ライフサイエンスコーパス: vasculogenic

1 er, there has been controversy regarding the vasculogenic ability of BM cells.

2 play opposite roles in the regulation of the vasculogenic ability of TNBC, acting as facilitator and

3 cell populations have higher angiogenic and vasculogenic activities.

4 We tested hemangioma-derived stem cells for vasculogenic activity in vivo after implantation into im

5 anded safely ex vivo, and can produce robust vasculogenic activity in vivo.

6 differentiation potential, and inhibits the vasculogenic activity of these cells in vivo.

7 s (EPCs) have the required proliferative and vasculogenic activity to create vascular networks in viv

8 urther sought to determine the comprehensive vasculogenic and angiogenic characteristics of human and

9 We show that this process involves both vasculogenic and angiogenic elements, including an initi

10 omplex morphogenetic process, requiring both vasculogenic and angiogenic mechanisms.

11 Derivation of vasculogenic and multipotent pericytes from hPSC can be

12 We studied vasculogenic and nonvasculogenic intracranial murine gli

13 hind limb ischemia model to test angiogenic-vasculogenic and therapeutic effects.

14 ious in vitro endothelial differentiation or vasculogenic assays were conducted.

15 D31 is a novel marker of a circulating angio-vasculogenic cell population and to establish the cells'

16 opment of vasculogenic models using multiple vasculogenic cell types for basic research and drug scre

17 Vasculogenic cell-based therapy combined with tissue eng

18 D31(+) cells represent highly angiogenic and vasculogenic cells and can be a novel and highly promisi

19 ive, we demonstrate that bone marrow-derived vasculogenic cells exhibit enhanced angiogenic functions

20 s antibodies inhibit epithelial migration of vasculogenic cells from the proepicardium.

21 e serosal mesothelium is the major source of vasculogenic cells in developing mouse gut.

22 examine the development of hematopoietic and vasculogenic cells in normal zebrafish and characterize

23 ieved by either direct targeting of putative vasculogenic cells in the proepicardium in ovo or taggin

24 ological significance of bone marrow-derived vasculogenic cells in the response to injury during tran

25 Efficient generation of competent vasculogenic cells is a critical challenge of human indu

26 how that, in this model, bone marrow-derived vasculogenic cells primarily contribute to the formation

27 cing the contribution of bone marrow-derived vasculogenic cells to transplantation sites may help to

28 mangioma-derived stem cell population, human vasculogenic cells, which we had previously discovered.

29 r that designates circulating angiogenic and vasculogenic cells.

30 y of these vessels is likely to have a large vasculogenic component.

31 g embryonic lethality; brain hemorrhage; and vasculogenic, craniofacial, and neural tube defects in m

32 To define vasculogenic developmental pathways and enhance differen

33 pulations have been shown to overexpress the vasculogenic differentiation markers CD144 (VE-cadherin)

34 actor (VEGF) on the extent of osteogenic and vasculogenic differentiation of human mesenchymal stem c

35 ormal embryos that the arch arteries form by vasculogenic differentiation of pharyngeal mesoderm.

36 resulted in highest extent of osteogenic and vasculogenic differentiation of the encapsulated hMSCs a

37 We conclude that vasculogenic endothelial cells and nascent vessels are c

38 n animals for more than 4 weeks, after which vasculogenic, geometric, and functional parameters were

39 dothelial growth factor (VEGF) expression by vasculogenic glioma cells and spontaneously arising vasc

40 hat CUL2 is required for expression of other vasculogenic HIF targets.

41 nes (such as EphA2 and VE-cadherin) and form vasculogenic-like networks when cultured on a three-dime

42 MP-2) activity, critical in the formation of vasculogenic-like networks.

43 enotypic changes associated with aggressive, vasculogenic melanoma cells.

44 migrating epithelial epicardium, delaminated vasculogenic mesenchyme and vascular smooth muscle cells

45 Vasculogenic mimicry (VM) describes the unique ability o

46 s found in patient tumor slices displaying a vasculogenic mimicry (VM) phenotype.

47 Tumor cell vasculogenic mimicry (VM) refers to the plasticity of ag

48 E-cadherin) and cytokeratins consistent with vasculogenic mimicry (VM), a process whereby tumour cell

49 display the ability to drive blood-perfused vasculogenic mimicry (VM), an alternative microvascular

50 in) and TIE1 and are associated with CD31(-) vasculogenic mimicry (VM), an established biomarker asso

51 alpha expression and an increase in CD144(+) vasculogenic mimicry (VM), leading to formation of chann

52 Vasculogenic mimicry (VM), the formation of matrix-rich

53 -2 expression with known prognostic factors, vasculogenic mimicry (VM), the mature vasculature (von W

54 nd participate in a PECAM1-dependent form of vasculogenic mimicry (VM).

55 ng vessel-like channels, a phenomenon termed vasculogenic mimicry (VM).

56 ternative microvascular circulation known as vasculogenic mimicry (VM).

57 In addition, Notch4 function in vasculogenic mimicry and anchorage-independent growth in

58 an essential role during the acquisition of vasculogenic mimicry and angiogenic properties associate

59 events that regulate the process of melanoma vasculogenic mimicry and identify new signal transductio

60 he ability of these tumor cells to engage in vasculogenic mimicry and neovascularization.

61 /or its cleavage fragments, are required for vasculogenic mimicry by aggressive melanoma cells.

62 Vasculogenic mimicry describes a process where aggressiv

63 Vasculogenic mimicry is posited to contribute to melanom

64 lular and molecular determinants of melanoma vasculogenic mimicry is presented.

65 Mig-7 protein primarily co-localized with vasculogenic mimicry markers factor VIII-associated anti

66 highly invasive uveal melanoma cells forming vasculogenic mimicry patterns after exposure to a lamini

67 tissue samples, uveal melanoma cells within vasculogenic mimicry patterns assumed the spindle A morp

68 s of primary uveal melanomas lacking looping vasculogenic mimicry patterns either did not stain for o

69 The histological detection of laminin-rich vasculogenic mimicry patterns in human primary uveal mel

70 on of human rather than mouse laminin in the vasculogenic mimicry patterns in this model demonstrates

71 Thus, the generation of vasculogenic mimicry patterns is accompanied by dampenin

72 Vasculogenic mimicry patterns were reconstructed from se

73 highly invasive uveal melanoma cells forming vasculogenic mimicry patterns, and genes associated with

74 Vasculogenic mimicry patterns, composed of human laminin

75 In primary melanomas containing looping vasculogenic mimicry patterns, strong osteopontin staini

76 After forming vasculogenic mimicry patterns, uveal melanoma cells inva

77 ith their increased invasion, migration, and vasculogenic mimicry plasticity.

78 echanical and molecular events that regulate vasculogenic mimicry provide opportunities for the devel

79 The unique patterning characteristic of vasculogenic mimicry provides an opportunity to design n

80 an carcinoma cells could engage in molecular vasculogenic mimicry reflected by their plasticity, comp

81 We recently have introduced the term vasculogenic mimicry to describe the unique ability of a

82 Recently, the term "vasculogenic mimicry" has been used by our laboratory an

83 egulated, aggressive tumor cells was termed "vasculogenic mimicry" to emphasize their de novo generat

84 y to form tube-like structures on collagen ("vasculogenic mimicry").

85 osome nucleation, motility, neoangiogenesis, vasculogenic mimicry, and osteoclastogenesis in the abse

86 MEF2C was found to mediate VEGF-induced vasculogenic mimicry, angiogenesis and migration/invasio

87 lial-cadherin, which plays a pivotal role in vasculogenic mimicry, as well as interleukin-8, fibronec

88 erized to invade aggressively and to undergo vasculogenic mimicry, expressed Mig-7.

89 EF2C on cell proliferation, and VEGF-induced vasculogenic mimicry, migration/invasion as well as angi

90 aggressive melanoma cells to participate in vasculogenic mimicry, particularly their expression of e

91 y human melanoma cells in vivo and in vitro: vasculogenic mimicry," by Maniotis and colleagues, which

92 rs have recently described a process termed "vasculogenic mimicry," which consists of the formation o

93 These data indicate that vasculogenic mimicry-like laminin networks, in addition

94 adapted to a pseudoendothelial phenotype in vasculogenic mimicry.

95 sis that VE-cadherin is critical in melanoma vasculogenic mimicry.

96 in tyrosine kinases are involved in melanoma vasculogenic mimicry.

97 may not be applicable to tumors that express vasculogenic mimicry.

98 noma mitogen, laminin, a phenomenon known as vasculogenic mimicry.

99 ell dissemination by increasing invasion and vasculogenic mimicry.

100 cell invasion, migration, and inhibition of vasculogenic mimicry.

101 ddition to tumor cell plasticity as shown by vasculogenic mimicry.

102 from hPSC can be used for the development of vasculogenic models using multiple vasculogenic cell typ

103 ial cells, which form a primitive, patterned vasculogenic network.

104 es in vitro), that mimics endothelial-formed vasculogenic networks and correlates with poor clinical

105 lanoma cells abrogated their ability to form vasculogenic networks and directly tested the hypothesis

106 imensional culture, which "mimics" embryonic vasculogenic networks formed by differentiating endothel

107 studies in men with erectile dysfunction of vasculogenic, neurogenic, psychogenic, and mixed causes.

108 Vasculogenic pathways are unexplored targets for the tre

109 grammed bone marrow progenitors toward a pro-vasculogenic phenotype that was positive for c-Kit, the

110 behavior and identifies the "mesenchymal-to-vasculogenic" phenotypic transition as an essential step

111 The vasculogenic potential of adult BM-derived cells and the

112 Although the vasculogenic potential of circulating and cord blood (CB

113 We next characterized the myogenic and vasculogenic potential of immunoselected human MPCs and

114 a murine model, dexamethasone inhibited the vasculogenic potential of stem cells derived from human

115 Furthermore, the vasculogenic potential of these cells is under debate.

116 In vitro vasculogenic potential was assessed by quantifying EPC c

117 Herein, we analyzed whether this vasculogenic process is regulated by estrogen.

118 Coronary artery development is a complex vasculogenic process that begins shortly after heart loo

119 looxygenase (COX)-2 signaling regulates this vasculogenic process.

120 tromal cell-derived factor 1/CXCR4-dependent vasculogenic progenitor cell mobilization and promotes v

121 eutic approach to inhibit PDGFRbeta-mediated vasculogenic properties of TNBC, focusing on miR-9 and m

122 ve demonstrated that human ECFCs have robust vasculogenic properties.

123 men with erectile dysfunction of neurogenic, vasculogenic, psychogenic, or mixed causes, respectively

124 The vasculogenic, rather than angiogenic, nature of this neo

125 rs are expressed in the lateral plate and in vasculogenic regions of the avian somite and are able to

126 n and proliferation of progenitor cells with vasculogenic/reparative potential.

127 groups also showed a significantly improved vasculogenic response in the EPCM group.

128 2 (Tie2) expression appears in hemogenic and vasculogenic sites shortly after SCL.

129 ment and decreased Smad1/5/8 activity in key vasculogenic structures.

130 tumor cells, suggesting the possibility of a vasculogenic switch.

131 genic glioma cells and spontaneously arising vasculogenic tumors in NF1+/-:Trp53+/- mice, but not by

132 lation, have an abnormal distribution within vasculogenic vessels.