ライフサイエンスコーパス: variola

1 ects, supporting the efficacy of MVA against variola.

2 ), a genus that includes the human pathogens variola and monkeypox and the vaccine species vaccinia v

3 ncompetent vaccinia strains being tested for variola and monkeypox prevention and for the delivery of

4 Although variola and vaccinia share remarkable DNA homology, the

5 Variola and vaccinia viruses, the two most important mem

6 Variola causes the contagious disease smallpox, which ha

7 we demonstrate the functional advantage of a variola complement regulatory protein over that of its v

8 identified, including an interaction between variola G1R, an ankryin/F-box containing protein, and hu

9 verwhelming systemic infection suggests that variola gene products may ablate this response.

10 ur understanding of variola pathogenesis and variola-host interactions, we examined the molecular and

11 Variola infection elicited striking and temporally coord

12 rently being developed as an animal model of variola infection in humans.

13 erged from an ancestral African rodent-borne variola-like virus either approximately 16,000 or approx

14 Variola major (smallpox) infection claimed hundreds of m

15 served among vaccinia virus Western Reserve, variola major and modified vaccinia Ankara, supporting t

16 indicate that the divergence of alastrim and variola major occurred earlier than previously believed.

17 ses include many important pathogens such as variola major virus, camelpox, buffalopox, monkeypox, co

18 Variola major virus, the etiological agent of smallpox,

19 rmer being closely related to a protein from variola major virus, the smallpox etiological agent.

20 alization titers to vaccinia, monkeypox, and variola major were assessed and cell-mediated immune res

21 xviruses, including vaccinia, monkeypox, and variola major, and broad T-cell responses, indicating th

22 ) that is conserved in J8R of smallpox virus variola major.

23 camelpox, buffalopox, monkeypox, cowpox, and variola minor viruses.

24 ed the identification and differentiation of variola, monkeypox, camelpox, vaccinia, and cowpox virus

25 raccoonpox viruses, as well as those such as variola, monkeypox, vaccinia, and camelpox viruses, whic

26 ybridize these GeneChips with some known non-Variola orthopoxvirus isolates, including monkeypox, cow

27 have arisen about the possible existence of variola outside these sites and the potential for using

28 To improve our understanding of variola pathogenesis and variola-host interactions, we e

29 Smallpox virus (variola) poses a significant threat as an agent of biote

30 uire development of an animal model in which variola produces a disease course with features consiste

31 Because authentic variola proteins are not available for study, we molecul

32 SPICE provides the first evidence that variola proteins are particularly adept at overcoming hu

33 in the more potent complement inhibitor from Variola (small pox) virus.

34 dimeric N1L protein is a potent vaccinia and variola (smallpox) virulence factor.

35 ted orthopoxvirus proteins, the vaccinia and variola (smallpox) virus complement control proteins, wh

36 For DNA viruses such as variola (smallpox), three target genomes provide suffici

37 f antiviral agents, including agents against variola (smallpox), which has an almost identical E3L.

38 homologous complement regulatory proteins of variola (SPICE) and vaccinia (VCP).

39 x persists because clandestine stockpiles of variola still exist.

40 kidney BSC-40 and VERO-E6 cells in vitro by variola strain Solaimen is blocked by CI-1033, primarily

41 cynomolgus macaques were exposed to several variola strains through aerosol and/or i.v. routes.

42 le DNA homology, the strict human tropism of variola suggests that its proteins are better suited tha

43 e orthopoxviruses infect mammals and include variola, the causative agent of smallpox, and monkeypox,

44 Variola, the causative agent of smallpox, and the relate

45 Most poxviruses, including variola, the causative agent of smallpox, express a secr

46 Variola, the causative agent of smallpox, is a highly in

47 MPXV) is an orthopoxvirus closely related to variola, the etiological agent of smallpox.

48 rains belonging to the orthopoxvirus species variola, vaccinia, camelpox, mousepox, cowpox, and monke

49 rld, African-Eurasian orthopoxviruses (OPV): variola, vaccinia, cowpox, monkeypox, camelpox, ectromel

50 ratures (T(m)s) determined for 46 strains of variola virus (T(m)s, 55.9 to 57.8 degrees C) differed s

51 duce the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro

52 ited the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro

53 rus genus, which includes Vaccinia virus and Variola virus (the causative agent of smallpox).

54 monkeypox virus, and the potential biothreat variola virus (the causative agent of smallpox).

55 man infections on an intermittent basis, and variola virus (VARV) has potential for use as an agent o

56 dae family members monkeypox virus (MPX) and variola virus (VarV) use conserved mechanisms for actin

57 mescale of emergence of the causative agent, variola virus (VARV), and how it evolved in the context

58 Human disease likely attributable to variola virus (VARV), the etiologic agent of smallpox, h

59 Within the family of poxviruses, variola virus (which causes smallpox) is the most pathog

60 Whereas the human variola virus and mouse ectromelia virus encode one vTNF

61 eutic intervention against infections by the variola virus and other poxviruses.

62 as a global illness more than 30 years ago, variola virus and other related pathogenic poxviruses, s

63 hage host range protein, myxoma virus M011L, variola virus B22R, four ankyrin repeat proteins, three

64 rotein, D7L BTB/POZ domain protein, and B22R variola virus B22R-like protein.

65 With genomic DNA purified from variola virus Bangladesh 1975, the limit of detection wa

66 naturally occurring systemic infection with variola virus both lead to the characteristic skin "pox"

67 Of the 43 samples that contained purified variola virus DNA ranging in concentration from 1 fg/ mi

68 Of the 206 samples that contained variola virus DNA ranging in concentrations from 100 fg/

69 Contained within those 322 samples were variola virus DNA, obtained from purified viral preparat

70 The Poxviridae family members vaccinia and variola virus enter mammalian cells, replicate outside t

71 hat confer cross-protective immunity against variola virus for decades after immunization.

72 lpox) in a scenario involving the release of variola virus from a laboratory, 19 deaths in a human-ve

73 Thus, proteomic screening of variola virus has the potential to uncover modulators of

74 The vaccinia and variola virus homolog sequences predict 94% identical am

75 amino acid differences compared with its B6 variola virus homologue, B6 might be a better choice for

76 ata suggest that a subunit vaccine using the variola virus homologues might exhibit improved protecti

77 interaction, in contrast to results for the Variola virus IL-18BP, which has been shown to primarily

78 Survivors of variola virus infection demonstrated VV-specific CD4 mem

79 Of 8 individuals with a history of variola virus infection, 1 had a VV-specific IFN- gamma

80 n magnitude to that achieved through natural variola virus infection, and this may explain the notabl

81 ection in nonhuman primates, a surrogate for variola virus infection, were characterized.

82 fection, and 8 individuals with a history of variola virus infection.

83 tive genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the sma

84 the 14-kDa fusion protein gene of each of 14 variola virus isolates of the Russian World Health Organ

85 otection of macaques from monkeypox virus, a variola virus ortholog.

86 time polymerase-chain-reaction assay for non-variola virus orthopoxviruses were positive, and DNA seq

87 eins encoded by the ectromelia virus and the variola virus possess E3 ubiquitin ligase activity in bi

88 te that despite the enhanced activity of the variola virus protein, its cofactor activity in the fact

89 protein interaction screening of the unique variola virus proteome by using yeast 2-hybrid screening

90 In this study, we used a variola virus proteome microarray to characterize and di

91 d alone or in combination with inhibitors of variola virus replication.

92 hed sequencing is required using Marburg and variola virus sequences.

93 encing GeneChips for the rapid sequencing of Variola virus strains in the WHO Repository of the Cente

94 etected among the 116 samples not containing variola virus tested; i.e., the overall specificity of t

95 s the model because it is closely related to variola virus that causes smallpox.

96 jority of the orthopoxviruses, including the variola virus that causes the dreaded smallpox disease,

97 poxviruses such as vaccinia virus (VACV) and variola virus that fail to form inclusions.

98 O) vaccination campaign in the 1970s and the variola virus was restricted to repositories in the Unit

99 If variola virus were used as a biological weapon, however,

100 Outbreaks of smallpox (i.e., caused by variola virus) resulted in up to 30% mortality, but thos

101 Immunization against smallpox (variola virus) with Dryvax, a live vaccinia virus (VV),

102 e sequences of 24 strains of smallpox virus (variola virus), for rapid characterization of this human

103 (OPVs), which include the agent of smallpox (variola virus), the zoonotic monkeypox virus, the vaccin

104 concern over the use of pathogens, including variola virus, as biological weapons.

105 Similar to the human pathogen variola virus, ectromelia virus has a limited host range

106 the disease is essential because its cause, variola virus, is considered a potential biological weap

107 Many pathogenic orthopoxviruses like variola virus, monkeypox virus, and cowpox virus (CPXV),

108 ACV) affords long-lasting protection against variola virus, the agent of smallpox.

109 irus affords long-lasting protection against variola virus, the agent of smallpox.

110 by modified vaccinia virus Ankara as well as variola virus, the agent of smallpox.

111 stablished as the result of the concern that variola virus, the causative agent of smallpox, as well

112 Variola virus, the causative agent of smallpox, enters a

113 Variola virus, the causative agent of smallpox, is a pot

114 Interestingly, CrmB from variola virus, the causative agent of smallpox, is the m

115 Variola virus, the causative agent of smallpox, is the m

116 T-lymphocyte (CTL) epitopes are defined for variola virus, the causative agent of smallpox, or for v

117 MPXV) is an orthopoxvirus closely related to variola virus, the causative agent of smallpox.

118 ved (>90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox.

119 re encoded by all orthopoxviruses, including variola virus, the causative agent of smallpox.

120 use as a vaccine enabled the eradication of variola virus, the etiologic agent of smallpox.

121 The potential use of variola virus, the etiological agent of smallpox, as a b

122 Variola virus, the most virulent member of the genus Ort

123 Prior to the eradication of variola virus, the orthopoxvirus that causes smallpox, o

124 is nearly identical in vaccinia virus and in variola virus, which causes smallpox.

125 erived from virus-infected cell cultures and variola virus-infected tissues; thus, the DNA material c

126 Assuming that B6 contains similar variola virus-specific epitopes, our data suggest that a

127 By use of variola virus-specific primers and long-range PCR, 22 ov

128 , we detail the design and validation of two variola virus-specific real-time PCR assays, since previ

129 in pathogenicity between vaccinia virus and variola virus.

130 virulence mechanisms of the causative agent, variola virus.

131 dvantage that it can simultaneously identify variola virus.

132 ed genomic DNA from 48 different isolates of variola virus; 25 different strains and isolates of came

133 epitopes are completely conserved among VV, variola viruses, and most mammalian poxviruses, includin

134 74-82), which is shared between vaccinia and variola viruses, may be a CD8(+) T-cell epitope of vacci

135 ilarity between the proteins of vaccinia and variola viruses, these new inhibitors are anticipated to

136 pitopes are highly conserved in vaccinia and variola viruses.

137 camelpox, cowpox, ectromelia (mousepox), and variola viruses.

138 After inoculation, variola was disseminated by means of a monocytic cell-as

139 ion of protective efficacy against authentic variola will require development of an animal model in w