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1 ion (body mass relative to size) behave more variably.
2 l cells to which individual units contribute variably.
3 nged consistently with fat fraction but more variably.
4 ereas its catalytic USP domain is positioned variably.
5 p3 also attenuated skin disease, albeit more variably.
6      Many elements in the telomere have been variably 5'-truncated apparently by gradual erosion and
7 ed by the effectiveness of adaptation to the variably acidic environment of the host stomach.
8 t the alphaLbeta2 of CLL cells is already in variably activated conformations, which are not further
9        These compounds were synthesized from variably acylated glycopyranosyl azides and either 3- or
10    Intriguingly, although seahorse mutations variably affect fluid flow in Kupffer's vesicle, they ca
11 w that these tumor-mediated alterations also variably affect NK cell subsets.
12 ion evaluation revealed that these mutations variably affect transcription, protein expression, prote
13 stigated at multiple locations in an aquifer variably affected by a large, wastewater-derived contami
14 c systems (high delta(15)N, low delta(18)O), variably affected by denitrification.
15 lpha1-M1 domain impaired GABA activation and variably affected etomidate sensitivity.
16 e a hormone response element-driven reporter variably affected the strength and polarity of these res
17                    Protein glycosylation was variably affected.
18                           T lymphocytes were variably affected.
19 every case, whereas the entorhinal cortex is variably affected.
20                 In vivo inhibition of mAChRs variably affects CD4(+) T-cell subsets, and desiccating
21                                 K. brevis is variably allelopathic to multiple competitors, typically
22 mannopyranosyl residues (D-Rha4NFo) that are variably alpha(1-->2)- and alpha(1-->3)-linked.
23  express vascular cell adhesion molecule and variably alpha-smooth muscle actin and vimentin, portend
24 did not disrupt intracellular expression and variably altered cell surface expression.
25  greatly enhanced light sensitivity, mutants variably altered in Pfr-to-Pr thermal reversion and nucl
26 if protein was expressed over time, although variably, and these changes could not be linked to mutat
27 lighted that regulatory definitions are only variably applicable and used at present.
28 ical and pathological criteria, which may be variably applied.
29 ogic variants of Borrelia burgdorferi, known variably as "cyst forms" and "L-forms," are responsible
30 lyses demonstrated that hydroxamates can act variably as substrates for MPO and convert the enzyme to
31  8 (CDK8), cyclin C, MED12, and MED13 form a variably associated Mediator subcomplex (termed the CDK8
32 hindbrain malformation ('molar tooth sign'), variably associated retinal dystrophy, nephronophthisis,
33 sive spastic paraparesis and polyneuropathy, variably associated with behavioral changes, cognitive i
34       The term cardiorenal syndrome has been variably associated with cardiorenal failure, worsening
35           Monoallelic deletions of 20p12 are variably associated with cleft palate, short stature, an
36 on, three polymorphisms in the GALC gene are variably associated with disease mutations and have unkn
37 itivity to ionizing irradiation (IR) and are variably associated with growth retardation, microcephal
38 l learning, and visuomotor coordination were variably associated with HVI, Crus I, Crus II, HVII B an
39 se in the context of immunodeficiency and is variably associated with liver damage.
40 en found, vestibulopathy with normal hearing variably associated with migraine is likely monogenic an
41                       Vascular anomalies are variably associated with overgrowth, skeletal anomalies,
42             A locus for triphalangeal thumb, variably associated with pre-axial polydactyly, was prev
43 mum in aerodynamic diameter (PM2.5) has been variably associated with preterm birth (PTB).
44 ized by a distinctive hindbrain malformation variably associated with retinal dystrophy and cystic ki
45       Polymorphisms in these genes have been variably associated with susceptibility to TB among diff
46 ant inheritance of thoracic aortic aneurysms variably associated with the bicuspid aortic valve was u
47 , and prenatal vitamin D deficiency has been variably associated with these disorders in offspring.
48        A general theme is that JAK2 V617F is variably associated with thrombosis and, more consistent
49 ic regions, and sociopolitical settings, and variably associates with different risk factors, suggest
50    This latter paradoxical activity has been variably attributed to GAP/enzymatic or non-GAP/scaffold
51                  These extinctions have been variably attributed to the impacts of climate change and
52 or agonist efficacies were significantly and variably augmented in RSK2 KO MEFs compared with WT MEFs
53 B, with a trend for microglial activation to variably be above control.
54 ration in response to specific antigens have variably been described, specific immunological abnormal
55 -12 (IL-12), IL-23, IL-17A, and IL-17RA have variably beneficial effects in psoriasis, Crohn's diseas
56 an genome (core genes plus genes distributed variably between strains) probably supported by an atypi
57      We found that VVOs expressed caveolin-1 variably but, in contrast to caveolae, were present in n
58         Changes in eye position are known to variably, but inconsistently, shift sound localization,
59 H NMR, UV-vis, and infrared spectroscopy and variably by elemental analysis, mass spectrometry, and X
60                    The senescence program is variably characterized by several non-exclusive markers,
61 ant phenotypic variation is progenitor cells variably choosing between two alternative fates during d
62 resented sequentially with two directions of variably coherent random dot patterns (40 degrees apart)
63 on, involving recruitment of pre-positioned, variably committed neurons into memory networks.
64 lected FeOx with variable aggregate size and variably composed FeOx-associated organic matter (OM) to
65                                              Variably conductive nanoribbons with dimensions down to
66 ts seen in primary care practices seem to be variably connected with a specific physician, and less c
67 permitted the geographical discrimination of variably contaminated herring gull eggs from the Great L
68 actor has homology to these two proteins and variably contributes to ionizing radiation-induced DSB r
69           Survival of memory B cells appears variably controlled by affinity for antigen, allowing a
70 e an underlying mechanism for generating the variably curved lattice in authentic capsids.
71         Projecting from the tufts were thin, variably curved strands with lengths (15 to 70 nm) in so
72                                          The variably curved structure of the strands suggests they m
73 es, retroviral capsids are pleomorphic, with variably curved, closed fullerene shells composed of app
74        The HIV capsid is a fullerene cone: a variably curved, closed shell composed of approximately
75    Available systemic therapies for CTCL may variably decrease tumor burden and improve quality of li
76  of GCG+ neurons did reduce food intake, and variably decreased hepatic glucose production, other GLP
77 of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis i
78                                           HK variably defined as serum K>4.5, 5, or 5.5 mmol/L occurr
79                                      ICR was variably defined if any lesion with diameter stenosis (D
80 ally across the plasma membrane by tethering variably deformable ECMs to the contractile cytoskeleton
81 tent with this process, ELISAs incorporating variably deiminated HSP90 as substrate Ag indicate a dir
82 nes we identify two siblings and a singleton variably demonstrating severe neonatal anemia, membranop
83 il with increasing soil available N that was variably dependent on carbon (C) availability.
84 ted by different anti-Gal IgG subclasses was variably dependent on FcgammaRIII, with IgG1>IgG2b>>IgG2
85                        These drugs have been variably designed to deplete specific T and B cell subse
86 t of cultures of whole embryonic kidney with variably desulfated heparin compounds indicated a requir
87                  Mosaic variants of APC were variably detected in leukocyte DNA and/or non-neoplastic
88 n both genes were deleted, ductal growth was variably diminished (likely due to variable Cre-recombin
89         Although PGM3 protein expression was variably diminished, impaired function was demonstrated
90  chronic lymphocytic leukemia (CLL), but are variably discordant with IGHV mutation status.
91 rived from cutaneous T cell lymphomas (CTCL) variably display some aspects of the T regulatory phenot
92  direct an avatar's limb to distinct targets variably displayed on a screen.
93 ed at the primary tumor site, progressing to variably distant metastatic sites in a fairly predictabl
94                              C. briggsae has variably divergent orthologs of nearly all genes in the
95 ometry to measure p53 and AID protein within variably divided blasts, qRT-PCR of p53 mRNA from cultur
96 tic epigenetic variation, identifying highly variably DNA-methylated regions in mouse and human liver
97 -1 sequences in vivo, our findings support a variably dynamic process of shifting CTL clonality laggi
98             Available influenza vaccines are variably effective each season, are of limited scope at
99                       We find pan-1(RNAi) is variably effective in knocking down PAN-1 protein and re
100 sired edits, but HDR has been reported to be variably efficient.
101 cose levels following glucose challenge, and variably elevated insulin and C-peptide levels in the no
102 tarting at 3 or 10 wk of age still contained variably elevated leukocytic infiltrates in their islets
103 ate several degenerate primers each of which variably encode the peptide region of interest.
104  heterogeneous set of cortical atrophy sites variably encompassing temporoparietal components of Wern
105 ncogenic hotspots of RAS genes and conferred variably enhanced RRAS function and stimulus-dependent M
106 ese results show that oculomotor information variably enhances auditory spatial resolution even when
107 y tumor-derived MV were MAGE 3/6(+) and were variably enriched in 42-kDa Fas ligand and MHC class I b
108 d oncogenesis, resulting in tumors that were variably ERalpha-positive, but were progesterone recepto
109 s respond selectively to bile acids that are variably excreted in male and female mouse faeces, and o
110 cellular pathology relating to 3 individuals variably exhibiting the core features of the SAVI phenot
111 uding diffuse large B-cell lymphoma (DLBCL), variably express CD30.
112 ative erythrocyte receptors for invasion and variably express cognate ligands encoded by the erythroc
113            Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which link
114 miR-30 family members were both robustly and variably expressed across functionally distinct cell typ
115 blished glioblastoma subtype classifiers are variably expressed across individual cells within a tumo
116       Since an interferon (IFN) signature is variably expressed among RA patients, we investigated wh
117                        Mutations in LMNA are variably expressed and may cause cardiomyopathy, atriove
118                   The chimeric proteins were variably expressed at the cell surface.
119           Four variants of IgA proteases are variably expressed by H. influenzae during infection of
120 D4(+), CD8(+), and CD4(-)CD8(-) subsets, and variably expressed CD56, CD161, HLA-DR, and NKG2D but ne
121                  The protein was nuclear and variably expressed during the cell cycle, maximally duri
122                           This suggests that variably expressed genes, due to the functional organiza
123 malian gene neighborhoods contain highly and variably expressed genes.
124 e (COPD) exhibit stereotyped traits that are variably expressed in each person.
125           TLRs and TLR-related proteins were variably expressed in melanoma cell lines, with 42% expr
126                                      ARC was variably expressed in samples from patients with AML.
127 ly, genes related to the cell cycle are more variably expressed in the 2i and a2i conditions.
128 ns in PSTPIP1 are incompletely penetrant and variably expressed in the PAPA syndrome.
129 ry that involves both female cooperation and variably expressed male siblicidal conflict.
130                                        Phase variably expressed N(6)-adenine DNA methyltransferases (
131                                      CD33 is variably expressed on acute myeloid leukemia (AML) blast
132       Among the outer membrane proteins, the variably expressed outer membrane protein adhesins (Vomp
133 s of a three-generation family exhibited the variably expressed phenotype, three of whom manifested C
134 8(+) HIV gag-specific T-cell responses which variably expressed several intracellular markers.
135                                      The few variably fractionated syntenic genes that were identifie
136 region of the mutant BA1 was prematurely and variably fused with loss of distal markers eHand and Msx
137 mplications (excluding mortality), which are variably grouped in published analyses using ACS NSQIP d
138 eloped for the proteomic characterization of variably-heated milk products, highlighting their limits
139 inated action of a receptor-binding protein (variably HN, H, or G) and a more conserved metastable fu
140                         These structures are variably homologized with jointed appendages of the seco
141 ermodynamic ramifications of the exposure of variably hydrated Ca-rich montmorillonites to supercriti
142                          Reactions involving variably hydrated super critical CO(2) (scCO(2)) and a N
143 n Paleocene adapisoriculids, which have been variably identified as stem euarchontans, stem primates,
144 an transitional B cells have previously been variably identified based on the high level of expressio
145 ch iteratively stitches together a number of variably illuminated, low-resolution intensity images in
146                       Vessel-derived ECs are variably immunogenic, depending upon tissue source, and
147 in floc compared to bed sediments across six variably impacted aquatic ecosystems.
148 circulating bone marrow progenitor cells and variably improve global function in heart failure.
149                      Workplace interventions variably improve MVPA levels and related cardiometabolic
150 cerebellum, the labeled terminals were found variably in all of the cerebellar nuclei.
151 rly OA cartilage, GADD45beta was distributed variably in chondrocyte clusters, in middle and deep zon
152  several forms of endocytosis may contribute variably in different conditions.
153  lacks a solid anatomic basis and results in variably inaccurate measurements for 2 reasons.
154 ral stenosis or mechanical heart valves, but variably included patients with other VHD and valve surg
155  Previous studies of resident attrition have variably included preliminary residents and likely overe
156 on of predicted microRNA target sites in the variably included region.
157                    The OpBR mutant phenotype variably includes bone expansion and fusion, Op duplicat
158 y maximal electroshock (MES) or pilocarpine, variably including electroencephalography, electrocardio
159 s variability correlated in blastocysts with variably increased 5mC/5hmC in gene bodies and repetitiv
160 nt V max for thrombin-catalyzed cleavage but variably increased the K m for procofactor up to 7-fold,
161              The existing evidence, however, variably indicates that M1 is under-activated with movem
162 anscripts for SOCS proteins were rapidly but variably induced in PBMCs from patients with metastatic
163 ng in the adventitia/perivascular tissue and variably inflaming/damaging the wall during progression
164 idual protein and chemical contaminants that variably inhibit Taq polymerase and primer annealing.
165 own of RalA, and to a lesser extent of RalB, variably inhibited the tumorigenic growth of melanoma ce
166 enhancement peppering the pons and extending variably into the medulla, brachium pontis, cerebellum,
167 eterogeneous non-Hodgkin's lymphoma that may variably involve the skin, lymph nodes, and peripheral b
168 athway, distinct signaling intermediates are variably involved in cytotoxicity and/or IFN-gamma secre
169 mechanism and that this activation mechanism variably involves DUOX1 and NOX2.
170 ctivity, we documented both consistently and variably labeled CNS structures across individuals.
171 ST131 isolates; representative isolates were variably lethal in a mouse subcutaneous sepsis model.
172     Mesophyll conductance significantly, and variably, limits photosynthesis but we currently have no
173    Multiple small human genetic studies have variably linked single nucleotide polymorphisms in these
174 s, such as ozone and particulates, have been variably linked to epithelial injury, inflammation, and
175                              Her stools were variably loose.
176 al ions in the affected individuals revealed variably low levels of Mn and Zn in blood and elevated l
177  than CHC17 in muscle, other cell types have variably lower amounts of CHC22, and endogenous CHC22 an
178 Synechocystis Most active site substitutions variably lowered maximal catalytic activity without mark
179                              Extending this, variably methylated genic CGs in maize and Brachypodium
180                            About half of the variably methylated IAP LTRs tend to be hypomethylated i
181 e highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop o
182  the C alleles at rs143383 and rs143384 were variably methylated, and treatment of a heterozygous cel
183 d estimate that >6.7% of the mouse genome is variably methylated.
184 ors (PIs) prescribed to HIV-infected persons variably modulate cathepsin activities in human APCs, de
185                               Thus, TRPV1 is variably N-glycosylated and glycosylation is a key deter
186                              The complex was variably named the mitochondrial contact site complex, m
187           Furthermore, zoonotic SARS-CoV was variably neutralized by antibodies that were effective a
188 e A reductase inhibitors (statins) have been variably noted to affect hepatitis C virus (HCV) treatme
189                   Here, we have identified a variably occupied CTCF site in the Drosophila Ultrabitho
190                          This indicates that variably open DHS sites are often occupied by rotational
191 igin includes a poly(T)-rich tract and eight variably oriented, GAGGC-like pentanucleotide sequences
192 collagen binding and ADAMTS13 cleavage) were variably oxidized, one completely.
193 are the cell cycle inhibitors, pRb, p57, and variably, p21: none of the cyclins or cdks necessary to
194 volves the conversion of recently discovered variably participating neurons to reliable status.
195 mic lupus erythematosus (SLE) kidneys have a variably patterned and often extensive infiltrate of pre
196 ebrafish mutant blowout that presents with a variably penetrant coloboma phenotype.
197 n vivo Embryos lacking this enhancer display variably penetrant defects in anterior-posterior axis or
198 s yielded Arf(Cre/FL) progeny that exhibited variably penetrant defects in visual acuity ranging to t
199 nsport and submucosal gland fluid secretion; variably penetrant meconium ileus (MI); pancreatic, live
200 ssion of autosomal genes as well as into the variably penetrant pathophysiological spectrum of phenot
201 he truncated, repressor form of GLI3, have a variably penetrant phenotype that includes an increase i
202 ings suggest that CFEOM3 is an asymmetrical, variably penetrant, congenital cranial dysinnervation di
203 genetic variants are currently thought to be variably penetrant, we hypothesise that when disorders e
204                                    Residents variably perform a purposeful pause ("time-out") when in
205 p53 loss) in murine melanocytes, we observed variably pigmented and highly metastatic melanoma with 1
206 a was a flat, irregularly shaped lesion with variably pigmented and irregularly distributed globules
207 is residue (Phe(B1) in placental mammals) is variably positioned within crystal structures and exhibi
208                    Serum IgA1 responses were variably positive, and individuals were rarely positive
209 igible substrate activity for RFC but showed variably potent (nanomolar) and selective inhibitory act
210              The tradition of consanguinity, variably practiced in the Persian Gulf region, North Afr
211 outinely used or randomly allocated, but was variably prescribed by clinicians.
212 resence of axonal loss, axonal spheroids and variably present pigmented macrophages on pathological e
213  is a clonal disorder of mast cells that may variably present with characteristic skin lesions, episo
214 dal dysfunction and/or peripheral neuropathy variably present), who are clinically indistinguishable
215 n a population where pathology is common and variably present, 'reserve' may be defined as the differ
216 iegated aneuploidy (MVA) syndrome, were more variably present.
217 asticity, dystonia, tremor and migraine were variably present; cognitive impairment was severe in ear
218 normal counterparts, cancer cell glycans are variably produced and often structurally distinct, servi
219   The most common form of periodontitis is a variably progressive dynamic pathologic process that cau
220 gehog/Smoothened (Hh/Smo) signaling has been variably proposed to stimulate overall fin regenerative
221                This means that five cases of variably protease-sensitive prionopathy have been identi
222                                              Variably protease-sensitive prionopathy is a newly descr
223 man prion diseases, these data indicate that variably protease-sensitive prionopathy is a rare phenot
224 nt prion protein fragment that characterizes variably protease-sensitive prionopathy is detectable at
225                Two cases that conform to the variably protease-sensitive prionopathy phenotype have b
226 linical grounds, and one was a known case of variably protease-sensitive prionopathy previously repor
227  To determine the incidence and phenotype of variably protease-sensitive prionopathy within a single
228 bstitution of the original designation with "variably protease-sensitive prionopathy" (VPSPr).
229 e-resistant prion protein that characterizes variably protease-sensitive prionopathy, followed by neu
230 e found in certain brain regions of cases of variably protease-sensitive prionopathy, indicating mole
231 med biochemically and neuropathologically as variably protease-sensitive prionopathy.
232 chemically, yielding four candidate cases of variably protease-sensitive prionopathy.
233      We found that BRD2, BRD3, and BRD4 were variably recruited to GATA1-regulated genes, with BRD3 b
234                  KDSR enzymatic activity was variably reduced in all patients, resulting in defective
235              Biochemical analyses documented variably reduced levels of TBCD, indicating relative ins
236 eplication in transfected cells but produced variably reduced virus yields.
237             Hippocampal volume reduction was variably related to Abeta deposition.
238                           Health values were variably related to factors such as demographics, VAS sc
239 s in which the 6-deoxy-l-talose residues are variably replaced with O-acetyl and O-methyl modificatio
240 icacy in long-QT syndrome type 1 is good but variably reported, and the causes of cardiac events desp
241        Other outcomes were heterogeneous and variably reported, but no study showed an increase in ad
242 87 genes conserved in all strains, and 1,860 variably represented genes.
243 d-chaining rules to take information that is variably represented in source databases and integrating
244 ity and specificity, but IFA is impractical, variably reproducible, and cumbersome for large epidemio
245            Colonies arising with Sendai were variably reprogrammed (10%-80% TRA-1-60(+)), with variab
246 s leads to an innate immune response that is variably responsive to challenges across the circadian d
247 s in a population studied in an eight-option variably rewarded choice task were sensitive to both sac
248 nential function for DW imaging analysis and variably sampled diffusion weighting plays a substantial
249                            Three-dimensional variably saturated flow and multicomponent biogeochemica
250 ide range of other multisystem features were variably seen, including dysmorphism, skeletal abnormali
251 ructurally conserved DNA-binding domains, is variably sensitive to methylation of their target genes.
252 s C and large, randomly spaced aggregates of variably shaped Hulle cells.
253 ult B cell subsets but were either unique or variably shared between the two or even among all three
254 enetic background and environmental factors, variably shift the probabilities of phenotypes along a p
255  during laparoscopic partial nephrectomy has variably shown increased intraoperative blood loss when
256 hic lesions with a small hyperpigmented rim, variably sized and predominantly located along the arcad
257  Cleavage of HA results in the generation of variably sized fragments that stimulate multiple angioge
258 of a linear chromosome and a large number of variably sized linear and circular plasmids.
259        Here, we describe the use of a set of variably sized nonpolar thymidine and uracil mimics as m
260 arged, uncharged but polar, hydrophobic, and variably sized primary amines.
261 eep sequencing libraries from small RNAs and variably sized RNA fragments obtained from ribonucleopro
262 ustering methods in 21 tumor types to detect variably sized significantly mutated regions (SMRs).
263                                Heterozygous, variably sized, contiguous gene deletions causing haploi
264          The underlying chronic strokes were variably sized, predominantly affected white matter trac
265  in stretches of DNA containing multiple and variably spaced A-tracts and AT-tracts.
266 ensitivity of a neural circuit to a train of variably spaced pulses, as is observed in physiological
267 TP, while complex sites, containing multiple variably spaced TGGT elements arranged as opposing clust
268                    NS1 recognizes two to six variably spaced, more-or-less degenerate forms of the 5'
269 rkably, the remaining motifs are composed of variably-spaced half-sites (12%) or 'emergent' sites (16
270                           It consists of six variably spliced exons.
271 ndrome cell adhesion molecule (Dscam) can be variably spliced to encode 152,064 distinct single-pass
272  AMP binds to the HCN channel C terminus and variably stabilizes its open state.
273  constitutively associate with each other in variably stable signaling complexes.
274 structure as a proxy for the distribution of variably sticky information in a population.
275 mia (CLL) is a tumor of circulating B cells, variably stimulated and anergized following exposure to
276           Method development and results for variably substituted aryl acetonitriles and aldehydes in
277 rformed a computational study on a series of variably substituted trans-polyacetylenes, polyynes, and
278  pools in forests have been inconsistent and variably successful in the past.
279  pools in forests have been inconsistent and variably successful in the past.
280 s trials with antiretroviral drugs have been variably successful.
281    Furthermore, analysis of a minilibrary of variably sulfated derivatives of Escherichia coli K5 pol
282 FG method is used, with a new technique that variably suppresses the non-resonant (NR) background usi
283 coded on the X chromosome, in 5 males with a variably syndromic, normocytic CSA.
284 ers because the T3SS pilus must grow through variably thick plant cell walls before contacting the ho
285 or by existing approaches to modularity that variably threshold, binarize, or arbitrarily weight thes
286 ion, and beta-cell apoptosis, which interact variably to cause the different diabetes syndromes.
287 ecombinant subdomains, except for SD2, bound variably to human erythrocytes, with constructs containi
288              CD20-expressing T cells respond variably to immunomodulatory treatments given to MS pati
289           Concomitant fundoplication is used variably to prevent complications of gastroesophageal re
290 ith heterogeneous symptomatology and respond variably to therapeutic interventions.
291 the lipid-facing regions of TM3 and TM4 were variably tolerant.
292 components of both pathogens and self, which variably trigger endocytic, phagocytic, proinflammatory,
293 ted blockage of development and reintroduced variably truncated fragments of the pxr region to test f
294 = 3, >/= 4, or >/= 5 abnormalities have been variably used for its definition.
295 eural dynamics underlying the maintenance of variably visible stimuli using magnetoencephalography.
296                                          The variably weighted Odum dissimilarity (DwOdum) allows for
297 ing with forsterite (Mg(2)SiO(4)) exposed to variably wet supercritical CO(2) (scCO(2)).
298 threatening ventricular arrhythmias combined variably with epilepsy and delayed neurodevelopment.
299              However, these antibodies react variably with parvalbumin from different fish species.
300 tionship, high-volume operators were defined variably, with annual PCIs ranging from >11 to >270, wit

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