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1 o form muscle fibers as well as cells of the ventral neural tube.
2 forming a dynamic, punctate gradient in the ventral neural tube.
3 CL and the transcription factor Olig2 in the ventral neural tube.
4 pressed by mesenchymal cells surrounding the ventral neural tube.
5 overlaps with Gli1 activator function in the ventral neural tube.
6 ity of the ngn2 enhancer specifically in the ventral neural tube.
7 fate acquisition and diversification in the ventral neural tube.
8 ls located at different positions within the ventral neural tube.
9 nitor cell identity and neuronal fate in the ventral neural tube.
10 eted by mesodermal cell types that flank the ventral neural tube.
11 ence for a gradient of endogenous Shh in the ventral neural tube.
12 ibute to the patterning of cell types in the ventral neural tube.
13 ertebrate embryogenesis in the notochord and ventral neural tube.
14 ry signals produced by the lateral plate and ventral neural tube.
15 Neurog1-like expression specifically in the ventral neural tube.
16 l specification of neural progenitors in the ventral neural tube, a process known to require a gradie
17 ose-dependent loss of cell identities in the ventral neural tube and facial and skeletal defects, als
18 ramework to understand the patterning of the ventral neural tube and is permitting molecular analyses
19 yo, patched is initially detected within the ventral neural tube and later in the somites and limb bu
20 expressed by motor neuron progenitors in the ventral neural tube and that treatment of ventral neural
22 ections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced
23 then most prominently in the primitive node, ventral neural tube, and intermediate and lateral plate
24 enitor gene is specifically expressed in the ventral neural tube, and its activity is required for mo
25 point to an important role for Sulf1 in the ventral neural tube, and suggests a mechanism whereby Su
26 on gradient of Shh is thought to pattern the ventral neural tube, and these ventral cell types are ab
27 midbrain, hindbrain, trigeminal ganglia, and ventral-neural tube appear redundant and are spread both
28 Furthermore, Neurog1 progenitor cells in the ventral neural tube are largely fated to interneuron lin
29 Using Sonic hedgehog (Shh) patterning of the ventral neural tube as an example, we show that the fram
30 receptor family members were detected in the ventral neural tube at approximately the time of initial
31 the differentiation of motor neurons in the ventral neural tube, but the intervening steps are poorl
32 g signaling pathway organizes the developing ventral neural tube by establishing distinct neural prog
33 naling controls cell fates in the developing ventral neural tube by regulating the patterned expressi
35 rocyte progenitor cells are induced from the ventral neural tube by the Sonic hedgehog (Shh) signal.
39 In contrast to dorsal neural tube, pieces of ventral neural tube, dorsal ectoderm or neural crest cel
41 he ventral neural tube and that treatment of ventral neural tube explants with the trkB ligand Brain-
43 and for normal expression of Nodal, and the ventral neural tube fails to express Shh, Foxa2 and Ebaf
44 ns are generated at defined positions in the ventral neural tube in response to a gradient of Sonic H
45 enon in the context of the patterning of the ventral neural tube in response to a gradient of the mor
49 The identity of distinct cell types in the ventral neural tube is generally believed to be specifie
51 e deficiencies in the dorsal mesendoderm and ventral neural tube, leading to neural defects and cyclo
52 xpressed Shh-N, leading to the activation of ventral neural tube markers such as Ptc, HNF-3beta, and
58 e dorsal neural tube (via BMP and Wnts), the ventral neural tube/notochord (via Shh) and the somite i
59 s disrupted, as evidenced by abnormal dorsal-ventral neural tube patterning and diminished expression
60 se results bear significance on the model of ventral neural tube patterning as they suggest a dual ro
62 or mesoderm in spt(-);ntl(-) embryos, dorsal-ventral neural tube patterning is relatively normal, wit
64 on of Hedgehog signaling, which patterns the ventral neural tube, produced a two-fold increase in the
66 nd CaP, occupy distinct locations within the ventral neural tube relative to overlying somites, expre
69 Strikingly, PRDM13 also ensures a battery of ventral neural tube specification genes such as Olig1, O
70 ryos lacking Shh express Lpp1 throughout the ventral neural tube, suggesting negative regulation of L
71 or identity and neuronal fate throughout the ventral neural tube, supporting a gradient mechanism whe
72 different progenitor cell populations in the ventral neural tube that are defined by the expression o
73 flect different sources of Shh, one from the ventral neural tube that controls trabecular morphogenes
74 dbrain, the midbrain-hindbrain boundary, the ventral neural tube, the developing eye, and the apical
75 c midline structures - the floorplate in the ventral neural tube, the notochord and the dorsal endode
76 ification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) tran
77 pation by tungsten needle, and the remaining ventral neural tube was labeled with DiI to examine any
78 s sufficient to drive lacZ expression in the ventral neural tube, whereas a 1.0-kb fragment located 3
79 ds the domain of Brn-3.0 expression into the ventral neural tube, while ectopic grafts of notochord t
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