ライフサイエンスコーパス: very long chain

1 and severity of neuropathy and the levels of very-long-chain 1-deoxyceramides such as C24 (P < 0.05),

2 romoter between the two human genes encoding very long chain acyl-CoA dehydrogenase (VLCAD) and posts

3 ferase, very long chain acyl-CoA synthetase, very long chain acyl-CoA dehydrogenase) in livers of the

4 re we provide evidence that in this organism very long chain acyl-CoA esters are hydrolyzed by the Px

5 raphy and demonstrated a 10-fold increase in very long chain acyl-CoA specific activity (C24:0/C16:0)

6 hibited markedly decreased expression of the very long chain acyl-CoA synthase-related gene (VLACSR),

7 cell extracts suggested that FATP1 exhibits very long chain acyl-CoA synthetase (ACS) activity and t

8 Members of the fatty acid transport protein/very long chain acyl-CoA synthetase (FATP/Acsvl) family

9 The very long chain acyl-CoA synthetase activity of the two

10 These results indicate that FATP1 is a very long chain acyl-CoA synthetase and suggest that a p

11 , liver carnitine palmitoyl-CoA transferase, very long chain acyl-CoA synthetase, very long chain acy

12 nthetase activity (C16:0), characteristic of very long chain acyl-CoA synthetases, whereas both mutan

13 The 11 long-chain (ACSL) and very long chain acyl-coenzyme A (acyl-CoA) synthetases [

14 in skin homeostasis, which may be due to its very long chain acyl-coenzyme A synthetase activity.

15 t exogenous long-chain fatty acids, and have very long-chain acyl CoA synthetase activities that were

16 The depression in very long-chain acyl CoA synthetase activities were not

17 though many patients have been found to have very long-chain acyl-CoA dehydrogenase (VLCAD) deficienc

18 Very long-chain acyl-CoA dehydrogenase (VLCAD) deficienc

19 long-chain acyl-CoA dehydrogenase (LCAD) and very long-chain acyl-CoA dehydrogenase revealed that 5-t

20 unsaturated acyl-CoAs are poor substrates of very long-chain acyl-CoA dehydrogenase when compared wit

21 , and deficiency of mitochondrial medium- or very long-chain acyl-CoA dehydrogenase.

22 ls suggest that, in contrast to yeast cells, very long-chain acyl-CoA esters are transported into per

23 s been associated with decreased peroxisomal very long-chain acyl-CoA synthetase (VLCS) activity and

24 creased VLCFA beta-oxidation and peroxisomal very long-chain acyl-CoA synthetase (VLCS) activity.

25 We reported previously that homolog 2 of very long-chain acyl-CoA synthetase (VLCS) can activate

26 inked adrenoleukodystrophy, are activated by very long-chain acyl-CoA synthetase (VLCS) normally foun

27 LACS1 thus appears to function as a very long-chain acyl-CoA synthetase in wax metabolism.

28 A human homolog of very long-chain acyl-CoA synthetase, hVLCS-H2, has two r

29 002 is a prodrug that requires activation by very long-chain acyl-CoA synthetase-1 (ACSVL1) to modula

30 The family of proteins that includes very long-chain acyl-CoA synthetases (ACSVL) consists of

31 fatty acid transport proteins (FATP) and the very long-chain acyl-CoA synthetases (VLACS).

32 The most recently identified family is the very long-chain acyl-CoA synthetases (VLCS).

33 Other long- and very long-chain acyl-CoA synthetases were incapable of a

34 Very-long-chain acyl-CoA dehydrogenase (VLCAD) catalyzes

35 Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a majo

36 Very-long-chain acyl-CoA dehydrogenase (VLCAD) is a memb

37 trate specificity, it appears that ACAD9 and very-long-chain acyl-CoA dehydrogenase are unable to com

38 In three patients with very-long-chain acyl-CoA dehydrogenase deficiency, this

39 istribution and gene regulation of ACAD9 and very-long-chain acyl-CoA dehydrogenase identify the pres

40 function that is highly homologous to human very-long-chain acyl-CoA dehydrogenase was identified by

41 Gel filtration analysis indicated that, like very-long-chain acyl-CoA dehydrogenase, ACAD-9 is a dime

42 ACBP binds very-long-chain acyl-CoA esters, which is required for i

43 We generated very-long-chain acyl-coenzyme A dehydrogenase (VLCAD)-de

44 decreased ability of cells to activate (via very-long-chain acyl-coenzyme A synthetase [VLCS]) and s

45 ly hydrophobic compounds including saturated very-long-chain alkanes, ketones, and alcohols.

46 In summary, the CoA thioesters of very-long-chain and branched-chain fatty acids are much

47 ) is very similar to the multigene family of very long chain (C20-C26) acyl-CoA synthetases.

48 Very long chain (C22-C24) ceramides are synthesized by c

49 (N-palmitoyl sphingosine) and nonsaturated, very long chain C24:1 ceramide (N-nervonoyl sphingosine)

50 le of activating both long-chain (C16:0) and very long-chain (C24:0) fatty acids.

51 hat confluence caused selective increases in very long chain ceramide C(24:1) (370 +/- 54%) and C(24:

52 bases in blood, accompanied by increases in very long chain ceramide species, and have defective lym

53 d cellular levels of specific long-chain and very long-chain ceramide species relative to vector cont

54 nt with a significant reduction in long- and very-long-chain ceramide levels.

55 f growth arrest on the increase in levels of very long chain ceramides.

56 Stress increased the amounts of long- and very long-chain ceramides in HEK293 cells, and this was

57 haCER1 catalyzed the hydrolysis of very long-chain ceramides to generate sphingosine (SPH).

58 terestingly, elevated levels of only certain very long-chain ceramides were evident in V5-aSMase(S508

59 Ablation of very-long-chain ceramides (Cers) with consecutive elevat

60 ication of several endogenous long-chain and very-long-chain ceramides using two nonphysiological odd

61 s in the retina with special emphasis on the very-long-chain-containing saturated (VLC-FA) and polyun

62 Typically very long chain diacetylene lipids formed gels in ethano

63 d seed coats with a severalfold reduction in very long chain dicarboxylic acid and omega-hydroxy fatt

64 with FA, the rate of flip-flop of saturated very long chain FA (C20:0, C:22:0, and C24:0) was shown

65 carboxylase, inhibited only elongation into very long chain FAs (>or=20 carbons) but not synthesis o

66 ptor CD36 is required both for the uptake of very long chain FAs (VLCFAs) in cultured cells and the a

67 The elongases of very long chain fatty acid (ELOVL or ELO) are essential

68 isorder characterized by reduced peroxisomal very long chain fatty acid (VLCFA) beta-oxidation.

69 ed to provide insight into the regulation of very long chain fatty acid (VLCFA) biosynthesis in Brass

70 letion of ALD gene (ABCD1) and the resultant very long chain fatty acid (VLCFA) derangement has drama

71 roxisomal transmembrane protein required for very long chain fatty acid (VLCFA) metabolism.

72 Utilizing the plasma very long chain fatty acid assay, supplemented by mutati

73 ese studies reveal roles for Rvs161p and the very long chain fatty acid elongase, Sur4p, in the local

74 sequence identity with previously identified very long chain fatty acid elongases.

75 ,3-enoyl-CoA reduction reactions in long and very long chain fatty acid elongation, respectively.

76 n precursor, suggesting that it functions in very long chain fatty acid hydroxylation using an altern

77 tly linked to the (omega-1)-hydroxy group of very long chain fatty acid in bradyrhizobial lipid A.

78 Although FATP4 deficiency primarily affected very long chain fatty acid metabolism, mutant fibroblast

79 etabolic pathways, ether lipid synthesis and very long chain fatty acid oxidation.

80 CoA synthetase that preferentially activates very long chain fatty acid substrates, such as C24:0, to

81 3-ketoacyl-CoA synthase which is involved in very long chain fatty acid synthesis in vegetative tissu

82 r C18:1, suggesting that in vivo, defects in very long chain fatty acid uptake may underlie the skin

83 oblasts, FATP4 is the major enzyme producing very long chain fatty acid-CoA for lipid metabolic pathw

84 the condensation of a long chain base with a very long chain fatty acid.

85 s7p is required for the hydroxylation of the very long chain fatty acid.

86 tachyzoites synthesized a range of long and very long chain fatty acids (C14:0-26:1).

87 cid elongases that catalyze the synthesis of very long chain fatty acids (C24 to C26) required for ce

88 n of VLCFA synthesizing enzymes, elongase of very long chain fatty acids (ELOVLs) (1 and 3) in both c

89 Abnormalities in the transport of saturated very long chain fatty acids (VLCFA; >C18:0) contribute t

90 mal disorder with impaired beta-oxidation of very long chain fatty acids (VLCFAs) and reduced functio

91 adrenoleukodystrophy is the accumulation of very long chain fatty acids (VLCFAs) due to impaired per

92 he bubblegum mutant shows elevated levels of very long chain fatty acids (VLCFAs), as seen in the hum

93 The assay of plasma very long chain fatty acids (VLCFAs), developed in our l

94 id elongase required for the biosynthesis of very long chain fatty acids (VLCFAs).

95 ngation pathway responsible for formation of very long chain fatty acids (VLCFAs, or fatty acids with

96 Elongation of very long chain fatty acids 4 (ELOVL4) is a novel member

97 ed in exon six of a gene named Elongation of very long chain fatty acids 4 (ELOVL4).

98 ed by mutations in the ELOVL4 (Elongation of very long chain fatty acids 4) gene.

99 nvolved in the peroxisomal beta-oxidation of very long chain fatty acids and are associated with defe

100 contain unique lipids such as mycolic acids, very long chain fatty acids and multimethyl-branched fat

101 Cuticular waxes are complex mixtures of very long chain fatty acids and their derivatives that c

102 The very long chain fatty acids are crucial building blocks

103 Degradation of very long chain fatty acids decreased by 47% and resulte

104 he expression of ACOX protein and accumulate very long chain fatty acids in blood.

105 mical parameters, including accumulations of very long chain fatty acids in plasma and deficient eryt

106 S), the enzyme responsible for production of very long chain fatty acids of plant seed oils.

107 miR-219 and its target ELOVL7 (elongation of very long chain fatty acids protein 7) were identified a

108 Analysis of sphingolipid-derived very long chain fatty acids revealed an approximately 40

109 longation systems that produce the 26-carbon very long chain fatty acids that are precursors for cera

110 In contrast, synthesis of very long chain fatty acids was primarily dependent on a

111 dehydratases are required for elongation of very long chain fatty acids, and HACD1 has a role in ear

112 golipids, substantial levels of hydroxylated very long chain fatty acids, and the full complement of

113 lar endothelial cells causes accumulation of very long chain fatty acids, but much later than the imm

114 We found very long chain fatty acids, medium chain acylcarnitines

115 Elongation of very long chain fatty acids-4 (ELOVL4) has been identifi

116 in the expression of the gene elongation of very long chain fatty acids-like 2, an enzyme needed for

117 ulin-induced gene 2a, Insig2a, elongation of very long chain fatty acids-like 3, Elovl3 and sterol 12

118 A Met299Val variant in the elongation of very long chain fatty acids-like 4 (ELOVL4) gene was sig

119 TmELO2 function to synthesize long chain and very long chain fatty acids.

120 activity, with an apparent preference toward very long chain fatty acids.

121 ormalities in these cells are not limited to very long chain fatty acids.

122 gation of a second stearate molecule to form very long chain fatty acids.

123 active on long chain fatty acids relative to very long chain fatty acids.

124 saturases, enzymes involved in elongation of very long chain fatty acids.

125 roteins that function in the biosynthesis of very long chain fatty acids.

126 kodystrophy protein, with an accumulation of very long chain fatty acids.

127 utive reactions to preferentially metabolize very long chain fatty acids.

128 and ELO3 produce defects in the formation of very long chain fatty acids.

129 in the ABCD1 gene leading to accumulation of very long chain fatty acids.

130 haracterized by the abnormal accumulation of very long chain fatty acids.

131 (VLCFAs) and reduced function of peroxisomal very long chain fatty acyl-CoA synthetase (VLCS) that le

132 PpORS condenses a very long chain fatty acyl-CoA with four molecules of ma

133 ption mutant (DeltafoxA) was eliminated on a very long-chain fatty acid (C(22:1)), growth was only pa

134 classes on the stem and leaf, except in the very long-chain fatty acid (VLCFA) class wherein acids l

135 In this study, we investigated the roles of very long-chain fatty acid (VLCFA) synthesis by fatty ac

136 the elongase system of enzymes required for very long-chain fatty acid (VLCFA) synthesis.

137 ecrease in peroxisomal VLCS activity and the very long-chain fatty acid accumulation in the yeast FAT

138 nted the defects in fatty acid transport and very long-chain fatty acid activation associated with a

139 mBG1 appears to play a minor role in very long-chain fatty acid activation in these cells, in

140 transport protein 4 (FATP4), which each have very long-chain fatty acid acyl-CoA synthetase (VLCFA-AC

141 phingolipid pathway, such as deletion of the very long-chain fatty acid elongase, Sur4, suppress the

142 tivity that is essential for normal cellular very long-chain fatty acid homeostasis.

143 Very long-chain fatty acid levels were partially restore

144 other acyl-CoA synthetases are necessary for very long-chain fatty acid metabolism in Neuro2a cells.

145 and is capable of activating both long- and very long-chain fatty acid substrates.

146 f the ACC and elevation of the ceramides and very long-chain fatty acid syntheses with normal cell-cy

147 synthase that catalyzes the initial step of very long-chain fatty acid synthesis.

148 amily of six FATPs that facilitate long- and very long-chain fatty acid uptake.

149 smembrane proteins that facilitate long- and very long-chain fatty acid uptake.

150 Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated wit

151 , which is responsible for the elongation of very long-chain fatty acids (at least 26 carbons).

152 ese cells are devoid of ABCD1 and accumulate very long-chain fatty acids (C26:0 and C26:1).

153 defect in synthesis of unsaturated long and very long-chain fatty acids (LCFAs and VLCFAs) and deple

154 Sphingolipids are synthesized de novo from very long-chain fatty acids (VLCFA) and sphingoid long-c

155 bers of this group are capable of activating very long-chain fatty acids (VLCFA), one is a bile acid-

156 ve disorder characterized by accumulation of very long-chain fatty acids (VLCFA).

157 re of X-ALD is increased levels of saturated very long-chain fatty acids (VLCFA; carbon chains of 22

158 Very long-chain fatty acids (VLCFAs) are essential lipid

159 (del/del) mice revealed a global decrease in very long-chain fatty acids (VLFAs) (i.e., carbon chain

160 X-ALD is characterized by an accumulation of very long-chain fatty acids and partially impaired perox

161 possibility that intermediate metabolites of very long-chain fatty acids and peroxisomal beta-oxidati

162 p and Elo3p are inviable confirming that the very long-chain fatty acids are essential for cellular f

163 tol-ceramides [IPC, MIPC, and M(IP)(2)C] and very long-chain fatty acids C(24) and C(26) declined sha

164 ssion pattern and ability of BG1 to activate very long-chain fatty acids implicates this enzyme in th

165 icantly inhibited the omega-hydroxylation of very long-chain fatty acids in cultured human keratinocy

166 rely impaired as degradation of unesterified very long-chain fatty acids in X-ALD and is abolished in

167 Mycolic acids are very long-chain fatty acids representing essential compo

168 Major cuticular wax compounds, such as very long-chain fatty acids, alcohols, alkanes, and keto

169 and Elo3p are required for synthesis of the very long-chain fatty acids, and mutants lacking both El

170 of linoleic acid, odd-chain fatty acids, and very long-chain fatty acids, was associated with lower i

171 Very long-chain fatty acids, which accumulate in tissues

172 l membrane proteins involved in transport of very long-chain fatty acids, which are a unique componen

173 NA library, we have identified elongation of very long-chain fatty acids-like 1 (ELOVL1) and fatty ac

174 nd C24:0 as substrates), and accumulation of very long-chain fatty acids.

175 xogenous fatty acids or in the activation of very long-chain fatty acids.

176 t-chain and severely restricted on long- and very long-chain fatty acids.

177 methyl group addition occurs was a family of very long-chain fatty acids.

178 er dextrose or oleic acid medium accumulated very long-chain fatty acids.

179 long-chain fatty acids and the activation of very long-chain fatty acids; these activities intrinsic

180 ble exceptions, the fatty acid transport and very long-chain fatty acyl-CoA synthetase activities wer

181 ates, the levels of fatty acid accumulation, very long-chain fatty acyl-CoA synthetase activities, an

182 coenzyme A derivatives using long-chain and very-long chain fatty acids, bile acids and bile acid pr

183 ts, led us to discover that BacA affects the very-long-chain fatty acid (27-OHC28:0 and 29-OHC30:0) c

184 We showed that NLMs lost saturated very-long-chain fatty acid (FA; C24:0) SM in cancer cell

185 and Schefflera elegantissima) contained only very-long-chain fatty acid (VLCFA) derivatives such as a

186 Notably, an unusual very-long-chain fatty acid (VLCFA) is found in the lipid

187 chological, electrophysiological, and plasma very-long-chain fatty acid (VLCFA) measurements were use

188 se complex are required for the synthesis of very-long-chain fatty acid (VLCFA) precursors of cuticul

189 reviously undescribed desaturase activity on very-long-chain fatty acid (VLCFA) substrates and exhibi

190 slation initiation factor 2B (eIF2B) and the very-long-chain fatty acid (VLCFA) synthesis keto-reduct

191 CS2), which catalyze two successive steps in very-long-chain fatty acid (VLCFA) synthesis.

192 and B. abortus are unusually modified with a very-long-chain fatty acid (VLCFA; C > or = 28) and we d

193 ectrometry (LC/MS) method for long-chain and very-long-chain fatty acid analysis and its application

194 not ZS, fibroblasts there was an increase in very-long-chain fatty acid beta-oxidation and plasmaloge

195 X-ALD fibroblasts synergistically increased very-long-chain fatty acid beta-oxidation, indicating th

196 lasmalogen concentrations, and a decrease in very-long-chain fatty acid concentrations.

197 its production of a substantial reduction of very-long-chain fatty acid levels in the brain and adren

198 drenoleukodystrophy (X-ALD) is a disorder of very-long-chain fatty acid metabolism, adrenal insuffici

199 ALD) is a peroxisomal disorder with impaired very-long-chain fatty acid metabolism.

200 Reduction of very-long-chain fatty acid sphingolipid levels leads in

201 distribution of LPS fatty acids, including a very-long-chain fatty acid thought to be unique to the a

202 amily of six FATPs that facilitate long- and very-long-chain fatty acid uptake.

203 he PM showed an enrichment of 2-hydroxylated very-long-chain fatty acid-containing GIPCs and polyglyc

204 ision, suggesting that enhanced synthesis of very-long-chain fatty acid/trihydroxy LCB ceramides prom

205 Individuals with ABCD1 mutations accumulate very-long-chain fatty acids (VLCFA) (carbon length >22).

206 Very-long-chain fatty acids (VLCFA) and branched-chain f

207 X-ALD) is associated with elevated levels of very-long-chain fatty acids (VLCFA; C(>22:0)) that have

208 Long-chain and very-long-chain fatty acids (VLCFAs) are also metabolize

209 The extension of very-long-chain fatty acids (VLCFAs) for the synthesis o

210 TSC13 is required for the biosynthesis of very-long-chain fatty acids (VLCFAs) in yeast.

211 des accumulation of peroxisomal educts (like very-long-chain fatty acids [VLCFAs] or branched-chain f

212 flammatory demyelination in the brain, where very-long-chain fatty acids accumulate within phospholip

213 1/lpcat2 mutant showed increased contents of very-long-chain fatty acids and decreased PUFA in TAG an

214 lopmental and environmental requirements for very-long-chain fatty acids and flavonoids, whose synthe

215 ACC (ScACC) is crucial for the production of very-long-chain fatty acids and the maintenance of the n

216 This led to a significant increase in the very-long-chain fatty acids C24 and C26 in the cuticular

217 synthetase [VLCS]) and subsequently degrade very-long-chain fatty acids in peroxisomes.

218 n GIPCs and sterols and suggested a role for very-long-chain fatty acids in the interdigitation betwe

219 mutations in ABCD1 lead to incorporation of very-long-chain fatty acids into phospholipids, we separ

220 litate the transfer of long-chain as well as very-long-chain fatty acids into the apoplast, depending

221 Our findings implicate very-long-chain fatty acids or their derivative complex

222 ein, required for the efficient transport of very-long-chain fatty acids out of the cytoplasm.

223 have shown that larval oenocytes synthesize very-long-chain fatty acids required for tracheal waterp

224 an acyl CoA synthetase activity specific for very-long-chain fatty acids suggesting this protein play

225 (CER6) is necessary for the biosynthesis of very-long-chain fatty acids with chain lengths beyond C(

226 mutations in the ELOVL4 gene (elongation of very-long-chain fatty acids).

227 of Elovl proteins that mediate elongation of very-long-chain fatty acids, block or dramatically slow

228 ngation of not only linear but also branched very-long-chain fatty acids, leading to production of th

229 n cause accumulation of unbranched saturated very-long-chain fatty acids, particularly in brain and a

230 pecies with C16 fatty acids rather than with very-long-chain fatty acids, which are more commonly enr

231 ndensing enzyme involved in the synthesis of very-long-chain fatty acids, which are precursors of epi

232 ng patterns of saturated and monounsaturated very-long-chain fatty acids, with the observed pattern c

233 ingle allelic mutations in the elongation of very-long-chain fatty acids-like 4 (ELOVL4), whereas rec

234 hase--an enzyme involved in the synthesis of very-long-chain fatty acids.

235 showed that AtLtpI-4 protein can bind these very-long-chain fatty acids.

236 tent, with some molecular species containing very-long-chain fatty acids.

237 ber of genes involved in the biosynthesis of very-long-chain fatty acids.

238 ed levels of and increased beta-oxidation of very-long-chain fatty acids; increased expression of the

239 3 (At1g19260)-encoded ceramide synthases use very-long-chain fatty acyl-CoA and trihydroxy LCB substr

240 oxidation chain shortening of long-chain and very-long-chain fatty acyl-coenzyme (CoAs), long-chain d

241 vity of class II ceramide synthases that use very-long-chain fatty acyl-coenzyme A and trihydroxy LCB

242 t jojoba FAO and FADH proteins are active on very-long-chain fatty alcohol and fatty aldehyde substra

243 gest that jojoba FAO and FADH constitute the very-long-chain fatty alcohol oxidation pathway that is

244 Upon germination, WE hydrolysis releases very-long-chain fatty alcohols, which must be oxidized t

245 ax profile (especially on leaves) toward the very-long-chain free fatty acids tetracosanoic acid (C(2

246 pressed in photoreceptor cells and generates very long chain (>/=C28) polyunsaturated fatty acids inc

247 isomal functions, including the breakdown of very long-chain (>20 carbons) fatty acids, phytanic acid

248 ancer suggest that 1-deoxysphingolipids, the very-long-chain in particular, play a role as molecular

249 istics suggest that it may interact with the very long chain intermediates in mycolic acid biosynthes

250 he other hand, was missing O-antigens of the very long chain length, indicating the Wzz2 protein is r

251 ed with other fatty acids and because of its very long chain length, the effect of dietary behenic ac

252 responsible for the expression of different very long chain lengths despite high sequence homology.

253 out for long chain palmitic acid (C16:0) and very long chain lignoceric acid (C24:0) as well as for A

254 ut for long chain (palmitic acid, C16:0) and very long chain (lignoceric acid, C24:0) fatty acids as

255 suppressor demonstrates that low amounts of very long chain lipids are sufficient for pollen hydrati

256 Very long chain lipids contribute to the hydrophobic cut

257 Mutations in Arabidopsis CER genes eliminate very long chain lipids from the cuticle surface and, in

258 e display massive increases in a rare set of very long chain LPS lipids that have been previously rep

259 NA bases influences the global properties of very-long-chain molecules.

260 and a dramatic increase in the percentage of very-long-chain monounsaturated fatty acids in the acyl-

261 whether red blood cell (RBC) long-chain and very-long-chain MUFAs are associated with risk of CAD in

262 c and lipotoxicity effects of long-chain and very-long-chain MUFAs on cardiomyocytes.

263 ional enzyme that catalyzes the synthesis of very long chain multiple methyl branched fatty acids cal

264 Therefore, the very long chain n-3 PUFAs in eggs were protected from un

265 Proportions of n-3 PUFAs (very long-chain n-3 [VLC n-3; sum of eicosapentaenoic ac

266 f refrigerated stored hen eggs enriched with very long-chain n-3 fatty acids, was investigated.

267 Higher proportions of certain VLC n-3 and very long-chain n-6 PUFAs in plasma phospholipids at age

268 he effect and the mechanism of action of the very-long-chain n-3 (omega-3) polyunsaturated fatty acid

269 Serum linoleic acid and very-long-chain n-3 PUFAs, partly reflecting vegetable o

270 feasibility for CEC-ESI-MS analysis of these very long chain nonionic surfactants for the first time.

271 in place of the proximal glucosamine, and a very long chain omega-1 hydroxy fatty acid, 27-hydroxyoc

272 ELONGASE1 is required for the production of very long chain omega-7s in the aleurone.

273 function.We tested the effects of high-dose, very-long-chain omega-3 fatty acids on adipose tissue in

274 Very long chain polyunsaturated fatty acid (VLC-PUFA)-co

275 e activity and approximately 40% decrease in very long chain polyunsaturated fatty acid chain shorten

276 is therefore a key step in the production of very long chain polyunsaturated fatty acid in oil-seed s

277 aturated fatty acids (VLC-FA) and of C28-C38 very long chain polyunsaturated fatty acids (VLC-PUFA),

278 nsiderable beneficial effects of n-3 and n-6 very long chain polyunsaturated fatty acids (VLC-PUFAs),

279 We report the production of two very long chain polyunsaturated fatty acids, arachidonic

280 an elongase required for the biosynthesis of very long-chain polyunsaturated fatty acids (VLC-PUFAs).

281 ptor-specific phosphatidylcholine containing very long-chain polyunsaturated fatty acids and severely

282 nthesized in the stroma, then converted into very-long-chain polyunsaturated fatty acids (FAs) at the

283 acid, as well as decreased incorporation of very-long-chain polyunsaturated fatty acids (PUFAs), par

284 mal models clearly indicates that a group of very-long-chain polyunsaturated fatty acids, the n-3 fat

285 of peroxisomes in the oxidation of complex, very long chain, polyunsaturated fatty acids.

286 etion may prevent the conversion of ALA into very-long-chain PUFAs.

287 enrichment in sterols and sphingolipids with very long chain saturated fatty acids when compared with

288 saturates, but also include medium-chain and very long-chain saturated fatty acids.

289 an oxidase required for the biosynthesis of very-long-chain saturated alpha,omega-bifunctional aliph

290 (DNL) FAs and low n-6 (omega-6) FAs, 2) high very-long-chain saturated FAs, 3) high n-3 (omega-3) FAs

291 Circulating very-long-chain saturated fatty acids (VLCSFAs) may play

292 id, stearic acid, odd-chain fatty acids, and very-long-chain saturated fatty acids and low concentrat

293 lly expressed in Arabidopsis, GPAT5 produced very-long-chain saturated monoacylglycerols and free fat

294 6-ceramide, which occurred at the expense of very long chain, saturated ceramides.

295 16:0) are associated with diabetes; however, very-long-chain SFAs (VLSFAs), with 20 or more carbons,

296 llowed by the more challenging separation of very long chain TX-series with a large number (n = 30-70

297 nsation reaction catalyzing the formation of very-long-chain (VLC) (C-28 to C-40) fatty acids, satura

298 In land plants, very-long-chain (VLC) alkanes are major components of cu