ライフサイエンスコーパス: vesicular trafficking

1 osphate, a lipid that controls intracellular vesicular trafficking.

2 y for membrane fusion during eukaryotic cell vesicular trafficking.

3 at modified host membranes and exploits host vesicular trafficking.

4 nchoring target proteins to membranes and in vesicular trafficking.

5 a, a protein required for accurate polarized vesicular trafficking.

6 ng that dysferlin is important for nonmuscle vesicular trafficking.

7 umulate transferrin-488, reflecting abnormal vesicular trafficking.

8 cating a role for NAADP in the regulation of vesicular trafficking.

9 ellular processes, including endocytosis and vesicular trafficking.

10 with the intraflagellar transport system and vesicular trafficking.

11 ylation factors (ARFs) have crucial roles in vesicular trafficking.

12 ycle progression, inflammatory response, and vesicular trafficking.

13 oteins implicated in signal transduction and vesicular trafficking.

14 oskeleton, but also plays important roles in vesicular trafficking.

15 migrate in a head-to-tail fashion, requires vesicular trafficking.

16 in- and clathrin-binding protein involved in vesicular trafficking.

17 ociated with early endosomes and involved in vesicular trafficking.

18 gulating receptor-mediated signaling through vesicular trafficking.

19 nhibition of Rab family proteins involved in vesicular trafficking.

20 factor (ARF) GTPases, which are required for vesicular trafficking.

21 -ribosylation factors (ARFs) are critical in vesicular trafficking.

22 g their function in regulating intracellular vesicular trafficking.

23 block in endoplasmic reticulum (ER)-to-Golgi vesicular trafficking.

24 t activators of ADP-ribosylation factors for vesicular trafficking.

25 association in both early and late stages of vesicular trafficking.

26 interaction with Rab11, a GTPase involved in vesicular trafficking.

27 se in insulin demand and/or a dysfunction in vesicular trafficking.

28 cytoskeletal regulation, cell polarity, and vesicular trafficking.

29 d problem with respect to the specificity of vesicular trafficking.

30 proteins, supporting a role of golgin-160 in vesicular trafficking.

31 an important aspect of protein targeting via vesicular trafficking.

32 g, mRNA modification, vesicle formation, and vesicular trafficking.

33 y, gene expression, microtubule dynamics and vesicular trafficking.

34 t be viewed in a broader context than simple vesicular trafficking.

35 transduction, cytoskeletal organization and vesicular trafficking.

36 cted HeLa cells by a mechanism that requires vesicular trafficking.

37 between intraendosomal pH and regulation of vesicular trafficking.

38 n apoptosis, cell cycling, and intracellular vesicular trafficking.

39 d to Hrs, an endosomal ATPase that regulates vesicular trafficking.

40 link heterotrimeric G protein signaling and vesicular trafficking.

41 e of which have been shown to be involved in vesicular trafficking.

42 in specific cellular compartments affecting vesicular trafficking.

43 -phosphate phospholipid, a known mediator of vesicular trafficking.

44 signaling complex thought to be involved in vesicular trafficking.

45 have opposing actions on a common pathway of vesicular trafficking.

46 dification of endocytic vesicles also arrest vesicular trafficking.

47 id metabolism during signal transduction and vesicular trafficking.

48 nt with a role for ARD1 in the regulation of vesicular trafficking.

49 ortant for normal intercellular adhesion and vesicular trafficking.

50 ignals, respectively, that could function in vesicular trafficking.

51 osphatidylcholine and has been implicated in vesicular trafficking.

52 of the AP-3 adaptor complex, which regulates vesicular trafficking.

53 lay a role in determining the specificity of vesicular trafficking.

54 cleotide exchange factor (GEF) implicated in vesicular trafficking.

55 gous to Vps27p, a yeast protein required for vesicular trafficking.

56 suggested to participate in clathrin-coated vesicular trafficking.

57 to explore the cellular dynamics underlying vesicular trafficking.

58 s including signal transduction and membrane vesicular trafficking.

59 tner of CaVbeta that is directly involved in vesicular trafficking.

60 nteract with cytosolic factors to facilitate vesicular trafficking.

61 of vestigial kinocilia, suggesting impaired vesicular trafficking.

62 n and examined its impact on endocytosis and vesicular trafficking.

63 od to analyze protein sorting and post-Golgi vesicular trafficking.

64 o guarantee remodeling processes crucial for vesicular trafficking.

65 thrin coat assembly, Golgi architecture, and vesicular trafficking.

66 Eps8 at the nexus of receptor signalling and vesicular trafficking.

67 acellular domains to the plasma membrane via vesicular trafficking.

68 en suggested to participate in autophagy and vesicular trafficking.

69 is responsible for organelle biogenesis and vesicular trafficking.

70 ediated endocytosis, bacterial invasion, and vesicular trafficking.

71 ced cell signalling, and 10 genes regulating vesicular trafficking, a pathway important for ciliogene

72 This shows that vesicular trafficking also is required in yeast for norm

73 ion profiles, whereas transcripts related to vesicular trafficking and abiotic stress were enriched i

74 TP-binding protein that regulates peripheral vesicular trafficking and actin cytoskeletal dynamics, a

75 itination of beta-arrestin1, which regulates vesicular trafficking and activation of ERK1/2.

76 y have recently been shown to play a role in vesicular trafficking and as activators of phospholipase

77 arious cellular activities), participates in vesicular trafficking and autophagosome maturation in ma

78 hospholipase D (PLD) is strongly involved in vesicular trafficking and cell signaling, making this en

79 nd messenger implicated in the regulation of vesicular trafficking and cytoskeletal reorganization.

80 es of HIV viral transfer to T cells via cave/vesicular trafficking and de novo replication were obser

81 sicles, revealing a novel regulation of EGFR vesicular trafficking and degradation by the microtubule

82 oinflammatory phenotype caused by defects in vesicular trafficking and demonstrate a requirement of A

83 ependent anterograde bias distinct from both vesicular trafficking and diffusion of untagged PAGFP.

84 rotein receptor (SNARE) proteins involved in vesicular trafficking and exocytosis.

85 ral homology with SNARE proteins involved in vesicular trafficking and fusion.

86 nd Akt activation at the plasma membrane and vesicular trafficking and intracellular bacterial replic

87 cts of postnatal heart maturation, including vesicular trafficking and intracellular membrane dynamic

88 Yeast orthologs function in vesicular trafficking and mammalian proteins have been i

89 Intracellular vesicular trafficking and membrane fusion are important

90 Additionally, RalB phosphorylation regulated vesicular trafficking and membrane fusion by regulating

91 otein phosphatases play an important role in vesicular trafficking and membrane fusion processes.

92 further demonstrate that AS plays a role in vesicular trafficking and membrane organization.

93 gulated sites in multiple pathways including vesicular trafficking and phosphoinositide metabolism.

94 These results implicate ATP13A2 in vesicular trafficking and provide a platform for further

95 During vesicular trafficking and release of enveloped viruses,

96 Vesicular trafficking and selective autophagy have emerg

97 an important model for the understanding of vesicular trafficking and selective autophagy in mammali

98 gulated aminopeptidase (IRAP) is involved in vesicular trafficking and shares common regional distrib

99 a membrane invaginations that participate in vesicular trafficking and signal transduction events.

100 To facilitate polarized vesicular trafficking and signal transduction, neuronal

101 s of caveolae, which have been implicated in vesicular trafficking and signal transduction.

102 idylinositol (PtdIns) with critical roles in vesicular trafficking and signaling.

103 g homology to the COPI coatamers involved in vesicular trafficking and that human SRP mutations affec

104 These complexes limit intracellular vesicular trafficking and trap AMPARs inside the dendrit

105 these exogenous peptides required uptake and vesicular trafficking and was comparable in DCs derived

106 culum stress) and Golgi apparatus, increased vesicular trafficking, and a depletion of mature beta-gr

107 ule important to intracellular signaling and vesicular trafficking, and anionic phospholipids were se

108 tide exchange factor) GLO-4, which regulates vesicular trafficking, and another that involves the F-b

109 ranscriptional regulation, oxidative stress, vesicular trafficking, and apoptosis.

110 cesses, including cytoskeletal organization, vesicular trafficking, and apoptosis.

111 ar functions from cytoskeletal organization, vesicular trafficking, and cell proliferation to apoptos

112 racellular processes such as cell migration, vesicular trafficking, and homeostasis of the Golgi comp

113 including endocytosis, signal transduction, vesicular trafficking, and immune modulation, and is a m

114 s, including roles in intracellular defense, vesicular trafficking, and inflammatory signaling.

115 ing RNA transport, transcription, apoptosis, vesicular trafficking, and intracellular signaling.

116 proteins involved in membrane organization, vesicular trafficking, and late endosomal function, as w

117 ation of protein levels, signaling pathways, vesicular trafficking, and many other cellular processes

118 has pleiotropic effects on Golgi morphology, vesicular trafficking, and membrane bulk fluidity.

119 dress the relationship between autophagy and vesicular trafficking, and the significance of both for

120 n involvement of APP in axonal transport and vesicular trafficking, and with a potential association

121 NOM is lost as well as when auxin efflux and vesicular trafficking are chemically disrupted.

122 e unraveled, it appears that endocytosis and vesicular trafficking are involved.

123 acquisition, and underscore its function in vesicular trafficking as a central determinant.

124 Because previous work has implicated vesicular trafficking as a mechanism of regulating capac

125 ased, further implicating the involvement of vesicular trafficking as a mode of action for mutant Cu/

126 onensin, agents known to block intracellular vesicular trafficking, as well as apoA-I-mediated cellul

127 tein appears to participate in intracellular vesicular trafficking, based on its cellular localizatio

128 e was found in other mutants with defects in vesicular trafficking between ER and Golgi complex, but

129 ses has been implicated in the regulation of vesicular trafficking between membrane compartments in e

130 Substrates of HIP require vesicular trafficking between the ER and Golgi apparatus

131 onary conserved heterotetramer that promotes vesicular trafficking between the trans-Golgi network an

132 her lipids out of late endosomes by means of vesicular trafficking, but it is not known whether NPC1

133 a key role in cytoskeletal organization and vesicular trafficking, but the exact mechanisms by which

134 upon receiving PDG-specific proteins through vesicular trafficking, but their maturation process is n

135 ins critical for continuity of intracellular vesicular trafficking by accelerating the replacement of

136 Manipulation of vesicular trafficking by chemical inhibitors or with con

137 iral replication, including some involved in vesicular trafficking, cell cycling, and protein modific

138 upporting various cellular events, including vesicular trafficking, cell migration, and stereociliary

139 ARFs are small GTPases that regulate vesicular trafficking, cell shape, and movement.

140 The discovery of multiple genes regulating vesicular trafficking, cell surface receptor turnover, a

141 fundamental processes, including retrograde vesicular trafficking, ciliary/flagellar motility, and c

142 Constitutive-like secretion involves vesicular trafficking corresponding kinetically and bioc

143 entry, we investigated whether disruption of vesicular trafficking could lead to decreased capacitati

144 R, alpha1 subunit of L-type VDCC, or various vesicular trafficking curators, including synaptotagmins

145 Evi5 may cooperate with Rab11 to coordinate vesicular trafficking, cytokinesis, and cell cycle contr

146 We discuss the putative role of ADL1Ap in vesicular trafficking, cytokinesis, and other aspects of

147 The Rho GTPases regulate vesicular trafficking, cytoskeletal dynamics, and cell s

148 that play an important role in intracellular vesicular trafficking, depends on guanine nucleotide-exc

149 d PKCalpha down-regulation and inhibitors of vesicular trafficking did not prevent degradation of the

150 es for these two events in processes such as vesicular trafficking, DNA damage repair and RNA splicin

151 Because of the presence of vesicular trafficking domain within CgA we engineered so

152 in the regulation of DE-cadherin-containing vesicular trafficking during AJ remodeling in live epith

153 rdinate with each other in the regulation of vesicular trafficking during primary ciliogenesis.

154 dulation of Rab11, an important molecule for vesicular trafficking, especially membrane protein recyc

155 amins are large GTPases that act in multiple vesicular trafficking events.

156 lation factors (ARFs), GTPases that regulate vesicular trafficking events.

157 rotein required for almost all intracellular vesicular trafficking events; we also show that transpor

158 ct means of transport and need not depend on vesicular trafficking for its delivery to the plasma mem

159 ffector and is involved in the regulation of vesicular trafficking for primary cilium formation.

160 the involvement of HAP1 in the regulation of vesicular trafficking from early endosomes to the late e

161 is their biogenesis pathway, which involves vesicular trafficking from the endoplasmic reticulum thr

162 itional defects in Sec proteins required for vesicular trafficking from the ER or in Pex3p, a protein

163 It also contributes to retrograde vesicular trafficking from the Golgi apparatus to the en

164 Vesicular trafficking genes affected by AS during normal

165 echanisms, but pharmacological inhibition of vesicular trafficking had no effect.

166 Lipid and vesicular trafficking have been studied extensively in n

167 ons and reveal novel mechanisms that control vesicular trafficking, hematopoiesis, and innate immunit

168 enes supporting involvement of intracellular vesicular trafficking, immune response and endo/lysosoma

169 of small GTPases that controls intracellular vesicular trafficking in a compartment-specific manner.

170 the major component of axonemes, or general vesicular trafficking in a flagellum assembly context.

171 DPPA3 has a significant role in cytoplasmic vesicular trafficking in addition to its previously repo

172 bosylation factor GTPases) are essential for vesicular trafficking in all eukaryotic kingdoms, but of

173 it tethering complexes (MTCs), which control vesicular trafficking in eukaryotic cells by tethering t

174 n shown to modify Rab1b, a main regulator of vesicular trafficking in eukaryotic cells, by transfer o

175 uggesting a potential role for Rab6-mediated vesicular trafficking in HCMV assembly.

176 Given the importance of vesicular trafficking in macrophages, we investigated th

177 ieu, but the molecular mechanisms regulating vesicular trafficking in neutrophils are not well unders

178 hese two isoforms function differentially in vesicular trafficking in nonneuronal cells.

179 o determine the effect of REP-1 depletion on vesicular trafficking in phagocytic and secretory pathwa

180 is an important component of Rab8a-mediated vesicular trafficking in photoreceptors.

181 or L27 domain interactions and Hrs regulated vesicular trafficking in postsynaptic protein clustering

182 we describe involvement of clathrin-mediated vesicular trafficking in PV generation and the engagemen

183 roteins involved in proteasomal function and vesicular trafficking in Rpgr(ko) PSC, prior to onset of

184 tration and alpha-syn splice isoforms affect vesicular trafficking in synucleinopathies is warranted.

185 results reveal a role for Golgi-to-endosome vesicular trafficking in TORC1-controlled nuclear transl

186 nsistent with a role for FKBP13 and FK506 in vesicular trafficking, influencing ARF activity through

187 orylation, indicating the ability to utilize vesicular trafficking inhibitors to target different flg

188 uced FLS2 degradation, pretreatment with the vesicular trafficking inhibitors Wortmannin or Tyrphosti

189 ent studies have demonstrated that polarized vesicular trafficking involving the small GTPase Rab8 an

190 the function of small GTPases that regulate vesicular trafficking is a strategy employed by several

191 Vesicular trafficking is controlled by ADP-ribosylation

192 Vesicular trafficking is critical for the function of bo

193 Although vesicular trafficking is essential for a large variety o

194 These results show that vesicular trafficking is involved in transporting a sign

195 Vesicular trafficking is likely but non-vesicular mechan

196 Intracellular vesicular trafficking is regulated by approximately 60 m

197 ety of cellular processes, the regulation of vesicular trafficking is still poorly understood.

198 eta-SNAP (Soluble NSF Attachment Protein) in vesicular trafficking is well established; however, the

199 ow that dynamin 2 (Dyn2), a key regulator of vesicular trafficking, is a binding partner of Nef that

200 studies demonstrate for the first time that vesicular trafficking likely plays a role in the apicopl

201 Perturbations are observed in vesicular trafficking, lipid metabolism and in the endop

202 involve the co-ordination of the function of vesicular trafficking machinery and the cytoskeleton.

203 on and characterization of components of the vesicular trafficking machinery that are associated with

204 srupt numerous cellular processes, including vesicular trafficking, mainly through energy depletion.

205 ases are molecular switches that orchestrate vesicular trafficking, maturation and fusion by cycling

206 gests that transport of neurotrophins during vesicular trafficking may occur through a direct interac

207 gs establish the existence of a differential vesicular trafficking mechanism for specific Usher prote

208 one ecdysone is mediated through a regulated vesicular trafficking mechanism.

209 of intracellular organelles is regulated by vesicular trafficking mechanisms controlled by effector

210 Upregulation of the Rab27a-dependent vesicular trafficking mechanisms rescued the defective l

211 a critical role for membrane microdomains in vesicular trafficking-mediated cell polarity.

212 ions of tubby-like proteins include roles in vesicular trafficking, mediation of insulin signaling an

213 We tested if microtubule-based vesicular trafficking might be a mechanism by which merl

214 ctors with roles in endosomal acidification, vesicular trafficking, mitochondrial metabolism, and RNA

215 Sec7, first identified in vesicular trafficking mutants in yeast, and its phylogen

216 translation and cytoplasmic RNA processing, vesicular trafficking, nuclear transport, and DNA mainte

217 in integration of cytoskeletal networks with vesicular trafficking, nucleocytosolic shuttling, transc

218 ctor (ADF)/cofilin regulated actin-dependent vesicular trafficking of acetylcholine receptors (AChRs)

219 Actin-based vesicular trafficking of Cdc42, leading to a polarized c

220 In the myofiber, Thbs4 selectively enhances vesicular trafficking of dystrophin-glycoprotein and int

221 ed through mutant strains compromised in the vesicular trafficking of excess CPY*.

222 gration by modulating the endocytosis and/or vesicular trafficking of its associated integrins.

223 the first time the regulated and unregulated vesicular trafficking of Mct1 in cerebrovascular endothe

224 roscopic evidence of previously unidentified vesicular trafficking of phosphorylated tau in normal as

225 and suggested that TULP1 is involved in the vesicular trafficking of photoreceptor proteins, both at

226 Vesicular trafficking of presynaptic and postsynaptic co

227 ulates events in endocytosis and exocytosis, vesicular trafficking of proteins, transduction of extra

228 block cholesterol transport by affecting the vesicular trafficking of the Niemann-Pick C1 protein (NP

229 Here, we characterize the vesicular trafficking of Wg and its receptors, Arrow and

230 targeting (Cvt) pathway is an unconventional vesicular trafficking pathway in yeast, which is topolog

231 This release occurred through the vesicular trafficking pathway initiated by ATP uptake in

232 /Rab-RP1 in an adaptor protein 3-independent vesicular trafficking pathway of pigment granule biogene

233 In contrast, inhibiting the vesicular trafficking pathway or cathepsin D release fro

234 LGMD2B muscle also showed an increase in vesicular trafficking pathway proteins not normally obse

235 en associated with mutations in genes in the vesicular trafficking pathway that cause disruption of g

236 ion in LGMD2B muscle provides a compensatory vesicular trafficking pathway that is able to repair mem

237 Autophagy is a vesicular trafficking pathway that regulates the degrada

238 y share some subcellular compartments in the vesicular trafficking pathway with PIN auxin efflux carr

239 The vesicular trafficking pathways co-opted by C. burnetii f

240 binding proteins, are critical components of vesicular trafficking pathways in eukaryotes.

241 -syn revealed the molecular determinants and vesicular trafficking pathways underlying this pathologi

242 Rab proteins regulate vesicular trafficking pathways, behaving as membrane-ass

243 ich was dependent on intact microtubules and vesicular trafficking pathways.

244 ation factors (ARFs), critical components of vesicular trafficking pathways.

245 ospholipase D and are critical components of vesicular trafficking pathways.

246 ulting in different autophagic responses and vesicular trafficking patterns of endoplasmic reticulum-

247 an essential role for MUNC13-4 in selective vesicular trafficking, phagosomal maturation, and intrac

248 Vesicular trafficking plays a key role in tuning the act

249 kdown, nuclear import, autophagic recycling, vesicular trafficking, polarized morphogenesis, and the

250 component of a membrane complex involved in vesicular trafficking process, a function similar to tha

251 in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of m

252 d in clathrin-mediated endocytosis and other vesicular trafficking processes.

253 65-kD Gbps coordinate a potent oxidative and vesicular trafficking program to protect the host from i

254 ial display, including the small GTP-binding vesicular trafficking protein Rab3A and the enzyme guany

255 They are found in proteins involved in vesicular trafficking, protein sorting, and lipid modifi

256 er plays a significant role in intracellular vesicular trafficking, protein targeting, and other cell

257 f genes for microtubule-associated proteins, vesicular trafficking proteins and neurotransmitter rece

258 f ATP11B with fluorescent cisplatin and with vesicular trafficking proteins, such as syntaxin-6 (STX6

259 important control elements of many stages of vesicular trafficking, providing new insight into the re

260 y for thylakoids and photosystem biogenesis (vesicular trafficking, provision of material for thylako

261 lements similar to those used in heterotypic vesicular trafficking reactions between different organe

262 es in actin cytoskeletal organization, Golgi vesicular trafficking, receptor endocytosis, and cell cy

263 TPase-activating function of GIT1 toward the vesicular trafficking regulator Arf6 GTPase is required

264 mily of GTPases, had decreased intracellular vesicular trafficking relative to normal human Schwann c

265 ane structure as well as elevated demands in vesicular trafficking required for parasite remodeling d

266 The specific vesicular trafficking route taken by postsynaptic recept

267 tical role in cell growth and proliferation, vesicular trafficking, secretion, and endocytosis.

268 Activity modulation through endocytosis and vesicular trafficking significantly impacts downstream t

269 ta suggest that the COG complex orchestrates vesicular trafficking similarly in yeast and mammalian c

270 e idea that Chc1p and Inp53p act at a common vesicular trafficking step but that Chc1p is used at oth

271 through the endoplasmic reticulum and Golgi vesicular trafficking system is initiated by the binding

272 otic structures, such as membrane repair and vesicular trafficking system, anchoring of the actin and

273 terial phagosomes excluded this regulator of vesicular trafficking that controls membrane tethering a

274 Golgi dispersal underlies the pro-metastatic vesicular trafficking that is associated with epithelial

275 are involved in some aspect of intracellular vesicular trafficking, that is, protein sorting and vesi

276 to predict that this organism can manipulate vesicular trafficking, the actin cytoskeleton and apopto

277 ors and SNAREs control the last two steps of vesicular trafficking: the initial interaction and the f

278 with endocytic proteins, may play a role in vesicular trafficking through its PAP activity.

279 hering complex, a major coordinator of Golgi vesicular trafficking, thus remodeling Golgi membrane tr

280 ptional response, and by the manipulation of vesicular trafficking to avoid the toxicity of lysosomal

281 The molecular mechanisms of EGFR vesicular trafficking to lysosomes have recently receive

282 mutations of the granule group also disrupt vesicular trafficking to lysosomes.

283 mpletely understood, and the contribution of vesicular trafficking to physiological function is unkno

284 urther demonstrate the requirement of intact vesicular trafficking to support sustained cold response

285 pical membrane, provides actin filaments for vesicular trafficking to the apical dome, and mediates a

286 the trans-Golgi network where it influences vesicular trafficking to the plasma membrane by regulati

287 shown to be required for optimal anterograde vesicular trafficking to the plasma membrane.

288 e previously showed that OCRL is involved in vesicular trafficking to the primary cilium.

289 adhesion dynamics are disorganized and that vesicular trafficking to the tip of HGF-induced cell ext

290 lay a direct role in vacuolar biogenesis and vesicular trafficking to the vacuole in plants.

291 d on the correct regulation of intracellular vesicular trafficking to transport biological material.

292 im101 signaling pathway and may also require vesicular trafficking to vacuoles.

293 ly regulates a Rab GTPase pathway to promote vesicular trafficking via late endosomes.

294 effects of BIG1 and BIG2 phosphorylation on vesicular trafficking, via alterations in ARF activation

295 Abnormal vesicular trafficking was evidenced by delayed retrograd

296 Since Rab8a is implicated in vesicular trafficking, we next examined this process in

297 Both phospholipase D activity and vesicular trafficking were required for effects of BIG1

298 by disruption of ROP1-dependent F-actin and vesicular trafficking, which indicates that REN1 targeti

299 gmentation of currents, as did inhibition of vesicular trafficking with bafilomycin A1.

300 complex is strongly implicated in retrograde vesicular trafficking within the Golgi apparatus.