ライフサイエンスコーパス: vector

1 ting its potential as a new muscle-targeting vector.

2 ientations to construct the recombinant RNAi vector.

3 lysis to reduce the dimension of the feature vector.

4 ansferase compared with mice given a control vector.

5 nd beta-chains were cloned into a retroviral vector.

6 ead locally or over long distances without a vector.

7 ce injected intramuscularly with an AAV-TFEB vector.

8 availability of nutrients in the tsetse fly vector.

9 nds upon the abundance and behavior of their vectors.

10 lavivirus transmitted primarily by arthropod vectors.

11 ine a polyhedral convex set of feasible flux vectors.

12 ZIKV and the biology and ecology of these 2 vectors.

13 prevent onward spread of the virus by insect vectors.

14 ata4, Mef2c, and Tbx5 (GMT) using retrovirus vectors.

15 the best recombinant adeno-associated virus vectors.

16 k connecting flaviviruses and their mosquito vectors.

17 fection at first detection in both hosts and vectors.

18 odulate the efficiency of gene therapy viral vectors.

19 gineered to be replication-defective (RD-Ad) vectors.

20 populations as previously observed in other vectors.

21 e effective management of Anopheles mosquito vectors.

22 ndocytic trafficking of polyplexes and other vectors.

23 herapy clinical trials using recombinant AAV vectors.

24 generate the same immune responses as RD-Ad vectors.

25 ing and modeling arboviruses within mosquito vectors.

26 oncoding RNAs specifically responsive to TRV vectors.

27 gions compared to gammaretrovirus/lentivirus vectors.

28 s oncolytic therapeutics and as gene therapy vectors.

29 higher transduction than their parental AAV vectors (2- to 9-fold over AAV2), with the highest of th

30 using a cardiotropic adeno-associated viral vector 9.

31 Given the importance of biting midges as vectors, a key area of future research is to establish t

32 ous dose of the adeno-associated virus (AAV) vector, AAV-BR1-CAG-NEMO, delivering the Nemo gene to th

33 with the highest of these being the haploid vector AAV2/8 3:1.

34 the haploid virus, we produced the triploid vector AAV2/8/9 by co-transfecting AAV2, AAV8 and AAV9 h

35 ed local injection of adeno-associated viral vectors (AAVs) encoding ligand-specific antagonists into

36 The modified vector accumulated similarly to the original vector in N

37 o toxicity or adverse immune consequences of vector administration are observed.

38 een developed for the major mosquito disease vector Aedes aegypti Here, we describe the generation of

39 xchange interactions, and the resultant spin vector alignments that are found within the 3-D C-type a

40 ement of a directly observable Boolean state vector and allowing uncertainty in the measurement proce

41 We also developed a lentiviral vector and cloning strategy to generate high-complexity

42 PIV5 is a promising live viral vector and has been used to develop vaccines.

43 for transmission from humans to the mosquito vector and has emerged as a target for intervention in e

44 cine platform transduced with the adenoviral vector and loaded in tandem with the recombinant protein

45 valuated based on control targets, including vector and parasite.

46 insect cells from a recombinant baculovirus vector and the phosphoprotein cofactor (P) in Escherichi

47 emapping, is highly dependent on the saccade vector and the spatial arrangement of current and future

48 We conclude that this viral vector and this delivery route hold great promise for ge

49 pecific CD4 T cell responses elicited by Ad5 vectors and compared them to those induced by an acute L

50 A-SCID children treated with gammaretroviral vectors and found clear evidence of genotoxicity, indica

51 5 (Ad5) is one of the most widely used viral vectors and is known to generate potent T cell responses

52 ieved by combining R21 with TRAP-based viral vectors and protective efficacy was significantly enhanc

53 ome of liver-directed gene therapy using AAV vectors and showed in a proof-of-principle study how thi

54 total Anopheles species and primary malaria vectors and the EIR (P<.001).

55 provide guidance for the design of HDR donor vectors and the selection of HDR-enhancing factors for a

56 s for extended periods of time in their tick vectors and vertebrate reservoirs is crucial for continu

57 joining pursuer and target (called the range vector) and an external reference line, is held constant

58 from a frame with [Formula: see text] rows (vectors) and [Formula: see text] columns (dimensions), w

59 e lidars measuring aerosol backscatter, wind vector, and CO2 concentration profiles may all produce d

60 s that block parasite development within the vector, and then use the nuclease-based homing reaction

61 gh which the innate immune response to viral vectors, and potentially other stimuli, may be controlle

62 r ear connexin expression in vivo using BAAV vectors, and to identify the optimal route of vector del

63 y adult life habits in the absence of gamete vectors, appear to be incompatible with sustained rarity

64 This vector approach enables simple uniform particles to form

65 Viral vectors are effective tools in gene therapy, but their l

66 Larger clinically-relevant vectors are needed.

67 elers to spread the virus to countries where vectors are present and the population is susceptible.

68 In conclusion, AAV1 vectors are suitable for gene delivery to TG sensory neu

69 However, rickettsial symbionts in these vectors are underexplored.

70 characterize systemic delivery of a rAAV2/9 vector as a non-invasive means of cochlear transduction.

71 a set of other adeno-associated virus (AAV) vectors as a potent vector for the cochlear cell targets

72 oncept to a 2D colloidal system and realize 'vector assembly' by manipulating particles on a colloida

73 milies of plant-infecting viruses, increases vector attraction and reproduction on infected hosts.

74 lement different computational rules such as vector averaging, winner-take-all or superposition.

75 This study demonstrates the use of non-viral vector based oral delivery of GLP-1 gene through enteroh

76 Vectors based on adeno-associated virus type 2 (AAV2) ar

77 ge and the state of polarization of an input vector beam can be simultaneously determined in a single

78 y, we show that this system can be used as a vector beam polarization state spectrum analyzer, where

79 t could be manipulated as a means to control vector-borne disease.

80 interventions against the ongoing burden of vector-borne diseases such as malaria and dengue.

81 of this heterogeneity is seen in the case of vector-borne pathogens, which spread between 'hosts' and

82 d by viruses from either zoonotic sources or vector-borne sources.

83 attributed to the success of Aedes mosquito vectors, but local epidemiological drivers are still poo

84 based vaccines demonstrated that these viral vectors can mediate more potent protection against influ

85 more controllable, stimulus-responsive viral vectors capable of sensing and responding to specific en

86 Vector carrying shRNA against TGF-beta, though did not i

87 o overcome this obstacle, we constructed AAV vectors carrying the channelrhodopsin-2 (ChR2) gene unde

88 ared to analogous gammaretrovirus/lentivirus vectors carrying the same enhancers/promoters, an effect

89 al enhancers/promoters placed in foamy viral vectors caused extremely low immortalization of primary

90 o mechanistic and in vivo studies and future vector-centered approaches to limit ZIKV infection and s

91 establish the impact of this endosymbiont on vector competence.

92 Here, we adapt this raster/vector concept to a 2D colloidal system and realize 'vec

93 a indicate that very low doses of Adenovirus-vectored consensus vaccines induce superior levels of im

94 Health Organization threshold for successful vector control agents.

95 great help in the investigating of possible vector control candidates for paratransgenic control app

96 he options for translational research in the vector control field.

97 In Papua New Guinea, vector control has been intensified since 2008, and impr

98 Current national vector control policy in India restricts use of residual

99 Vector control programs need to be expanded to curtail n

100 ons dominated by zoophilic vectors, existing vector control tactics will be insufficient to achieve e

101 ive for mobilization, renewed strategies for vector control, and biomedical research.

102 lysis was performed on HMEC lines expressing vector control, PELP1-wt, or mutant PELP1 in which the n

103 ground levels observed in wild-type IDH2 and vector control, similar to the original study.

104 of scale-up of other interventions, such as vector control, transmission would return to pre-adminis

105 is not an effective replacement for existing vector control.

106 ption of NADPH compared to wild-type IDH2 or vector control.

107 ineered to express inducible tagged SPDEF or vector (control) and subcutaneously injected into immuno

108 22, to overexpress MIR122 in hepatocytes) or vector (control).

109 Traditional insecticide-based vector-control programmes have limited effectiveness, an

110 KBP1b substantially outperformed age-matched vector controls and performed similarly to each other an

111 ies, dramatically improved in GT mice with a vector copy number/genome higher than 1 in the BM and 2

112 fferent Lyme disease spirochetes within tick vectors could potentially aid development of novel metho

113 ials separated goal switches, OFC population vectors decorrelated rapidly after each switch, but did

114 h stereotaxic injection of 5-HT2CR shRNA AAV vector decreased vocalizations and anxiety- and depressi

115 ectors, and to identify the optimal route of vector delivery.

116 Vectors derived from foamy virus, a nonpathogenic retrov

117 human EC cells to transduction by retroviral vectors derived from three different retroviral genera.

118 Vector-derived factor IX coagulant activity was sustaine

119 Stimulus-responsive viral vector design considerations as well as gaps in current

120 avenously injected with the AAV-BR1-CAG-NEMO vector developed no hepatocellular carcinoma or other ma

121 We show that the proportion of vectors developing transmissible infections (sporozoites

122 and on exercise to inform optimal S-ICD ECG vector development.

123 ional studies, generation of oncolytic virus vectors, development of delivery platforms of genes for

124 ypes of flour sifter, constructed a velocity vector diagram of flour dust dispersal by each type of s

125 The absolute and vector differences between the 2 methods were >0.50 D in

126 appears, and the k component of the ICM wave vector disappears.

127 ns per infected farm is greater than one for vector dispersal, but below one for livestock movements.

128 showed that tumor progression modulated drug vector distribution in tumor-associated capillaries.

129 We describe the energy and k-vector distribution of exciton-polaritons along the hybr

130 However, the high vector doses required to reach therapeutic levels of tra

131 es transduced with an adeno-associated viral vector driving the GCaMP6f reporter behind a synapsin pr

132 ebellar cortex of rhesus macaques and tested vector efficacy in three ways.

133 binogenic adeno-associated virus (AAV) donor vectors enables site-specific gene insertion by homology

134 zed adeno-associated virus serotype 5 (AAV5) vector encoding a B-domain-deleted human factor VIII (AA

135 transduced with the adjuvant, an adenoviral vector encoding a dominant negative isoform of Src homol

136 Injection of a BAAV vector encoding GFP-tagged Cx30 via canalostomy in P4 mi

137 t for the delivery of adeno-associated viral vector encoding Rab Escort Protein 1 is described as a p

138 earning approach we call Neuron Registration Vector Encoding.

139 Here, we immunized mice with Ad5 vectors encoding lymphocytic choriomeningitis virus (LCM

140 mate data relative to optimal conditions for vector establishment, could be applied to this context.

141 The vectors exhibited stable RSV F expression in vitro and i

142 that in such regions dominated by zoophilic vectors, existing vector control tactics will be insuffi

143 oregional and systemic delivery of a rAAV2/8 vector expressing a canine microdystrophin (cMD1) is eff

144 in vivo In conclusion, an attenuated rHPIV1 vector expressing a pre-F-stabilized form of RSV F demon

145 However, the vector expressing full-length RSV F from the pre-N posit

146 reen monkeys immunized with two doses of the vector expressing GP from the pre-N position developed h

147 We are developing a chimeric rB/HPIV3 vector expressing RSV F as a bivalent RSV/HPIV3 vaccine

148 e 3 (rB/HPIV3) was developed previously as a vector expressing RSV fusion (F) protein to confer bival

149 Experimental CMV-based vaccine vectors expressing a single MHC class I-restricted high-

150 the recombinant parainfluenza virus 5 (PIV5) vectors expressing RSV glycoproteins for their immunogen

151 5 gene provided no protection, although MCMV vectors expressing the high-avidity epitope SSIEFARL ind

152 for direct simultaneous measurement of each vector field component.

153 stic eigenmodes (field and frequency) of the vector-field elastic wave equation with a given propagat

154 from in utero mouse embryos and multi-angle, vector-flow algorithms were applied to the data to provi

155 s to design a recombinant microbial delivery vector for a GLP-1 analogue and assess the efficacy of t

156 o-associated virus (AAV) vectors as a potent vector for the cochlear cell targets.

157 was shown to be a highly effective and safe vector for the delivery of foreign immunogens for vaccin

158 ablish latency in mice, can be utilized as a vector for the heterologous expression of EHV-1 glycopro

159 oirs as well as amplifying and disseminating vectors for B. bronchiseptica and reveal an important ro

160 We investigated adeno-associated virus (AAV) vectors for gene delivery to the TG after intradermal wh

161 influence marine nutrient cycles, and act as vectors for horizontal gene transfer.

162 The use of viral vectors for inner ear gene therapy is receiving increase

163 Introduction of expression vectors for miR-424 reduced both the levels of HPV genom

164 d site-specifically modified single-stranded vectors for replication in primate (COS7) or Escherichia

165 ource of donor cells for transplantation and vectors for the delivery of gene therapy.

166 ating peptides (MPPs) are specific targeting vectors for the localization of small molecules to the m

167 ticated animals, and are being engineered as vectors for vaccines and cancer therapy.

168 ficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG) BCG-refractory

169 ber alignment and captures outward alignment vectors from the tumor spheroid, corresponding to high i

170 al malaria infection levels in wild-captured vectors from West and East Africa.

171 ur dose-ranging cohorts (cohort 1, 2 x 10(8) vector genomes (vg); cohort 2, 2 x 10(9) vg; cohort 3, 6

172 Three weeks after injection, vector genomes were recovered from the few persisting ce

173 group subjects received low-dose (1 x 10(10) vector genomes) and 3 high-dose (1 x 10(11) vector genom

174 vector genomes) and 3 high-dose (1 x 10(11) vector genomes) rAAV.sFLT-1 via subretinal injection.

175 at the expense of large file sizes, whereas vector graphics encrypts shape information into vectors

176 ter vector injection, demonstrating that the vector has a favorable safety profile.

177 Adeno-associated virus (AAV) vectors have been used successfully in clinical trials f

178 eceptor.IMPORTANCE Over the past decade, AAV vectors have emerged as leading gene delivery tools for

179 Adeno-associated virus (AAV) vectors have made great progress in their use for gene t

180 nomes among mammalian retroviruses and their vectors have shown potential for gene therapy in preclin

181 ggesting a conserved role for the protein in vector-host interactions.

182 tion due to spillover from zoonotic hosts or vectors, identifying where index cases could present.

183 e therapy for WAS using a Upsilon-retroviral vector improved immunological parameters substantially b

184 vector accumulated similarly to the original vector in N. benthamiana after agroinfiltration, thus ma

185 ovirus immediate early promoter into the VC2 vector in place of the HSV-1 thymidine kinase (UL23) gen

186 n intimate relationship with their hosts and vectors in order to infect, replicate, and disseminate;

187 mbryonic kidney 293 cells with this reporter vector increased luciferase activity upon stimulation wi

188 The two replicating NYVAC-C-KC vectors induced enhanced and similar HIV-1-specific CD4(

189 Vector-induced short- and long-term Mef2c upregulation i

190 Blowflies and houseflies are mechanical vectors inhabiting synanthropic environments around the

191 BS electrode implantation ipsilateral to the vector-injected SN.

192 other major adverse effects 11 months after vector injection, demonstrating that the vector has a fa

193 he latter an important Zika and Dengue virus vector insensitive to Ls Bin.

194 We injected these vectors into the cerebellar cortex of rhesus macaques an

195 agreement between the concentration-centroid vectors is significantly affected by in planta and soil

196 of plant viruses are transmitted via insect vectors, little is known at the molecular level as to ho

197 tors of pathological diagnosis using support vector machine (SVM) algorithms.

198 ecific melt curves are identified by Support Vector Machine learning, and individual pathogen loads a

199 eatures are then used to construct a support vector machine that can be used for accurate prediction

200 d the features to predictive models (support vector machine, elastic net) and validated those models

201 stricted Boltzmann Machines (RBM) or Support Vector Machines (SVM).

202 haracteristics Curve (AUC) using the Support Vector Machines (SVM).

203 e of three machine learning methods (support vector machines (SVMs), multilayer perceptrons (MLP), an

204 Discrimination Analysis "PLS-DA" and Support Vectors Machines "SVM"), was able to discriminate the wi

205 tective efficacy of a single dose adenovirus-vectored malaria vaccine in a mouse model of malaria by

206 lth Organization (WHO) recommends integrated vector management (IVM) strategy for combating VBD trans

207 Thus, efficient, non-integrating SeV vectors may serve as a powerful system for cardiac regen

208 between tolerance and immunogenicity in AAV vector-mediated gene transfer are not fully understood,

209 Here, we utilized a shuttle vector method to examine the efficiency and fidelity wit

210 the possibility of developing tools based on vector molecules to manage the disease in endemic areas.

211 li could be used to attract and kill malaria vectors more successfully than individual stimuli, and a

212 all of which are transmitted by the disease vector mosquito Aedes aegypti.

213 unable microwave interferometer (MIM) with a vector network analyzer (VNA) for signal measurement and

214 The nonreplicating attenuated poxvirus vector NYVAC expressing clade C(CN54) HIV-1 Env(gp120) a

215 The EXAFS results reveal a metal-metal vector of 2.74-2.75 A and an intense light-atom (C/N/O)

216 exchange (RMCE) system to Aedes aegypti, the vector of dengue, chikungunya, and Zika viruses.

217 rly in Neotropical regions, is the principal vector of dengue, yellow fever, Zika and Chikungunya vir

218 The mosquito Aedes aegypti is a major vector of numerous viral diseases, because it requires a

219 E, shows that PE did not act as a measurable vector of PCBs.

220 Then, we build feature vectors of homogeneity, standard deviation of pixel valu

221 he self-immolative nanoparticles as delivery vectors of therapeutic miRNA capable of simultaneously t

222 on the similarity between the word frequency vectors of viruses and bacterial hosts have been develop

223 To identify unknown vectors of Zika, we developed a data-driven model linkin

224 root tips growing along the natural gravity vector over prolonged periods of time, as well as the ab

225 better captures the observed biology of the vector-parasite interaction.

226 st together with the relative word frequency vector performs the best in identifying viruses infectin

227 the cDNA fragment was chosen to insert into vector pFGC1008 at forward and reverse orientations to c

228 n to orbital angular momentum conversion and vector polarization formation, which serve as bridges co

229 The introduction of realistic seasonality in vector population dynamics facilitates gene drive succes

230 a high transmission region in India, malaria vector populations show a high propensity to feed on liv

231 e the surveillance and monitoring of malaria vector populations under control.

232 creased air travel and uncontrolled mosquito vector populations.

233 Mice injected with a control vector presented with neither C-SWDs nor SRSs.

234 dynamically respond to the presence of their vectors, promoting insect performance and transmission o

235 transgene induction involve the use of viral vectors prone to silencing and insertional mutagenesis o

236 Stereodynamics describes how the vector properties of molecules, such as the directions i

237 This set of vectors provide an organized comprehensive gene editing

238 KCSRNRQYL, and show that a mouse CMV (MCMV) vector provides complete immune control of recombinant v

239 ampus of middle-aged male mice using a viral vector rejuvenates hippocampal function and improves hip

240 mice lacking such capacity with a lentiviral vector resulted in a temperature elevation in response t

241 ne augmentation using adeno-associated virus vectors robustly sustained the rescue of rod function an

242 This provides an improved vectored RSV vaccine candidate suitable for pediatric cl

243 his association and the implications for AAV vector safety.

244 constructs are then expressed from mammalian vectors, secreted into culture media, purified by affini

245 These results will be useful for vector selection for various applications.

246 fection of cell lines with ZNHIT3 expression vectors showed that the PEHO syndrome mutant protein is

247 n adeno-associated virus (AAV) gene transfer vector significantly prevented pathology and produced si

248 therapeutic RNAi applications where delivery vector space is limiting.

249 ntify similarity/overlap of high dimensional vector spaces.

250 ka, we developed a data-driven model linking vector species and the Zika virus via vector-virus trait

251 We also find evidence for a shift in vector species complex towards increased zoophilic behav

252 ic protein highly mosquitocidal to important vector species including Anopheles gambiae, Culex quinqu

253 Vector species occurrence decreased notably in undisturb

254 V) that explicitly includes two key mosquito vector species: Aedes aegypti and Aedes albopictus The m

255 A model that captured human mobility and vector suitability successfully discriminated districts

256 can be employed to enhance efficacy of this vector system.

257 Using viral vectors taken up at axon terminals, we expressed chemoge

258 generated a drug-free, all-in-one dCAS9-SAM vector that can activate endogenous gene expression with

259 ions of recombinant adeno-associated virus 8 vector that expressed the primary miR-122 transcript (pr

260 tor graphics encrypts shape information into vectors that allow small file sizes and operational tran

261 s a potential approach to create therapeutic vectors that can be photoactivated in vivo with high spa

262 is known regarding R. typhi biology in flea vectors that, importantly, do not suffer lethality due t

263 t range is likely to increase as the insects vectoring the "Ca.

264 cally have many desirable properties as gene vectors, there are several practical barriers to success

265 We also estimated exposure to malaria vectors through genetic matching of blood from 1094 wild

266 proven safe, Modified Vaccinia Ankara (MVA) vector, thus averting the potential risk of ADE associat

267 This trial used a prototype adenoviral vector to express aquaporin-1 (AQP1), presumably in the

268 ls that were gene-modified with a retroviral vector to express the CD30-specific CAR (CD30.CAR-Ts) en

269 gene (C(Delta170)) as an intranasal vaccine vector to express the EBOV glycoprotein GP.

270 tinin protein and require substantially less vector to generate the same immune responses as RD-Ad ve

271 ibuted to the inability of conventional gene vectors to achieve gene transfer throughout highly disse

272 cent protein genes, and piggyBac transposase vectors to demonstrate that this can be a reliable, effi

273 A related approach uses AAV vectors to edit specific regions of the DMD gene using C

274 ch results in increased attraction of insect vectors to the plant, and, hence, to increased pathogen

275 AV receptors contribute significantly to AAV vector transduction efficiency and tropism.

276 th CREB alone and CREB plus HIPK2 over empty vector-transfected control displayed 14- and 32-fold upr

277 ination impaired pathogen acquisition by the vector, transmission from ticks to hosts, or induction o

278 Thus, coastal C. ignobilis were a biological vector transporting Hg from freshwater environments into

279 ns persist at the antiferromagnetic ordering vector up to dopings of about 15 per cent.

280 challenge in the field of therapeutic viral vector/vaccine manufacturing is maximizing production.

281 inking vector species and the Zika virus via vector-virus trait combinations that confer a propensity

282 , there has been a growing interest in using vector vortex modes, spatial modes of light with entangl

283 An adeno-associated viral vector was also used to reconstitute ORMDL3 expression i

284 Additionally, one NYVAC-C-KC vector was generated by deleting the viral gene B19R, an

285 The vaccine potential of the rISFV vector was investigated in a well-established alphavirus

286 Further, the efficacy of AAV-Clrn1 vector was significantly attenuated, revealing the poten

287 l and intrathecal injections of the same AAV vector were combined.

288 Interstitial loops of a 0 /2 [111] Burgers vector were directly observed as a result of the displac

289 Both the rVSV and rISFV vectors were attenuated by using an approach that has de

290 Contaminant-centroid vectors were calculated from tree-core data to reveal co

291 The directions of these force vectors were co-ordinated such that the overall body swa

292 nal tree samples at a higher resolution, and vectors were correlated with soil-gas characterization c

293 Finally, vectors were switched and systemically administered to t

294 e achieved with the haploid AAV2/8 1:3 virus vector when compared to that of AAV8.

295 In such spaces, individuals are encoded as vectors where identity is primarily conveyed by directio

296 elicited by a fibroblast-adapted rhesus CMV vector with limited tissue tropism; a repaired vector wi

297 ctor with limited tissue tropism; a repaired vector with normal tropism elicited conventional respons

298 aligned along the axis of the electric field vector with respect to the CT species.

299 Here we provided series of integrative vectors with various affinity tags, including single tag

300 pathogens, which spread between 'hosts' and 'vectors'-with each group possessing distinct epidemiolog