ライフサイエンスコーパス: vault

1 revealed 48-fold rotational symmetry for the vault.

2 ction and 48 copies of MVP forming each half vault.

3 ensity bands lining the inner surface of the vault.

4 persistent unossified areas within the skull vault.

5 e in morphogenesis and growth of the cranial vault.

6 ed to form the central barrel portion of the vault.

7 than previously observed for the intact rat vault.

8 ttack, especially in those with greater lens vault.

9 lity, chondrodysplasia and loss of the skull vault.

10 nce tomography was performed to measure lens vault.

11 tial prion seeding activity lining the nasal vault.

12 e of Jagged1 in the development of the skull vault.

13 ted with development of the face and cranial vault.

14 ranslated vault RNA are also associated with vaults.

15 of vault-interacting proteins into preformed vaults.

16 s well as wild-type and TEP1-deficient mouse vaults.

17 s in their co-assembly into regularly shaped vaults.

18 reported as a protein that co-purifies with vaults.

19 The AUC for lens vault (0.816) and ACD (0.822) for detecting narrow angle

20 serve a structural or organizing role in the vault, a particle with eight-fold symmetry.

21 Purified vaults also contain the poly(ADP-ribosyl)ation activity,

22 RNA and affected its stable association with vaults, although there were no telomerase-related change

23 , Kenya, provides evidence of intact cranial-vault and basicranial morphology, brain size and craniof

24 ority of the bones of the vertebrate cranial vault and craniofacial complex develop via intramembrano

25 the frontal and parietal bones of the skull vault and deployment of the coronal (fronto-parietal) an

26 suture is a major growth center of the skull vault and develops at a boundary between cells derived f

27 Lens vault and PCAL explained 76.8% of the variability in ACD

28 al characteristics similar to endogenous rat vaults and display the distinct vault-like morphology wh

29 gation into the link between upregulation of vaults and malignancy, the mechanism behind non-P-gp-med

30 pression system to form MVP-only recombinant vaults and performed a series of protein-mixing experime

31 we examine the local stiffness of individual vaults and probe their structural stability with atomic

32 Vaults and telomerase are ribonucleoprotein (RNP) partic

33 The sharing of the TEP1 protein between vaults and telomerase suggests that TEP1 may play a comm

34 omponent of two ribonucleoprotein complexes: vaults and telomerase.

35 nent of a ribonucleoprotein organelle called vault, and has been implicated in multiple drug resistan

36 halization and in supraorbital, neurocranial vault, and nuchal gracilization.

37 a, iris curvature, lens vault (LV), anterior vault, angle opening distance (AOD500, AOD750), and trab

38 ith curvature (such as waisted nanotubes and vaulted architecture) and to develop novel methods for s

39 Vaults are 13 million Da ribonucleoprotein particles wit

40 Vaults are 13-MDa ribonucleoprotein particles composed l

41 Vaults are 13-MDa ribonucleoprotein particles with an in

42 The modified vaults are compatible with living cells.

43 ough their function has not been determined, vaults are found in nearly all eukaryotic cells.

44 Vaults are highly conserved ubiquitous ribonucleoprotein

45 Vaults are large cytoplasmic ribonucleoprotein complexes

46 Vaults are large ribonucleoprotein particles that have b

47 Vaults are naturally occurring ovoid nanoparticles const

48 Mammalian vaults are ribonucleoprotein (RNP) complexes, composed o

49 Vaults are self-assembled ribonucleoprotein nanocapsules

50 Vaults are the largest (13 megadalton) cytoplasmic ribon

51 Vaults are the largest ribonucleoprotein particles found

52 The membranous bones of the mammalian skull vault arise from discrete condensations of neural crest-

53 The use of vaults as functional transporters requires a profound un

54 Understanding vault assembly will enable us to design agents that disr

55 To gain insight into the mechanisms for vault assembly, we have expressed rat MVP in the Sf9 ins

56 hermore, we show that one substrate for this vault-associated PARP activity is the MVP.

57 The vault-associated small RNA, termed vault RNA (VR), is de

58 The central vault at 3 months was measured using optical coherence t

59 ctron microscopy (TEM) of negatively stained vaults at pH 6.5 and 3.4 confirmed the fluorescence spec

60 F candidate backfill cement, Nirex Reference Vault Backfill (NRVB), in a model system.

61 n of one or more of the sutures of the skull vault before the brain completes its growth, is a common

62 diazoacetate, B(OPh)(3), and a molecule of a vaulted biaryl ligand (VAPOL or VANOL).

63 solid-state structure and properties of the vaulted biaryl ligand VAPOL were investigated.

64 -mediated deracemization of the C2-symmetric vaulted biaryl ligands VANOL and VAPOL has been investig

65 s prepared from triphenylborate and both the vaulted binaphthol (VANOL) and vaulted biphenanthrol (VA

66 and both the vaulted binaphthol (VANOL) and vaulted biphenanthrol (VAPOL) ligands.

67 nd fluorescent properties on the recombinant vaults, both of which can be detected by their emission

68 ce normalized many dimensions of the cranial vault, but did not correct all craniofacial anatomy.

69 e central stem and the lateral struts of the vault cartilages.

70 , resulted in their sequestration within the vault cavity.

71 ter biologically active materials within the vault cavity.

72 posterior-frontal suture (PF) of the cranial vault closes through endochondral ossification, while ot

73 Eyes with narrow angles had greater lens vault compared to eyes with open angles (775.6 microm vs

74 (MVP) is the primary component of the 13 MDa vault complex.

75 ing of the specimen's well preserved cranial vault confirms that Aegyptopithecus had relatively unexp

76 (QCM) as tools in investigating recombinant vault conformational change in response to a varied solu

77 The mammalian skull vault consists of several intricately patterned bones th

78 nes from the mandible and the expanded brain vault could be correlated.

79 accompanied by structural adjustments to the vault, cranial base, and face.

80 Glenoid morphology (version, vault depth, erosion), injury or disease (osteoarthritis

81 The flat bones of the vertebrate skull vault develop from two migratory mesenchymal cell popula

82 Anomalies in skull vault development are relatively common in humans.

83 At the onset of skull vault development, these mesenchymal cells emigrate from

84 M findings by providing visual evidence that vaults disassemble into halves as the solution pH is low

85 Identification of conditions for reversible vault disassembly and reassembly could enable applicatio

86 This result prompted the hypothesis that vaults dissociate at least partially at low pH.

87 self-assembled monolayers, data that suggest vault dissociation at low pH, even when the vault is in

88 have suggested pH as a parameter to control vault dynamics.

89 removed, inconsistent with suggestions that vaults either act to prevent the drug from entering the

90 VPARP and TEP1 are able to incorporate into vaults even after the formation of the MVP vault particl

91 The face and cranial vault evolve faster than other regions, showing several

92 , the temporomandibular joint, and the brain vault evolved incrementally through mammaliaform evoluti

93 H 3.4 compared to that at pH 6.5, suggesting vaults exhibit a more open conformation at low pH.

94 environment highest in lactate, the cranial vault, expressed high levels of lactate importers, harbo

95 here is a pronounced rounding of the cranial vault, extension of the mandible beyond the maxilla, and

96 We show here that, in the fetal mouse skull vault, Fgfr2 transcripts are most abundant at the periph

97 olumetric loss of ~0.11% of the intracranial vault for each daily drink (0.25 g/kg), and selective vu

98 The bones of the mammalian skull vault form through intramembranous ossification.

99 will enable us to design agents that disrupt vault formation and hence aid in elucidating vault funct

100 shift of associated vRNA, demonstrating that vault formation is limited by expression of MVP or the m

101 exquisitely balanced to ensure proper skull vault formation.

102 estimates of the long-term effect of cranial vault fractures on the risk of dying have been generated

103 FP) from the jellyfish Aequorea victoria has vaulted from obscurity to become one of the most widely

104 vault formation and hence aid in elucidating vault function in vivo.

105 how that the barrel, the central part of the vault, governs both the stiffness and mechanical strengt

106 xc1 results in a dramatic reduction in skull vault growth and causes an expansion of Msx2 expression

107 On multivariate analysis, subjects with lens vault >667.6 microm were more likely to have narrow angl

108 Recently, assembly of recombinant vaults has been established in insect cells expressing o

109 In humans, vaults have been implicated in multidrug resistance duri

110 Vaults have been implicated in multidrug resistance of h

111 e TEP1 is a component of the vault particle, vaults have no detectable telomerase activity.

112 Mammalian vaults have two high molecular mass proteins of 193 and

113 The vault height (distance between the posterior ICL surface

114 A smaller vault height was associated with the development of lens

115 ve an absence of flat bones within the skull vault, hypertelorism, open-bite malocclusion, cleft pala

116 e affected by factors outside of the cranial vault in addition to the local effects of the TBI.

117 e craniofacial phenotypes, including cranial vault in adult Ts65Dn mice.

118 tidrug resistance supports a direct role for vaults in drug resistance.

119 gp-mediated drug resistance, and the role of vaults in human cells.

120 microm vs 438.56 microm, P < .001), and lens vault increased significantly with age (P for trend <.00

121 s in defects in the development of the skull vault indicating Tgfbr2 has a critical role in intramemb

122 of selective mortality on males with cranial vault injuries who survived long enough for bones to hea

123 The vault-interacting domain of vault poly(ADP-ribose)-polym

124 a possible mechanism for in vivo assembly of vault-interacting proteins into preformed vaults.

125 bility analysis and spectroscopic studies of vault-interacting proteins were used to confirm this res

126 Finally, this study suggests that the vault interior may functionally interact with the cellul

127 exogenous proteins from interacting with the vault interior.

128 The vault is a highly conserved ribonucleoprotein particle f

129 vault dissociation at low pH, even when the vault is in an adsorbed state, were also obtained.

130 However, mouse models in which the vaginal vault is inoculated with C. trachomatis do not recapitul

131 important cellular role, the function of the vault is unknown.

132 Although the precise function of vaults is unknown, their wide distribution and highly co

133 ar body length (r = 0.68; p < 0.01), cranial vault length (r = -0.57; p < 0.05), and the mandibular s

134 ifferences (p < 0.05) were noted for cranial vault length, maxillary length, mandibular body length,

135 500, TISA-500), anterior chamber angle, lens vault, lens thickness, anterior chamber depth (ACD), and

136 n the absence or after resolution of cranial vault lesions, and once the primary tumor is resected, P

137 of FDG blocked PET visualization of cranial vault lesions.

138 dogenous rat vaults and display the distinct vault-like morphology when negatively stained and examin

139 CI: 1.070-4.526) compared to those with lens vault </=462.7 microm.

140 release rate of biomolecular cargo from the vault lumen is related to the interaction between MVP an

141 a shuttle to pack biomolecular cargo in the vault lumen.

142 ea (ACA) (P < .001), as well as greater lens vault (LV) (P = .007), compared with fellow eyes.

143 curvature (I-Curv), iris area (I-Area), lens vault (LV), and angle opening distance (AOD750), trabecu

144 ckness (IT), iris area, iris curvature, lens vault (LV), anterior vault, angle opening distance (AOD5

145 me (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), iris area (I-area), and

146 el ocular biometric parameters, such as lens vault (LV), posterior corneal arc length (PCAL), and iri

147 ACD), anterior chamber width (ACW), and lens vault (LV).

148 erior chamber area (ACA, R(2)=0.49) and lens vault (LV, R(2)=0.47); for AOD750, these were LV (R(2)=0

149 rea, volume, and width [ACA, ACV, ACW], lens vault [LV], iris thickness at 750 mum from the scleral s

150 al features present in the face and anterior vault, many of which are related to the masticatory appa

151 Higher lens vault may play a role in the development of an acute att

152 purification and intracellular distribution, vaults may be involved in the nucleocytoplasmic transpor

153 One month after surgery, vault measurements correlated with TIA (R = -.309; P = .

154 N termini interacting non-covalently at the vault midsection and 48 copies of MVP forming each half

155 une the release of molecular cargos from the vault nanoparticles, we determined the interactions betw

156 Enlargement of the skull vault occurs by appositional growth at the fibrous joint

157 was evaluated by applying it to the vaginal vault of macaques (n = 4) 15 min before each weekly expo

158 determine the structure of nine recombinant vaults of various composition, as well as wild-type and

159 Using the QCM to study adsorption of the vault onto self-assembled monolayers, data that suggest

160 leaping towards a vertical surface by first vaulting onto an obstacle with variable traction to indu

161 rior chamber depth, iris curvature, and lens vault (P </= 0.002 for all).

162 = 0.77), lens thickness (P = 0.44), or lens vault (P = 0.053).

163 sociation of the vault RNA with the purified vault particle and also resulted in a decrease in the le

164 te that the protein shell of the recombinant vault particle is a dynamic structure and suggest a poss

165 stable association of the vault RNA with the vault particle is dependent on its interaction with the

166 o vaults even after the formation of the MVP vault particle shell is complete.

167 protein is not entirely associated with the vault particle, suggesting that it may interact with oth

168 e show that while TEP1 is a component of the vault particle, vaults have no detectable telomerase act

169 d entire exterior shell of the barrel-shaped vault particle.

170 also sufficient to target the protein to the vault particle.

171 100/MVP) and a small RNA comprise the 13-MDa vault particle.

172 tion and recruitment of the vault RNA to the vault particle.

173 As both the function of vault particles and the mechanism of drug resistance in

174 Vault particles are naturally occurring proteinaceous ca

175 ultidrug-resistant cell lines, the levels of vault particles have not been investigated.

176 Sedimentation measurements of vault particles in multidrug resistance cells have indee

177 nitor the structural evolution of individual vault particles while changing the pH in real time.

178 The ability to engineer vault particles with designed properties and functionali

179 ilize the barrel region, the central part of vault particles, and leads to the aggregation of the cag

180 ange of pHs on the stability and dynamics of vault particles.

181 These data suggest that vaults play no direct role in the MDR phenotype in non-s

182 Vault poly(ADP-ribose) polymerase (VPARP) and telomerase

183 s composed of the major vault protein (MVP); vault poly(ADP-ribose) polymerase (VPARP); telomerase-as

184 The vault-interacting domain of vault poly(ADP-ribose)-polymerase (INT) has been used as

185 separately, abdominal mesh repair of vaginal vault prolapse compared with vaginal non-mesh repair.

186 approach for treatment of uterine or vaginal vault prolapse following hysterectomy.

187 al and abdominal mesh procedures for vaginal vault prolapse repair are associated with similar effect

188 een considered the gold standard for vaginal vault prolapse repair for several decades.

189 que for the treatment of symptomatic vaginal vault prolapse that is rapidly gaining popularity among

190 rectocele, uterine prolapse, enterocele and vault prolapse.

191 nal antibody LRP56 recognizes a 110-kD major vault protein (lung-resistance protein [LRP]) overexpres

192 The 100-kD major vault protein (MVP) accounts for >70% of the particle ma

193 rotein particles primarily composed of major vault protein (MVP) are highly expressed in cells that e

194 urification method, we have identified major vault protein (MVP) as a novel interacting partner for C

195 trate-trapping mutants to identify the major vault protein (MVP) as a putative SHP-2 substrate.

196 The 100-kDa major vault protein (MVP) constitutes approximately 75% of the

197 The human major vault protein (MVP) is the primary component of the 13 M

198 NLS mutant PTEN did not interact with major vault protein (MVP), a previously hypothesized nuclear-c

199 copies of a single protein, termed the major vault protein (MVP), is sufficient to form the minimal s

200 ion signal-like sequences required for major vault protein (MVP)-mediated nuclear translocation.

201 miR-193a interacts with major vault protein (MVP).

202 that is composed of multiple copies of major vault protein (MVP).

203 haped structure and is composed of the major vault protein (MVP); vault poly(ADP-ribose) polymerase (

204 entified a partial cDNA encoding the 240-kDa vault protein and determined it is identical to the mamm

205 We have identified the 193-kD vault protein by its interaction with the MVP in a yeast

206 a novel role for TEP1 in vivo as an integral vault protein important for the stabilization and recrui

207 In this report, we identify the major vault protein in sea urchins as a 107-kDa polypeptide th

208 Within the nucleus, the sea urchin major vault protein is concentrated in the region of the nucle

209 crotubule preparations, the sea urchin major vault protein is not predominantly microtubule-associate

210 Rather, the sea urchin major vault protein is present throughout the cytoplasm in egg

211 The expression of the unique 100-kDa major vault protein is sufficient to form the basic vault stru

212 In addition, the vault protein localizes to short linear strings juxtapos

213 d largely of a 104-kDa protein, termed major vault protein or MVP, and a small vault RNA, vRNA.

214 omain-containing protein (TbArmtor), a major vault protein, and LST8 to form a unique TOR complex, Tb

215 of multiple copies of three proteins (major vault protein, VPARP, and TEP1) and an untranslated RNA.

216 )-like sequences that are required for major vault protein-mediated nuclear import.

217 s occur along the contacts between two major vault proteins and disappear over time.

218 ion of MVP with one or both of the other two vault proteins results in their co-assembly into regular

219 is limited by expression of MVP or the minor vault proteins.

220 Although vaults purified from the livers of mTep1(-/-) mice appea

221 of craniosynostosis require complex cranial vault reconstruction that is associated with a high risk

222 ere viable, fertile, and did not display any vault-related or telomerase-related phenotype, whereas d

223 erefore do not clearly favour any particular vault repair procedure.

224 which serve as growth centers for the skull vault, result in craniosynostosis.

225 dimensional reconstruction of the mTep1(-/-) vault revealed less density in the cap than previously o

226 iated protein 1 (TEP1) are components of the vault ribonucleoprotein complex.

227 La interacts with the vault RNA (both in vivo and in vitro) presumably through

228 The vault-associated small RNA, termed vault RNA (VR), is dependent upon TEP1 for its stable as

229 Vault RNA (vRNA) genes have been cloned from several ver

230 in 1 in mice led to reduced stability of the vault RNA and affected its stable association with vault

231 ns, VPARP and TEP1, and a small untranslated vault RNA are also associated with vaults.

232 equences from the 7SL RNA gene, U6 RNA gene, vault RNA gene, and BC1 gene increase transcription of A

233 We find that a portion of the vault RNA is complexed with the La autoantigen in a sepa

234 for the stabilization and recruitment of the vault RNA to the vault particle.

235 tely disrupted the stable association of the vault RNA with the purified vault particle and also resu

236 we have shown that stable association of the vault RNA with the vault particle is dependent on its in

237 rmed major vault protein or MVP, and a small vault RNA, vRNA.

238 entify other proteins that interact with the vault RNA, we used a UV-cross-linking assay.

239 decrease in the levels and stability of the vault RNA.

240 we show that a 106-nucleotide noncoding RNA vault RNA2-1 (vtRNA2-1), previously misannotated as miR8

241 Here, we found that vault RNAs (vtRNAs) were greatly induced in A549 cells a

242 several host RNAP III transcripts, including vault RNAs and Alu transcripts.

243 telomerase RNA and with several of the human vault RNAs in a yeast three-hybrid assay.

244 ncRNA species, including tRNAs, Y RNAs, and Vault RNAs.

245 to certain geometric constraints, might help vaults safely pass through the nuclear pore complex and

246 s in the intrinsic fluorescence intensity of vaults showed a 60% increase at pH 3.4 compared to that

247 Twist function causes a foramen in the skull vault similar to that caused by loss of Msx2 function.

248 ns reflect the breadth of the skull, cranial vault size and shape, and aspects of nasal morphology.

249 ching studies provided further evidence of a vault structural change at low pH.

250 ault protein is sufficient to form the basic vault structure.

251 as LV greater than one-third of the anterior vault (sum of LV and ACD), was present in 61.5% of the c

252 he transvaginal uterosacral ligament vaginal vault suspension is increasingly our procedure of choice

253 The uterosacral ligament vault suspension is the most anatomic of the repairs and

254 here are proponents for uterosacral ligament vault suspension, iliococcygeus and sacrospinous ligamen

255 sis cases, but most studies focus on cranial vault sutures.

256 The observation that vault synthesis is linked directly to multidrug resistan

257 are unknown, we decided to determine whether vault synthesis was coupled to MDR.

258 indeed revealed up to a 15-fold increase in vault synthesis, coupled with a comparable shift of asso

259 Attachment of a vault-targeting peptide to two proteins, luciferase and

260 Women had significantly greater lens vault than men (497.28 microm vs 438.56 microm, P < .001

261 MVP is the predominant component of vaults that are cytoplasmic ribonucleoprotein complexes

262 unction plays in the ontogeny of the cranial vault, the maxilla, and, most notably, the mandible.

263 improvement in SFC that has the potential to vault their performance to levels of similar reproducibi

264 es as the sphenoid bone connects the cranium vault to the facial bones.

265 er protein or non-protein coding genes, have vaulted to prominence.

266 Lens vault was defined as the perpendicular distance between

267 The vaginal vault was exteriorized as a stoma in the lower right abd

268 Lens vault was highest in AACG eyes, followed by fellow eyes,

269 Lens vault was independently associated with narrow angles an

270 and endochondral ossification of the cranial vault were delayed in the mutant embryos, and cranial bo

271 lations with ocular variables including lens vault were examined.

272 sition were less and lens thickness and lens vault were greater in angle-closure than open-angle eyes

273 , significant associations with greater lens vault were shorter axial length, shallower anterior cham

274 occurring cellular nanoparticle known as the vault, which is named for its morphology with multiple a

275 nt upon TEP1 for its stable association with vaults, while the association of telomerase RNA with the

276 Reconstruction of a recombinant vault with a cysteine-rich tag revealed 48-fold rotation

277 posed for the organization of MVP within the vault with all of the MVP N termini interacting non-cova

278 Recombinant vaults with MVP N-terminal peptide tags showed internal