ライフサイエンスコーパス: vesicular glutamate transporter

1 tinguished by the gene expression for type 1 vesicular glutamate transporter.

2 cholinergic terminals and contain the type 2 vesicular glutamate transporter.

3 eal afferents contain both neuropeptides and vesicular glutamate transporters.

4 re enriched in glutamate, but none expressed vesicular glutamate transporters.

5 for Nissl substance, cytochrome oxidase, and vesicular glutamate transporters.

6 er crushing the tibial nerve (TN), and using Vesicular GLUtamate Transporter 1 (VGLUT1) and the 65 kD

7 (shRNA) vectors to target expression of the vesicular glutamate transporter 1 (VGLUT1) following inj

8 ion of NL3 or NL2 after IUEP does not affect vesicular glutamate transporter 1 (vGlut1) in the glutam

9 evidence for an increased expression of the vesicular glutamate transporter 1 (vGluT1) in the striat

10 ne-related peptide (CGRP), substance P (SP), vesicular glutamate transporter 1 (VGluT1), or VGluT2.

11 s were also immunolabeled with antibodies to vesicular glutamate transporter 1 (VGLUT1), vesicular ga

12 IR (approximately 41%) was found, but not in vesicular glutamate transporter 1 (VGLUT1)/p38 IR.

13 We investigated expression of glutamatergic [vesicular glutamate transporter 1 (VGLUT1)] and GABA/gly

14 immunocytochemical markers [parvalbumin and vesicular glutamate transporter 1 (VGLUT1)] showed that

15 layers was shown by using antibodies against vesicular glutamate transporter 1 [labeling all ON and O

16 easure glutamatergic innervation using pre- (vesicular glutamate transporter 1 and 2) and postsynapti

17 colocalization with synaptic vesicle protein vesicular glutamate transporter 1 in stratum radiatum.

18 icle transporter Sv2 (now known as SV2A) and Vesicular glutamate transporter 1 in the outer molecular

19 napse-enriched components, including vGLUT1 (vesicular glutamate transporter 1), EAAT5 (excitatory am

20 yrosine hydroxylase in periglomerular cells, vesicular glutamate transporter 1, a presynaptic protein

21 naptic marker proteins synaptophysin and the vesicular glutamate transporter 1, but not with the post

22 the light microscopic level, the density of vesicular glutamate transporter 1-positive (i.e. cortico

23 excitatory synapses, defined by overlapping vesicular glutamate transporter 1-positive (VGlut1+) and

24 ve excitatory synapses (i.e., the overlap of vesicular glutamate transporter 1-positive [VGlut1+] pun

25 icroscopy studies showing that the number of vesicular glutamate transporter 1-positive terminals and

26 es formed in response to Kal7 are apposed to vesicular glutamate transporter 1-positive, bassoon-posi

27 gamma isoform, neurofilament light chain and vesicular glutamate transporter 1.

28 ker for myelinated primary afferents) or the vesicular glutamate transporter 1.

29 de, nitric oxide synthase, somatostatin, and vesicular glutamate transporters 1 and 2 accounted for a

30 ated by primary afferents immunoreactive for vesicular glutamate transporters 1 and 2 and by intraspi

31 we mapped the entire macaque thalamus using vesicular glutamate transporters 1 and 2 to label cortic

32 An inversely correlated increase in vesicular glutamate transporter-1 (VGluT-1) occurred in

33 lutamate transporter 2 (EAAT2) and increased vesicular glutamate transporter-1 (VGLUT1) immunoreactiv

34 ic subclasses of neurons; in particular, the vesicular glutamate transporter-1 (VGLUT1) promoter supp

35 Tuj1), synaptic vesicle protein-2 (SV2), and vesicular glutamate transporter-1 (VGLUT1).

36 ferent terminals [i.e., terminals containing vesicular glutamate transporter-1 (VGLUT1)] on SOL moton

37 and the total number of synapses defined by vesicular glutamate transporter-1 antibody staining.

38 ibitory neurochemical phenotypes such as the vesicular glutamate transporters-1 and 2 (VGLUT-1, VGLUT

39 te decrboxylase (for GABAergic cells) or the vesicular glutamate transporter 2 (for glutamatergic cel

40 ype 1 (TRPV1), neurofilament 200 (NF200), or vesicular glutamate transporter 2 (VGluT1).

41 Brains were then processed for vesicular glutamate transporter 2 (VGLUT2) and examined

42 ic boutons by their immunoreactivity for the vesicular glutamate transporter 2 (VGluT2) and performed

43 ing Trpv1-Cre-expressing neurons or inducing vesicular glutamate transporter 2 (VGLUT2) deficiency in

44 ated Trpv1-Cre expressing neurons or induced vesicular glutamate transporter 2 (Vglut2) deficiency in

45 ting the effect of deleting the gene for the vesicular glutamate transporter 2 (Vglut2) from neurons

46 Based on PTH2R and vesicular glutamate transporter 2 (VGlut2) immunolabelin

47 Here we generated mice in which the vesicular glutamate transporter 2 (VGLUT2) is ablated se

48 We have previously shown that vesicular glutamate transporter 2 (VGLUT2) is the predom

49 ry findings, including the expression of the vesicular glutamate transporter 2 (VGluT2) mRNA in Ipc n

50 Vesicular glutamate transporter 2 (VGLUT2) mRNA was dete

51 ns) contain the transcription factor Phox2b, vesicular glutamate transporter 2 (VGLUT2) mRNA, and a s

52 Most SST-ir neurons (>90%) contained vesicular glutamate transporter 2 (VGLUT2) mRNA, and ter

53 tion, their bouton size, and the presence of vesicular glutamate transporter 2 (Vglut2) or parvalbumi

54 uorescent protein (GFP) under control of the vesicular glutamate transporter 2 (vGluT2) promoter.

55 e used a conditional knock-out mouse lacking vesicular glutamate transporter 2 (VGLUT2) specifically

56 neurons, the VTA has many neurons expressing vesicular glutamate transporter 2 (VGluT2) that also pro

57 rons in the AVPV of female rats express both vesicular glutamate transporter 2 (VGLUT2), a marker of

58 cts from nonprimary boutons that express the vesicular glutamate transporter 2 (VGLUT2), and form asy

59 BN and lPBN-->CeA CGRP projections coexpress vesicular glutamate transporter 2 (VGLUT2), providing ev

60 neurons projected to MDmc and expressed the vesicular glutamate transporter 2 (VGLUT2), which is fou

61 nd perisomatic rings of terminals expressing vesicular glutamate transporter 2 (VGLUT2)--to subdivide

62 sis revealed that CRH neurons are apposed by vesicular glutamate transporter 2 (VGLUT2)-containing te

63 oxylase (TH)-ir and the same proportion were vesicular glutamate transporter 2 (VGLUT2)-ir.

64 yperalgesia, with or without the presence of vesicular glutamate transporter 2 (VGLUT2)-mediated glut

65 glutamic acid decarboxylase 67 (GAD67)- and vesicular glutamate transporter 2 (VGLUT2)-positive term

66 covered glutamatergic neurons expressing the vesicular glutamate transporter 2 (VGluT2).

67 tudies glutamate activity was examined using vesicular glutamate transporter 2 (VGLUT2).

68 for cytochrome oxidase, Nissl bodies, or the vesicular glutamate transporter 2 (vGluT2).

69 markers, the transcription factor Phox2b and vesicular glutamate transporter 2 (VGLUT2).

70 so on VTA glutamatergic neurons that express vesicular glutamate transporter 2 (VgluT2).

71 ome oxidase, ionic zinc, neurofilaments, and vesicular glutamate transporter 2 (VGluT2).

72 d neuronal markers [neurofilament, NeuN, and vesicular glutamate transporter 2 (VGlut2)], and culture

73 indin-D28k (to visualize Purkinje cells) and vesicular glutamate transporter 2 (VGluT2, to visualize

74 rised of septal GnRH neurons that colocalize vesicular glutamate transporter 2 and green fluorescent

75 s in the superficial dorsal horn contain the vesicular glutamate transporter 2 and hence are glutamat

76 : five interneurons had axons that contained vesicular glutamate transporter 2 and hence were glutama

77 a subpopulation of dopamine neurons express vesicular glutamate transporter 2 and make glutamatergic

78 We used immunohistochemical staining for vesicular glutamate transporter 2 and the neuronal serot

79 ntaining nNOS in the elPBN co-localized with vesicular glutamate transporter 2 following BK stimulati

80 glutamatergic because most of them contained vesicular glutamate transporter 2 mRNA (77 +/- 9%; n = 3

81 Fos-ir neurons that contained vesicular glutamate transporter 2 mRNA (glutamatergic ne

82 te corelease, we disrupted the expression of vesicular glutamate transporter 2 selectively in dopamin

83 mn (VRC), Phox2b was present in many VGlut2 (vesicular glutamate transporter 2) mRNA-containing neuro

84 GnIH/RFRP-3 on kisspeptin-activated vGluT2 (vesicular glutamate transporter 2)-GnRH neurons as well

85 phalin and dynorphin partly colocalized with vesicular glutamate transporter 2, a marker of glutamate

86 synaptic proteins, including piccolo, Rab3C, vesicular glutamate transporter 2, and cholecystokinin 2

87 terminals in these synapses coexpressed the vesicular glutamate transporter 2, and that the majority

88 ined with glutamic acid decarboxylase 67/65, vesicular glutamate transporter 2, glial fibrillary acid

89 These glutamatergic neurons express the vesicular glutamate transporter 2, VGluT2.

90 the IC were GABAergic and were contacted by vesicular glutamate transporter 2-containing somatic ter

91 rons (detected in transgenic mice expressing vesicular glutamate transporter 2-enhanced green fluores

92 th the presynaptic markers synaptophysin and vesicular glutamate transporter 2.

93 xpress markers for both glutamate signaling (vesicular glutamate transporter 2; VGluT2) and GABA sign

94 ntermixed with glutamate neurons (expressing vesicular glutamate transporter 2; VGluT2), which play r

95 axonal varicosities were immunoreactive for vesicular glutamate transporter-2 (78%).

96 ed throughout the medulla were processed for vesicular glutamate transporter-2 (VGLUT-2), tryptophan-

97 varicosities contained detectable levels of vesicular glutamate transporter-2 (VGLUT2) but only 5% c

98 amatergic, in that their cell bodies contain vesicular glutamate transporter-2 (VGLUT2) mRNA and spin

99 idase (CO), acetylcholinesterase (AChE), and vesicular glutamate transporter-2 (VGluT2) preparations,

100 VTA glutamatergic neurons--expressing vesicular glutamate transporter-2 (VGluT2)--project to l

101 we also performed antibody stainings against vesicular glutamate transporter-2, which suggested that

102 on of a DR-originating pathway consisting of vesicular glutamate transporter 3 (VGluT3) containing ne

103 Recent identification of vesicular glutamate transporter 3 (VGLUT3) has provided

104 The vesicular glutamate transporter 3 (VGLUT3) is expressed

105 Vesicular glutamate transporter 3 (VGLUT3) loads glutama

106 The vesicular glutamate transporter 3 (VGLUT3) marks glutama

107 ing was absent in mutants that lacked either Vesicular glutamate transporter 3 (Vglut3) or Ca(V)1.3.

108 terminals in the mammalian brain contain the vesicular glutamate transporter 3 (VGLUT3), indicating t

109 lamp recordings to characterize responses of vesicular glutamate transporter 3 (VGluT3)-expressing am

110 circuits of basket cells expressing CCK and vesicular glutamate transporter 3 (VGlut3).

111 vae for auditory/vestibular mutants, encodes vesicular glutamate transporter 3 (Vglut3).

112 an immediate early gene, opioid peptides and vesicular glutamate transporter 3 (VGLUT3).

113 oth of which depend on the expression of the vesicular glutamate transporter 3 (VGLUT3).

114 /system A transporter 1(+), somatostatin(+), vesicular glutamate transporter 3 (VGLUT3)/cholecystokin

115 s demonstrate synaptic colocalization of the vesicular glutamate transporter 3 with the vesicular GAB

116 Moreover, there is no vesicular glutamate transporter 3-immunoreactive bouton,

117 Vesicular glutamate transporter 3-positive (VGluT3(+)) p

118 rm; GAD-67), and glutamatergic transmission (vesicular glutamate transporter 3; VGLUT3) have been det

119 in the identification of this protein as the vesicular glutamate transporter (3, 4).

120 Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenita

121 Terminals stained for the type 2 vesicular glutamate transporter, a potential marker of t

122 copy to investigate expression of the VGLUT2 vesicular glutamate transporter, an isoform reported in

123 pons (A5 and A6) do not contain either known vesicular glutamate transporter and are most likely not

124 By expressing vesicular glutamate transporters at high levels in plasm

125 her these presympathetic neurons express the vesicular glutamate transporter BNPI/VGLUT1 or the close

126 DVGLUT functions not only as a vesicular glutamate transporter but also serves as an ac

127 lutamate in synaptic vesicles is mediated by vesicular glutamate transporters called VGLUTs.

128 With the recent cloning of the Drosophila vesicular glutamate transporter (DVGLUT), it is now poss

129 nsic H(+) /Na(+) exchange via the Drosophila vesicular glutamate transporter (DVGLUT).

130 he synaptic vesicle machinery, including the vesicular glutamate transporter eat-4/VGLUT, induction o

131 fining feature of glutamatergic neurons, the vesicular glutamate transporter EAT-4/VGLUT, is expresse

132 The blu gene encodes a vesicular glutamate transporter expressed by retinal gan

133 TATEMENT VGLUT3 is an atypical member of the vesicular glutamate transporter family.

134 evidence for early expression of the type 2 vesicular glutamate transporter in mesencephalic DA neur

135 ic contribution of the different isoforms of vesicular glutamate transporters in subcortical pathways

136 r to mammals, zebrafish HCRT neurons express vesicular glutamate transporters indicating conservation

137 Specifically, the vesicular glutamate transporter is upregulated, leading

138 VGLUT1, the first identified vesicular glutamate transporter, is only expressed in a

139 within the DRN contain immunoreactivity for vesicular glutamate transporters (isoforms vGlut1 and vG

140 als in the LC that also contained either the vesicular glutamate transporter or CRF.

141 DISC is attenuated by an inhibitor of vesicular glutamate transporters or of vesicular fusion.

142 dentified with antibodies to the presynaptic vesicular glutamate transporter protein (vGlut1) and pos

143 the hypothalamus expressed low levels of the vesicular glutamate transporters relative to other areas

144 Along with the closely related vesicular glutamate transporters, sialin belongs to the

145 GnRH neurons express vesicular glutamate transporters, suggesting they may co

146 neuromuscular junction and mutations of the vesicular glutamate transporter suggests that one transp

147 c, complementary expression of two different vesicular glutamate transporters suggests functional div

148 icle proteins, including SNARE proteins, and vesicular glutamate transporters that are required to fi

149 Glutamatergic sites were localized with vesicular glutamate transporter type 1 (VGLUT1) as presy

150 m in contrast with an enhanced expression of vesicular glutamate transporter type 1 (VGluT1) at the m

151 re identified by the selective expression of vesicular glutamate transporter type 1 (VGluT1) by corti

152 First, knockout mice lacking vesicular glutamate transporter type 1 do not have gluta

153 tosomal-associated protein 25, syntaxin, and vesicular glutamate transporter type 1), together with a

154 1 (VGluT1) by corticostriatal afferents and vesicular glutamate transporter type 2 (VGluT2) by thala

155 We generated conditional null mice in which vesicular glutamate transporter type 2 (VGLUT2)-dependen

156 Immunostaining of vesicular glutamate transporter type 2 demonstrated a de

157 Using vesicular glutamate transporter type 2 immunohistochemis

158 mmetric synapses and were immunoreactive for vesicular glutamate transporter type 2.

159 The atypical vesicular glutamate transporter type 3 (VGLUT3) is expre

160 axon terminals that lack VMAT2, but contain vesicular glutamate transporters type 2 (VGluT2).

161 At glutamatergic synapses, the vesicular glutamate transporter (VGLUT) fills vesicles w

162 Smear et al. demonstrate that mutation of a vesicular glutamate transporter (Vglut) found in the ret

163 f neurotransmitter phenotypes, including the vesicular glutamate transporter (VGLUT) genes for glutam

164 kers of transmitter phenotype, including the vesicular glutamate transporter (VGLUT) genes for glutam

165 Vesicular glutamate transporter (VGLUT) has been reporte

166 distribution of the three known isoforms of vesicular glutamate transporter (VGLUT) in the cat retin

167 The vesicular glutamate transporter (VGLUT) plays an essenti

168 Vesicular glutamate transporter (VGLUT) proteins regulat

169 ridization study with probes for the lamprey vesicular glutamate transporter (VGLUT) provides an anat

170 set of glutamatergic synapses expressing the vesicular glutamate transporter (VGLUT) type 2 ( approxi

171 ate is loaded into synaptic vesicles via the vesicular glutamate transporter (VGLUT), a mechanism con

172 ctively express three different types of the vesicular glutamate transporter (VGLUT).

173 Among these SV cargos is the vesicular glutamate transporter (vGlut).

174 the synapse by controlling expression of the vesicular glutamate transporter (VGlut).

175 nduced hyperacidification is mediated by the vesicular glutamate transporter (VGLUT).

176 ltage-dependent calcium channel (unc-2) or a vesicular glutamate transporter (VGLUT; eat-4), the abun

177 d nitric oxide synthase as well as the three vesicular glutamate transporters (VGLUT 1-3) in the locu

178 cular GABA transporter [vGAT]) or glutamate (vesicular glutamate transporter [vGLUT]) into vesicles,

179 We now find that vesicular glutamate transporter VGLUT1 interacts directl

180 esicular monoamine transporter VMAT2 and the vesicular glutamate transporter VGLUT1 to compare the lo

181 up-III mGluR immunolabeling and that for the vesicular glutamate transporter VGLUT1.

182 ic synapses based on the recently identified vesicular glutamate transporter VGLUT1.

183 ile and proprioceptive afferents contain the vesicular glutamate transporter VGLUT1.

184 ere tested, most also expressed mRNA for the vesicular glutamate transporter VGLUT1.

185 We used immunohistochemistry to localize vesicular glutamate transporters VGLUT1 and VGLUT2 in th

186 l a dynamic scaling in vesicular excitatory (vesicular glutamate transporters VGLUT1 and VGLUT2) and

187 By using the vesicular glutamate transporters vGluT1 and vGluT2, as m

188 We therefore mapped boutons expressing the vesicular glutamate transporters VGluT1 and VGluT2, toge

189 d into synaptic vesicles for release via the vesicular glutamate transporters VGLUT1 and VGLUT2.

190 heral afferents and of central neurons (with vesicular glutamate transporters VGLUT1 or VGLUT2, respe

191 oreactive (ir) for markers of glutamatergic (vesicular glutamate transporters VGLUT1-3), gamma-aminob

192 sion via the two predominant isoforms of the vesicular glutamate transporter (VGLUT1 and VGLUT2) part

193 Double labeling with the vesicular glutamate transporter (VGLUT1) was used to ide

194 AST or excitatory amino acid transporter 1), vesicular glutamate transporter (VGLUT1), and the AMPA r

195 a subset of glutamate neurons expresses this vesicular glutamate transporter (VGLUT1).

196 terise contacts formed by axons that contain vesicular glutamate transporters (VGLUT1 and VGLUT2) and

197 e (TH), glutamate decarboxylase (GAD67), and vesicular glutamate transporters (vGLUT1 and vGLUT2) in

198 ith antibodies against the type 1 and type 2 vesicular glutamate transporters (vGLUT1 and vGLUT2) wit

199 Vesicular glutamate transporters (vGluT1)-containing ter

200 ergic neurons express one of the three known vesicular glutamate transporters (VGLUT1, 2, or 3).

201 burtoni using in situ hybridization to label vesicular glutamate transporters (vglut1, vglut2.1, vglu

202 The reported expression of all three vesicular glutamate transporters (VGLUT1-3) by astrocyte

203 Vesicular glutamate transporters (VGLUT1-3) carry glutam

204 Two isoforms of the vesicular glutamate transporter, VGLUT1 and VGLUT2, were

205 In addition, we show that this vesicular glutamate transporter, VGLUT1, exhibits a cond

206 Based on our findings that the vesicular glutamate transporters, VGLUT1 and VGLUT2, are

207 used digoxigenin-labeled cRNA probes for the vesicular glutamate transporters, VGLUT1 and VGLUT2, for

208 t central synapses depend on two isoforms of vesicular glutamate transporters, VGluT1 and VGluT2.

209 ry structures, which can be identified using vesicular glutamate transporters, VGLUT1 and VGLUT2.

210 ynaptic vesicle marker SV2, parvalbumin, the vesicular glutamate transporter VGluT2 and the glycine t

211 R with the synaptic vesicle protein SV2, the vesicular glutamate transporter VGluT2 and the glycine t

212 vivo RGC-specific genetic disruption of the vesicular glutamate transporter VGLUT2 or the obligatory

213 e were immunopositive for met-enkephalin and vesicular glutamate transporter VGLUT2, but not for GABA

214 matergic presynaptic machinery including the vesicular glutamate transporter VGLUT2, several synaptic

215 ated gene DNPI, the rat homolog of the mouse vesicular glutamate transporter VGLUT2.

216 ons identified through the expression of the vesicular glutamate transporter VGLUT2.

217 notype based on coexpression of mRNA for the vesicular glutamate transporter (vGlut2) and the GABA sy

218 aled that most neurons in the GT express the vesicular glutamate transporter (VGluT2) mRNA, indicatin

219 mic acid decarboxylase 65 (GAD65) and type 2 vesicular glutamate transporter (VGLUT2) mRNAs, respecti

220 Frequent PTH2R coexpression with a vesicular glutamate transporter (VGlut2) suggests that T

221 unctionally identify a second isoform of the vesicular glutamate transporter (VGLUT2) that was previo

222 ression for the glutamatergic marker, type 2 vesicular glutamate transporter (VGLUT2), and the GABA s

223 izes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2).

224 bution of fos immunoreactive nuclei with the vesicular glutamate transporters (VGlut2 and VGlut3) and

225 A vesicular glutamate transporter, VGluT2, has been sugges

226 preferentially labeled by an isoform of the vesicular glutamate transporter, VGluT2.

227 comparing them with staining patterns of the vesicular glutamate transporter, VGLUT2.

228 cells in the DRG expresses the low abundance vesicular glutamate transporter VGLUT3 (also known as SL

229 The expression of unconventional vesicular glutamate transporter VGLUT3 by neurons known

230 Interestingly, the third vesicular glutamate transporter (VGLUT3) is primarily fo

231 The discovery of a third vesicular glutamate transporter, VGLUT3, has brought abo

232 n the brain, the complementary expression of vesicular glutamate transporters (VGLUTs) 1 and 2 accoun

233 Vesicular glutamate transporters (VGLUTs) 1 and 2 show a

234 ith nonisotopic in situ hybridization of the vesicular glutamate transporters (VGLUTs) 1, 2, and 3.

235 Vesicular glutamate transporters (VGLUTs) are essential

236 The three vesicular glutamate transporters (VGLUTs) are expressed

237 The three vesicular glutamate transporters (VGLUTs) are expressed

238 The three vesicular glutamate transporters (VGLUTs) are found in d

239 At glutamatergic synapses, vesicular glutamate transporters (VGLUTs) are responsibl

240 Vesicular glutamate transporters (VGLUTs) have been exte

241 The vesicular glutamate transporters (VGLUTs) package glutam

242 The identification of several vesicular glutamate transporters (VGLUTs) similarly reve

243 rstood whether astrocytes express functional vesicular glutamate transporters (VGLUTs) that are criti

244 Vesicular glutamate transporters (VGLUTs) that load glut

245 smission from glutamatergic neurons requires vesicular glutamate transporters (VGLUTs) to concentrate

246 Glutamatergic neurotransmission requires vesicular glutamate transporters (VGLUTs) to sequester g

247 ferent synapse in NTS, we determined whether vesicular glutamate transporters (VGLUTs) were different

248 ology to record currents associated with the vesicular glutamate transporters (VGLUTs), we characteri

249 Vesicular glutamate transporters (VGLUTs), which selecti

250 Previous work showed that vesicular glutamate transporters (VGluTs; specific marke

251 ng stains for Nissl, cytochrome oxidase, and vesicular glutamate transporters, we investigated the pr

252 h in vivo, we have identified the Drosophila vesicular glutamate transporter, which we name DVGLUT.