ライフサイエンスコーパス: vibriocidal

1 The vibriocidal activities of sera from all vaccine groups a

2 rum samples, a correlation was found between vibriocidal activity and protection.

3 Vibriocidal activity in the IgG fraction following prima

4 Although serum vibriocidal activity is used extensively as a marker of

5 S antibodies of the IgG and IgM classes with vibriocidal activity to strains of capsulated V. cholera

6 The majority of the serum vibriocidal activity was of the immunoglobulin M (IgM) i

7 dicate that the conjugates elicited IgG with vibriocidal activity.

8 (2-ME) reduced, but did not eliminate, their vibriocidal activity.

9 e 40 volunteers, 37 developed rises in their vibriocidal and antitoxin titers similar to those in pre

10 immunogen is justified by the correlation of vibriocidal anti-LPS response with immunity.

11 train CVD 103-HgR, elicits seroconversion of vibriocidal antibodies (a correlate of protection) withi

12 the vaccinees had a >/=4-fold rise in serum vibriocidal antibodies after vaccination.

13 duced, as measured by the induction of serum vibriocidal antibodies and by serum and mucosal anti-CTB

14 DeALPS alone did not elicit serum LPS or vibriocidal antibodies in mice and only low levels of im

15 ose levels, and it stimulated high levels of vibriocidal antibodies in most inpatient volunteers and

16 Conjugate-induced IgG vibriocidal antibodies persisted longer than those elici

17 O1, infection with V. cholerae O139 induces vibriocidal antibodies specific to the surface polysacch

18 i-LPS and 2-mercaptoethanol (2-ME)-resistant vibriocidal antibodies was 0.81 (P = 0.0004).

19 conjugates and the cellular vaccine elicited vibriocidal antibodies: after 8 months, recipients of ce

20 , serum was tested for antibody responses by vibriocidal antibody and immunoglobulin G antitoxin enzy

21 econd dose, CVD 103-HgR was given, and serum vibriocidal antibody levels were measured before and 10

22 ne response to oral vaccines, we studied the vibriocidal antibody response to the oral cholera vaccin

23 Vibriocidal antibody responses, reflective of in vivo co

24 oxin A immunoglobulin G and anti-V. cholerae vibriocidal antibody responses.

25 15 with a buffer showed significant rises in vibriocidal antibody titer.

26 Vibriocidal antibody titers were equivalent in all group

27 Stool culture, measurement of serum vibriocidal antibody titers, and determination of immune

28 gender, and baseline anti-cholera toxin and vibriocidal antibody titers.

29 , 98% showed at least a fourfold increase in vibriocidal antibody titers.

30 We were, however, able to measure increased vibriocidal immune responses against vaccine strains in

31 G1 and IgG3 subclass responses supported the vibriocidal isotype data.

32 mmunoglobulin M [IgM] and IgG1) were neither vibriocidal nor protective in the infant mouse cholera m

33 Abs in mice, but the immune response was not vibriocidal or protective.

34 hallenge within 4 months mounted a secondary vibriocidal response (P = 0.0009).

35 n HIV-infected individuals resulted in lower vibriocidal responses against Vibrio cholerae O1, and th

36 tionship between the CD4(+) T-cell count and vibriocidal responses following vaccination.

37 conditions operative in producing secondary vibriocidal responses in North American volunteers prime

38 Secondary serum vibriocidal responses occurred under two distinct second

39 ess frequent and of lower magnitude than the vibriocidal responses, antitoxin responses were seen in

40 was not associated with the magnitude of the vibriocidal responses.

41 significant association was observed between vibriocidal seroconversion rates and treatment group, su

42 112 delta tcpA developed a fourfold rise in vibriocidal titer (P < 0.01).

43 a mshA developed at least a fourfold rise in vibriocidal titer after immunization.

44 escent sera from cholera patients had a mean vibriocidal titer of 2,525 that was removed by treatment

45 o 3,200: absorption with the CPS reduced the vibriocidal titer of all sera to < or =50.

46 t rise in antitoxin antibodies but the serum vibriocidal titer was attenuated compared to that seen a

47 High baseline vibriocidal titers (>80) were observed in 21% of the par

48 reactive IgG and IgM Ab responses as well as vibriocidal titers and provided a much greater degree of

49 patients infected with V. cholerae O139 had vibriocidal titers ranging from 100 to 3,200: absorption