several L chain-included B cells in

209 A/HBV peptide complexes through the TCR-like variable regions of the antibodies.

210 engineered IgA2m(1) antibody containing the variable regions of the EGFR antibody cetuximab.

211 within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and m

212 eliciting immunodominant responses targeting variable regions of the HIV proteome are hurdles in the

213 rse antibody repertoire against constant and variable regions of the therapeutic antibody immunogen.

214 Starting from the parent murine variable regions of three currently marketed mAbs target

215 The variable regions of two anti-murine CD8-depleting antibo

216 ion process, and by the introduction, in BCR variable regions, of N-glycosylation acceptor sites harb

217 Hemizygous deletion of a variable region on chromosome 11q containing FLI1 causes

218 Grafting the mAb variable regions onto the IgG2 constant region dramatica

219 A new picture emerges of the central V (variable) region, predicted to contain a carbohydrate-bi

220 sequencing of an immunoglobulin heavy chain variable region repertoire before vaccination revealed a

221 ognition, and seemingly minor changes to its variable region reprogram recognition outcomes.

222 The use of complex disulfide bonds within variable regions required for receptor binding is found

223 nserved bocaparvovirus-specific features and variable regions resulting in unique surface topologies

224 olymorphisms (SNPs) immediately flanking its variable region (rs25531 and rs25532), the intron 2 VNTR

225 ur different human single chain Fragments of variable regions (scFv) were tested, three of which show

226 to make mice that more efficiently use human variable region segments in their humoral responses by p

227 em for analyzing vast amounts of heavy chain variable region sequences and exploring the resulting da

228 Analysis of 1833 B cell receptor heavy chain variable region sequences demonstrated that antigen-expe

229 significantly higher antibody titers to tprK variable region sequences found in the inoculum compared

230 Analysis of variable region sequences of 16 clones suggests that the

231 y coexpressing paired heavy- and light-chain variable region sequences of 51 plasma cell clones and 2

232 showed that these antibodies have different variable region sequences, suggesting that the individua

233 Matched heavy- and light-chain variable-region sequences were amplified from single IgG

234 IgH) class switch recombination (CSR) and Ig variable region somatic hypermutation (SHM) in B lymphoc

235 pathogens and toxins through the coupling of variable region specificity to Fc-triggered cellular act

236 se two vaccine-elicited mAbs and the topside variable region spike cap, whereas the bNAbs duck under

237 Highly variable regions, such as the density assigned to the la

238 t of the outer membrane, with its C-terminal variable region surface exposed.

239 A T-cell receptor (TCR)-variable region, TCR-Vbeta13, is required for susceptibi

240 ounder virus with shorter, less glycosylated variable regions than matched chronic viruses.

241 veral evolutionary conserved residues in TCR variable regions that contact MHC.

242 re, but achieve functional diversity through variable regions that determine how the catalytic core i

243 provide protection exclusively through their variable region; the contributions of mechanisms conferr

244 ell receptors (TCRs) can use the same set of variable regions to bind both proteins, we have presente

245 bilized gp120 core (0G) deleted of its major variable regions to preferentially expose the conformati

246 actions between targeted switch (S) regions, variable region transcription before somatic hypermutati

247 es of recipient T-cell receptor beta-subunit variable region (TRbetaV) were analyzed.

248 igen-specific chimeric human IgE (with mouse variable regions) upon the immunization with ovalbumin a

249 a chains and the need for prior knowledge of variable region usage in the TCRbeta chain, resulting in

250 or generating fully human mAbs from nonhuman variable regions using information from the human germli

251 of the Igh locus works at long distances on variable region (V(H)) and switch region (I) region prom

252 ere, we review known interactions at the Igh variable region (V(H)) promoters and present our perspec

253 tibody is domain exchange of the heavy-chain variable region (V(H)) with the V(H) of the adjacent Fab

254 respectively, IgH switch (S) regions and Ig variable region (V) exons.

255 and bioinformatic analysis to mine antibody variable region (V)-gene repertoires from bone marrow pl

256 tify large numbers of heavy- and light-chain variable regions (V(H) and V(L)) in a given B-cell reper

257 n this study, amino acid sequences of 27 cAb variable regions (V(H)H) were aligned with the respectiv

258 ers and bind antigens by their single domain variable regions (V-NARs).

259 Furthermore, our results indicate that Env variable regions V1, V2, V3, and V5 do not represent a m

260 olated, and PCR amplicons from 16S rRNA gene variable regions V1-V3 and V3-V5 from these fractions we

261 n tolerate a high degree of mutation in five variable regions (V1-V5), and also at N-linked glycosyla

262 he region consisting of the first and second variable regions (V1V2) of gp120 plays vital roles in th

263 esence of antibodies to the first and second variable regions (V1V2) of gp120 was associated with the

264 hat the presence of antibodies to the second variable region (V2) of HIV-1 gp120 was responsible for

265 rabbit MAbs, R56 and R20, against the third variable region (V3) of HIV-1 gp120.

266 The third variable region (V3) of the gp120 is immunodominant and

267 The levels of antibodies to the third variable region (V3) of the HIV envelope protein correla

268 idging sheet and the base of the third major variable region (V3), which are elements of the CoRbs.

269 pping predominantly to the gp120 third major variable region (V3).

270 Analysis of the two most variable regions (V4 and V6) in five sequential specimen

271 he T cell antigen receptor (TCR) alpha-chain variable region (Valpha) and beta-chain variable region

272 n 3 (CDR3) regions containing the beta-chain variable region (Vbeta) demonstrated a more diverse repe

273 irrespective of the member of the beta-chain variable region (Vbeta) family present in the TCR or the

274 hain variable region (Valpha) and beta-chain variable region (Vbeta).

275 ell clone expansion involved the heavy chain variable region (Vh) 5 and Vh7 B-cell receptor families

276 single rearranged immunoglobulin heavy chain variable region (VH) sequence for each clone.

277 sequenced the paired heavy- and light-chain variable regions (VH and VL, respectively) from large po

278 equencing of immunoglobulin (Ig) heavy chain variable regions (VH) from CSF and subsorted peripheral

279 osition 41, a non-CDR residue in heavy chain variable regions (VH), is important for humanization of

280 Most of these antibodies use the heavy-chain variable region VH1-69 gene, and structural data demonst

281 The variable regions (VHH) in these heavy chain-only Abs dem

282 the present study, we developed GPI-anchored variable regions (VHHs) of two heavy chain-only antibodi

283 The variable regions (VHHs) of two heavy chain-only antibodi

284 n scissile bond specificity, we identified 3 variable regions (VR1, -2, and -3) in the ADAMTS family

285 Using a bioinformatics approach, six variable regions (VRI-VRVI) were identified.

286 tional differences in two of the AAV surface variable regions (VRs), VR-IV and VR-VII.

287 t the major ADK8 epitope is formed by an AAV variable region, VRVIII (amino acids 586 to 591 [AAV8 VP

288 The tumor immunoglobulin heavy chain variable region was more frequently unmutated in CLL cel

289 lysines, serines, and threonines in the NS-1 variable region was necessary to significantly reduce ub

290 Somatic mutations within the immunoglobulin variable region were almost exclusively presented by MHC

291 the PCR results, 20 amplicons of the cagA 3' variable region were sequenced, and analyzed in silico,

292 Variable regions were cloned and expressed as recombinan

293 Two novel variable regions were identified.

294 ibodies directed against the gp120 V2 and V3 variable regions were isolated from the immunized monkey

295 The cloned IgG-specific AHA-variable regions were mutated from germ line-derived seq

296 Interestingly, the variable region, which binds to PICK1, is not essential

297 ptor variable region; increased frequency of variable regions with higher content of positively charg

298 mAbs, comprising fully human variable regions with subnanomolar Ag affinity and carry

299 and one guanylate kinase domain, flanked by variable regions with unknown structures.

300 by segmental recombination between discrete variable regions within mgpB and mgpC and multiple archi