ライフサイエンスコーパス: vascularized

1 stringent orchestration by the tissue being vascularized.

2 transgenic mice were hyperplastic and highly vascularized.

3 oms; however, the gastric conduits were well vascularized.

4 ients, is decidedly heterogeneous and highly vascularized.

5 They are well vascularized.

6 e biomedical applications.The fabrication of vascularized 3D tissues requires an understanding of how

7 tence of adenomas with delayed appearance of vascularized adenocarcinomas in PAR2(-/-) mice.

8 ipocytes in mice produces well-organized and vascularized adipose tissue, capable of beta-adrenergic-

9 The mouse retina is vascularized after birth when angiogenic blood vessels g

10 ma multiforme (GBM) is a highly invasive and vascularized aggressive brain tumor.

11 ower A20 expression or function in donors of vascularized allografts may inform risk and severity of

12 , is critical for memory T-cell migration to vascularized allografts.

13 Durable immune tolerance supporting vascularized allotransplantation offers the possibility

14 Despite this, Notch2ICD tumors were highly vascularized, although the vessels were smaller and comp

15 describe a detailed method for performing a vascularized and aerated mouse orthotopic lung transplan

16 relation of the IOH to the junction between vascularized and avascular retina.

17 -like cellular microarchitectures resembling vascularized and bone marrow tissue architectures.

18 ining microtissue spheroids resulted in well-vascularized and cellular pulp-like tissues, compared wi

19 t, we showed that fully allogeneic primarily vascularized and conventional skin transplants were reje

20 lesions from IL-33 treated mice were highly vascularized and exhibited increased proliferation.

21 ll) immunodeficient host mice regenerate new vascularized and innervated myofibers from human myogeni

22 During this progression, tumors become vascularized and mitotically active.

23 e skin reservoir or the presence of a poorly vascularized and mobile wound bed.

24 d with Dll4 were significantly smaller, less vascularized and more hypoxic than controls, and display

25 ongs fully allogeneic graft survival in both vascularized and nonvascularized allograft transplantati

26 Follicle-seeded scaffolds become highly vascularized and ovarian function is fully restored when

27 n building human-scale constructs, which are vascularized and readily implantable.

28 anted pancreatic and renal buds were rapidly vascularized and self-organized into functional, tissue-

29 lastic cells, whereas central marrow remains vascularized and splenic vascular niches expand.

30 We found that the endosteum is well vascularized and that vasculature is frequently localize

31 In this study, we used heart (vascularized) and skin (nonvascularized) transplantation

32 LA2/alpha1-null mice were also smaller, less vascularized, and exhibited reduced cell proliferation a

33 of tumorigenesis, yet produced smaller, less vascularized, and less metastatic tumors than TRAMP cont

34 he mitoNEET-enriched fat pads feature a more vascularized, anti-inflammatory and less fibrotic enviro

35 In air controls, both the vascularized area of the retina and the density of super

36 ; P < 0.001) and, to a lesser extent, in the vascularized areas of the SeTA specimens (SeTA:normal ra

37 phery of the tumors, corresponding with well-vascularized areas of the tumor.

38 analysis suggested that the interpositional vascularized augmentation neogenesis (IVAN) technique ca

39 fabrication of scalable constructs that are vascularized, autologous, functional, implantable, cost-

40 th ACT to enhance inhibition of established, vascularized, B16 melanoma (P = 0.009) and improve survi

41 kin (IL)-10 (CD19-Cre::IL-10) mice, received vascularized BALB/c cardiac allografts.

42 odular tissue engineering results in an s.c. vascularized bed that enables the transplantation of pan

43 l sources, graft sites, and ultimately fully vascularized bioengineered insulin-secreting microtissue

44 Transplantable vascularized bioengineered intestine could restore nutri

45 ble/tongue allograft containing lymphoid and vascularized BM components.

46 ilage template that completely remodels into vascularized bone and involves a dynamic interplay among

47 CSC and endothelial cell interactions during vascularized bone formation.

48 thelial cells are essential for FCSC-derived vascularized bone formation.

49 develop a two-stage protocol for generating vascularized bone grafts using mesenchymal stem cells (h

50 The transplantation of a large volume of vascularized bone marrow in composite tissue allografts

51 tor cells (EPCs) could significantly enhance vascularized bone regeneration.

52 veloped to overcome the challenge of forming vascularized bone tissue.

53 nlagen, which is subsequently remodeled into vascularized bone using an ectopic transplantation model

54 eplace the avascular cartilage template with vascularized bone.

55 ral integrity and characteristics as seen in vascularized bones and osteochondral tissues.

56 Glioblastoma is a highly vascularized brain tumor, and antiangiogenic therapy imp

57 ated by pulse-chase experiments, EECs in the vascularized, but not in the avascular, region efficient

58 and CXCR3 are functional in the rejection of vascularized, but not nonvascularized, allografts.

59 ssociated with C3 glomerulonephritis are not vascularized, but rather of serous type.

60 Lymphoid tissue in diseased rats was vascularized by aquaporin-1(+) high endothelial venules

61 In patients who were re-vascularized by CABG, mortality and major adverse cardia

62 s system is unique in that it is secondarily vascularized by sprouting angiogenesis from a surroundin

63 in low-risk (nonvascularized) and high-risk (vascularized) C57BL/6 (H-2b) recipients using Balb/c (H-

64 In the mouse vascularized cardiac allograft model, transient depletio

65 x class II- and class I-mismatched models of vascularized cardiac allograft rejection, blocking anti-

66 diac allograft induces H4 immunodominance in vascularized cardiac allograft.

67 The efficacy of donor ECDI-SPs in protecting vascularized cardiac allografts and mechanism(s) of prot

68 C57BL/6 (H-2) mice received vascularized cardiac allografts from A/J (H-2) donors an

69 Interestingly, non-primarily vascularized cardiac allografts mimicked skin grafts in

70 ges upon transplantation in a BALB/c into B6 vascularized cardiac transplant model.

71 in allograft rejection in a murine model of vascularized cardiac transplantation.

72 s spontaneously formed a BM cavity through a vascularized cartilage intermediate in vivo that was pro

73 demonstrate a novel strategy to engineer pre-vascularized, cell-laden hydrogel pulp-like tissue const

74 neering is producing three-dimensional (3D), vascularized cellular constructs of clinically relevant

75 would postpone the regression of the highly vascularized CL in vivo, and this effect could be replic

76 Germinal matrix (GM) is a richly vascularized collection of neuronal-glial precursor cell

77 r and extracellular microenvironment, highly vascularized compared to non-neurogenic periventricular

78 harnessing mechanical properties to generate vascularized, complex organ buds with broad applications

79 The definition of vascularized composite allograft (VCA) and the nomenclat

80 previously demonstrated that tolerance to a vascularized composite allograft (VCA) can be achieved a

81 Monitoring vascularized composite allograft (VCA) hand recipients f

82 Current knowledge of the impact of facial vascularized composite allograft (VCA) procurement on th

83 Vascularized composite allograft (VCA) transplantation c

84 ent of acute rejection of the abdominal wall vascularized composite allograft (VCA).

85 ascular lesions and prospects for defining a vascularized composite allograft rejection classificatio

86 cells may function toward maintenance of the vascularized composite allograft.

87 Chronic rejection of vascularized composite allografts (VCA) is an emerging p

88 d with animal modeling of transplantation of vascularized composite allografts (VCA).

89 Vascularized composite allografts (VCAs) are unique amon

90 Achieving tolerance of vascularized composite allografts (VCAs) would improve t

91 erved for the primarily vascularized skin of vascularized composite allografts (VCAs).

92 To date, there are more than 80 reports of vascularized composite allografts (VCAs; a.k.a. composit

93 or-host hematopoietic chimerism and accepted vascularized composite allografts for periods ranging be

94 Vascularized composite allografts from marrow donors wer

95 ed with extensive infiltrates in biopsies of vascularized composite allografts from marrow donors.

96 Biopsies of muscle and skin of vascularized composite allografts from mixed chimeras sh

97 nd 90 weeks; in turn, marrow donors rejected vascularized composite allografts from their respective

98 atory cells were found in skin and muscle of vascularized composite allografts of mixed chimeras comp

99 Vascularized composite allografts, particularly hand and

100 ing compared with nondraining lymph nodes of vascularized composite allografts.

101 st chimerism leads to tolerance of antigenic vascularized composite allografts.

102 Cellular therapies for immunomodulation in vascularized composite allotransplantation (VCA) have ga

103 We used our nonhuman primate model of facial vascularized composite allotransplantation (VCA) to stud

104 Approaches to safely induce tolerance in vascularized composite allotransplantation (VCA) with ch

105 ey immediate goals for clinical expansion of vascularized composite allotransplantation (VCA).

106 Vascularized composite allotransplantation has become es

107 Skin chronic rejection (CR) in vascularized composite allotransplantation has not been

108 The effect of cold ischemia (CI) in vascularized composite allotransplantation is unknown.

109 Ischemia times in vascularized composite allotransplantation should be kep

110 proceeding ethically with research on penile vascularized composite allotransplantation will require

111 y reported for the treatment of rejection in vascularized composite allotransplantation.

112 duces donor-specific tolerance to kidney and vascularized composite allotransplants (VCA).

113 Vascularized composite tissue allografts (VCA) can under

114 Vascularized composite tissue allografts (VCA) have beco

115 ly, the donor-recipient matching process for vascularized composite tissue allotransplantation (VCTA)

116 Well-vascularized composite tissue offers improved outcomes f

117 hniques has facilitated the establishment of vascularized composite tissue transplant models in small

118 After transplantation of vascularized condensed progenitors into immunodeficient

119 We propose that a high risk vascularized cornea behaves like a vascularized solid or

120 d to increase the survival rate of high-risk vascularized corneal allografts.

121 ival rate of corneal allografts in high-risk vascularized corneal bed recipients is poor, similar to

122 rogressive keratopathy, resulting in a dense vascularized corneal pannus, and eventually leading to v

123 For these vascularized corneas at high risk for immunologic reject

124 asic fibroblast growth factor (bFGF)-induced vascularized corneas.

125 This survival advantage was lost when vascularized CXCR3-/- skin grafts were used as donors in

126 nd effective strategy for engineering of pre-vascularized dental pulp constructs offering potentially

127 Transplantation of vascularized donor thymic tissue along with a kidney tra

128 Kaposi's sarcoma is a highly vascularized, endothelial cell-based tumor supporting la

129 cells, and, in the future, for implantable, vascularized engineered tissues or organs.

130 ropylene fumarate) scaffolds is proposed for vascularized engineered tissues.

131 crocapsules (Micro) in the confined and well-vascularized epididymal fat pad (EFP) site, a model of t

132 Brown adipose tissue is highly vascularized, facilitating delivery of nutrients to brow

133 and that specific rhombomeres are invariably vascularized first.

134 porated T cells mediated regression of large vascularized flank mesothelioma tumors in NOD/scid/gamma

135 The patients presented with vascularized, focally cystic, nonulcerated eyelid margin

136 were differentiated into nonvascularized and vascularized forms with 3 main underlying etiologies: AM

137 med in 31 eyes of 31 patients with a central vascularized full-thickness leukoma, resulting from infe

138 We then fabricated pre-vascularized, full-length, dental pulp-like tissue const

139 laminin alpha5beta2gamma1 is not assembled, vascularized glomeruli fail to form, and animals die at

140 er maturation of kidney tissue, formation of vascularized glomeruli with fully differentiated capilla

141 Intrathymic tolerance to vascularized grafts in large animals has not previously

142 inflammatory response due to it being highly vascularized, having constant exposure to environmental

143 ed direct evidence that chronic rejection of vascularized heart allografts occurs in the complete abs

144 al ear-heart transplantation and heterotopic vascularized heart transplantation models to evaluate im

145 t tumors, as well as human JGCTs, are highly vascularized, hemorrhagic and mitotically active.

146 Ab-mediated rejection, we developed a mouse vascularized heterotopic cardiac allograft model in whic

147 Murine hearts were transplanted as fully vascularized heterotopic grafts from BALB/c donors into

148 lethally irradiated before receiving skin or vascularized heterotopic heart grafts from C57Bl/6 mice.

149 r graft prolongation was observed in a fully vascularized heterotopic heart transplantation model (DB

150 was performed in hemevascularized and lymph-vascularized high-risk host beds, and graft recipients r

151 to grafting performed on inflamed and highly vascularized host beds.

152 ntation, where the graft bed is inflamed and vascularized, immature APCs in the donor corneal stroma

153 systemic intravascular injection only in SVF-vascularized implants demonstrating that SVF cell-derive

154 the most common primary brain tumors, highly vascularized, infiltrating, and resistant to current the

155 jaw and that they are properly mineralized, vascularized, innervated and can start to form roots.

156 We report on an unusual case of a vascularized iris lesion in a three year old Caucasian p

157 uli were capable of engrafting on the highly vascularized iris.

158 in immunodeficient mice, grafted cells form vascularized islet-like structures containing MAFA/C-pep

159 , not only does the brain need to be densely vascularized, it also requires a tightly controlled envi

160 and recipient cells after transplantation of vascularized kidney and cardiac allografts in mice.

161 Transplantation of hands, larynx, vascularized knee, trachea, face, and abdominal wall has

162 ted access of the drug to tumor loci in hypo-vascularized lesions has hampered clinical application.

163 nsport in 3D cell cultures representing hypo-vascularized lesions, enhancing drug uptake and effect.

164 eatic ductal adenocarcinoma (PDAC), a poorly vascularized lethal KRAS-driven malignancy.

165 outcome is that liver metastases are poorly vascularized, limiting the ability to deliver therapeuti

166 The highly vascularized lung holds up to 40% of blood, and thus, th

167 c lymphatics, developed a surgical model for vascularized lymph node transplantation, and confirmed P

168 Search terms were focused on vascularized, lymph node transfer (also autologous, lymp

169 ficant potential for the treatment of highly vascularized, malignant NB.

170 The dura mater is a vascularized membrane surrounding the brain and is heavi

171 e pancreatic islets of Langerhans are highly vascularized micro-organs that play a key role in the re

172 Here we describe in vitro vascularized microtumors (VMTs).

173 Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growt

174 Because adipose tissue is highly vascularized, modifying adipose tissue vasculature may p

175 y prolonged survival of fully MHC-mismatched vascularized mouse cardiac allografts.

176 nlike transplantation of other solid organs, vascularized mouse lung transplantation has only recentl

177 e demonstrate in a novel model of orthotopic vascularized mouse lung transplantation that acute rejec

178 or tumor angiogenesis and survival in highly vascularized murine lung tumor xenografts.

179 o underwent a tracheal reconstruction with a vascularized myofascial flap and 2-year follow-up was in

180 As an alternative, we used a vascularized myofascial flap for tracheal reconstruction

181 LSCI can be used to distinguish between well vascularized (n = 32) and compromised (n = 27) parathyro

182 Bioengineering intestine on vascularized native scaffolds could bridge the gap betwe

183 in the slight RPE detachment, confirming its vascularized nature.

184 The ability to generate vascularized nephrons from single-cell suspensions marks

185 r volume reduction at 3 months than did less-vascularized nodules (10.9% +/- 14.5 vs 41.5% +/- 20.3,

186 4), or used to close the abdomen while still vascularized on the forearm (n = 2).

187 None of the preoperative corneas were vascularized or had pronounced subepithelial fibrosis on

188 tical for the migration of memory T cells to vascularized organ allografts.

189 nt depends on the placenta, a highly complex vascularized organ comprised of both maternal and foetal

190 The kidney is a highly vascularized organ that normally receives a fifth of the

191 In vascularized organ transplants, gender mismatches have h

192 s also observed after placement of different vascularized organ transplants, including hearts and kid

193 Brown adipose tissue (BAT) is a highly vascularized organ with abundant mitochondria that produ

194 ging of cellular and subcellular dynamics in vascularized organs requires image resolution and image

195 enesis is vital for tumor growth but in well-vascularized organs such as the lung its importance is u

196 approach toward regenerating functional and vascularized organs.

197 ALB/c; H-2d), or F1 (BALB/cxC57Bl/6; H-2d/b) vascularized, orthotopic small intestine grafts.

198 n a fully MHC mismatched mouse VCA such as a vascularized osteomyocutaneous as compared to a non-VCA

199 epithem is composed of a lacunar and highly vascularized parenchyma offering a direct connection bet

200 Functionally, vascularized patches actively contracted, could be elect

201 PCV patients had large, vascularized, peaked PEDs associated with polyps and a v

202 vascularized PEDs (drusenoid and serous) and vascularized PEDs (type 1 and type 3 neovascularization)

203 Eyes with vascularized PEDs secondary to AMD may show specific OCT

204 n, especially when assessing the response of vascularized PEDs to antiangiogenic therapy.

205 precise underlying etiology and manage both vascularized PEDs, where evidence-based treatment exists

206 ost fatal cancers, characterized by a strong vascularized phenotype.

207 to overcome thrombocytopenia associated with vascularized pig-to-primate xenotransplantation.

208 In all eyes, pretear images revealed a vascularized pigment epithelial detachment (PED) contain

209 Confocal images provide evidence for vascularized plaque in the saline-treated group but not

210 s suggest that baboon thymopoiesis occurs in vascularized porcine thymus xenografts.

211 A recent innovation is the use of vascularized posterior rectus sheath to enable closure o

212 fies both these criteria, the site is poorly vascularized, precluding its utility.

213 n this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.

214 atically decreases in hosts with inflamed or vascularized recipient beds.

215 osed algorithm accurately identified densely vascularized regions from the rest of the tumor.

216 an infection that primarily affects the most vascularized regions of the growing skeleton.

217 o(2) at the border between the avascular and vascularized retina; hyperoxia significantly increased t

218 In vascularized retinas, mitochondria in the synaptic termi

219 ed classic and occult neovascular membranes, vascularized RPE detachments, polypoidal choroidal vascu

220 ofile from the microbeads resulted in highly vascularized s.c. tissue containing up to 16-fold more c

221 Choroid plexuses (ChPs) are vascularized secretory organs involved in the regulation

222 Adoptive cell transfer and vascularized segmental pancreas transplantation were per

223 that islet transplantation in confined well-vascularized sites like the epididymal fat pad (EFP) imp

224 nses (IL-2 and IFN-gamma), whereas primarily vascularized skin allografts failed to trigger a signifi

225 Finally, we show that long-term survival of vascularized skin allografts induced by anti-CD40L Abs w

226 nti-CD40L Abs achieved long-term survival of vascularized skin and cardiac transplants but not conven

227 60 immunodominance was observed in primarily vascularized skin grafts.

228 ce" would also be observed for the primarily vascularized skin of vascularized composite allografts (

229 KSHV) is the infectious cause of this highly vascularized skin tumor.

230 d corneal bed recipients is poor, similar to vascularized solid organ allografts.

231 high risk vascularized cornea behaves like a vascularized solid organ transplant.

232 latform provides a unique model for studying vascularized solid tumors in vitro.

233 y be a valuable target for therapy of poorly vascularized solid tumors.

234 ry hypertrophic vitreous, an optically dense vascularized structure located in the vitreous humor bet

235 terials due to the challenges in fabricating vascularized structures.

236 These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signa

237 growth of 5 different types of established, vascularized syngeneic tumors in 2 different strains of

238 io of the activity in middle cerebral artery-vascularized territories in each hemisphere.

239 ts in immunosuppressed mice that were better vascularized than corresponding control tumors and expre

240 ng bones were significantly thinner and less vascularized than those of controls.

241 Two hundred and eleven (99.5%) became vascularized through zone III without needing treatment.

242 Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly i

243 loped significantly larger and markedly more vascularized thymic tumors than those observed in Rpl22(

244 tissue engineering applications where both a vascularized tissue environment and control of tissue re

245 ignificant factor to reduce tissue damage in vascularized tissue transplantation.

246 ne defects naturally regenerate via a highly vascularized tissue which progressively remodels into ca

247 characterized by progressive growth of white vascularized tissue with associated traction on the reti

248 iscale mathematical model of tumor growth in vascularized tissue, we investigated the selection press

249 These thick vascularized tissues are actively perfused with growth f

250 Spatial models of vascularized tissues are widely used in computational ph

251 detailed three-dimensional (3D) datasets of vascularized tissues at the scale of individual cells.

252 port a method for bioprinting 3D cell-laden, vascularized tissues that exceed 1 cm in thickness and c

253 endly composition of efficient, 3D models of vascularized tissues, and comparison of predictions with

254 vivo, may aid in the regenerative repair of vascularized tissues.

255 s remarkable given the cornea's proximity to vascularized tissues.

256 lial cells regulate diverse processes in all vascularized tissues.

257 are enriched in endothelial cells and highly vascularized tissues.

258 enesis is essential for fluid homeostasis in vascularized tissues.

259 "Accommodation" refers to a vascularized transplant that has acquired resistance to

260 Vascularized tumor growth is characterized by both abnor

261 tor deprivation characteristic of the poorly vascularized tumor microenvironment and has aided in the

262 tumor burden (VTB), a measure of the area of vascularized tumor on computed tomographic (CT) images,

263 , colonization was most pronounced in poorly vascularized tumor regions.

264 amics to simulate chemotherapy with the same vascularized tumor under different vascular pathologies.

265 Metastatic melanoma, a highly vascularized tumor with strong expression of vascular en

266 KS is a highly disseminated and vascularized tumor.

267 tive tumors and vascular defects, as well as vascularized tumors and juvenile nasopharyngeal angiofib

268 ability of CD8(+) T cells to collapse large vascularized tumors by triggering programmatic changes i

269 In clinical specimens of cancer, less vascularized tumors exhibited lower microvascular expres

270 is associated with the development of highly vascularized tumors in multiple organs.

271 The growth of highly vascularized tumors in PLK3-null mice suggests a role fo

272 expression in a manner with smaller and less vascularized tumors in vivo.

273 xpression with the net consequence of poorly vascularized tumors in vivo.

274 surgery, the control rats had large, highly vascularized tumors that contained proliferating cells.

275 HOXB9 promotes the formation of large, well-vascularized tumors that metastasize to the lung.

276 at form rapidly growing, invasive and highly vascularized tumors, as compared with non-stem cancer ce

277 Importantly, loss of TAp73 results in highly vascularized tumors, as well as an increase in vessel pe

278 s can be effective in the treatment of large vascularized tumors, but they rely on adoptive transfer

279 ced their tumorigenicity and produced highly vascularized tumors, suggesting the importance of this c

280 on type of kidney cancer and it forms highly vascularized tumors.

281 ppressor gene and is characterized by highly vascularized tumors.

282 nd mediated significant regression of large, vascularized tumors.

283 formation of aggressive, invasive and highly vascularized tumors.

284 abolism to promote cell survival in a poorly vascularized tumour microenvironment.

285 ofound survival advantage to cells in poorly vascularized tumour regions.

286 and an IFNgamma-GFP fusion protein in large, vascularized tumours growing in mice that express the IF

287 vels in ageing tissues in mice and in highly vascularized tumours in both murine and human melanoma.

288 ses the proportions of oxidative and densely vascularized type IIA and IIX myofibers and decreases gl

289 myofibers and decreases glycolytic and less vascularized type IIB myofibers.

290 Given that liver is highly vascularized, we reasoned that fluctuations in oxygenati

291 fer, the engineered muscle flaps were highly vascularized, were well-integrated within the surroundin

292 )CD44(+)) and were less invasive than tumors vascularized with control endothelial cells.

293 In vivo, tumor xenografts vascularized with EGF-silenced endothelial cells exhibit

294 rs formed by CD14-high cells are more highly vascularized with higher myeloid cell infiltration.

295 Epithelial tumors were highly vascularized with tight cell-cell junctions, compared wi

296 An initial rejection of transplanted vascularized xenograft is attributed to Galalpha1,3Galbe

297 hibition of MGP resulted in smaller and less vascularized xenografts.

298 Ultimately, these cells form the vascularized YS that functions in nutrient transfer to t

299 ct the boundary between the ischemic and the vascularized zones in this experimental model.

300 corresponding to the ischemic, marginal, and vascularized zones, respectively).