ライフサイエンスコーパス: vascular tone

1 the functional roles of MaxiK is to regulate vascular tone.

2 es, regulate inflammation, angiogenesis, and vascular tone.

3 uscle have a well-defined role in regulating vascular tone.

4 particles (MPs) participate in regulation of vascular tone.

5 unctional consequences for S1P signaling and vascular tone.

6 rterioles are dependent on concentration and vascular tone.

7 in vasculature is critical in regulating the vascular tone.

8 tase activity and increasing contraction and vascular tone.

9 racrine factors to regulate inflammation and vascular tone.

10 ose tissue (BAT) thermogenesis and cutaneous vascular tone.

11 two pathways in the regulation of peripheral vascular tone.

12 pe are required for the normal regulation of vascular tone.

13 ellular signalling, endothelial function and vascular tone.

14 ooth muscle cell-specific PPARgamma in basal vascular tone.

15 t reduction in blood pressure due to reduced vascular tone.

16 e calcium currents, which ultimately reduces vascular tone.

17 Ca2+ sparklets that increase Ca2+ influx and vascular tone.

18 ermy in amphibian oocytes, and regulation of vascular tone.

19 s where they contribute to the regulation of vascular tone.

20 acids (EETs), modulate sodium transport and vascular tone.

21 rophils also contribute to the regulation of vascular tone.

22 local vasodilating substances that influence vascular tone.

23 le in regulating both vascular responses and vascular tone.

24 a target of signaling pathways that regulate vascular tone.

25 e of fibronectin also contributes to resting vascular tone.

26 potassium channels (KATP) channels regulate vascular tone.

27 r function as heart rate, contractility, and vascular tone.

28 ocesses such as neurotransmitter release and vascular tone.

29 ization observed in ventilation or pulmonary vascular tone.

30 egulation of nitric oxide-mediated pulmonary vascular tone.

31 eby regulating both peripheral and pulmonary vascular tone.

32 vented a compensatory increase in peripheral vascular tone.

33 and cardiac excitability, and regulation of vascular tone.

34 + channels (MaxiK, BK) are key regulators of vascular tone.

35 ay contribute to the development of abnormal vascular tone.

36 including pain perception and the control of vascular tone.

37 stress, affects endothelial permeability and vascular tone.

38 the endothelium in the control of pulmonary vascular tone.

39 salt and water homeostasis and regulation of vascular tone.

40 smooth muscle and an important regulator of vascular tone.

41 ET-1 and 4 Ala ET-1 did not change pulmonary vascular tone.

42 channels is important for the regulation of vascular tone.

43 clinical syndrome characterized by increased vascular tone.

44 r this critical subunit in the regulation of vascular tone.

45 nases (ERK1/2) play a key role in regulating vascular tone.

46 s supports the notion that it also regulates vascular tone.

47 cipate in renal K metabolism and to regulate vascular tone.

48 regulating cerebral sympathetic activity and vascular tone.

49 hereby nitric oxide (NO) maintains pulmonary vascular tone.

50 and the factors that modulate its effect on vascular tone.

51 xide synthase (eNOS) is a key determinant of vascular tone.

52 of glomerular thrombosis and restitution of vascular tone.

53 an alteration of the hemostatic balance and vascular tone.

54 id not change resting coronary or peripheral vascular tone.

55 he transduction of sympathetic activity into vascular tone.

56 ion of sympathetic nerve activity (SNA) into vascular tone.

57 ular functions, such as calcium handling and vascular tone.

58 +) release channels (RyRs), causing enhanced vascular tone.

59 tion, cardiac and neuronal excitability, and vascular tone.

60 se activity, which associates with increased vascular tone.

61 t a role for plasma ABA in the regulation of vascular tone.

62 luding cell growth, migration, survival, and vascular tone.

63 d release vasoactive molecules that regulate vascular tone.

64 luding cell growth, migration, survival, and vascular tone.

65 muscle cells (SMCs), is a key determinant of vascular tone.

66 1), indicating NO tonically reduces cerebral vascular tone.

67 the ADM gene in the modulation of peripheral vascular tone.

68 he importance of ATP in the control of basal vascular tone.

69 role in modulating intravascular volume and vascular tone.

70 nary blood velocity) was used as an index of vascular tone.

71 e role of HIF-1alpha in modulating pulmonary vascular tone.

72 and may play a role in the autoregulation of vascular tones.

73 blood pressure control through modulation of vascular tone across multiple tissues.

74 ribution of ET-1 to the maintenance of basal vascular tone acting through the ET(A) receptor.

75 bnormal nitric oxide-dependent regulation of vascular tone, adhesion, platelet activation, and inflam

76 diamond microelectrode and video imaging of vascular tone allow real time local measurement of the t

77 Vascular tone, an important determinant of blood pressur

78 aptor protein p66Shc as a regulator of renal vascular tone and a driver of impaired renal vascular fu

79 to 72 hrs was associated with an increase in vascular tone and a reduction in both cardiac index and

80 (eNOS) plays an important role in control of vascular tone and angiogenesis among other functions.

81 ceptors (RyRs) are important determinants of vascular tone and arteriolar resistance, but the mechani

82 yperplasia, inflammation, and maintenance of vascular tone and barrier function.

83 n denitrosylation, regulates both peripheral vascular tone and beta-adrenergic agonist-stimulated car

84 e synthase (eNOS) is a critical modulator of vascular tone and blood flow and plays major roles in li

85 (SMCs), K(+) channels regulate contraction, vascular tone and blood flow.

86 nd redox-sensing enzyme in the regulation of vascular tone and blood flow.

87 to arterial KATP channels in the control of vascular tone and blood flow.

88 ucial role in human physiology by regulating vascular tone and blood flow.

89 ascular health by maintaining and regulating vascular tone and blood flow.

90 The nitric oxide (NO)-cGMP pathway regulates vascular tone and blood pressure by mechanisms that are

91 r mineralocorticoid receptors play a role in vascular tone and blood pressure regulation, might parti

92 is essential for alpha(1D)-AR regulation of vascular tone and blood pressure.

93 helial cells is a fundamental determinant of vascular tone and blood pressure.

94 l homeostasis and function that impacts upon vascular tone and blood pressure.

95 (2+)-permeable cation channels contribute to vascular tone and blood vessel remodeling and represent

96 ndicate that systemic hemodynamic responses (vascular tone and cardiac contractility), both under bas

97 ilure, resulting in a decrease in peripheral vascular tone and cardiac contractility, which results i

98 NO-dependent endothelial function, including vascular tone and cell proliferation.

99 /=150 microM) would have negatively affected vascular tone and contributed to virus-induced shock.

100 (BK) channel is an important determinant of vascular tone and contributes to blood pressure regulati

101 eral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs.

102 -deficient mice exhibited reduced peripheral vascular tone and depressed beta-adrenergic inotropic re

103 ygb has a critical role in the regulation of vascular tone and disease.

104 scular function in humans: the regulation of vascular tone and endogenous fibrinolysis.

105 Cortisol supports vascular tone and endothelial integrity, modulates a lar

106 In addition to modulating vascular tone and extracellular matrix turnover, ET-1 up

107 ling molecules involved in the regulation of vascular tone and homeostasis.

108 ntra- and extracellular processes, including vascular tone and immune responses.

109 y processes, for example, the maintenance of vascular tone and inflammation.

110 llikrein-kinin systems are key regulators of vascular tone and inflammation.

111 thus, these functional microdomains control vascular tone and local perfusion in the brain.

112 l development and integrity, heart rate, and vascular tone and maturation by activating G protein-cou

113 system, which participate in their increased vascular tone and may predispose them to atherosclerosis

114 an early increase in systemic and pulmonary vascular tone and oxygen extraction, whereas both cardia

115 and innervate resistance arteries to control vascular tone and participate in blood pressure regulati

116 etabolite, has been implicated in regulating vascular tone and participating in chronic and acute kid

117 naling plays a key role in the regulation of vascular tone and platelet activation.

118 Nitric oxide (NO) is a critical regulator of vascular tone and plays an especially prominent role in

119 cific TP receptor blocker, decreases hepatic vascular tone and portal pressure in rats with cirrhosis

120 peroxide (*O2-) and NO*, thereby controlling vascular tone and reactivity in the brain.

121 gulation of hemostasis and thrombosis, local vascular tone and redox balance, and the orchestration o

122 mediators and may play a role in maintaining vascular tone and regulation of insulin sensitivity to d

123 ) signaling plays a major role in modulating vascular tone and remodeling in the pulmonary circulatio

124 aemodynamic mechanical forces act to control vascular tone and remodelling in disease.

125 ases within parenchymal arterioles increased vascular tone and simultaneously decreased resting pyram

126 se inhibitors) aimed at regulating pulmonary vascular tone and structure.

127 rs of ion channel activity and regulators of vascular tone and systemic blood pressures.

128 nhibitory A3 adenosine receptor (AR) impacts vascular tone and that rat vascular smooth muscle cells

129 p66Shc (encoded by Shc1) in regulating renal vascular tone and the development of renal vascular dysf

130 ver, the direct effect of lactate on retinal vascular tone and the possible underlying signaling mech

131 y SMC (PASMC) HIF-1alpha modulates pulmonary vascular tone and the response to hypoxia.

132 nduces actin depolymerization, which reduces vascular tone and the response to vasoconstrictors.

133 vascular diseases associated with increased vascular tone and thickness, such as pulmonary hypertens

134 e to eliminate sympathoadrenal influences on vascular tone and thus isolate local vasodilatation.

135 ) to eliminate sympathoadrenal influences on vascular tone and thus isolate local vasodilatory mechan

136 in vascular smooth muscle cells to regulate vascular tone and tissue perfusion.

137 he sympathetic nervous system, and increased vascular tone and total peripheral resistance.

138 dly hypotensive with accompanying defects in vascular tone and VSMC contractility.

139 controls stuttering persistent Ca2+ influx, vascular tone, and blood pressure under physiological co

140 required for the regulation of NO formation, vascular tone, and blood pressure.

141 required for basal endothelial NO formation, vascular tone, and blood pressure.

142 rolling inflammation, thrombosis/hemostasis, vascular tone, and blood vessel development.

143 l regulator of renal sodium excretion, renal vascular tone, and BP.

144 The endothelium is a critical regulator of vascular tone, and dysfunction of the endothelium contri

145 ndothelium-dependent vasodilation, increased vascular tone, and hypertension.

146 (K(ATP)) channels regulate insulin release, vascular tone, and neuronal excitability.

147 rol permeability of the blood-brain barrier, vascular tone, and the expression of MMPs.

148 , including platelet aggregation, control of vascular tone, and the local inflammatory response.

149 riate immune responses, synaptic plasticity, vascular tone, angiogenesis, and cardiac remodeling.

150 A pathway for the regulation of vascular tone appears to involve coupling between integr

151 ramework regarding how muscle blood flow and vascular tone are regulated in contracting muscles of hu

152 at the balance between mechanisms regulating vascular tone are shifted to favor vasoconstriction in t

153 he alpha-adrenoceptor subtypes to basal limb vascular tone are unknown.

154 ate, heart rate variability, blood pressure, vascular tone, blood coagulability, and the progression

155 rd enteric disease by altering gut motility, vascular tone, blood supply, mucosal barrier function, s

156 de that BK channel activity directly affects vascular tone but influences blood pressure independent

157 d pressure suppresses endothelial control of vascular tone but it remains uncertain (1) how pressure

158 Losartan did not alter resting coronary vascular tone, but epicardial FMD improved from 5.6 +/-

159 ates angiogenesis, vascular permeability and vascular tone, but it also promotes vascular inflammatio

160 tabolites have important roles in regulating vascular tone, but their function and specific pathways

161 ere are sex differences in the regulation of vascular tone, but, to date, no study has investigated w

162 rule pathway, suggest that RGS5 may balance vascular tone by attenuating vasodilatory signaling in v

163 ing endothelial NO and endothelium-dependent vascular tone by deacetylating eNOS.

164 ia, PASMC HIF-1alpha maintains low pulmonary vascular tone by decreasing myosin light chain phosphory

165 culature plays a critical role in modulating vascular tone by endothelial release of an unusually div

166 siological role for APE1/ref-1 in regulating vascular tone by governance of eNOS activity and bioavai

167 yperpolarizing factors contribute to resting vascular tone by K(+)(Ca) channel activation and epoxyei

168 EETs regulate cardiac electrophysiology and vascular tone by KATP channel activation, albeit through

169 channels (Cl(Ca)) are crucial regulators of vascular tone by promoting a depolarizing influence on t

170 ere any sex differences in the regulation of vascular tone by PVAT.

171 noid which participates in the regulation of vascular tone by sensitizing the smooth muscle cells to

172 the lack of M(5) receptors led to changes in vascular tone by using several in vivo and in vitro vasc

173 was a physiological mechanism for regulating vascular tone by vasoconstrictors.

174 cardiovascular system, such as regulation of vascular tone, cardiac hypertrophy, phenotypic modulatio

175 aglandin E(2) production in SMCs, modulating vascular tone, cellular signaling, proliferation, and mi

176 ng and supports the emerging hypothesis that vascular tone contributes directly to systemic blood pre

177 th BPD, suggesting that heightened pulmonary vascular tone contributes to pulmonary vascular disease

178 d echocardiographic assessments of pulmonary vascular tone (DeltaPmax) were made during euoxia and du

179 At the molecular level, vascular tone depends on the level of regulatory myosin

180 In addition to affecting respiration and vascular tone, deviations from normal CO(2) alter pH, co

181 to the sympathetically-mediated increase in vascular tone during diving.

182 se from rest to SS hypoxia; (2) NO regulates vascular tone during hypoxia independent of the COX path

183 f the COX pathway, whereas PGs only regulate vascular tone during hypoxia when NOS is inhibited; and

184 as by quantifying how each inhibitor reduced vascular tone during hypoxia.

185 ndothelial derived substances that influence vascular tone during hypoxic exercise.

186 implicated in the control of skeletal muscle vascular tone during mismatches in oxygen delivery and d

187 We speculate that the changes in cerebral vascular tone during sleep onset are mediated neurally,

188 el is a critical player in the regulation of vascular tones during hypercapnic acidosis.

189 ation of hypertensive states caused by local vascular tone dysfunctions.

190 vascular resistance (IHVR) and intrahepatic vascular tone (endothelial dysfunction and hyperresponsi

191 otype encompassing defects in maintenance of vascular tone, endothelial cell function and blood press

192 anscriptional regulator of genes controlling vascular tone [endothelin-1, endothelin-1 receptor type

193 ffect of oral sildenafil on resting coronary vascular tone, endothelium-dependent and -independent fu

194 tude of the vasodilation and served to reset vascular tone following activity-dependent vasodilation.

195 hese opposing influences of insulin on renal vascular tone has not been explored.

196 ion, and migration; angiogenesis; apoptosis; vascular tone; host defenses; and genomic stability.

197 NO is a critical regulator of vascular tone; however, whether insulin regulates NO pro

198 ed that flow-mediated shear stress regulates vascular tone; however, whether this operates in the hum

199 of airflow limitation and arousal on digital vascular tone in 10 patients with obstructive sleep apne

200 ases in VE-cadherin expression and function, vascular tone in aortic rings, cholesterol efflux from m

201 er in many tissue types, including mediating vascular tone in blood vessels as well as neuromodulatio

202 ormoxic animal, whereas it lowered pulmonary vascular tone in chronically hypoxic animals.

203 ndothelial dysfunction and increased hepatic vascular tone in cirrhosis.

204 playing a central role in the regulation of vascular tone in health and disease.

205 hanism may regulate endothelial function and vascular tone in heart failure patients.

206 degranulation, and mediates dysregulation of vascular tone in heart failure.

207 ndothelial dysfunction and the regulation of vascular tone in human obesity and type 2 diabetes.

208 ribution of blood-transported NO to regional vascular tone in humans before and during NO inhalation.

209 pairment in exercising muscle blood flow and vascular tone in humans is unknown.

210 ronic hypoxia and contribute to the enhanced vascular tone in hypoxic pulmonary hypertension.

211 rrent in human atrial myocytes and regulates vascular tone in multiple peripheral vascular beds.

212 Vascular heme oxygenase (HO) regulates vascular tone in normal conditions and in some pathologi

213 the elevated basal [Ca(2+)](i) in PASMCs and vascular tone in PAs of chronic hypoxic animals, but nif

214 on of bradykinin to the maintenance of basal vascular tone in patients with heart failure receiving c

215 To determine the role of high pulmonary vascular tone in pulmonary hypertension, we studied the

216 These findings suggest that vascular tone in rat retinal arterioles is maintained by

217 itical role in modulating neonatal pulmonary vascular tone in response to common clinical treatments

218 ptors nor Y(1) receptors contribute to basal vascular tone in skeletal muscle, but both contribute to

219 s make sorcin a viable candidate to modulate vascular tone in smooth muscle.

220 Purinergic control of vascular tone in the CNS has been largely unexplored.

221 ATIONALE: Hydrogen peroxide (H2O2) regulates vascular tone in the human microcirculation under physio

222 vascular smooth muscle cells, in controlling vascular tone in the in vivo rat retina.

223 Phosphatases appear to modulate pulmonary vascular tone in the normoxic and hypoxic newborn piglet

224 covery that CO2/H(+)-dependent regulation of vascular tone in the RTN is the opposite to the rest of

225 e endothelial dysfunction and alterations of vascular tone in these conditions.

226 hysiology and target treatments to pulmonary vascular tone in this population.

227 e physiological regulation of human coronary vascular tone in vivo.

228 olar myogenic response and during changes in vascular tone induced by vasomotor agonists.

229 ical processes, including neuronal activity, vascular tone, inflammation, and energy metabolism.

230 essential for neuronal survival, but whether vascular tone influences resting neuronal function is no

231 tric oxide (NO)-mediated local regulation of vascular tone is considered to involve endothelial NO sy

232 Vascular tone is controlled by a dual mechanism.

233 The results indicate that while cephalic vascular tone is controlled by endogenous nitric oxide s

234 transfer of sympathetic nerve activity into vascular tone is increased, so that for a given level of

235 et the exact influence of this modulation on vascular tone is not understood, even in normotensive co

236 wever, the relationship between sickling and vascular tone is not well understood.

237 adrenergic vasoconstriction to basal forearm vascular tone is reduced with age in healthy men.

238 During CHF, vascular tone is regulated by the interplay of neurohorm

239 Pulmonary vascular tone is strongly influenced by the resting memb

240 mportant for understanding how regulation of vascular tone is tailored to support neural function and

241 two in the context of endothelium-dependent vascular tone is unknown.

242 mor cells that regulates bone metabolism and vascular tone, is a naturally occurring angiogenesis inh

243 ic oxide synthase (eNOS), a key regulator of vascular tone, is activated in endothelial cells by dive

244 Nitric oxide (NO), essential for maintaining vascular tone, is produced from arginine by nitric oxide

245 ated K(+) (BK) channel, a key determinant of vascular tone, is regulated by angiotensin II (Ang II) t

246 Endothelial integrity regulates vascular tone, luminal patency, and the immune reactivit

247 nvolvement of integrins in the modulation of vascular tone may be particularly important in vascular

248 fibers and alterations in the regulation of vascular tone may result in an age-related, regional inc

249 ich is required for the normal regulation of vascular tone, may be decreased in preeclampsia, thus co

250 SC/P RhoA, but not by interfering with other vascular tone mediators.

251 rtension (PAH) is characterized by increased vascular tone, neointimal hyperplasia, medial hypertroph

252 s as diverse as vasodilation, maintenance of vascular tone, neurotransmission, and immune response.

253 iators, sEH contributes to the regulation of vascular tone, nociception, angiogenesis and the inflamm

254 a concentration range sufficient to regulate vascular tone of the mesenteric blood vessels where the

255 potentially adverse alterations in baseline vascular tone or compliance.

256 ch an abnormality in autonomic regulation of vascular tone or heart rate results in vasodilation or b

257 m), P2X7 antagonists, had no effect on basal vascular tone (P = 0.99 and P = 1.00 respectively).

258 athogenesis of ARDS via effects on pulmonary vascular tone/permeability, epithelial cell survival, an

259 We conclude that in addition to enhanced vascular tone, pseudopod formation with lack of normal f

260 receptor (beta2AR) plays a critical role in vascular tone regulation and neoangiogenesis.

261 e role of Orai1- and TRPC1-dependent SOCC in vascular tone regulation and their possible interaction

262 ive substances, playing an important role in vascular tone regulation.

263 The K(ATP) channel is an important player in vascular tone regulation.

264 of store-operated Ca(2+) channels (SOCC) in vascular tone regulation.

265 n represents one of the antiinflammatory and vascular tone regulatory mechanisms maintaining normal e

266 Augmenting pulmonary vascular tone restores HPV in the absence of cPLA(2) act

267 Manipulation of vascular tone resulted in heightened peak CEST contrast

268 Lung BH4 availability controlled pulmonary vascular tone, right ventricular hypertrophy, and vascul

269 gical processes, including the regulation of vascular tone, sodium excretion, pressure-volume homeost

270 ha(2)-adrenoceptors contribute more to basal vascular tone than alpha(1)-adrenoceptors in the forearm

271 ular ATP and ADP are important regulators of vascular tone, thrombosis, inflammation, and angiogenesi

272 that NO/cGMP/cGKI signaling maintains basal vascular tone through active inhibition of calcium sensi

273 ooth muscle, hypoxia may influence pulmonary vascular tone through an effect on RBCs.

274 a cells seize control over the regulation of vascular tone through Ca(2+)-dependent release of K(+).

275 ansmitter in the normotensive RVLM to affect vascular tone through interaction with the vasopressin V

276 olume homeostasis, cardiac contractility and vascular tone through renal, neural or endocrine systems

277 (iPLA(2)s) participate in the regulation of vascular tone through smooth muscle cell (SMC) Ca(2+) si

278 utes an essential element for the control of vascular tone throughout the cardiovascular system.

279 c system modulates neuronal excitability and vascular tone throughout the cerebral cortex and hippoca

280 Renal preglomerular arterioles regulate vascular tone to ensure a large pressure gradient over s

281 responsible for orchestrating adjustments in vascular tone to match local tissue perfusion with oxyge

282 ing the effects of CR on the endothelium and vascular tone to SIRT1-mediated deacetylation of eNOS.

283 en radicals contribute to the enhanced basal vascular tone, tubuloglomerular feedback, monocyte/macro

284 on intra-brain heat production and cutaneous vascular tone, two critical factors that control brain t

285 may in turn contribute to the regulation of vascular tone via the modulation of H2S production.

286 against TNF) and its impact on modulation of vascular tone was assessed.

287 While vascular tone was consistently increased in all BKbeta1(

288 Basal forearm vascular tone was not different in young men and older m

289 ith this, the contribution of BK channels to vascular tone was reduced during hypertension.

290 much as ET-1 is one of the key regulators of vascular tone, we chose to examine in more detail the ef

291 Because eNOS is important in regulating vascular tone, we investigated whether phosphorylation o

292 vity act in opposing directions to determine vascular tone, we simultaneously evaluated alpha-adrener

293 The effects of TRPA1 activity on vascular tone were examined using isolated, pressurized

294 kinase (MLCK) activity-major determinants of vascular tone-were increased in patients with PAH.

295 uscle cells, acute hypoxia induces increased vascular tone, which is attenuated if hypoxia persists.

296 or systemic oxygenation is the modulation of vascular tone, which is mediated in part by changes in t

297 reases or decreases in parenchymal arteriole vascular tone, which result in arteriole constriction an

298 transfer of sympathetic nerve activity into vascular tone, will be effective in reducing blood press

299 iator that is involved in the maintenance of vascular tone within the healthy circulation.

300 development and is an important regulator of vascular tone, yet the transcriptional regulation of the