ライフサイエンスコーパス: vascularize

1 stringent orchestration by the tissue being vascularized.

2 transgenic mice were hyperplastic and highly vascularized.

3 ients, is decidedly heterogeneous and highly vascularized.

4 They are well vascularized.

5 e biomedical applications.The fabrication of vascularized 3D tissues requires an understanding of how

6 ved stromal vascular fraction (SVF) cells to vascularize a human liver cell (HepG2) implant.

7 tence of adenomas with delayed appearance of vascularized adenocarcinomas in PAR2(-/-) mice.

8 ipocytes in mice produces well-organized and vascularized adipose tissue, capable of beta-adrenergic-

9 The mouse retina is vascularized after birth when angiogenic blood vessels g

10 ma multiforme (GBM) is a highly invasive and vascularized aggressive brain tumor.

11 ower A20 expression or function in donors of vascularized allografts may inform risk and severity of

12 , is critical for memory T-cell migration to vascularized allografts.

13 Transplanted metanephroi vascularize and develop features of mature kidney.

14 describe a detailed method for performing a vascularized and aerated mouse orthotopic lung transplan

15 relation of the IOH to the junction between vascularized and avascular retina.

16 -like cellular microarchitectures resembling vascularized and bone marrow tissue architectures.

17 ining microtissue spheroids resulted in well-vascularized and cellular pulp-like tissues, compared wi

18 t, we showed that fully allogeneic primarily vascularized and conventional skin transplants were reje

19 lesions from IL-33 treated mice were highly vascularized and exhibited increased proliferation.

20 ll) immunodeficient host mice regenerate new vascularized and innervated myofibers from human myogeni

21 During this progression, tumors become vascularized and mitotically active.

22 e skin reservoir or the presence of a poorly vascularized and mobile wound bed.

23 d with Dll4 were significantly smaller, less vascularized and more hypoxic than controls, and display

24 ongs fully allogeneic graft survival in both vascularized and nonvascularized allograft transplantati

25 Follicle-seeded scaffolds become highly vascularized and ovarian function is fully restored when

26 n building human-scale constructs, which are vascularized and readily implantable.

27 anted pancreatic and renal buds were rapidly vascularized and self-organized into functional, tissue-

28 lastic cells, whereas central marrow remains vascularized and splenic vascular niches expand.

29 We found that the endosteum is well vascularized and that vasculature is frequently localize

30 In this study, we used heart (vascularized) and skin (nonvascularized) transplantation

31 LA2/alpha1-null mice were also smaller, less vascularized, and exhibited reduced cell proliferation a

32 of tumorigenesis, yet produced smaller, less vascularized, and less metastatic tumors than TRAMP cont

33 he mitoNEET-enriched fat pads feature a more vascularized, anti-inflammatory and less fibrotic enviro

34 In air controls, both the vascularized area of the retina and the density of super

35 ; P < 0.001) and, to a lesser extent, in the vascularized areas of the SeTA specimens (SeTA:normal ra

36 phery of the tumors, corresponding with well-vascularized areas of the tumor.

37 analysis suggested that the interpositional vascularized augmentation neogenesis (IVAN) technique ca

38 fabrication of scalable constructs that are vascularized, autologous, functional, implantable, cost-

39 th ACT to enhance inhibition of established, vascularized, B16 melanoma (P = 0.009) and improve survi

40 kin (IL)-10 (CD19-Cre::IL-10) mice, received vascularized BALB/c cardiac allografts.

41 odular tissue engineering results in an s.c. vascularized bed that enables the transplantation of pan

42 l sources, graft sites, and ultimately fully vascularized bioengineered insulin-secreting microtissue

43 Transplantable vascularized bioengineered intestine could restore nutri

44 ble/tongue allograft containing lymphoid and vascularized BM components.

45 ilage template that completely remodels into vascularized bone and involves a dynamic interplay among

46 CSC and endothelial cell interactions during vascularized bone formation.

47 thelial cells are essential for FCSC-derived vascularized bone formation.

48 develop a two-stage protocol for generating vascularized bone grafts using mesenchymal stem cells (h

49 The transplantation of a large volume of vascularized bone marrow in composite tissue allografts

50 tor cells (EPCs) could significantly enhance vascularized bone regeneration.

51 veloped to overcome the challenge of forming vascularized bone tissue.

52 nlagen, which is subsequently remodeled into vascularized bone using an ectopic transplantation model

53 eplace the avascular cartilage template with vascularized bone.

54 ral integrity and characteristics as seen in vascularized bones and osteochondral tissues.

55 Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy imp

56 ated by pulse-chase experiments, EECs in the vascularized, but not in the avascular, region efficient

57 and CXCR3 are functional in the rejection of vascularized, but not nonvascularized, allografts.

58 ssociated with C3 glomerulonephritis are not vascularized, but rather of serous type.

59 Lymphoid tissue in diseased rats was vascularized by aquaporin-1(+) high endothelial venules

60 In patients who were re-vascularized by CABG, mortality and major adverse cardia

61 s system is unique in that it is secondarily vascularized by sprouting angiogenesis from a surroundin

62 in low-risk (nonvascularized) and high-risk (vascularized) C57BL/6 (H-2b) recipients using Balb/c (H-

63 In the mouse vascularized cardiac allograft model, transient depletio

64 x class II- and class I-mismatched models of vascularized cardiac allograft rejection, blocking anti-

65 diac allograft induces H4 immunodominance in vascularized cardiac allograft.

66 The efficacy of donor ECDI-SPs in protecting vascularized cardiac allografts and mechanism(s) of prot

67 C57BL/6 (H-2) mice received vascularized cardiac allografts from A/J (H-2) donors an

68 Interestingly, non-primarily vascularized cardiac allografts mimicked skin grafts in

69 ges upon transplantation in a BALB/c into B6 vascularized cardiac transplant model.

70 in allograft rejection in a murine model of vascularized cardiac transplantation.

71 s spontaneously formed a BM cavity through a vascularized cartilage intermediate in vivo that was pro

72 demonstrate a novel strategy to engineer pre-vascularized, cell-laden hydrogel pulp-like tissue const

73 neering is producing three-dimensional (3D), vascularized cellular constructs of clinically relevant

74 would postpone the regression of the highly vascularized CL in vivo, and this effect could be replic

75 r and extracellular microenvironment, highly vascularized compared to non-neurogenic periventricular

76 harnessing mechanical properties to generate vascularized, complex organ buds with broad applications

77 The definition of vascularized composite allograft (VCA) and the nomenclat

78 previously demonstrated that tolerance to a vascularized composite allograft (VCA) can be achieved a

79 Monitoring vascularized composite allograft (VCA) hand recipients f

80 Current knowledge of the impact of facial vascularized composite allograft (VCA) procurement on th

81 Vascularized composite allograft (VCA) transplantation c

82 ent of acute rejection of the abdominal wall vascularized composite allograft (VCA).

83 ascular lesions and prospects for defining a vascularized composite allograft rejection classificatio

84 cells may function toward maintenance of the vascularized composite allograft.

85 Chronic rejection of vascularized composite allografts (VCA) is an emerging p

86 d with animal modeling of transplantation of vascularized composite allografts (VCA).

87 Vascularized composite allografts (VCAs) are unique amon

88 Achieving tolerance of vascularized composite allografts (VCAs) would improve t

89 erved for the primarily vascularized skin of vascularized composite allografts (VCAs).

90 To date, there are more than 80 reports of vascularized composite allografts (VCAs; a.k.a. composit

91 or-host hematopoietic chimerism and accepted vascularized composite allografts for periods ranging be

92 Vascularized composite allografts from marrow donors wer

93 ed with extensive infiltrates in biopsies of vascularized composite allografts from marrow donors.

94 Biopsies of muscle and skin of vascularized composite allografts from mixed chimeras sh

95 nd 90 weeks; in turn, marrow donors rejected vascularized composite allografts from their respective

96 atory cells were found in skin and muscle of vascularized composite allografts of mixed chimeras comp

97 Vascularized composite allografts, particularly hand and

98 ing compared with nondraining lymph nodes of vascularized composite allografts.

99 st chimerism leads to tolerance of antigenic vascularized composite allografts.

100 Cellular therapies for immunomodulation in vascularized composite allotransplantation (VCA) have ga

101 We used our nonhuman primate model of facial vascularized composite allotransplantation (VCA) to stud

102 Approaches to safely induce tolerance in vascularized composite allotransplantation (VCA) with ch

103 ey immediate goals for clinical expansion of vascularized composite allotransplantation (VCA).

104 Vascularized composite allotransplantation has become es

105 Skin chronic rejection (CR) in vascularized composite allotransplantation has not been

106 The effect of cold ischemia (CI) in vascularized composite allotransplantation is unknown.

107 Ischemia times in vascularized composite allotransplantation should be kep

108 proceeding ethically with research on penile vascularized composite allotransplantation will require

109 y reported for the treatment of rejection in vascularized composite allotransplantation.

110 duces donor-specific tolerance to kidney and vascularized composite allotransplants (VCA).

111 Vascularized composite tissue allografts (VCA) can under

112 Vascularized composite tissue allografts (VCA) have beco

113 ly, the donor-recipient matching process for vascularized composite tissue allotransplantation (VCTA)

114 Well-vascularized composite tissue offers improved outcomes f

115 hniques has facilitated the establishment of vascularized composite tissue transplant models in small

116 After transplantation of vascularized condensed progenitors into immunodeficient

117 We propose that a high risk vascularized cornea behaves like a vascularized solid or

118 d to increase the survival rate of high-risk vascularized corneal allografts.

119 ival rate of corneal allografts in high-risk vascularized corneal bed recipients is poor, similar to

120 rogressive keratopathy, resulting in a dense vascularized corneal pannus, and eventually leading to v

121 For these vascularized corneas at high risk for immunologic reject

122 nd effective strategy for engineering of pre-vascularized dental pulp constructs offering potentially

123 Transplantation of vascularized donor thymic tissue along with a kidney tra

124 Kaposi's sarcoma is a highly vascularized, endothelial cell-based tumor supporting la

125 cells, and, in the future, for implantable, vascularized engineered tissues or organs.

126 ropylene fumarate) scaffolds is proposed for vascularized engineered tissues.

127 crocapsules (Micro) in the confined and well-vascularized epididymal fat pad (EFP) site, a model of t

128 Brown adipose tissue is highly vascularized, facilitating delivery of nutrients to brow

129 and that specific rhombomeres are invariably vascularized first.

130 porated T cells mediated regression of large vascularized flank mesothelioma tumors in NOD/scid/gamma

131 The patients presented with vascularized, focally cystic, nonulcerated eyelid margin

132 were differentiated into nonvascularized and vascularized forms with 3 main underlying etiologies: AM

133 med in 31 eyes of 31 patients with a central vascularized full-thickness leukoma, resulting from infe

134 We then fabricated pre-vascularized, full-length, dental pulp-like tissue const

135 er maturation of kidney tissue, formation of vascularized glomeruli with fully differentiated capilla

136 Intrathymic tolerance to vascularized grafts in large animals has not previously

137 inflammatory response due to it being highly vascularized, having constant exposure to environmental

138 ed direct evidence that chronic rejection of vascularized heart allografts occurs in the complete abs

139 al ear-heart transplantation and heterotopic vascularized heart transplantation models to evaluate im

140 t tumors, as well as human JGCTs, are highly vascularized, hemorrhagic and mitotically active.

141 Ab-mediated rejection, we developed a mouse vascularized heterotopic cardiac allograft model in whic

142 Murine hearts were transplanted as fully vascularized heterotopic grafts from BALB/c donors into

143 lethally irradiated before receiving skin or vascularized heterotopic heart grafts from C57Bl/6 mice.

144 r graft prolongation was observed in a fully vascularized heterotopic heart transplantation model (DB

145 was performed in hemevascularized and lymph-vascularized high-risk host beds, and graft recipients r

146 to grafting performed on inflamed and highly vascularized host beds.

147 ntation, where the graft bed is inflamed and vascularized, immature APCs in the donor corneal stroma

148 systemic intravascular injection only in SVF-vascularized implants demonstrating that SVF cell-derive

149 the most common primary brain tumors, highly vascularized, infiltrating, and resistant to current the

150 jaw and that they are properly mineralized, vascularized, innervated and can start to form roots.

151 We report on an unusual case of a vascularized iris lesion in a three year old Caucasian p

152 uli were capable of engrafting on the highly vascularized iris.

153 in immunodeficient mice, grafted cells form vascularized islet-like structures containing MAFA/C-pep

154 , not only does the brain need to be densely vascularized, it also requires a tightly controlled envi

155 and recipient cells after transplantation of vascularized kidney and cardiac allografts in mice.

156 Transplantation of hands, larynx, vascularized knee, trachea, face, and abdominal wall has

157 ted access of the drug to tumor loci in hypo-vascularized lesions has hampered clinical application.

158 nsport in 3D cell cultures representing hypo-vascularized lesions, enhancing drug uptake and effect.

159 eatic ductal adenocarcinoma (PDAC), a poorly vascularized lethal KRAS-driven malignancy.

160 outcome is that liver metastases are poorly vascularized, limiting the ability to deliver therapeuti

161 The highly vascularized lung holds up to 40% of blood, and thus, th

162 c lymphatics, developed a surgical model for vascularized lymph node transplantation, and confirmed P

163 Search terms were focused on vascularized, lymph node transfer (also autologous, lymp

164 ficant potential for the treatment of highly vascularized, malignant NB.

165 The dura mater is a vascularized membrane surrounding the brain and is heavi

166 e pancreatic islets of Langerhans are highly vascularized micro-organs that play a key role in the re

167 Here we describe in vitro vascularized microtumors (VMTs).

168 Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growt

169 Because adipose tissue is highly vascularized, modifying adipose tissue vasculature may p

170 y prolonged survival of fully MHC-mismatched vascularized mouse cardiac allografts.

171 nlike transplantation of other solid organs, vascularized mouse lung transplantation has only recentl

172 e demonstrate in a novel model of orthotopic vascularized mouse lung transplantation that acute rejec

173 or tumor angiogenesis and survival in highly vascularized murine lung tumor xenografts.

174 o underwent a tracheal reconstruction with a vascularized myofascial flap and 2-year follow-up was in

175 As an alternative, we used a vascularized myofascial flap for tracheal reconstruction

176 LSCI can be used to distinguish between well vascularized (n = 32) and compromised (n = 27) parathyro

177 Bioengineering intestine on vascularized native scaffolds could bridge the gap betwe

178 in the slight RPE detachment, confirming its vascularized nature.

179 The ability to generate vascularized nephrons from single-cell suspensions marks

180 r volume reduction at 3 months than did less-vascularized nodules (10.9% +/- 14.5 vs 41.5% +/- 20.3,

181 4), or used to close the abdomen while still vascularized on the forearm (n = 2).

182 None of the preoperative corneas were vascularized or had pronounced subepithelial fibrosis on

183 tical for the migration of memory T cells to vascularized organ allografts.

184 nt depends on the placenta, a highly complex vascularized organ comprised of both maternal and foetal

185 The kidney is a highly vascularized organ that normally receives a fifth of the

186 In vascularized organ transplants, gender mismatches have h

187 s also observed after placement of different vascularized organ transplants, including hearts and kid

188 Brown adipose tissue (BAT) is a highly vascularized organ with abundant mitochondria that produ

189 ging of cellular and subcellular dynamics in vascularized organs requires image resolution and image

190 enesis is vital for tumor growth but in well-vascularized organs such as the lung its importance is u

191 approach toward regenerating functional and vascularized organs.

192 ALB/c; H-2d), or F1 (BALB/cxC57Bl/6; H-2d/b) vascularized, orthotopic small intestine grafts.

193 n a fully MHC mismatched mouse VCA such as a vascularized osteomyocutaneous as compared to a non-VCA

194 epithem is composed of a lacunar and highly vascularized parenchyma offering a direct connection bet

195 Functionally, vascularized patches actively contracted, could be elect

196 PCV patients had large, vascularized, peaked PEDs associated with polyps and a v

197 vascularized PEDs (drusenoid and serous) and vascularized PEDs (type 1 and type 3 neovascularization)

198 Eyes with vascularized PEDs secondary to AMD may show specific OCT

199 n, especially when assessing the response of vascularized PEDs to antiangiogenic therapy.

200 precise underlying etiology and manage both vascularized PEDs, where evidence-based treatment exists

201 ost fatal cancers, characterized by a strong vascularized phenotype.

202 to overcome thrombocytopenia associated with vascularized pig-to-primate xenotransplantation.

203 In all eyes, pretear images revealed a vascularized pigment epithelial detachment (PED) contain

204 Confocal images provide evidence for vascularized plaque in the saline-treated group but not

205 s suggest that baboon thymopoiesis occurs in vascularized porcine thymus xenografts.

206 A recent innovation is the use of vascularized posterior rectus sheath to enable closure o

207 fies both these criteria, the site is poorly vascularized, precluding its utility.

208 n this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.

209 atically decreases in hosts with inflamed or vascularized recipient beds.

210 osed algorithm accurately identified densely vascularized regions from the rest of the tumor.

211 an infection that primarily affects the most vascularized regions of the growing skeleton.

212 o(2) at the border between the avascular and vascularized retina; hyperoxia significantly increased t

213 In vascularized retinas, mitochondria in the synaptic termi

214 ed classic and occult neovascular membranes, vascularized RPE detachments, polypoidal choroidal vascu

215 ofile from the microbeads resulted in highly vascularized s.c. tissue containing up to 16-fold more c

216 Choroid plexuses (ChPs) are vascularized secretory organs involved in the regulation

217 Adoptive cell transfer and vascularized segmental pancreas transplantation were per

218 that islet transplantation in confined well-vascularized sites like the epididymal fat pad (EFP) imp

219 nses (IL-2 and IFN-gamma), whereas primarily vascularized skin allografts failed to trigger a signifi

220 Finally, we show that long-term survival of vascularized skin allografts induced by anti-CD40L Abs w

221 nti-CD40L Abs achieved long-term survival of vascularized skin and cardiac transplants but not conven

222 60 immunodominance was observed in primarily vascularized skin grafts.

223 ce" would also be observed for the primarily vascularized skin of vascularized composite allografts (

224 KSHV) is the infectious cause of this highly vascularized skin tumor.

225 d corneal bed recipients is poor, similar to vascularized solid organ allografts.

226 high risk vascularized cornea behaves like a vascularized solid organ transplant.

227 latform provides a unique model for studying vascularized solid tumors in vitro.

228 y be a valuable target for therapy of poorly vascularized solid tumors.

229 ry hypertrophic vitreous, an optically dense vascularized structure located in the vitreous humor bet

230 terials due to the challenges in fabricating vascularized structures.

231 These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signa

232 growth of 5 different types of established, vascularized syngeneic tumors in 2 different strains of

233 io of the activity in middle cerebral artery-vascularized territories in each hemisphere.

234 ts in immunosuppressed mice that were better vascularized than corresponding control tumors and expre

235 ng bones were significantly thinner and less vascularized than those of controls.

236 eometries and local vessels are recruited to vascularize the developing construct.

237 the zebrafish embryo comprises vessels that vascularize the gut, liver and pancreas and, as such, re

238 tif chemokine receptor Cxcr4a and migrate to vascularize the ventricle under the guidance of the myoc

239 Two hundred and eleven (99.5%) became vascularized through zone III without needing treatment.

240 Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly i

241 loped significantly larger and markedly more vascularized thymic tumors than those observed in Rpl22(

242 tissue engineering applications where both a vascularized tissue environment and control of tissue re

243 ignificant factor to reduce tissue damage in vascularized tissue transplantation.

244 ne defects naturally regenerate via a highly vascularized tissue which progressively remodels into ca

245 characterized by progressive growth of white vascularized tissue with associated traction on the reti

246 iscale mathematical model of tumor growth in vascularized tissue, we investigated the selection press

247 r nanoparticles may be therapeutic tools for vascularizing tissue constructs and treating ischemic di

248 These thick vascularized tissues are actively perfused with growth f

249 Spatial models of vascularized tissues are widely used in computational ph

250 detailed three-dimensional (3D) datasets of vascularized tissues at the scale of individual cells.

251 port a method for bioprinting 3D cell-laden, vascularized tissues that exceed 1 cm in thickness and c

252 endly composition of efficient, 3D models of vascularized tissues, and comparison of predictions with

253 vivo, may aid in the regenerative repair of vascularized tissues.

254 s remarkable given the cornea's proximity to vascularized tissues.

255 lial cells regulate diverse processes in all vascularized tissues.

256 are enriched in endothelial cells and highly vascularized tissues.

257 enesis is essential for fluid homeostasis in vascularized tissues.

258 "Accommodation" refers to a vascularized transplant that has acquired resistance to

259 Vascularized tumor growth is characterized by both abnor

260 tor deprivation characteristic of the poorly vascularized tumor microenvironment and has aided in the

261 tumor burden (VTB), a measure of the area of vascularized tumor on computed tomographic (CT) images,

262 , colonization was most pronounced in poorly vascularized tumor regions.

263 amics to simulate chemotherapy with the same vascularized tumor under different vascular pathologies.

264 Metastatic melanoma, a highly vascularized tumor with strong expression of vascular en

265 KS is a highly disseminated and vascularized tumor.

266 tive tumors and vascular defects, as well as vascularized tumors and juvenile nasopharyngeal angiofib

267 ability of CD8(+) T cells to collapse large vascularized tumors by triggering programmatic changes i

268 In clinical specimens of cancer, less vascularized tumors exhibited lower microvascular expres

269 is associated with the development of highly vascularized tumors in multiple organs.

270 The growth of highly vascularized tumors in PLK3-null mice suggests a role fo

271 expression in a manner with smaller and less vascularized tumors in vivo.

272 xpression with the net consequence of poorly vascularized tumors in vivo.

273 surgery, the control rats had large, highly vascularized tumors that contained proliferating cells.

274 HOXB9 promotes the formation of large, well-vascularized tumors that metastasize to the lung.

275 at form rapidly growing, invasive and highly vascularized tumors, as compared with non-stem cancer ce

276 Importantly, loss of TAp73 results in highly vascularized tumors, as well as an increase in vessel pe

277 s can be effective in the treatment of large vascularized tumors, but they rely on adoptive transfer

278 ced their tumorigenicity and produced highly vascularized tumors, suggesting the importance of this c

279 on type of kidney cancer and it forms highly vascularized tumors.

280 ppressor gene and is characterized by highly vascularized tumors.

281 nd mediated significant regression of large, vascularized tumors.

282 formation of aggressive, invasive and highly vascularized tumors.

283 Given that MSCs are recruited within vascularizing tumors and are believed to contribute to t

284 abolism to promote cell survival in a poorly vascularized tumour microenvironment.

285 ofound survival advantage to cells in poorly vascularized tumour regions.

286 and an IFNgamma-GFP fusion protein in large, vascularized tumours growing in mice that express the IF

287 vels in ageing tissues in mice and in highly vascularized tumours in both murine and human melanoma.

288 ses the proportions of oxidative and densely vascularized type IIA and IIX myofibers and decreases gl

289 myofibers and decreases glycolytic and less vascularized type IIB myofibers.

290 Given that liver is highly vascularized, we reasoned that fluctuations in oxygenati

291 fer, the engineered muscle flaps were highly vascularized, were well-integrated within the surroundin

292 )CD44(+)) and were less invasive than tumors vascularized with control endothelial cells.

293 In vivo, tumor xenografts vascularized with EGF-silenced endothelial cells exhibit

294 rs formed by CD14-high cells are more highly vascularized with higher myeloid cell infiltration.

295 Epithelial tumors were highly vascularized with tight cell-cell junctions, compared wi

296 An initial rejection of transplanted vascularized xenograft is attributed to Galalpha1,3Galbe

297 hibition of MGP resulted in smaller and less vascularized xenografts.

298 Ultimately, these cells form the vascularized YS that functions in nutrient transfer to t

299 ct the boundary between the ischemic and the vascularized zones in this experimental model.

300 corresponding to the ischemic, marginal, and vascularized zones, respectively).