ライフサイエンスコーパス: variegation

1 ochromatin phenomenon called position effect variegation.

2 region that protects against position effect variegation.

3 lation, suggests a model for position-effect variegation.

4 cing classically observed as position effect variegation.

5 gative thymocytes, but there was no apparent variegation.

6 dentified as a Suppressor of Position-Effect Variegation.

7 hat is probably analogous to position-effect variegation.

8 but clearly different from, position effect variegation.

9 the P0 protein in modifying position effect variegation.

10 cis, a hallmark of classical position-effect variegation.

11 h correlated in magnitude with the degree of variegation.

12 ition, Low weakly suppresses position effect variegation.

13 transformed hel+ behaves as a suppressor of variegation.

14 nt, chromosomal proteins and position effect variegation.

15 hromatin protein involved in position-effect variegation.

16 lassic genetic suppressor of position-effect variegation.

17 85 are strong suppressors of position effect variegation.

18 into VAR2 function and the mechanism of var2 variegation.

19 ains, as shown by monitoring position effect variegation.

20 is not the principle cause of hCD2 transgene variegation.

21 hat this resulted in the suppression of var2 variegation.

22 henotype associated with suppression of var2 variegation.

23 rganization in cis and trans position-effect variegation.

24 teristic for the green and yellow sectors of variegation.

25 of heterochromatin-mediated position effect variegation.

26 en-up, a known suppressor of position effect variegation.

27 enhancer and a suppressor of position-effect variegation.

28 hanism to explain nuclear gene-induced plant variegations.

29 heterozygous for mutations in Suppressor of variegation 205 [Su(var)205], a gene implicated in the c

30 heterozygous for a mutation in Suppressor of variegation 205, the gene that encodes the telomere-capp

31 The Enhancer of variegation 3-9 [E(var)3-9] gene was one of over a hundr

32 kdown screen identified SUVR4 {SUPPRESSOR OF VARIEGATION 3-9 [SU(VAR)3-9]-RELATED 4} as a histone H3

33 the histone methyltransferase suppressor of variegation 3-9 homolog 1 (SUV39H1) selectively augments

34 Snail interacted with Suv39H1 (suppressor of variegation 3-9 homolog 1), a major methyltransferase re

35 interaction between Smad5 and suppressor of variegation 3-9 homolog 2 (Suv39h2), a chromatin modifie

36 r of zeste homolog2 (EZH2) and suppressor of variegation 3-9 homolog1 (SUV39H1), which are two histon

37 display reduced expression of suppressor of variegation 3-9 homologs2, 4, and 9 and reduced DNA meth

38 Sirtuin 1 (SIRT1) and suppressor of variegation 3-9 homologue 1 (SUV39H1) are amongst the en

39 g (TGS) involve members of the suppressor of variegation 3-9-homologous (SUVH) group of putative hist

40 To address the mechanisms underlying variegation, a 30-kb genomic fragment containing a singl

41 Plastid MSH1 depletion results in variegation, abiotic stress tolerance, variable growth r

42 bination of two modifiers of position effect variegation, adding an extra Y chromosome and increasing

43 previously established linkage between var2 variegation and chloroplast rRNA processing/chloroplast

44 generation and mechanisms of position-effect variegation and demonstrate the utility of rho-GFP as a

45 hat dLDH and L-2HG influence position effect variegation and DNA methylation, suggesting that this co

46 LCRs protect transgenes from position effect variegation and heterochromatinization and also promote

47 ne behaves as an enhancer of position-effect variegation and interacts genetically with mod(mdg4), wh

48 how chemical contrast between the sectors of variegation and quantitative changes as the ablation rea

49 hibitors of human plasmin (PLA) by iterative variegation and selection.

50 hetic PATCs are resistant to position effect variegation and stochastic silencing in the germline.

51 rns similar to those seen in position-effect variegation and yet most inserts were in euchromatic loc

52 an array closer to heterochromatin enhanced variegation, and enhancement was reverted by recombinati

53 aging agents, suppression of position-effect variegation, and female sterility in which ovaries are u

54 Deletion of mutation of hel enhances white variegation, and this can be reversed by a transformed c

55 This variegation appears to be due to expression of the CHS a

56 erent Ly49 genes, and the sequences imposing variegation are located proximally to Ly49 genes.

57 Many variegations are caused by mutations in nuclear genes th

58 PEV revealed that it is not a suppressor of variegation, as concluded by other investigators.

59 insufficiency for E(var)3-9 enhances omegam4 variegation, as would be expected from increased heteroc

60 regulators using a GAL4Colon, two colonsGFP variegation assay.

61 model is proposed to explain the patterns of variegation associated with both "wild type" active Ac a

62 SC80 transgenes are subject to silencing and variegation at a high frequency.

63 is 1360 element contributes to HP1-dependent variegation at a pericentric insertion site, as demonstr

64 0 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-fun

65 is variable (position effect and expression variegation) because retroviruses are highly susceptible

66 ne is non-centromeric and that the extent of variegation can be developmentally regulated.

67 t as dominant suppressors of position effect variegation, confirming a role in heterochromatin spread

68 lted in a decrease, increase or no effect on variegation depending upon the site of integration.

69 ABCD (Asymmetry, Border irregularity, Color variegation, Diameter >6 mm) acronym for the appraisal o

70 Therefore, Ly49 variegation does not require competition in cis between

71 the nuclear VAR2 locus of Arabidopsis cause variegation due to loss of a chloroplast thylakoid membr

72 ber of the positive regulatory/suppressor of variegation, enhancer of zeste, trithorax (PR/SET) domai

73 (Win) motif and the catalytic suppressor of variegation, enhancer of zeste, trithorax (SET) domain.

74 estigation, we report that the suppressor of variegation, enhancer of zeste, trithorax (SET) domains

75 Here we present that suppressor-of-variegation, enhancer-of-zeste, trithorax protein from B

76 12, and EED, in which the SET (suppressor of variegation-enhancer of zeste-trithorax) domain of EZH2

77 sgene with additional 3' sequences showed no variegation even when the latter integrated in centromer

78 sophila transgenes can cause heterochromatic variegation for transgene expression in a copy-number an

79 trans or by the spreading of position effect variegation from rearrangements having heterochromatic b

80 elanogaster for modifiers of position-effect variegation have revealed the basis of much of our under

81 ological processes including position-effect variegation, heterochromatin formation and transcription

82 Additional key features (variegation, heterophylly) evolved in the most species-r

83 vernalization in plants and position effect variegation in animals.

84 effectively prevents transgene silencing and variegation in cell lines, multipotent and pluripotent s

85 Similarities between position effect variegation in Drosophila and gene silencing in maize me

86 silencing, as exemplified by position effect variegation in Drosophila melanogaster and X-chromosome

87 Thus, like variegation in Drosophila, recruitment of mammalian HP1

88 wer temperatures, similar to position effect variegation in Drosophila.

89 d role of this DNA repeat in position effect variegation in facio- scapulohumeral muscular dystrophy

90 determinants of this pattern--recognized by variegation in females but not in males--have been descr

91 cle and is misregulated by TPE-OLD-dependent variegation in FSHD myoblasts.

92 atment efficacies will reflect the molecular variegation in individual tumors.

93 d in diverse systems such as position effect variegation in insects, silencing near yeast telomeres,

94 Collectively, these data suggest that variegation in levels of transgene expression are due to

95 or the origin and inheritance of green-white variegation in nature.

96 previously been shown to enhance expression variegation in petunia and tobacco and to carry a hot sp

97 istinguished from common melanocytic nevi by variegation in pigmentation and clinical appearance, as

98 disturbed phyllotaxis, fasciated stems, and variegation in plants), inhibit its growth, development,

99 endent regulation of domain size and memory, variegation in the absence of antagonists, and coexisten

100 Suppression of variegation in the first line, TAG-FN, was caused by dis

101 sed cloning revealed that the suppression of variegation in this line is due to a splice site mutatio

102 model is presented to explain the pattern of variegation in var2 in which AtFtsH8 provides a compensa

103 lation levels and suppresses position-effect variegation in various Drosophila tissues.

104 Our data suggest a model of variegation in which the IM protein functions early in c

105 z)12, a strong suppressor of position effect variegation, in PRC2 suggests that PRC2 may play a wides

106 ely affected by modifiers of position effect variegation including the Y chromosome, Su(var)205(2), p

107 The proportion of clones displaying marked variegation increased with progressive deletion.

108 utations in HP2 can suppress position effect variegation, indicating a role in gene silencing and het

109 hila PR-Set7 that suppresses position effect variegation, indicating that PR-Set7 indeed functions in

110 stwl mutants acted as Suppressors of variegation, indicating that stwl normally acts in chrom

111 otein, suggesting that the mechanism of var2 variegation involves the action of a redundant activity

112 Variegation is a common feature of gene silencing phenom

113 these data suggest that screening for yellow variegation is a very efficient method for recovering ce

114 of the AE1 promoter and that position effect variegation is associated with RNA transcription from th

115 ples are described in which a lesion causing variegation is capable of silencing the white transgene

116 Leaf variegation is expressed only in homozygous recessive pl

117 cterization of 004-003, a line in which var2 variegation is suppressed.

118 We have identified a new enhancer of variegation locus, Dmrnahel (hel).

119 Position effect variegation may be considered an abnormal manifestation

120 s found to display reciprocal dose-dependent variegation modifier phenotypes, similar to those for mu

121 ity described here underlies position effect variegation, molds the structure of polytene chromosomes

122 The Arabidopsis var2 variegation mutant defines a nuclear gene for a chloropl

123 The immutans (im) variegation mutant of Arabidopsis (Arabidopsis thaliana)

124 The immutans (im) variegation mutant of Arabidopsis defines the gene for P

125 The immutans (im) variegation mutant of Arabidopsis has green and white le

126 The immutans (im) variegation mutant of Arabidopsis thaliana is caused by

127 In this article, we show that the var1 variegation mutant, which is defective in AtFtsH5, has a

128 d plants and white sectors from the immutans variegation mutant.

129 Nuclear gene-induced variegation mutants provide a powerful system to dissect

130 The immutans (im) variegation mutation of Arabidopsis is nuclear and reces

131 We propose that variegation occurs because heterochromatin inhibits the

132 In addition, white transgene arrays cause variegation of a nearby gene in cis, a hallmark of class

133 exhibits a dosage-dependent modification of variegation of a yellow reporter transgene, indicating a

134 nic dystrophy and Friedreich's ataxia confer variegation of expression on a linked transgene in mice.

135 e far less susceptible to position-dependent variegation of expression than are the Mo-MuLV-based vec

136 Variegation of expression was observed in founders but p

137 guises the fundamental features of subclonal variegation of genetic lesions and of clonal phylogeny.

138 e normal physiology of GCs involves regional variegation of hypoxia, and HIF-dependent oxygen sensing

139 and signaling networks in DCs that guide the variegation of immune responses.

140 Variegation of lt was induced in the adult eye, larval s

141 The pattern of aleurone variegation of maize kernels carrying Ac and bz-m2(DI) a

142 Position effect variegation of most Drosophila melanogaster genes, inclu

143 ed for silencing, we propose that epigenetic variegation of telomeric gene expression is due to the b

144 nsitivity of the phenotypic landscape to the variegation of the genotypic landscape suggests that the

145 development, with its disruption leading to variegation of the plant.

146 satellites of Drosophila show repression and variegation of the reporter gene.

147 Position-effect variegation of the w(m4h) allele and different variegati

148 In Drosophila melanogaster, position-effect variegation of the white gene has been a useful phenomen

149 telomere-associated sequences (TAS) and that variegation of these genes is the result of competition

150 The lesions that cause variegation of white minimally disrupt the linear order

151 Rearrangements that lack the array enhanced variegation of white on a homologue bearing the array.

152 sion of nearby marker genes (position-effect variegation or silencing).

153 inactivation associated with position-effect variegation or X chromosome inactivation.

154 relied on mosaic silencing (position-effect variegation, or PEV) of the yellow gene present in the t

155 nation for such phenomena as position-effect variegation (PEV) and control of segment determination a

156 Heterochromatic position-effect variegation (PEV) describes the mosaic phenotype of a eu

157 Position-effect variegation (PEV) describes the stochastic transcription

158 ould be similar to a loss of position-effect variegation (PEV) in Drosophila.

159 s required for prevention of position effect variegation (PEV) in transgenic mice.

160 terozygotes display enhanced position effect variegation (PEV) indicative of the broad role of GAF in

161 Position effect variegation (PEV) is the clonal inactivation of euchroma

162 The classical phenomenon of position-effect variegation (PEV) is the mosaic expression that occurs w

163 Position effect variegation (PEV) occurs when a gene is located abnormal

164 romatin-induced silencing or position-effect variegation (PEV) of a reporter gene has provided insigh

165 7) dramatically increase the position effect variegation (PEV) of a yellow(+) body-color gene located

166 BID expression also enhances position-effect variegation (PEV) of the w(m4h) allele and a yellow tran

167 se are strong suppressors of position effect variegation (PEV) of the wm4 allele and that lack of JIL

168 out of 13 JmjC genes modify position effect variegation (PEV) phenotypes, consistent with their ascr

169 sion, such as is observed in position effect variegation (PEV) when the Drosophila melanogaster white

170 nogaster chromosomes exhibit position effect variegation (PEV), a mosaic silencing characteristic of

171 matic gene, which results in position-effect variegation (PEV), also causes the aberrant association

172 ing rRNA gene transcription, position-effect variegation (PEV), and the link among rDNA copy number,

173 calized protein required for position effect variegation (PEV), colocalized with DmORC2 at these site

174 and recessive suppressors of position-effect variegation (PEV), indicating that, as in yeast, dSir2 i

175 nd regulates heterochromatin position-effect variegation (PEV), organization of repetitive DNAs, and

176 ding of aneuploid syndromes, position-effect variegation (PEV), quantitative traits, and dosage compe

177 n of roX function suppresses position effect variegation (PEV), revealing functional alteration in he

178 dhtt acts as a suppressor of position-effect variegation (PEV), suggesting that it influences chromat

179 mutations in His2Av suppress position effect variegation (PEV), suggesting that this histone variant

180 eterochromatin can result in position effect variegation (PEV), the variable expression of heterochro

181 his contrasts with classical position effect variegation (PEV), where a given gene is either active o

182 n Drosophila melanogaster by position effect variegation (PEV).

183 lenced-a phenomenon known as position effect variegation (PEV).

184 ite dependent, and resembles position-effect variegation (PEV).

185 d counterbalancing effect on position-effect variegation (PEV).

186 three distinct loci showing position-effect variegation (PEV).

187 trong dominant suppressor of position effect variegation (PEV).

188 urvival and does not control position-effect variegation (PEV).

189 also found that whereas var2 displays a leaf variegation phenotype at 22 degrees C, it has a pronounc

190 r2-4 (a putative null allele) normalizes the variegation phenotype of the mutant and restores the two

191 The variegation phenotype of var1 (as well as var2, which is

192 cal library and employing the same iterative variegation procedures used to obtain PLA inhibitors.

193 Su(var)3-9 and Su(var)2-5 on position-effect variegation, providing evidence that a finely tuned bala

194 AtFtsH2/VAR2, normalizes the pattern of var1 variegation, restoring a nonvariegated phenotype.

195 r of Drosophila melanogaster correlates with variegation (silencing).

196 With position-effect variegation, similar responses were found as with gene e

197 igmatic in vivo function, as a Suppressor of Variegation [Su(var)] that is crucial to global heteroch

198 l assays of boundary activity and epigenetic variegation suggest that Nup2p and the Ran guanylyl-nucl

199 Studies of position effect variegation suggest that promoters of heterochromatic ge

200 alleles of dLsd1 suppress positional-effect variegation, suggesting a disruption of the balance betw

201 also acts as a suppressor of position effect variegation, suggesting that a possible function of Rga

202 Nap-1 are shown to suppress position effect variegation, suggesting that Nap-1 functions to help to

203 re recently shown to perturb position effect variegation, suggesting that the role of SIR2 in epigene

204 We have generated suppressors of var2 variegation to gain insight into factors and pathways th

205 Current models attribute variegation to the establishment of a heritable silent s

206 odel that may explain phenomena ranging from variegation to the neural restriction of Rett syndrome.

207 ion must strike a balance between sufficient variegation to thoroughly sample alternative functionali

208 Telomere-associated position-effect variegation (TPEV) in budding yeast has been used as a m

209 attenuated through telomere position-effect variegation (TPEV).

210 itable epigenetic trends leading to cellular variegation, trends endemic in a cell population based o

211 levels of expression and increased levels of variegation, upon maternal transmission; and this correl

212 two ilarvirus coat proteins, TSV and citrus variegation virus, is identified and also shown to conta

213 Genetic analyses showed that the variegation was always associated with the transposase c

214 In the second line (TAG-IE), suppression of variegation was caused by a lesion in SVR2, the gene for

215 Notably, triplet-repeat-associated variegation was not restricted to classical heterochroma

216 Consistent with this hypothesis, var2 variegation was repressed by chemical inhibitors of chlo

217 To study the mechanisms that cause variegation, we designed a transgene that we expected to

218 gene, SUP4-o, is subject to position effect variegation when located near a telomere and that this s

219 II (RNAP II) are subject to position effect variegation when located near yeast telomeres.

220 ased (but did not alleviate) position effect variegation within the expressing cell types.

221 NAs (piwi-interacting RNAs), position effect variegation, X-chromosome inactivation, parental imprint