1 iuretic peptide but unloads the heart due to venodilation.

2 c arterial blood pressure is proportional to venodilation and venous return to the heart, we hypothes

3 uces positive cardiac inotropy and selective venodilation in the normal in vivo circulation.

4 ation did play a major role in the selective venodilation observed under basal conditions.

5         Although sodium nitroprusside caused venodilation (p < 0.0001), apelin-36 and (Pyr(1))apelin-

6 d by L-NMMA (48.9+/-6.2% reversal of maximal venodilation, P<0.01).

7                          Both doses produced venodilation reflected by a 10% decline in left ventricu

8                            Carbachol-induced venodilation was inhibited by L-NMMA (48.9+/-6.2% revers

9  Infusion of carbachol caused dose-dependent venodilation, with a maximal reduction in forearm venous

10 rdiac preload volume and diastolic pressure (venodilation) without a change in arterial resistance.