ライフサイエンスコーパス: venular

1 0 microm initial diameter, n = 41) and large venular (50.0 to 100.0 microm initial diameter, n = 41)

2 Expression of the venular adhesion molecule P-selectin increased in endoth

3 ukocyte adhesion, an effect not found during venular adhesion.

4 PO2 (P < .05), whereas arteriolar alpha 1-, venular alpha 1, and venular alpha 2-AR constrictions we

5 These data demonstrate that venular alpha 1- and alpha 2-AR constrictions are insens

6 In addition, venular alpha 1- but not alpha 2-ARs appear to couple to

7 d by nifedipine (0.06 to 3 mumol/L), whereas venular alpha 1-AR tone was inhibited by 50% (P < .05),

8 nitric oxide blockade; importantly, however, venular alpha 2- and alpha 1-AR tone still remained inse

9 as arteriolar alpha 1-, venular alpha 1, and venular alpha 2-AR constrictions were unaffected.

10 , unlike arteriolar alpha 2-AR constriction, venular alpha 2-AR tone did not depend on KATP activity.

11 Finally, venular alpha 2-AR tone was unaffected by nifedipine (0.

12 cl-2-HUVECs can differentiate into arterial, venular, and capillary-like ECs when implanted in vivo,

13 Leukocytes can however penetrate the venular basement membrane at sites of inflammation, thou

14 endothelial cells (ECs), pericytes, and the venular basement membrane is a key component of innate i

15 confocal microscopy, we demonstrate that the venular basement membrane of multiple organs expresses r

16 The venular basement membrane plays a critical role in maint

17 haracteristics of specialized regions within venular basement membranes that are preferentially used

18 e-plate viscometer at shear rates typical of venular blood flow (100 s-1 to 500 s-1).

19 59; 95% CI, 1.29-1.97), and narrower retinal venular branching angle (OR, 1.22; 95% CI, 1.00-1.48) we

20 by immunostaining on infiltrating cells and venular (but not arterial) endothelium by 3 hours.

21 for trend = 0.012) and a 1.11-microm smaller venular caliber (P for trend = 0.029).

22 s associated with childhood narrower retinal venular caliber (standard deviation score per standardiz

23 Novel associations were found between venular caliber and beta-cell function (P = 0.011) and i

24 The authors assessed retinal arteriolar and venular caliber for all members of the cohort, including

25 ider retinal arteriolar caliber and narrower venular caliber, which are associated with a lower risk

26 ider retinal arteriolar caliber and narrower venular caliber.

27 associations between retinal arteriolar and venular calibers and cardiovascular disease risk factors

28 Retinal arteriolar and venular calibers are highly heritable and associated wit

29 Childhood retinal arteriolar and venular calibers were assessed at the age of 6 years.

30 he covariance between retinal arteriolar and venular calibers within the cohort.

31 5% of the covariance between arteriolar and venular calibers.

32 ants influencing both retinal arteriolar and venular calibers.

33 and [des-Arg9]-bradykinin on single cerebral venular capillaries has been investigated using the low

34 We conclude that in lung venular capillaries hyperosmolarity deteriorates barrier

35 te infusions of hyperosmolar sucrose in lung venular capillaries imaged in real time.

36 ncreasing effect of arachidonic acid on pial venular capillaries in vivo using the single microvessel

37 the fura 2 method in microscopically imaged venular capillaries of the isolated blood-perfused rat l

38 means of the split-drop technique in single venular capillaries of the isolated, blood-perfused rat

39 permeability response of slightly leaky pial venular capillaries to histamine was investigated using

40 Permeability of pial venular capillaries to Lucifer Yellow (PLY) was measured

41 ine H(2) agonist dimaprit on single cerebral venular capillaries, by using the single vessel occlusio

42 In lung venular capillaries, we determined endothelial [Ca(2+)](

43 ed real-time digital imaging studies in lung venular capillaries.

44 protein, and (3) proliferation occurs in the venular capillaries.

45 HIV-related venular changes were not detected.

46 RBC/endothelium adhesion under postcapillary venular conditions.

47 caused significant (P < 0.05) arteriolar and venular constrictions in a dose-dependent manner, with t

48 Venular constrictor responses in OZR were comparable to

49 of concept that our composite human EC/PC/BM venular construct can reveal new interactions in the inf

50 gic blockade heightened arteriolar and large venular contractile responses to norepinephrine, a nonse

51 Importantly, venular convergences are optimally equipped to support l

52 etinal arteriolar (CRAE) and central retinal venular (CRVE) calibers, measured from images produced w

53 weeks of age, skeletal muscle post-capillary venular density was reduced by approximately 20% in LZR

54 , capillary density and area, arteriolar and venular density, and percent collagen content were quant

55 iameter tends to narrow with age; concurrent venular diameter is independently associated with sex, b

56 These data show that retinal venular diameter tends to narrow with age; concurrent ve

57 Retinal venular diameter was measured from photographs at each e

58 cle microcirculation, retinal arteriolar and venular diameter, and markers for cerebral small vessel

59 functional capillary density, arteriolar and venular diameter, and Po2 tension distribution.

60 7% +/- 5.2% decrease in large vessel (mostly venular) diameter resulted.

61 multiple regression analyses, we found wider venular diameters and smaller arteriolar diameters were

62 odified the effect of retinal arteriolar and venular diameters in relation to HIV status, with a tend

63 techniques to determine mean arteriolar and venular diameters of each eye.

64 Unadjusted mean venular diameters were 267.77+/-18.21 microm in cases an

65 nstance, the median estimated arteriolar and venular diameters were approximately 12 mum greater in p

66 Arteriolar and venular diameters were increased by 2 days of stimulatio

67 ous transit times and retinal arteriolar and venular diameters were used to estimate stimulus-induced

68 eriovenous transit times, and arteriolar and venular diameters, from which retinal blood flow was cal

69 mulation-induced increases in arteriolar and venular diameters, which were unaffected by indomethacin

70 Venular dilatation to acetylcholine was blunted in OZR v

71 tion of the cremaster muscle (0.5, 1, 3 Hz), venular dilator and hyperaemic responses to lower freque

72 syndrome, both post-capillary and collecting venular dilator reactivity within the skeletal muscle of

73 ll vessels appear to respond to the level of venular distension and to recruitment of the vascular be

74 nd vascular cell adhesion molecule 1 only on venular ECs, whereas intercellular adhesion molecule-1 i

75 basal plasma extravasation in postcapillary venular endothelia in NEP-/- mice, which was reversed by

76 ECV-304 transfected cells) and postcapillary venular endothelial cells (CVEC).

77 rom human umbilical vein), and postcapillary venular endothelial cells (derived from bovine heart end

78 nes displayed on or specific Ag presented by venular endothelial cells (ECs), designated as chemokine

79 CpPLD-induced chemokine expression by human venular endothelial cells (HUVECs).

80 dhesion receptor preferentially expressed by venular endothelial cells at sites of lymphocyte extrava

81 dhesion receptor preferentially expressed by venular endothelial cells at sites of lymphocyte extrava

82 ssed on RBCs, capillaries, and postcapillary venular endothelial cells binds selective CXC and CC che

83 Moreover, the stimulation of human umbilical venular endothelial cells with thrombin induced rapid as

84 , especially the choice between arterial and venular endothelial cells, and between tip and trunk cel

85 d the activation of Rho-A in human umbilical venular endothelial cells.

86 and permeability properties of postcapillary venular endothelial cells.

87 (125)I-CXCL8 bound to venular endothelial cells; treatment with heparinases I

88 microvascular endothelial dysfunction, while venular endothelial function is preserved in this porcin

89 hepatocyte necrosis correlated with hepatic venular endothelial inflammation and centrilobular infla

90 lux was measured in cultured bovine coronary venular endothelial monolayers, which displayed a hyperp

91 al detection of P-selectin on the mesenteric venular endothelial surface demonstrated that rsPSGL.Ig

92 y migrate on TNF-alpha-activated cremasteric venular endothelium and exhibit marked polarization of s

93 t role in the firm adhesion of leukocytes to venular endothelium and facilitates leukocyte extravasat

94 res and PGI(2) released from capillaries and venular endothelium by a fall in their local act extralu

95 At FMLP-injected sites, venular endothelium developed increased surface wrinklin

96 livery of FAK-related non-kinase (FRNK) into venular endothelium did not alter basal barrier function

97 vesicles and vacuoles that together span the venular endothelium from lumen to ablumen.

98 Venular endothelium from the lung of children with LIP,

99 the adhesion of infected erythrocytes to the venular endothelium has been associated with some of the

100 bridization localized MCP-1 message to small venular endothelium in ischemic areas without myocyte ne

101 interacting (rolling and adherent) with the venular endothelium in TNF-alpha-treated wild-type, L-/-

102 ion to endothelial monolayers in vitro or to venular endothelium in vivo and that the end point of th

103 ly reduced leukocyte rolling and adhesion to venular endothelium of lipopolysaccharide (LPS)-treated

104 ress 0.5 to 8.0 dyne/cm(2)) and to activated venular endothelium on intravital microscopy were simila

105 xtensive attachment of MB(p) directly to the venular endothelium or to adherent platelet-leukocyte ag

106 , is capable of inducing MCP-1 expression in venular endothelium through AP-1 and NF-kappaB.

107 c shock triggered leukocytes adhesion to the venular endothelium to the same extent as hypoxemia.

108 ined the adherence of leukocytes to cerebral venular endothelium using rhodamine 6G.

109 Both C3a- and C5a-dependent adhesion to venular endothelium was blocked by ex vivo treatment of

110 ation of P-selectin expression on intestinal venular endothelium was significantly increased (P < 0.0

111 vates the adhesion of leukocytes to cerebral venular endothelium which contributes to disruption of t

112 ses permeability by inducing openings in the venular endothelium which do not retain macromolecules.

113 vacuoles that formed complex pathways across venular endothelium with multiple openings to both lumin

114 ted morphometric analysis, the proportion of venular endothelium within lamina propria that expresses

115 ngly, in vivo, Vav1/3ko leukocytes arrest on venular endothelium yet are unable to sustain adherence.

116 increases the permeability of capillary and venular endothelium, its effect on the integrity of arte

117 cation of c-Jun and NF-kappaB (p65) in small venular endothelium, only in the ischemic regions of the

118 dly elevated the albumin permeability of the venular endothelium.

119 eir attachment to leukocytes adherent to the venular endothelium.

120 ation of eosinophils and neutrophils through venular endothelium.

121 sters of vesicles and vacuoles that traverse venular endothelium.

122 on these cells bind to ligands expressed on venular endothelium.

123 it both neutrophil and eosinophil rolling on venular endothelium.

124 ia also triggered leukocytes adhesion to the venular endothelium.

125 rough which individual neutrophils traversed venular endothelium; in 10 of the 11 sets, neutrophils f

126 siently (0.1 to 180 s) with an attachment to venular endothelium; the remaining microbubbles passed t

127 ded PO(2) measurements at the arteriolar and venular ends of capillaries in the hamster retractor mus

128 We postulated that the venular enlargement necessary to form MV would require a

129 tors are adherence of cells to capillary and venular epithelial membranes creating increased resistan

130 le equivalent (CRAE) and the central retinal venular equivalent (CRVE) of the original and altered im

131 ethods and summarized as the central retinal venular equivalent (CRVE).

132 al arteriolar equivalent and central retinal venular equivalent measured from the Early Treatment Dia

133 sociated with changes in the central retinal venular equivalent.

134 ntral retinal arteriolar and central retinal venular equivalents (CRAE and CRVE, respectively) were m

135 sociated with central retinal arteriolar and venular equivalents.

136 hDAF/hCD59 lungs (group IV) showed trace venular fibrin plugs and moderate loss of alveolar archi

137 of circulating red blood cells, reduction of venular flow, and shortened survival.

138 d ECs to capture T cells under conditions of venular flow.

139 lar and capillary levels, investigation into venular function and how this impacts responses has rece

140 multi-faceted alterations to skeletal muscle venular function in OZR may contribute to alterations in

141 For the shift in skeletal muscle venular function with development of the metabolic syndr

142 (LZR) as controls), we determined indices of venular function.

143 on in a time course correlating with that of venular hyperpermeability.

144 response to several mediators that increase venular hyperpermeability.

145 tion determined whether mCMV+HC led to worse venular inflammation than either factor alone.

146 et contacts in response to TNF-alpha-induced venular inflammation with relevance to sickle cell disea

147 s during tumor necrosis factor alpha-induced venular inflammation.

148 d endothelial cells during TNF-alpha-induced venular inflammation.

149 B4 (LTB4) was efficacious at causing loss of venular JAM-C and promoting neutrophil reverse transendo

150 and adherent junction expressions and severe venular leakage exemplified intense cerebrovascular impa

151 and -independent arteriolar vasodilation and venular leukocyte and platelet adhesion in mice after in

152 caused temporary arteriolar dysfunction and venular leukocyte and platelet recruitment, which were e

153 yl ester (50 microM) significantly increased venular leukocyte rolling and adherence, which were also

154 onal dilator and hyperaemic responses at the venular level.

155 a process contingent upon the application of venular levels of shear stress.

156 ted in remodeling of airway capillaries into venular-like vessels that expressed venous markers like

157 during early reperfusion did not explain the venular localization of MCP-1 induction.

158 s through endothelial cells (ECs) lining the venular lumen (transendothelial migration (TEM)) in a lu

159 vascular enlargement, endothelial leakiness, venular marker expression, pericyte changes, and lymphat

160 teriolar (mean, 153.75 +/- 22.1 mum, SD) and venular (mean, 232.1 +/- 36.6 mum) calibers were measure

161 ange of blood flow conditions typical of the venular microcirculation.

162 versibly compromised the barrier function of venular microvessel endothelium.

163 c permeability (Lp) of individually perfused venular microvessels in frog mesentery when the perfusat

164 Here we used single perfused venular microvessels in rat mesentery, which enabled dir

165 situ (mouse aorta, and individually perfused venular microvessels of mouse and rat mesentery).

166 lectron microscopy studies on rat mesenteric venular microvessels reveal an average pericyte coverage

167 Our experiments in frog and rat venular microvessels under a variety of conditions revea

168 dilator reactivity in OZR reflects a loss in venular nitric oxide and PGI2 bioavailability, associate

169 ella retinitis, branch retinal arteriolar or venular occlusions, focal choroiditis, serous retinal de

170 Retinal arteriolar and venular oxygen saturation was comparable at flash settin

171 did not differ significantly from the median venular P(RSA)(s) (4.0 +/- 1.0 x 10(7) cm s(-1), N = 8,

172 nGRGDSPCA peptide dose-dependently increased venular permeability by 2- to 3-fold.

173 In addition, the increases in venular permeability caused by agents that are known to

174 dose-dependently attenuated the increase in venular permeability caused by histamine.

175 lication of VEGF induced a rapid increase in venular permeability, and the effect was blocked by PD98

176 thelial cells had impaired histamine-induced venular permeability, which was restored by injecting an

177 peptide GRADSP did not significantly affect venular permeability.

178 nate-BSA infusion was used to determine pial-venular permeability.

179 d by 5 mum (P < 0.001) and the arteriolar-to-venular ratio by 0.02 (P < 0.01).

180 tions in convergences compared with straight venular regions (20.7 + or - 1.2 versus 12.43 + or - 1.1

181 iminate capillary profiles as arteriolar and venular, respectively, showed that growth occurred in th

182 Endothelium-dependent venular responses to ADP and serotonin were maintained d

183 role in this differential arteriolar versus venular sensitivity to hypoxia.

184 Venular shear did not differ between septic and control

185 tment of the EC monolayer and application of venular shear force during the assay.

186 Under baseline conditions, lower venular shear rates and an increased number of rolling l

187 ons of systemic blood pressure or mesenteric venular shear rates were observed in any group.

188 Under postcapillary venular shear stress (1 dyne/cm2), sickle RBC adhered pr

189 than across the ECs (39.0% of control), and venular shear stress reduced transmigration across the E

190 ration of T helper cells under conditions of venular shear stress.

191 memory (EM) CD4+ T cells under conditions of venular shear stress.

192 dermal microvascular EC under conditions of venular shear stress.

193 nerated capillaries and extensive arteriolar-venular shunting.

194 cking (arrest) of circulating lymphocytes at venular sites of extravasation.

195 pha-adrenergic receptor (AR) constriction of venular smooth muscle is in fact protected against inhib

196 may be due to a paucity of KATP channels on venular smooth muscle.

197 cidated the role of Notch in arterial versus venular specification and have placed this pathway downs

198 eased CXCL1 from intracellular stores to the venular surface triggered beta2 integrin-dependent arres

199 Venular tone at approximately 25 mum (post-capillary) an

200 st vs. highest quartiles), decreased retinal venular tortuosity (OR, 1.59; 95% CI, 1.29-1.97), and na

201 as significantly smaller than the arteriolar-venular transit time ( approximately 500 ms), indicating

202 ogressively activated while rolling down the venular tree.

203 ATP channel opener cromakalim suggested that venular, unlike arteriolar, smooth muscle had no detecta

204 Venular V and Q were higher in NPDR than PDR subjects (P

205 France) or an equal volume of saline before venular vessel wall injuries was made by directed laser

206 Variable venular vs. arteriolar constrictor effects must be consi

207 sed by activated neutrophils adherent to the venular wall.

208 there was no evidence of remodelling of the venular wall.

209 ding to activated leukocytes adherent to the venular wall.

210 exit points by neutrophils in breaching the venular wall.

211 ed motility of leukocytes within and through venular walls and transient barrier disruption facilitat

212 vate neutrophils, enabling them to adhere to venular walls at sites of inflammation, cause a rapid Cl

213 The mechanism of leukocyte migration through venular walls in vivo is largely unknown.

214 Leukocyte migration through activated venular walls is a fundamental immune response that is p

215 Neutrophil transmigration through venular walls that are composed of endothelial cells (EC

216 olymorphonuclear neutrophils (PMNs) traverse venular walls, composed of the endothelium, pericyte she

217 prerequisite to neutrophil migration through venular walls, such as leukocyte luminal crawling and ce

218 ze of pericyte gaps and thickness of LERs in venular walls.

219 ed as presence of retinopathy and/or retinal venular widening.

220 ciated with retinal arteriolar narrowing and venular widening.