ライフサイエンスコーパス: vestigial

1 the transcriptional regulators Scalloped and Vestigial.

2 female song system is functional rather than vestigial.

3 ts transport functions are widely considered vestigial.

4 2) that is related to the Drosophila protein Vestigial.

5 ons by selective expression of Scalloped and Vestigial.

6 organelles previously thought by some to be vestigial.

7 marker for the time at which the VNO became vestigial.

8 Although the vestigial active site does not participate in epoxide hy

9 Surprisingly, a vestigial active site is found in the N-terminal domain

10 We suggest that Vestigial affects the conformation of Scalloped to creat

11 hat this robust DNA helicase activity is not vestigial and may have specifically evolved in HCV.

12 We further show that Vestigial and Notch collaborate with Wingless to subdivi

13 ," but later is repressed by the activity of Vestigial and Nubbin, which together define a more dista

14 nes, and a high density and diverse range of vestigial and presumably inactive mobile elements.

15 These results suggest the presence of a vestigial and unstable P/C-type mechanism of inactivatio

16 pression of the wing margin patterning genes vestigial and wingless, and strong mitotic activity.

17 Vestigial and Wingless, on the contrary, display synergi

18 th other BMP-dependent promoters (Drosophila vestigial and Xenopus Xvent-2), our studies of the gata2

19 , ectopic Delta expression induces wingless, vestigial, and cut and causes adult wing tissue outgrowt

20 transcribe the genes spalt, optomotor blind, vestigial, and Dad, that are known to be induced by dpp

21 The proteins Scalloped and Vestigial are known from genetic studies to play a part

22 and wingless signalling pathways to activate vestigial at the dorsoventral boundary.

23 he mitochondria in HAP1-A12 cells assemble a vestigial ATP synthase, with intact F1-catalytic and per

24 mnants of its sarcomere, but still retains a vestigial attachment to the ventral body wall.

25 These sperm centrioles appear as vestigial basal bodies, destroyed in the mid-to-lower co

26 inated expression of the key regulatory gene vestigial both in the Dorsal-Ventral (D/V) boundary cell

27 ignaling and thus determines the fate of the vestigial buds and later tooth patterning.

28 ppresses survival of the diastema or incisor vestigial buds by serving as an inhibitor of Lrp5- and L

29 The jaw of Pitx2 mutants was vestigial by midgestation, but significant size reductio

30 cates that unlike mutations in genes such as vestigial, calcineurin B2 does not cause a shift in cell

31 ctions between vgBE and the vgQE mediated by Vestigial can explain the interactions between the wing

32 ulted from epidemic expansion of imported or vestigial cases.

33 However, a fraction containing vestigial chlorosomes, denoted "carotenosomes," was part

34 sertion' domain together adopt the fold of a vestigial class II terpenoid cyclase.

35 The same vestigial complex plus associated c-subunits was charact

36 n results in loss of expression of wingless, vestigial, cut, and E(spl)-m8 at the D/V boundary.

37 presence of an N-terminal alpha-helix of the vestigial DbH domain suggest that the subfamily of PH do

38 c structural contacts between the PH and the vestigial DbH domain.

39 d mutant clones, implies that scalloped- and vestigial-dependent cell adhesion contributes to separat

40 s not participate in epoxide hydrolysis, the vestigial domain plays a critical structural role by sta

41 almost identical, whereas the structure of a vestigial editing 3'-5' exonuclease domain of Taq polyme

42 suggests that these class II enzymes possess vestigial editing functions.

43 Fab residues in both the polymerase and the vestigial editing nuclease domain of the enzyme reveal t

44 These 'vestigial' enhancers are hypomethylated and lack active

45 osphopeptide encompassing Tyr-1227 using its vestigial enzymatic active site.

46 46B8 binds to a conserved epitope in the vestigial esterase domain of hemagglutinin (HA) and bloc

47 g/1/96 reveal a conserved epitope in the HA1 vestigial esterase subdomain that is some distance from

48 First, in the hinge region vestigial exerts both a local inhibition and a long-rang

49 Second, clones of cells overexpressing vestigial exhibit altered cell affinities.

50 These and other observations imply that vestigial-expressing cells in the wing blade organize th

51 ions along with MAD as a direct activator of Vestigial expression in the wing pouch.

52 ight the importance of correct scalloped and vestigial expression levels to normal wing development.

53 distal wing tip due to induction of aberrant Vestigial expression, while a dominant-negative Drifter

54 roduct is also an input in the regulation of vestigial expression.

55 gnals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organ

56 This trench may be a vestigial feature of a bifunctional ("PAPS synthetase")

57 tions of both functional and dysfunctional ("vestigial") gates within the CFTR permeation pathway.

58 In Drosophila, the vestigial gene is required for wing formation and is abl

59 The Drosophila vestigial gene is selectively required for wing-cell pro

60 Our experiments show that the vestigial gene product is also an input in the regulatio

61 The scalloped and vestigial genes are both required for the formation of t

62 The presence of the transposon remnants and vestigial genes suggests that the pathway for 2,4-DNT de

63 tremely diverse, with the composition of the vestigial genome determining their translational require

64 maintained, yielding previously unrecognized vestigial gill arch branchial rays.

65 Clones of cells overexpressing vestigial grow smaller or larger than control clones, de

66 al half-life, evidence suggests that it is a vestigial half-cystine.

67 We also show that TSA is part of a larger vestigial helicase domain which has lost its helicase ac

68 ph sac development has been described as the vestigial homologue of the nascent stage of ancestral an

69 sruption, and chemical probes to reveal that vestigial host enzymes in the cytoplasm of Plasmodium-in

70 onal structural data for this loop, which is vestigial in bacterial pentameric ligand-gated ion chann

71 kidney of lower vertebrates; although it is vestigial in higher vertebrates, it is a necessary precu

72 many vertebrate species but is likely to be vestigial in humans.

73 main no longer has enzymatic activity and is vestigial in nature.

74 Old World monkeys and apes, but then became vestigial in the common ancestor of Old World monkeys an

75 ter and is responsible for the expression of vestigial in the developing wing blade.

76 We report for the first time the presence of vestigial incisors in Bradypus.

77 tion of new functions and removal of adverse vestigial interactions.

78 d our findings to human IP6K2, which retains vestigial IP3K activity.

79 Several vestigial IS elements appeared different from the IS dis

80 The wing-specific regulation of vestigial is mediated through two enhancers: (1) the Bou

81 This threadlike organelle, once considered vestigial, is now seen as a pivotal element for detectio

82 f actin or tubulin appeared at the region of vestigial kinocilia, suggesting impaired vesicular traff

83 forces and directional motion, although some vestigial lamellipodium-driven motility remained.

84 n wing development and ectopic expression of vestigial leads to the development of ectopic wings.

85 F showed Se concentrated inside small conic, vestigial leaves (cladode tips), the cladode vasculature

86 Members of the mammalian Vestigial-like (VGLL) family of transcriptional cofactor

87 vertebrate and vertebrate vestigial (vg) and vestigial-like (VGLL) genes are involved in embryonic pa

88 h a skeletal muscle-specific cofactor called Vestigial-like 2 (Vgl-2) that is related to the Drosophi

89 Vestigial-like 4 (Vgll4) functions as a transcriptional

90 e characterize Vgl-4, the only member of the Vestigial-like family expressed in the heart.

91 whole genome re-sequencing, we find that the vestigial-like family member 3 gene (VGLL3) exhibits sex

92 Here, we identify three mammalian vestigial-like genes, Vgl-1, Vgl-2, and Vgl-3, that shar

93 way in the wing margin, including scalloped, vestigial, mastermind, Chip, and the Nipped locus.

94 making them competent to undergo subsequent vestigial-mediated proliferation within the wing pouch.

95 We have introduced mutations into the vestigial MIDAS motif and report that, unlike the I doma

96 A1/lacZ fusion construct is expressed in the vestigial muscle cells of M. occulta larvae.

97 ability to express muscle actin mRNA in the vestigial muscle cells, suggesting that trans-acting fac

98 p into tailless larvae with undifferentiated vestigial muscle cells.

99 e from Haemophilus influenzae functions in a vestigial NAD(+) utilization pathway by dephosphorylatin

100 omers four or more units in length contained vestigial neutral (VN) absorption bands that arise from

101 sion of scalloped, and ectopic expression of vestigial on the development of the Drosophila wing imag

102 nerally lack antennal lobes, the calyces are vestigial or absent.

103 le consequence of the upregulation of either vestigial or wingless.

104 Such "vestigial order," which is subject to unambiguous macros

105 g is its dependence on the primary cilium, a vestigial organelle that is largely absent in flies.

106 Adult female CPEB knockout mice contained vestigial ovaries that were devoid of oocytes; ovaries f

107 Our studies of vestigial-overexpressing clones also reveal two further

108 form of the ribonucleotide reductase family, vestigial pi-helices, and a novel function for pi-helice

109 the posterior ovary precursors form a small vestigial posterior arm, the post-vulval sac; in other s

110 Hmx1dm/dm mouse embryos possess only a vestigial posterior auricular nerve, and general somatos

111 osite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opp

112 ly suggest that female tungara frogs exhibit vestigial preferences for ancestral calls, and provide a

113 opose that nonproline kinks are places where vestigial prolines were later removed during evolution.

114 The Drosophila Vestigial protein has been shown to play an essential ro

115 Two conserved domains of the Vestigial protein that are not required for Scalloped bi

116 wever, the molecular function of the nuclear Vestigial protein, which bears no informative similariti

117 target genes and forming a complex with the Vestigial protein.

118 In particular, Vestigial provides an important input for the regulation

119 MAD-dependent activation of the vestigial quadrant enhancer results in broad expression

120 least one of the modifiers is linked to the vestigial region and demonstrate that the background eff

121 Genetic and molecular analyses reveal that Vestigial regulates wing identity by forming a complex w

122 Escherichia coli PabB, binds tryptophan in a vestigial regulatory site.

123 a structural scaffold for proteins, but the vestigial remnant of a primordial genome that may have e

124 Here, we show that Vestigial requires the function of the Scalloped protein

125 elopment and patterning of the wing: loss of vestigial results in failures in wing development and ec

126 iation NTP, suggesting that the GTP mimics a vestigial RNA product.

127 ion and relaxation in hearts of animals with vestigial sarcoplasmic Ca(2+) release stores.

128 ed for the formation of the heterotetrameric Vestigial-Scalloped complex on DNA.

129 determined by Drosophila TCF (dTCF) and the Vestigial/Scalloped selector system and that temporal co

130 legic-activated genes such as spalt-related, vestigial, Serum Response Factor, and achaete-scute, who

131 istent with this, we show that Scalloped and Vestigial suppress terminal dendritic branching.

132 del that mimics the real case of the pennant/vestigial system describing plasticity of wing length to

133 The possible presence of vestigial t-tubules and larger Ca(2+) content of central

134 Mice homozygous for the recessive mutation vestigial tail (vt), which arose spontaneously on Chromo

135 f dental mineralization, and the presence of vestigial teeth, to distinguish between caniniforms and

136 tion must be a general feature of genes like vestigial, that regulate growth or patterning along more

137 The vestigial thymus in infants with severe combined immunod

138 e 1 thymocytes, resulting in a hypocellular, vestigial thymus.

139 primates, an order which shows a range from vestigial to demonstrably functional vomeronasal organs.

140 omolog Scalloped interacts with the cofactor Vestigial to drive differentiation of the wing and indir

141 We show that binding of Vestigial to Scalloped switches the DNA-binding selectiv

142 levated Wnt signaling and, as a consequence, vestigial tooth buds in the normally toothless diastema

143 We also show the presence of a vestigial tooth in front of the lower caniniform in both

144 we show that EGFR signaling is essential for vestigial transcription in these cells and for making th

145 me efficacy as Hsc70 and that DnaK possesses vestigial uncoating activity.

146 In addition, they show a vestigial vacuole morphology and a sensitivity to growth

147 These features are reminiscent of a vestigial variant surface glycoprotein (VSG) gene expres

148 ls to activate expression of the wing marker Vestigial (Vg) and transdetermine to wing cells.

149 Invertebrate and vertebrate vestigial (vg) and vestigial-like (VGLL) genes are invol

150 The vestigial (vg) gene is necessary for the development of

151 The vestigial (vg) gene of Drosophila plays a central role i

152 s defined by expression of the selector gene vestigial (vg) in a discrete subpopulation of cells with

153 ently been shown to activate targets such as vestigial (vg) indirectly through negative regulation of

154 anscription from the Drosophila melanogaster vestigial (vg) PRE/TRE switches the status of the elemen

155 h this conundrum, we focused our analysis on vestigial (vg), a critical wing gene initially identifie

156 In the wing blade, wg activates the gene vestigial (vg), which is required for the wing blade to

157 In contrast, lgl(-) clones in the Vestigial (Vg)-expressing distal wing epithelium were el

158 s specified by activity of the selector gene vestigial (vg).

159 levels of Dpp, hth repression also requires Vestigial (Vg).

160 umans and some related primates possess only vestigial VNOs and have no or significantly reduced abil

161 Among the known Dpp targets, vestigial was the only one tested that was required for

162 Phospho-Mad and the downstream target gene vestigial were elevated in l(2)gl tumors, thus linking D

163 for the activation of an enhancer within the vestigial wing-patterning gene in cells across the entir

164 utants display aberrant expression of DELTA, VESTIGIAL, WINGLESS, and CUT.