ライフサイエンスコーパス: venular

1 0 microm initial diameter, n = 41) and large venular (50.0 to 100.0 microm initial diameter, n = 41)

2 Expression of the venular adhesion molecule P-selectin increased in endoth

3 ukocyte adhesion, an effect not found during venular adhesion.

4 PO2 (P < .05), whereas arteriolar alpha 1-, venular alpha 1, and venular alpha 2-AR constrictions we

5 These data demonstrate that venular alpha 1- and alpha 2-AR constrictions are insens

6 In addition, venular alpha 1- but not alpha 2-ARs appear to couple to

7 d by nifedipine (0.06 to 3 mumol/L), whereas venular alpha 1-AR tone was inhibited by 50% (P < .05),

8 nitric oxide blockade; importantly, however, venular alpha 2- and alpha 1-AR tone still remained inse

9 as arteriolar alpha 1-, venular alpha 1, and venular alpha 2-AR constrictions were unaffected.

10 , unlike arteriolar alpha 2-AR constriction, venular alpha 2-AR tone did not depend on KATP activity.

11 Finally, venular alpha 2-AR tone was unaffected by nifedipine (0.

12 cl-2-HUVECs can differentiate into arterial, venular, and capillary-like ECs when implanted in vivo,

13 Reduced venular area was associated with HTG (-0.2 mm(2); 95% CI

14 natomic parameters, including arteriolar and venular arrangements and intercapillary pillar density a

15 Leukocytes can however penetrate the venular basement membrane at sites of inflammation, thou

16 endothelial cells (ECs), pericytes, and the venular basement membrane is a key component of innate i

17 confocal microscopy, we demonstrate that the venular basement membrane of multiple organs expresses r

18 The venular basement membrane plays a critical role in maint

19 s with endothelial cells, pericytes, and the venular basement membrane.

20 haracteristics of specialized regions within venular basement membranes that are preferentially used

21 e-plate viscometer at shear rates typical of venular blood flow (100 s-1 to 500 s-1).

22 function was associated with smaller retinal venular branching angle (beta: - 2.69 degrees ; 95% CI -

23 59; 95% CI, 1.29-1.97), and narrower retinal venular branching angle (OR, 1.22; 95% CI, 1.00-1.48) we

24 e Lrp5 loss of function causes predominantly venular BRB leakage.

25 by immunostaining on infiltrating cells and venular (but not arterial) endothelium by 3 hours.

26 Retinal arteriolar and venular caliber (central retinal arteriolar and venular

27 5% CI, 2.06-6.1], comparing Q2-4 vs. Q1) and venular caliber (MWv; OR, 4.2 [95% CI, 2.2-7.5]) predict

28 for trend = 0.012) and a 1.11-microm smaller venular caliber (P for trend = 0.029).

29 s associated with childhood narrower retinal venular caliber (standard deviation score per standardiz

30 Novel associations were found between venular caliber and beta-cell function (P = 0.011) and i

31 All venular caliber associations were not statistically sign

32 The authors assessed retinal arteriolar and venular caliber for all members of the cohort, including

33 Wider retinal venular caliber was associated with concomitant and futu

34 ider retinal arteriolar caliber and narrower venular caliber, which are associated with a lower risk

35 ider retinal arteriolar caliber and narrower venular caliber.

36 ions between baseline retinal arteriolar and venular calibers (central retinal arteriolar equivalent

37 % vs 20.8%, P = 0.017) as were thicker outer venular calibers (quartile 4) (33% vs 21.3%, P = 0.036).

38 associations between retinal arteriolar and venular calibers and cardiovascular disease risk factors

39 Retinal arteriolar and venular calibers are highly heritable and associated wit

40 Childhood retinal arteriolar and venular calibers were assessed at the age of 6 years.

41 he covariance between retinal arteriolar and venular calibers within the cohort.

42 5% of the covariance between arteriolar and venular calibers.

43 ants influencing both retinal arteriolar and venular calibers.

44 velocity, and central retinal arteriolar and venular calibers.

45 and [des-Arg9]-bradykinin on single cerebral venular capillaries has been investigated using the low

46 We conclude that in lung venular capillaries hyperosmolarity deteriorates barrier

47 te infusions of hyperosmolar sucrose in lung venular capillaries imaged in real time.

48 ncreasing effect of arachidonic acid on pial venular capillaries in vivo using the single microvessel

49 the fura 2 method in microscopically imaged venular capillaries of the isolated blood-perfused rat l

50 means of the split-drop technique in single venular capillaries of the isolated, blood-perfused rat

51 permeability response of slightly leaky pial venular capillaries to histamine was investigated using

52 Permeability of pial venular capillaries to Lucifer Yellow (PLY) was measured

53 ine H(2) agonist dimaprit on single cerebral venular capillaries, by using the single vessel occlusio

54 In lung venular capillaries, we determined endothelial [Ca(2+)](

55 ed real-time digital imaging studies in lung venular capillaries.

56 protein, and (3) proliferation occurs in the venular capillaries.

57 HIV-related venular changes were not detected.

58 RBC/endothelium adhesion under postcapillary venular conditions.

59 ever, the impact of hyperglycemia on retinal venular constriction remains unknown.

60 nd extracellular calcium (Ca(2+)) in retinal venular constriction to ET-1 and the impact of diabetes

61 Diabetes (after 2 weeks) enhanced venular constriction to ET-1, which was insensitive to P

62 ates p38 MAPK and NHE1, which cause enhanced venular constriction to ET-1.

63 caused significant (P < 0.05) arteriolar and venular constrictions in a dose-dependent manner, with t

64 Similarly, in vitro hyperglycemia augmented venular constrictions.

65 Venular constrictor responses in OZR were comparable to

66 of concept that our composite human EC/PC/BM venular construct can reveal new interactions in the inf

67 gic blockade heightened arteriolar and large venular contractile responses to norepinephrine, a nonse

68 Importantly, venular convergences are optimally equipped to support l

69 etinal arteriolar (CRAE) and central retinal venular (CRVE) calibers, measured from images produced w

70 luded vascular caliber (arteriolar-CRAE, and venular-CRVE) and diabetic retinopathy (DR).

71 Reductions in capillary, arteriolar, and venular density not only reduce the overall blood veloci

72 weeks of age, skeletal muscle post-capillary venular density was reduced by approximately 20% in LZR

73 , capillary density and area, arteriolar and venular density, and percent collagen content were quant

74 iameter tends to narrow with age; concurrent venular diameter is independently associated with sex, b

75 These data show that retinal venular diameter tends to narrow with age; concurrent ve

76 Retinal venular diameter was measured from photographs at each e

77 cle microcirculation, retinal arteriolar and venular diameter, and markers for cerebral small vessel

78 functional capillary density, arteriolar and venular diameter, and Po2 tension distribution.

79 7% +/- 5.2% decrease in large vessel (mostly venular) diameter resulted.

80 significantly smaller retinal arteriolar and venular diameters (p < 0.001).

81 multiple regression analyses, we found wider venular diameters and smaller arteriolar diameters were

82 odified the effect of retinal arteriolar and venular diameters in relation to HIV status, with a tend

83 techniques to determine mean arteriolar and venular diameters of each eye.

84 Unadjusted mean venular diameters were 267.77+/-18.21 microm in cases an

85 nstance, the median estimated arteriolar and venular diameters were approximately 12 mum greater in p

86 Arteriolar and venular diameters were increased by 2 days of stimulatio

87 ous transit times and retinal arteriolar and venular diameters were used to estimate stimulus-induced

88 eriovenous transit times, and arteriolar and venular diameters, from which retinal blood flow was cal

89 , and microvascular measures [arteriolar and venular diameters, tortuosity (simple and curvature) and

90 mulation-induced increases in arteriolar and venular diameters, which were unaffected by indomethacin

91 Retinal arterial tortuosity and venular dilatation are common in congenital heart diseas

92 Venular dilatation to acetylcholine was blunted in OZR v

93 associated with higher flicker light-induced venular dilation (beta percentage change over baseline:

94 d by measuring maximum arteriolar (aMax) and venular dilation (vMax) of retinal vessels in response t

95 intake was associated with impaired retinal venular dilation after full adjustment (STD beta: -0.07;

96 tina as flicker light-induced arteriolar and venular dilation and as central retinal arteriolar and v

97 ide the first evidence that impaired retinal venular dilation is a strong and independent predictor o

98 tion of the cremaster muscle (0.5, 1, 3 Hz), venular dilator and hyperaemic responses to lower freque

99 syndrome, both post-capillary and collecting venular dilator reactivity within the skeletal muscle of

100 ll vessels appear to respond to the level of venular distension and to recruitment of the vascular be

101 nd vascular cell adhesion molecule 1 only on venular ECs, whereas intercellular adhesion molecule-1 i

102 basal plasma extravasation in postcapillary venular endothelia in NEP-/- mice, which was reversed by

103 ECV-304 transfected cells) and postcapillary venular endothelial cells (CVEC).

104 rom human umbilical vein), and postcapillary venular endothelial cells (derived from bovine heart end

105 nes displayed on or specific Ag presented by venular endothelial cells (ECs), designated as chemokine

106 CpPLD-induced chemokine expression by human venular endothelial cells (HUVECs).

107 dhesion receptor preferentially expressed by venular endothelial cells at sites of lymphocyte extrava

108 dhesion receptor preferentially expressed by venular endothelial cells at sites of lymphocyte extrava

109 ssed on RBCs, capillaries, and postcapillary venular endothelial cells binds selective CXC and CC che

110 Moreover, the stimulation of human umbilical venular endothelial cells with thrombin induced rapid as

111 , especially the choice between arterial and venular endothelial cells, and between tip and trunk cel

112 d the activation of Rho-A in human umbilical venular endothelial cells.

113 and permeability properties of postcapillary venular endothelial cells.

114 (125)I-CXCL8 bound to venular endothelial cells; treatment with heparinases I

115 microvascular endothelial dysfunction, while venular endothelial function is preserved in this porcin

116 hepatocyte necrosis correlated with hepatic venular endothelial inflammation and centrilobular infla

117 lux was measured in cultured bovine coronary venular endothelial monolayers, which displayed a hyperp

118 al detection of P-selectin on the mesenteric venular endothelial surface demonstrated that rsPSGL.Ig

119 y migrate on TNF-alpha-activated cremasteric venular endothelium and exhibit marked polarization of s

120 t role in the firm adhesion of leukocytes to venular endothelium and facilitates leukocyte extravasat

121 res and PGI(2) released from capillaries and venular endothelium by a fall in their local act extralu

122 At FMLP-injected sites, venular endothelium developed increased surface wrinklin

123 livery of FAK-related non-kinase (FRNK) into venular endothelium did not alter basal barrier function

124 vesicles and vacuoles that together span the venular endothelium from lumen to ablumen.

125 Venular endothelium from the lung of children with LIP,

126 the adhesion of infected erythrocytes to the venular endothelium has been associated with some of the

127 phaC expression caused reduced elongation of venular endothelium in flow-direction, suggesting differ

128 bridization localized MCP-1 message to small venular endothelium in ischemic areas without myocyte ne

129 interacting (rolling and adherent) with the venular endothelium in TNF-alpha-treated wild-type, L-/-

130 ion to endothelial monolayers in vitro or to venular endothelium in vivo and that the end point of th

131 ly reduced leukocyte rolling and adhesion to venular endothelium of lipopolysaccharide (LPS)-treated

132 ress 0.5 to 8.0 dyne/cm(2)) and to activated venular endothelium on intravital microscopy were simila

133 xtensive attachment of MB(p) directly to the venular endothelium or to adherent platelet-leukocyte ag

134 , is capable of inducing MCP-1 expression in venular endothelium through AP-1 and NF-kappaB.

135 c shock triggered leukocytes adhesion to the venular endothelium to the same extent as hypoxemia.

136 ined the adherence of leukocytes to cerebral venular endothelium using rhodamine 6G.

137 Both C3a- and C5a-dependent adhesion to venular endothelium was blocked by ex vivo treatment of

138 ation of P-selectin expression on intestinal venular endothelium was significantly increased (P < 0.0

139 vates the adhesion of leukocytes to cerebral venular endothelium which contributes to disruption of t

140 ses permeability by inducing openings in the venular endothelium which do not retain macromolecules.

141 vacuoles that formed complex pathways across venular endothelium with multiple openings to both lumin

142 ted morphometric analysis, the proportion of venular endothelium within lamina propria that expresses

143 ngly, in vivo, Vav1/3ko leukocytes arrest on venular endothelium yet are unable to sustain adherence.

144 increases the permeability of capillary and venular endothelium, its effect on the integrity of arte

145 cation of c-Jun and NF-kappaB (p65) in small venular endothelium, only in the ischemic regions of the

146 dly elevated the albumin permeability of the venular endothelium.

147 eir attachment to leukocytes adherent to the venular endothelium.

148 ation of eosinophils and neutrophils through venular endothelium.

149 sters of vesicles and vacuoles that traverse venular endothelium.

150 on these cells bind to ligands expressed on venular endothelium.

151 it both neutrophil and eosinophil rolling on venular endothelium.

152 ia also triggered leukocytes adhesion to the venular endothelium.

153 rough which individual neutrophils traversed venular endothelium; in 10 of the 11 sets, neutrophils f

154 siently (0.1 to 180 s) with an attachment to venular endothelium; the remaining microbubbles passed t

155 ded PO(2) measurements at the arteriolar and venular ends of capillaries in the hamster retractor mus

156 We postulated that the venular enlargement necessary to form MV would require a

157 tors are adherence of cells to capillary and venular epithelial membranes creating increased resistan

158 k (0.98, 95% confidence interval 0.94-1.03); venular equivalent (0.99, 0.95-1.04) or individual parti

159 tral retinal arteriolar (0.99, 0.95-1.04) or venular equivalent (1.01, 0.97-1.05).

160 le equivalent (CRAE) and the central retinal venular equivalent (CRVE) of the original and altered im

161 riolar equivalent (CRAE) and central retinal venular equivalent (CRVE) of vessels at 1 disc diameter

162 riolar Equivalent (CRAE) and Central Retinal Venular Equivalent (CRVE) were extracted from these reti

163 riolar equivalent (CRAE) and central retinal venular equivalent (CRVE), and extended-zone vessels (>2

164 riolar equivalent (CRAE) and central retinal venular equivalent (CRVE), respectively) and incident de

165 ethods and summarized as the central retinal venular equivalent (CRVE).

166 lyses between central retinal arteriolar and venular equivalent and CKD stages 3-5 in the aggregate a

167 Central retinal venular equivalent decreased by 14 versus 19 mum at 2 ye

168 al arteriolar equivalent and central retinal venular equivalent measured from the Early Treatment Dia

169 ular caliber (central retinal arteriolar and venular equivalent) were assessed from retinal photograp

170 deviation) in central retinal arteriolar and venular equivalent.

171 sociated with changes in the central retinal venular equivalent.

172 ntral retinal arteriolar and central retinal venular equivalents (CRAE and CRVE, respectively) were m

173 lation and as central retinal arteriolar and venular equivalents, in plasma as a z score of endotheli

174 sociated with central retinal arteriolar and venular equivalents.

175 hDAF/hCD59 lungs (group IV) showed trace venular fibrin plugs and moderate loss of alveolar archi

176 endothelial cells (ECs) under conditions of venular flow and do so by binding to ICAM-1 and VCAM-1.

177 of circulating red blood cells, reduction of venular flow, and shortened survival.

178 d ECs to capture T cells under conditions of venular flow.

179 l function was associated with lower retinal venular fractal dimension (- 0.13Df; - 0.25, - 0.004).

180 lar and capillary levels, investigation into venular function and how this impacts responses has rece

181 multi-faceted alterations to skeletal muscle venular function in OZR may contribute to alterations in

182 For the shift in skeletal muscle venular function with development of the metabolic syndr

183 (LZR) as controls), we determined indices of venular function.

184 on in a time course correlating with that of venular hyperpermeability.

185 response to several mediators that increase venular hyperpermeability.

186 tion determined whether mCMV+HC led to worse venular inflammation than either factor alone.

187 et contacts in response to TNF-alpha-induced venular inflammation with relevance to sickle cell disea

188 s during tumor necrosis factor alpha-induced venular inflammation.

189 d endothelial cells during TNF-alpha-induced venular inflammation.

190 the choriocapillaris is non-random, and that venular insertions cluster around arteriolar ones.

191 d the relative arrangement of arteriolar and venular insertions.

192 B4 (LTB4) was efficacious at causing loss of venular JAM-C and promoting neutrophil reverse transendo

193 and adherent junction expressions and severe venular leakage exemplified intense cerebrovascular impa

194 and -independent arteriolar vasodilation and venular leukocyte and platelet adhesion in mice after in

195 caused temporary arteriolar dysfunction and venular leukocyte and platelet recruitment, which were e

196 yl ester (50 microM) significantly increased venular leukocyte rolling and adherence, which were also

197 onal dilator and hyperaemic responses at the venular level.

198 a process contingent upon the application of venular levels of shear stress.

199 ted in remodeling of airway capillaries into venular-like vessels that expressed venous markers like

200 during early reperfusion did not explain the venular localization of MCP-1 induction.

201 s through endothelial cells (ECs) lining the venular lumen (transendothelial migration (TEM)) in a lu

202 vascular enlargement, endothelial leakiness, venular marker expression, pericyte changes, and lymphat

203 teriolar (mean, 153.75 +/- 22.1 mum, SD) and venular (mean, 232.1 +/- 36.6 mum) calibers were measure

204 ange of blood flow conditions typical of the venular microcirculation.

205 the rheological environment in the inflamed venular microvasculature for platelet aggregation thereb

206 versibly compromised the barrier function of venular microvessel endothelium.

207 c permeability (Lp) of individually perfused venular microvessels in frog mesentery when the perfusat

208 Here we used single perfused venular microvessels in rat mesentery, which enabled dir

209 situ (mouse aorta, and individually perfused venular microvessels of mouse and rat mesentery).

210 lectron microscopy studies on rat mesenteric venular microvessels reveal an average pericyte coverage

211 Our experiments in frog and rat venular microvessels under a variety of conditions revea

212 underlying causes for retinal arteriolar and venular narrowing after treatment for PDR, and the possi

213 vented by KB-R7943, while mRNA expression of venular NCX isoforms was unaltered.

214 n with myofibre degeneration; arteriolar and venular networks remained intact.

215 h myofibre degeneration while arteriolar and venular networks remained intact; neutrophil depletion b

216 dilator reactivity in OZR reflects a loss in venular nitric oxide and PGI2 bioavailability, associate

217 ella retinitis, branch retinal arteriolar or venular occlusions, focal choroiditis, serous retinal de

218 significantly higher retinal arteriolar and venular oxygen saturation than that of the other two gro

219 Retinal arteriolar and venular oxygen saturation was comparable at flash settin

220 Both retinal arteriolar and venular oxygen saturation were measured using the non-in

221 did not differ significantly from the median venular P(RSA)(s) (4.0 +/- 1.0 x 10(7) cm s(-1), N = 8,

222 nGRGDSPCA peptide dose-dependently increased venular permeability by 2- to 3-fold.

223 In addition, the increases in venular permeability caused by agents that are known to

224 dose-dependently attenuated the increase in venular permeability caused by histamine.

225 lication of VEGF induced a rapid increase in venular permeability, and the effect was blocked by PD98

226 thelial cells had impaired histamine-induced venular permeability, which was restored by injecting an

227 peptide GRADSP did not significantly affect venular permeability.

228 nate-BSA infusion was used to determine pial-venular permeability.

229 d by 5 mum (P < 0.001) and the arteriolar-to-venular ratio by 0.02 (P < 0.01).

230 , PVD (20.44 vs. 26.41 mm/mm(2), p < 0.001), venular RBC velocity (402.2 vs. 693.9 um/s, p < 0.0004),

231 tions in convergences compared with straight venular regions (20.7 + or - 1.2 versus 12.43 + or - 1.1

232 governing tumor immune evasion, and proposes venular reprogramming as a therapeutic strategy to bolst

233 Venular reprogramming selectively promotes T cell recrui

234 iminate capillary profiles as arteriolar and venular, respectively, showed that growth occurred in th

235 Endothelium-dependent venular responses to ADP and serotonin were maintained d

236 ro and in vivo hyperglycemia enhance retinal venular responses to endogenous vasoconstrictors by acti

237 We examined retinal venular responsiveness to endogenous vasoconstrictors an

238 role in this differential arteriolar versus venular sensitivity to hypoxia.

239 Venular shear did not differ between septic and control

240 tment of the EC monolayer and application of venular shear force during the assay.

241 Under baseline conditions, lower venular shear rates and an increased number of rolling l

242 ons of systemic blood pressure or mesenteric venular shear rates were observed in any group.

243 Under postcapillary venular shear stress (1 dyne/cm2), sickle RBC adhered pr

244 than across the ECs (39.0% of control), and venular shear stress reduced transmigration across the E

245 memory (EM) CD4+ T cells under conditions of venular shear stress.

246 dermal microvascular EC under conditions of venular shear stress.

247 ration of T helper cells under conditions of venular shear stress.

248 nerated capillaries and extensive arteriolar-venular shunting.

249 cking (arrest) of circulating lymphocytes at venular sites of extravasation.

250 pha-adrenergic receptor (AR) constriction of venular smooth muscle is in fact protected against inhib

251 may be due to a paucity of KATP channels on venular smooth muscle.

252 cidated the role of Notch in arterial versus venular specification and have placed this pathway downs

253 eased CXCL1 from intracellular stores to the venular surface triggered beta2 integrin-dependent arres

254 Venular tone at approximately 25 mum (post-capillary) an

255 st vs. highest quartiles), decreased retinal venular tortuosity (OR, 1.59; 95% CI, 1.29-1.97), and na

256 Retinal arteriolar and venular tortuosity and width.

257 Increased venular tortuosity was associated with higher body mass

258 Automated measures of arteriolar and venular tortuosity, area, and width from retinal images

259 as significantly smaller than the arteriolar-venular transit time ( approximately 500 ms), indicating

260 ogressively activated while rolling down the venular tree.

261 ATP channel opener cromakalim suggested that venular, unlike arteriolar, smooth muscle had no detecta

262 Venular V and Q were higher in NPDR than PDR subjects (P

263 France) or an equal volume of saline before venular vessel wall injuries was made by directed laser

264 indicate that the location of arteriolar and venular vessels connected to the plane of the choriocapi

265 Variable venular vs. arteriolar constrictor effects must be consi

266 stroma cells promote dysregulated leukocyte-venular wall interactions and present the associated mol

267 sed by activated neutrophils adherent to the venular wall.

268 ding to activated leukocytes adherent to the venular wall.

269 there was no evidence of remodelling of the venular wall.

270 exit points by neutrophils in breaching the venular wall.

271 ed motility of leukocytes within and through venular walls and transient barrier disruption facilitat

272 vate neutrophils, enabling them to adhere to venular walls at sites of inflammation, cause a rapid Cl

273 ell accumulation in vascular lumina abutting venular walls in the retina and in vital non-ocular tiss

274 The mechanism of leukocyte migration through venular walls in vivo is largely unknown.

275 Leukocyte migration through activated venular walls is a fundamental immune response that is p

276 Neutrophil transmigration through venular walls that are composed of endothelial cells (EC

277 olymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte she

278 the ability of leukocytes to migrate through venular walls, engaging in sequential interactions with

279 prerequisite to neutrophil migration through venular walls, such as leukocyte luminal crawling and ce

280 the localization of directional cues across venular walls, thus causing neutrophils engaged in diape

281 ze of pericyte gaps and thickness of LERs in venular walls.

282 ed as presence of retinopathy and/or retinal venular widening.

283 ciated with retinal arteriolar narrowing and venular widening.