ライフサイエンスコーパス: vascular permeability

1 hich reduce retinal angiogenesis and retinal vascular permeability.

2 of VEGFR3 in the regulation of VEGF-induced vascular permeability.

3 endothelial Pak2 deletion leads to increased vascular permeability.

4 hematocrit, and lung weight as a measure of vascular permeability.

5 s and the ID8 model directly correlates with vascular permeability.

6 nterstitial fluid pressure (IFP) by reducing vascular permeability.

7 may promote early atherogenesis by enhancing vascular permeability.

8 lated PAH lungs without increasing pulmonary vascular permeability.

9 patients with thrombocytopenia and increased vascular permeability.

10 kocyte recruitment is accompanied by reduced vascular permeability.

11 ted with increased bronchial vascularity and vascular permeability.

12 Mmp-10 and Nur77, and inhibits VEGF-induced vascular permeability.

13 disrupted BTB tight junctions and increased vascular permeability.

14 ung, skin, kidney and liver showed increased vascular permeability.

15 uding angiopoietin 2 (ANG2), which increases vascular permeability.

16 ses such as angiogenesis, vasculogenesis and vascular permeability.

17 hano-transduction, metabolic regulation, and vascular permeability.

18 particles correlated with signs of increased vascular permeability.

19 levels of C5a, vasodilatation, and increased vascular permeability.

20 sms, such as through cellular recruitment or vascular permeability.

21 ctions and thereby restrains the increase in vascular permeability.

22 otension, acute pericyte loss, and increased vascular permeability.

23 oedema and other diseases caused by abnormal vascular permeability.

24 lar endothelial growth factor (VEGF)-induced vascular permeability.

25 inflammatory immune cells contribute to CNS vascular permeability.

26 g that uptake occurs in regions of increased vascular permeability.

27 r intratumoral pressure and increasing their vascular permeability.

28 tro and in vivo and prevents VEGF-stimulated vascular permeability.

29 activation of the c-Src tyrosine kinase and vascular permeability.

30 -specific, as it may have adverse effects on vascular permeability.

31 lation of endothelial cell junctions and for vascular permeability.

32 othelial cells, thereby preventing excessive vascular permeability.

33 d as a crucial modulator of angiogenesis and vascular permeability.

34 hed reports suggest a direct effect of LT on vascular permeability.

35 ng recruitment of leukocytes and increase of vascular permeability.

36 These effects correlated with decreased vascular permeability.

37 nulomas mature, they induce angiogenesis and vascular permeability.

38 hosphorylation of VE-cadherin, and increased vascular permeability.

39 diaphragm formation and maintenance of basal vascular permeability.

40 induced by sepsis and sustained increase in vascular permeability.

41 cs of endothelial junctions, thus permitting vascular permeability.

42 ty receptor for LTE4 that mediates cutaneous vascular permeability.

43 ing VEGF receptor 2 attenuates VEGFA-induced vascular permeability.

44 l cell functions, including angiogenesis and vascular permeability.

45 me protein regulates TGF-beta1-mediated lung vascular permeability.

46 lium and higher microvessel density increase vascular permeability.

47 te and sustained enhancement of cellular and vascular permeability.

48 very into treated tumor beds due to enhanced vascular permeability.

49 h important outcomes in contexts of enhanced vascular permeability.

50 l cell mitogenesis, angiogenesis, as well as vascular permeability.

51 vating this pathway and in vivo in enhancing vascular permeability.

52 the cascade of events leading to changes in vascular permeability, accumulation, and activation of C

53 vascular proinflammatory responses including vascular permeability, adhesion and migration of leukocy

54 rolipram attenuates ANP-induced increases in vascular permeability after infusion of exogenous ANP an

55 eed, alpha1AMPK exhibited heightened cardiac vascular permeability after lipopolysaccharide challenge

56 and activation of CD8(+) T cells, changes in vascular permeability and activation of caspase-3 on end

57 e tested the hypothesis that TRPC4 increases vascular permeability and alters the frequency of endoth

58 hat demonstrate an essential role of VEGF in vascular permeability and angiogenesis in both normal ph

59 The authors show in turn how this affects vascular permeability and can ultimately improve the eff

60 educes the polyphosphate-induced increase in vascular permeability and collagen- and epinephrine-medi

61 ensing shear flow and eicosanoid modulators, vascular permeability and contractility at the inner ret

62 This effect was associated with increased vascular permeability and decreased vascular perfusion o

63 ed ALI, as a critical initiator of increased vascular permeability and early neutrophil infiltration.

64 Manifestations of such injury are increased vascular permeability and edema, endothelial dysfunction

65 LTD4 plus PGE2 potentiated vascular permeability and edema, gearing the system towa

66 or molecule perforin fully protected against vascular permeability and edema.

67 Inflammatory signaling was associated with vascular permeability and endothelial activation, and re

68 enesis as assessed by functional readouts of vascular permeability and endothelial cell tube formatio

69 c drainage that is associated with increased vascular permeability and enhanced tumor permeability.

70 illing at baseline, rather than by pulmonary vascular permeability and filling pressures.

71 s have also been implicated in promoting CNS vascular permeability and functional deficit in murine m

72 n along EC junctions, resulting in increased vascular permeability and HSPC egress.

73 Septic shock is characterized by increased vascular permeability and hypotension despite increased

74 oxide in dengue is associated with increased vascular permeability and impaired homeostasis and may h

75 nockout mice grew faster and showed enhanced vascular permeability and increased angiogenesis as comp

76 , we here postulated that it could influence vascular permeability and inflammation, thereby countera

77 Finally, compound 16 reduced vascular permeability and inflammatory cell infiltration

78 Vascular permeability and inflammatory demyelination are

79 ritically to drug response via regulation of vascular permeability and innate immune cell infiltratio

80 ded monocyte de-adhesion, thereby increasing vascular permeability and lesion formation, whereas soma

81 Intraocular hemorrhage increases retinal vascular permeability and leukostasis, and these respons

82 ung histology, lung cell proliferation, lung vascular permeability and lung gene expression profiling

83 increases with tumor growth due to increased vascular permeability and lymphatic impairment, and is g

84 Vascular permeability and neovascularization are implica

85 otential therapy for diseases with increased vascular permeability and neutrophil extravasation.

86 wever, the processes that underlie increased vascular permeability and pathological plasma leakage du

87 l cell (PEC) dysfunction including increased vascular permeability and perivascular inflammation asso

88 ports the notion that excessively decreasing vascular permeability and pruning/rarefaction after beva

89 We demonstrate that increased vascular permeability and remodeling, after injury, can

90 t, to noninvasively monitor focal changes in vascular permeability and remodeling, after injury, in N

91 damage the endothelium leading to increased vascular permeability and remodeling.

92 ifying the pro-barrier mechanisms that block vascular permeability and restore the blood-retinal barr

93 njection of autologous blood induced retinal vascular permeability and retinal leukostasis, and these

94 newly synthesized lipid mediators that alter vascular permeability and smooth muscle tone.

95 ted stabilization of the ECs clearly reduced vascular permeability and suppressed alveolar hemorrhage

96 , an agent in clinical trials that increases vascular permeability and uptake of nanocarriers into tu

97 he stromal compartment, in the regulation of vascular permeability and vascular inflammation.

98 helial growth factor (VEGF) potently induces vascular permeability and vessel growth in the tumor mic

99 Denudation resulted in higher vascular permeability and vessel wall enhancement 7 days

100 lacking HIF2alpha in ECs had increased lung vascular permeability and water content, both of which w

101 pendent of the presence of sepsis, pulmonary vascular permeability, and cardiac filling pressures.

102 f histones by inhibiting endothelial damage, vascular permeability, and coagulation activation, as re

103 e, improved tumour vessel perfusion, reduced vascular permeability, and consequently mitigated hypoxi

104 feration, migration, tubulogenesis, enhanced vascular permeability, and endothelial-to-mesenchymal tr

105 arget inflamed vasculature, locally increase vascular permeability, and extravasate across inflamed e

106 o WT mice increased LDL clearance, increased vascular permeability, and increased vascular deposition

107 of inflammatory cells in the lung, increased vascular permeability, and induced histologic ALI in nai

108 Left ventricular function, edema, vascular permeability, and inflammation were assessed in

109 otease inhibitor that regulates coagulation, vascular permeability, and inflammation, with beneficial

110 des, endotoxin, endogenous antioxidants, and vascular permeability, and interventions to limit the in

111 ganized vasculature, significantly increased vascular permeability, and markedly retarded tumor growt

112 d its physiological properties, reducing its vascular permeability, and promoting a stabilized, quies

113 containing microvesicles (MVs) that increase vascular permeability; and (3) DV-triggered inflammasome

114 These isoforms have opposing actions on vascular permeability, angiogenesis, and vasodilatation.

115 Importantly, endotoxin-induced increases of vascular permeability are accompanied by concomitant inc

116 gly resembling those of MS, early changes in vascular permeability are associated with perivascular i

117 Pathological changes in vascular permeability are driven by growth factors such

118 ibition of NRP2 was hypothesized to decrease vascular permeability as well.

119 lectrophysiology, impedance measurements and vascular permeability assays, we show that the transient

120 (gadofosveset) could quantify the changes in vascular permeability associated with atherosclerosis pr

121 ation of multiple sized tracers to determine vascular permeability at a resolution of nearly one micr

122 ukocyte diapedesis, but not the induction of vascular permeability, attenuates bleeding.

123 g injury (ALI) was associated with increased vascular permeability attributable to loss of the Src fa

124 Airway vascular permeability (AVP) index was also assessed.

125 y domain 1, contribute to maintenance of the vascular permeability barrier and to its re-establishmen

126 nerating thrombin which in turn can increase vascular permeability both directly, acting on endotheli

127 kinase (MYLK), which not only increases lung vascular permeability but also serves as a scaffold to p

128 howed a dose-dependent loss of LTE4-mediated vascular permeability, but not to LTC4 or LTD4, revealin

129 acerbate inflammation, RvD2 did not increase vascular permeability, but reduced neutrophil accumulati

130 g1 (Angiopoietin-1) have opposing effects on vascular permeability, but the molecular basis of these

131 ce showing that hypoxic Muller cells promote vascular permeability by stabilizing hypoxia-inducible f

132 TBI increased cerebral vascular permeability by three-fold compared to sham.

133 at sites of inflammation, sgC1qR can enhance vascular permeability by upregulation of B1R expression

134 es to improve perfusion include reduction in vascular permeability by vascular normalization and vasc

135 Many of the signaling pathways promoting vascular permeability can also be triggered during disea

136 Prior stroke increased lung vascular permeability caused by P. aeruginosa pneumonia

137 cosal tissue, due to a temporary increase in vascular permeability caused by the release of vasoactiv

138 LPS-induced vascular permeability changes were reduced in EC-specifi

139 nflammatory response, resulting in increased vascular permeability, circulatory collapse, decreased c

140 ortant for the regulation of blood pressure, vascular permeability, clotting and transendothelial mig

141 arization (cerebral blood volume [CBV]), and vascular permeability (contrast enhancement after gadoli

142 Increased retinal vascular permeability contributes to macular edema, a le

143 Increased vascular permeability contributes to many diseases, incl

144 diet for 2 years were monitored for retinal vascular permeability, development of ME, and morphologi

145 gration and barrier function in a variety of vascular permeability disorders.

146 exhibit frequent haemorrhages and increased vascular permeability due to increased phosphorylation a

147 ort, high interstitial pressure and enhanced vascular permeability due to the presence of "leaky vess

148 Angioedema attacks result from increased vascular permeability due to the release of bradykinin f

149 recruitment to lungs and increases pulmonary vascular permeability during ALI.

150 ical trials, we link ANG-2/TIE2 signaling to vascular permeability during mycobacterial infection.

151 in inflammatory amplification and increased vascular permeability during severe forms of dengue.

152 observed in diseases associated with higher vascular permeability (e.g., systemic capillary leak syn

153 dify endothelial function in mouse models of vascular permeability, emphysema, primary tumour growth

154 terferon-gamma and mediate local increase in vascular permeability, enabling antibody access for vira

155 n myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, m

156 VEGF/vascular permeability factor (VEGF/VPF or VEGF-A) is a p

157 actor, was originally discovered as a potent vascular permeability factor (VPF), suggesting that othe

158 nction that form on organelles implicated in vascular permeability: fenestrae, transendothelial chann

159 lity during IAV infection and show decreased vascular permeability, fewer pulmonary neutrophils, and

160 infection, a finding confirmed by heightened vascular permeability following virus challenge.

161 We showed that vascular permeability, hemorrhage, edema, inflammation,

162 of LeTx-induced damage, including changes in vascular permeability, hepatic necrosis, and cellular ap

163 his phenomenon can be explained by increased vascular permeability immediately after NIR-PIT.

164 This phenomenon is explained by increased vascular permeability immediately after NIR-PIT.

165 , we investigated postnatal angiogenesis and vascular permeability in a DEP-1-deficient mouse.

166 e inhibition of MMP-9 decreased pathological vascular permeability in a murine model of diabetic reti

167 dition of exogenous SEMA3F protein inhibited vascular permeability in Balb/cJ mice, suggesting that t

168 BRB properties and correlates with increased vascular permeability in diabetic macular edema.

169 tastatic cancer cells induces metastasis and vascular permeability in distant organs, whereas inhibit

170 dence that platelets contribute to increased vascular permeability in DV infection by inflammasome-de

171 no consensus that apoptosis is the basis of vascular permeability in human dengue infections, we sho

172 h increased CD31(+) aggregates and increased vascular permeability in inflamed mucosa compared with t

173 S1P production in human cells and attenuated vascular permeability in mice, but did not lead to reduc

174 current knowledge on the nature of enhanced vascular permeability in multiple non-cancerous patholog

175 e examined the role of platelets in synovial vascular permeability in murine experimental arthritis.

176 neal mast cells in vitro and cause increased vascular permeability in rats in vivo.

177 ity in LPS-induced endotoxemia and increased vascular permeability in response to LPS or VEGF challen

178 all treatment protocols displayed decreased vascular permeability in response to OVA challenge after

179 anscriptional program that broadly regulates vascular permeability in response to progesterone.

180 in contrast to c-Src and Yes, which increase vascular permeability in response to stimuli, Lyn stabil

181 ssues, as well as in tumors, and exacerbated vascular permeability in response to VEGF, administered

182 ogether, these data support a role for islet vascular permeability in shaping beta-cell adaptive resp

183 ption of BBB tight junction proteins and CNS vascular permeability in the absence of neutrophil suppo

184 Increased vascular permeability in the allograft has been identifi

185 Vascular permeability in the lungs was assessed by accum

186 xcessive glutamate release lead to increased vascular permeability in the rat cerebral cortex, throug

187 mechanical and chemical stimuli and regulate vascular permeability in the retina is unknown.

188 therapeutics at the tumor site by modifying vascular permeability in the tumor to increase the thera

189 ration was also impaired, reflecting reduced vascular permeability in the tumors or a possible cell a

190 specific deletion of PR blocks physiological vascular permeability in the uterus, whereas misexpressi

191 The heterogeneous vascular permeability in tumor vessels, along with sever

192 cated that the mechanisms of MMP-1-dependent vascular permeability in tumors involve endothelial PAR1

193 FTY720-phosphate, on variables of pulmonary vascular permeability in vitro and alveolar-capillary pe

194 ial Ca(2+) signals mediated by TRPC4 enhance vascular permeability in vitro, but the contribution of

195 The absence of Eps8 also increases vascular permeability in vivo, but did not induce other

196 f AMP-activated protein kinase activation on vascular permeability in vivo.

197 t cells (BMMC) in vitro and had no effect on vascular permeability in vivo.

198 vessel regeneration and reduce VEGF-induced vascular permeability in vivo.

199 Excess vascular permeability, increased number of AC and PL, va

200 However, there are circumstances where vascular permeability increases, suggesting that platele

201 n patients with a maximum value of pulmonary vascular permeability index >3.8 and 37% in the group wi

202 A maximum value of pulmonary vascular permeability index >3.8 predicted day-28 mortal

203 the group with a maximum value of pulmonary vascular permeability index </= 3.8 (p < 0.0001).

204 extravascular lung water index and pulmonary vascular permeability index are independent prognostic f

205 dexed to predicted body weight and pulmonary vascular permeability index are two promising early mark

206 dexed to predicted body weight and pulmonary vascular permeability index as predictive markers of cli

207 Pulmonary vascular permeability index discriminated acute respirat

208 Pulmonary vascular permeability index effectively discriminated po

209 Extravascular lung water index and pulmonary vascular permeability index measured by transpulmonary t

210 dexed to predicted body weight and pulmonary vascular permeability index measurements were obtained i

211 dexed to predicted body weight and pulmonary vascular permeability index measurements.

212 extravascular lung water index and pulmonary vascular permeability index recorded during the acute re

213 Extravascular lung water index and pulmonary vascular permeability index were collected (PiCCO device

214 dexed to predicted body weight and pulmonary vascular permeability index were obtained within 2 hours

215 dexed to predicted body weight and pulmonary vascular permeability index would identify patients at r

216 g water index and maximum value of pulmonary vascular permeability index, respectively) were signific

217 ng water index or maximum value of pulmonary vascular permeability index, Simplified Acute Physiology

218 extravascular lung water index and pulmonary vascular permeability index, which can be measured by tr

219 4], p = 0.001 for maximum value of pulmonary vascular permeability index, Wilcoxon's test).

220 S879A-p120 mutant prevented the increase in vascular permeability induced by activation of the throm

221 brane VE-cadherin in ECs and in mice, blocks vascular permeability induced by ischaemia-reperfusion (

222 361F mutant in ECs prevented the increase in vascular permeability induced by the thrombin receptor,

223 we found increased leukocyte recruitment and vascular permeability/inflammation in sdc-1 knock-out mi

224 Increased vascular permeability is a fundamental characteristic of

225 Increased vascular permeability is a hallmark of inflammation.

226 Vascular permeability is a hallmark of several disease s

227 Here we show that lung vascular permeability is controlled mechanically by chan

228 Vascular permeability is frequently associated with infl

229 Vascular permeability is modulated by several factors, i

230 enhanced T1-weighted MRI, we determined that vascular permeability is not homogeneous but rather conf

231 A hallmark of inflammation, increased vascular permeability, is induced in endothelial cells b

232 nary edema--secondary to increased pulmonary vascular permeability--is common, unpredictable, and exa

233 uces biomechanical effects that increase the vascular permeability, leading to a locally enhanced ext

234 se in pericyte process length, and increased vascular permeability, leading to lethal cardiomyopathy

235 nse, and examined ear swelling, SK activity, vascular permeability, leukocyte recruitment, and produc

236 l injections of exogenous PK induced retinal vascular permeability, leukostasis, and retinal hemorrha

237 DSS is plasma leakage that leads to enhanced vascular permeability, likely due to a cytokine storm.

238 coagulopathy, proinflammatory cytokines, and vascular permeability, may serve as a receptor for Plasm

239 Vascular permeability measured by Evans blue extravasati

240 Pulmonary vascular resistance and vascular permeability measured in isolated perfused lung

241 We investigated whether vascular permeability measured in vivo by magnetic reson

242 We observed that VEGF regulates vascular permeability, monocyte infiltration, and scar-a

243 However, relative vascular permeabilities of the different nasal mucosal s

244 ute ocular inflammation, dilation, increased vascular permeability of choroidal vessels, and SRDs.

245 Glycyrrhizin also improved vascular permeability of endothelial cell-specific Fli1-

246 nt with methlut significantly decreases skin vascular permeability of Evans blue dye in mice passivel

247 l null mice respond poorly to VEGF-A-induced vascular permeability or angiogenesis, whereas other ago

248 itment of neutrophils to the lung, pulmonary vascular permeability, or histological evidence of damag

249 ssociated with indirect markers of increased vascular permeability, organ dysfunction, mortality, and

250 dexed to predicted body weight and pulmonary vascular permeability patient-important with important o

251 Inhibition of NO production reduced vascular permeability, preserved normal hematopoietic st

252 ed-enhanced MRI were used as measurements of vascular permeability (R1) and remodeling (vessel wall e

253 ural cell investment, leukocyte recruitment, vascular permeability, reactive gliosis and neuronal pat

254 alyzed in immunohistochemical, morphometric, vascular permeability, real-time polymerase chain reacti

255 herapeutic target in several angiogenic- and vascular permeability-related pathological conditions, i

256 Sustained amelioration of retinal vascular permeability (RVP) was demonstrated using a bes

257 dentifying areas with variable perfusion and vascular permeability, since individual tumor habitats v

258 lume and is influenced by agents that affect vascular permeability, such as antiangiogenic therapies.

259 cells require HIF--but not VEGF--to promote vascular permeability, suggesting that other HIF-depende

260 etes, including microaneurysms and increased vascular permeability, suggesting that pericyte cell los

261 gradation products are capable of modulating vascular permeability, suggesting that these fragments a

262 Concurrently with the initiation of vascular permeability, T2-weighted MRI revealed edema an

263 d-type bone marrow-derived cells have higher vascular permeability than wild-type mice, suggesting a

264 EH inhibitor prevented the pericyte loss and vascular permeability that are characteristic of non-pro

265 herapies are needed to reverse the increased vascular permeability that characterizes acute inflammat

266 Dengue can cause increased vascular permeability that may lead to hypovolemic shock

267 Here, we show that the physiological vascular permeability that precedes implantation is dire

268 ey role for the RhoA signalling circuitry in vascular permeability, thereby identifying novel pharmac

269 n activator (uPA) regulates angiogenesis and vascular permeability through proteolytic degradation of

270 microvasculature, the VI-V fragment promoted vascular permeability through the uncoordinated 5B (UNC5

271 ungs displayed significantly lower levels of vascular permeability to albumin, compared to day 1.

272 Ghrelin treatment restored vascular permeability to the level of shams.

273 atrial natriuretic peptide (ANP) to increase vascular permeability to the plasma protein albumin afte

274 Consistent with this, vascular permeability to vascular endothelial growth fac

275 sm for the bidirectional modulation of brain vascular permeability toward increased drug delivery and

276 eactive oxygen species (ROS) and exacerbates vascular permeability triggered by several inflammatory

277 ency led to decreased levels of intratumoral vascular permeability, tumor cell intravasation, and met

278 at 3 and 12 weeks, to quantify plaque area, vascular permeability, vasodilation, and stiffness and p

279 increased angiogenesis, tip cell formation, vascular permeability, VEGFR-2 accumulation, and Akt pho

280 sted to determine its effect on VEGF-induced vascular permeability via measurement of [(3)H]mannitol

281 Targeting granuloma-induced vascular permeability via vascular endothelial-protein t

282 VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), wher

283 BBB tight junction proteins; 2) reduced CNS vascular permeability visible by gadolinium-enhanced T1-

284 VEGF induces vascular permeability (VP) in ischemic diseases and canc

285 Moreover, VEGF-induced vascular permeability was decreased by 30% in Esm1(KO) m

286 imately 70-fold (FITC-lectin binding), tumor vascular permeability was enhanced by more than 30% (dyn

287 Retinal vascular permeability was measured using vitreous fluoro

288 NADPH oxidase, respectively), but increased vascular permeability was not significantly affected.

289 Because increased vascular permeability was observed early in the disease

290 dema attributable to ischemic stroke-induced vascular permeability was reduced by 50% in the absence

291 Vascular permeability was reduced only by nondiabetic ce

292 VEGF-mediated in vivo vascular permeability was significantly attenuated in PT

293 Vascular permeability was twofold greater in inflamed bl

294 e caveolae regulate endothelial function and vascular permeability, we hypothesized that defects in c

295 ie-2, pericyte/endothelial (EC) coverage and vascular permeability were assessed.

296 nanoparticles because of heterogeneities of vascular permeability, which limits nanoparticle penetra

297 ng a role in angiogenesis, inflammation, and vascular permeability, which might be of potential inter

298 Angioedema is a result of increased vascular permeability, with subsequent extravasation of

299 the blood-brain barrier (BBB) via increased vascular permeability, with the magnitude of changes dep

300 ADH-1 increased vascular permeability without effecting tumor interstiti