ライフサイエンスコーパス: ventralize

1 e produce embryos that are both bicaudal and ventralized.

2 rogenitors in Pax6 mutants are progressively ventralized, acquiring expression of regulatory genes no

3 Comparative analysis of the ventralizing activities of different N- and C-terminal l

4 because it ensures that the dorsalizing and ventralizing activities of Dpp and Wg are restricted to

5 The ventralizing activities of Tsg require an endogenous Xol

6 a a suppression of swirl-dependent, BMP-like ventralizing activities.

7 genes vox (vega1) and vent (vega2) both have ventralizing activity in overexpression assays, loss-of-

8 this transformation results from the loss of ventralizing activity in the developing eye field, and t

9 embrane association and multimerization, and ventralizing activity in the zebrafish forebrain.

10 A and catalytic C subunits of PP2A each have ventralizing activity in Xenopus embryos.

11 Mix.1, a PAX class homeodomain protein with ventralizing activity in Xenopus.

12 laborate with Hh signaling and reinforce its ventralizing activity.

13 we used nickel chloride (NiCl(2)), a potent ventralizing agent on echinoderm embryos, on the indirec

14 Thus, whereas both Wnt8 and zygotic BMP are ventralizing agents that regulate common target genes, t

15 e mesoderm is established by dorsalizing and ventralizing agents, which are presumably mediated by th

16 istent with the properties of experimentally ventralized amphibian embryos, cerebum mutants exhibit r

17 with SCL and LMO-2 leads to embryos that are ventralized and have blood throughout the dorsal-ventral

18 easome subunits were found to differ between ventralized and lateralized embryos.

19 genesis of the pronephros was examined in UV-ventralized and lithium-dorsalized embryos.

20 g, as eggs from aubergine mutant mothers are ventralized and seldom fertilized.

21 members such as BMPs 2, 4, and 7, which are ventralizing and anti-neuralizing signals.

22 ermomyotome involves antagonistic actions of ventralizing and dorsalizing signals originating from ti

23 rates axis formation largely by limiting the ventralizing and posteriorizing activity of bone morphog

24 s of both Medea and Mad (a class I Smad) are ventralized, as are embryos null for the TGF-beta-like l

25 biological effects of BMP-3 oppose those of ventralizing BMPs, but the mechanism for this antagonism

26 ssed antagonists Chordin and Noggin with the ventralizing BMPs.

27 is regulated by the antagonizing function of ventralizing bone morphogenetic proteins (BMPs) and dors

28 AFE is then ventralized by applying Wnt, BMP, fibroblast growth fact

29 f Mix.1 can restore a dorsal axis in embryos ventralized by ectopic BMP-4 expression.

30 oxus embryos, like those of vertebrates, are ventralized by exogenous BMP protein.

31 Unexpectedly, Msx-deficient embryos become ventralized by late gastrulation whereas misexpression o

32 also become L or Ser dependent when they are ventralized by removal of pnr or Iro-C gene function.

33 unable to rescue dorsal cell fate in embryos ventralized by UV irradiation.

34 Xwnt8 in animal caps, (2) rescue of embryos ventralized by Xwnt8 DNA and (3) inhibition of XmyoD exp

35 n allele is still functional but has reduced ventralizing capability compared to the wild type.

36 ants revealed that the expression of NckK229 ventralized dorsal mesoderm.

37 hat bind the third SH3 domain antagonize the ventralizing effect of the first two SH3 domains.

38 st beta-catenin-1 (MO1), by contrast, had no ventralizing effect on wild-type embryos.

39 Bmp4 knockdown was sufficient to rescue the ventralizing effects caused by loss of Chordin activity.

40 Taken together with the ventralizing effects of a mutant from of the XTcf-3 tran

41 1) which is a likely mediator of the ventralizing effects of BMP4 in the mesoderm.

42 nopus embryo animal caps mimics the mesoderm-ventralizing effects of BMP4.

43 en provided that Sonic Hedgehog mediates the ventralizing effects of notochord and floor plate, but t

44 The ventralizing effects of the xTsg mutants were stronger t

45 axis duplication and completely rescued the ventralizing effects of UV irradiation through the activ

46 xpression of Tsg mRNA in Xenopus embryos has ventralizing effects similar to Xolloid, a metalloprotea

47 In contrast, pAbp mutants lay ventralized eggs and enhance grk haploinsufficiency.

48 fect germline cyst development and result in ventralized eggs as a result of reduced Grk protein expr

49 Each mutant produces ventralized eggs, a phenotype typically associated with

50 hin the oocyte, leading to the production of ventralized eggs.

51 tion of eIF1A in spnB ovaries suppresses the ventralized eggshell phenotype by restoring Grk expressi

52 les are moderately fertile, laying eggs with ventralized eggshells that can hatch normal larvae.

53 that reducing tsg gene product results in a ventralized embryo, and that tsg morphants specifically

54 f both genes does not result in a completely ventralized embryo.

55 by antisense deoxyoligonucleotides leads to ventralized embryonic defects and a reduction of the exp

56 using antisense oligonucleotides results in ventralized embryos and reduced organizer gene expressio

57 nsible for both the loss of pronephroi in UV-ventralized embryos and the induction of pronephroi duri

58 ric mesoderm, as marginal zone explants from ventralized embryos are still competent to respond to pr

59 Dorsal development can be rescued in ventralized embryos if Tcf-dependent transcription is ac

60 oss of the capacity to form pronephroi in UV-ventralized embryos is caused by the loss of tissues cap

61 Because ventralized embryos still gastrulate, producing a mechan

62 This axis also arises in severely ventralized embryos, despite their deficient embryonic p

63 ut activation of Tcf after MBT cannot rescue ventralized embryos, suggesting that beta-catenin/Tcf-de

64 In UV-ventralized embryos, xBic-C is polyadenylated less than

65 ganizer formation, and ultimately results in ventralized embryos.

66 re of early embryos to UV irradiation, which ventralizes embryos and inhibits neural induction, reduc

67 Ectopic expression of BMP-4 ventralizes embryos and positively regulates the express

68 Ectopic expression of XSox17 beta ventralizes embryos by inhibiting the Wnt pathway downst

69 overexpressed in isolated animal caps and it ventralizes embryos.

70 es, our understanding of the role of Wnts in ventralizing embryos is less complete.

71 ) superfamily of growth factors, is a potent ventralizing factor and has been implicated in the commi

72 m in animal cap explants is repressed by the ventralizing factor BMP-4.

73 Previously, we have shown that the ventralizing factor bone morphogenetic protein 4 (BMP-4)

74 assays, Frzb antagonized Xwnt-8, a proposed ventralizing factor with an expression pattern complemen

75 in early Xenopus development by acting as a "ventralizing factor' and as an epidermal determinant: lo

76 which we have named vox and vent, are potent ventralizing factors in both zebrafish and Xenopus embry

77 ow, at low penetrance, early lethality and a ventralized gastrulation phenotype.

78 1 is inducible in uncommited ectoderm by the ventralizing growth factor BMP4 and counteracts the dors

79 In animal caps, PV.1 ventralizes induction by activin and inhibits expression

80 organizer, where it functions to oppose the ventralizing influence of bone morphogenetic proteins (B

81 vous system, and Sonic hedgehog (Shh), which ventralizes it.

82 y protein kinase A and is antagonized by the ventralizing morphogen Sonic hedgehog.

83 such as Vent 1, and, consequently, develops ventralized morphology.

84 lyzed in double mutant combinations with the ventralized mutants chordino/chordin and ogon, whose mol

85 in expression by midgastrulation, while some ventralized mutants had reduced expression; however, in

86 Some ventralized mutants recover and develop into fertile adu

87 Using dorsalized and ventralized mutants, we demonstrate that these domains a

88 rve an expansion of LE fate in dorsalized or ventralized mutants.

89 One hundred eighteen new ventralizing mutants on the second chromosome fell into

90 es in karyosome morphology, similar to other ventralizing mutants such as okra and spindle B.

91 tized system where subthreshold amounts of a ventralizing Nck mutant were expressed, co-expression of

92 llele (Gli3(Delta699)) can mostly rescue the ventralized neural tube phenotypes of Sufu mutant embryo

93 s to midgestation lethality and a completely ventralized neural tube, demonstrating that PKA is as st

94 7 in future dorsal blastomeres resulted in a ventralized or posteriorized phenotype in which the embr

95 adhesion is observed, embryos display both a ventralized phenotype and reduced dye transfer.

96 s partial axis duplication, which mimics the ventralized phenotype caused by reduced gurken-Egfr sign

97 ea activity in the early embryo results in a ventralized phenotype identical to that of null dpp muta

98 The ventralized phenotype is also dependent on the kinesin I

99 ing molecular markers indicates that the boz ventralized phenotype may be due, in part, to the derepr

100 Genetic epistasis experiments show that this ventralized phenotype occurs independently of Shh and th

101 Cactus-lacZ expressed in vivo normalizes the ventralized phenotype of embryos that lack Cactus and fa

102 i zygotic mutant embryos exhibit a partially ventralized phenotype similar to dpp embryonic lethal mu

103 The resulting ventralized phenotype, the effective dose, and the NiCl(

104 wild-type Xom and results in a more strongly ventralized phenotype.

105 nergistically enhances the penetrance of the ventralized phenotype.

106 ific for this gene (MO2) results in the same ventralized phenotypes as seen in ichabod embryos, and a

107 eover, loss of tsg1 partially suppressed the ventralized phenotypes of mutants of the BMP antagonists

108 ession of eve1 in embryos results in similar ventralized phenotypes to that seen in embryos overexpre

109 m60), and short tail(b180) mutations produce ventralized phenotypes, including expanded bmp2b/4 expre

110 sulted in a range of concentration-dependent ventralized phenotypes, including those lacking a brain

111 The enhanced individuals die with weakly ventralized phenotypes.

112 naive neural plate cells are converted into ventralized progenitors and a late period that extends w

113 on during the late period determines whether ventralized progenitors differentiate into motor neurons

114 ring which SHH drives the differentiation of ventralized progenitors into motor neurons.

115 ain-containing gene that is activated by the ventralizing signal BMP-4.

116 rafish yolk syncytial layer (YSL) secretes a ventralizing signal during gastrulation.

117 neural tube can compete with the diffusible ventralizing signal from the notochord.

118 the floor plate of the neural tube provide a ventralizing signal(s) directing sclerotome development,

119 ion and is important for the function of the ventralizing signal, Shh.

120 lly, activated protease cascade produces the ventralizing signal, so a distinct downstream step in th

121 ls and participates in the activation of the ventralizing signal.

122 g of the Drosophila embryo is initiated by a ventralizing signal.

123 rmed the action of chordin (chd) in opposing ventralizing signals at gastrulation.

124 ovides genetic evidence for the existence of ventralizing signals in the zebrafish gastrula and for a

125 Noggin and SHH-N have been implicated as the ventralizing signals produced by the notochord.

126 The ventrally located notochord provides the ventralizing signals to specify the sclerotome, while th

127 ene may normally function as an inhibitor of ventralizing signals, a function previously ascribed to

128 e or reduced levels of the notochord-derived ventralizing signals, as well as to the presence of domi

129 eral tissue passively reads graded levels of ventralizing signals, or whether local self-organizing r

130 lished, the organizer releases inhibitors of ventralizing signals, such as BMPs, and promotes dorsoan

131 itional mechanisms must exist to block these ventralizing signals.

132 Overexpression of PV.1 yields ventralized tadpoles and rescues embryos partially dorsa

133 y vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins a

134 Furthermore, nickel treatments ventralize the direct developing hemichordate, S. kowale

135 at both RA and FGF receptor (FGFR) signaling ventralize the eye, by expanding optic stalk and ventral

136 transcription factors are induced by Shh and ventralize the forebrain through a mechanism that is poo

137 We propose that Fgf signaling, known to ventralize the telencephalon in a Shh-independent manner

138 of Shh in the otic vesicle of ShhP1 embryos ventralized the adjacent hindbrain by inducing, rather t

139 terminal domain were unable to bind BMP, yet ventralized the embryo very effectively, indicating stro

140 uctures that require organizer signaling and ventralizes the embryo.

141 of these is Vax2, a homeodomain protein that ventralizes the vertebrate eye field by repressing trans

142 ty of the eggs laid by asun(d93) females are ventralized to varying degrees, from mild to severe; thi

143 Ventralizing transcriptional repressors in the Vox/Vent

144 tered abundance levels or isoform changes in ventralized versus lateralized embryos.

145 dino mutant embryos are ventralized, whereas swirl mutants are dorsalized.

146 oventral axis of the pituitary gland becomes ventralized, with dorsal extension of the transcriptiona

147 It also suggests that inhibiting ventralizing wnts parallels the opposition of BMPs by no

148 EH/eh-1 domain is necessary for rescue of UV-ventralized Xenopus embryos, it is dispensable for ectop

149 teins can rescue dorsoanterior structures in ventralized Xenopus embryos.