ライフサイエンスコーパス: vicious

1 Since 1900, such adjectives as ignorant, vicious, and recalcitrant have been used to describe pat

2 icrogliosis and COX-2 activity may stop this vicious circle and be valuable strategies in PD therapy.

3 flammation and excitotoxicity in a potential vicious circle and indicate that an activation of the mi

4 a-large letter spacing may help to break the vicious circle by rendering the reading material more ea

5 ces but may result in severe hypoxemia and a vicious circle due to hypoxemia induced pulmonary vasoco

6 deficits must be treated by reading more--a vicious circle for a dyslexic child).

7 atients with T2DM and hypomagnesemia enter a vicious circle in which hypomagnesemia causes insulin re

8 -volume hemofiltration (HVHF) might halt the vicious circle leading to death by improving myocardial

9 Eventually, a vicious circle of coagulation and inflammation is set in

10 and nighttime sleep such that an escalating vicious circle of disturbance in affect regulation durin

11 he sensation of unsteadiness, and so on in a vicious circle of escalating activity.

12 is one where male-killing bacteria trigger a vicious circle of increasing male fatigue and female pro

13 w generation of the data needed to break the vicious circle of underrecognition.

14 ic alterations, this interplay may trigger a vicious circle that leads to obesity and diabetes.

15 2 expression and activation can be seen as a vicious circle that ultimately leads to cartilage destru

16 the high-incidence equilibrium, there is a "vicious circle" in which inadequate treatment capacity l

17 nflammation is a core driver: the so-called "vicious circle" of inflammation.

18 ponses, may initiate and/or contribute to a "vicious circle" of the disease process, resulting in pro

19 ulation and alpha-syn oligomerization form a vicious circle, thereby influencing and/or potentiating

20 s LA remodeling, closing a self-perpetuating vicious circle.

21 l to fight microbial attack, thus inducing a vicious circle.

22 P(Sc) induces ER stress, our data point to a vicious cycle accelerating prion replication, which may

23 ment, thereby setting up a self-perpetuating vicious cycle among low local endothelial shear stress,

24 Malnutrition and cryptosporidiosis form a vicious cycle and lead to acute and long-term growth imp

25 in accumulation/aggregation, thus creating a vicious cycle and leading to Parkinson disease pathogene

26 lts are consistent with the development of a vicious cycle between AD and diabetes, potentiating both

27 A vicious cycle between AGE formation, lipoxidation, and m

28 an cause an immune imbalance that may fuel a vicious cycle between complement, inflammatory cells, an

29 tumour persistence, and the initiation of a vicious cycle between tumour and bone-resident cells tha

30 Interrupting this vicious cycle by triggering surface beta1-integrin inter

31 ired T cell-intrinsic NF-kappaB may create a vicious cycle conducive to tumor progression and further

32 ynthase at Thr-495, leading to a detrimental vicious cycle despite restoration of normoglycemia.

33 The vicious cycle established between bone-associated tumour

34 Mechanistic insights into this vicious cycle have suggested new therapeutic opportuniti

35 This vicious cycle highlights the pressing need for an S. aur

36 refore, sensory aberrations help construct a vicious cycle in post-traumatic stress disorder that is

37 RyR2 and mitochondrial ROS generation form a vicious cycle in the development of AF.

38 hronic inflammation-and creates a pathogenic vicious cycle in which dying CD4 T cells release inflamm

39 A vicious cycle in which ER stress promotes inflammation,

40 to MTB at sites of infection may initiate a vicious cycle in which immune activation and loss of ant

41 These effects may create a vicious cycle in which low-level inflammation promotes f

42 necrosis represents the starting point for a vicious cycle including the uptake of infected necrotic

43 This vicious cycle is thought to play a pivotal role in the d

44 pair mucosal healing, thereby establishing a vicious cycle leading to chronic inflammatory bowel dise

45 vated microglia and damaged neurons formed a vicious cycle mediating chronic, progressive neurodegene

46 is inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeut

47 data on these issues strongly suggest that a vicious cycle might exist in which HIV persistence cause

48 of the evidence supporting the mitochondrial vicious cycle model comes from pharmacological experimen

49 ut a patient at risk and then effectuate the vicious cycle now recognized as CRS type 1.

50 exposure to large amounts of drug produces a vicious cycle of additional maladaptive changes in brain

51 Stopping the vicious cycle of AGE-RAGE and RAGE axis signaling in the

52 In the mitochondria-mediated vicious cycle of Alzheimer's disease (AD), intracellular

53 n of autoreactive T cells, thus breaking the vicious cycle of autoimmunity and inflammation.

54 The vicious cycle of bone degradation and formation driven b

55 These episodes also play a key role in the vicious cycle of childhood diarrhea and malnutrition in

56 lipid accumulation in neurons, we uncover a vicious cycle of cholesterol synthesis and accretion, wh

57 eraction is a critical molecular link in the vicious cycle of chronic inflammation and metabolic dysf

58 nresolved paradigm that stems from the known vicious cycle of clot formation and tumor growth.

59 Common for the pathogenesis seems to be the vicious cycle of complement activation, endothelial cell

60 Such a vicious cycle of continuous virus replication and immuno

61 mented and full-length alphaSyns, creating a vicious cycle of cytotoxicity.

62 IL-7 produced by FRCs may thus perpetuate a vicious cycle of depletion of T cells and the FRC networ

63 rbidity and identifies children at risk of a vicious cycle of diarrhea and malnutrition.

64 eonatal and weaned mice provide models for a vicious cycle of enteroaggregative E. coli infection tha

65 This perpetuates a vicious cycle of epidermal inflammation and regeneration

66 The lethal triad comprises the vicious cycle of hypothermia, acidosis, and coagulopathy

67 malization of plasma glucose might break the vicious cycle of impaired glucose effectiveness in type

68 e concept of a photooxidative stress-induced vicious cycle of increased iron uptake leading to furthe

69 hat misdiagnosis of malaria contributes to a vicious cycle of increasing ill-health and deepening pov

70 The result is a vicious cycle of isoflurane-induced apoptosis, Abeta gen

71 ation of thymocytes by TSAbs could lead to a vicious cycle of iterative improvement of the affinity a

72 n and support the use of zinc to prevent the vicious cycle of malnutrition and diarrhea.

73 n may preclude or mitigate the later adverse vicious cycle of malnutrition and infection.

74 e a novel role of Runx2 in up-regulating the vicious cycle of metastatic bone disease, in addition to

75 ter cessation of hyperglycemic insult, and a vicious cycle of mitochondria damage continues.

76 opathy by preventing the continuation of the vicious cycle of mitochondrial damage.

77 nd proinflammatory cytokines, resulting in a vicious cycle of neurodegeneration.

78 This may in turn propagate a vicious cycle of oxidative stress and iron accumulation,

79 e load is believed to be responsible for the vicious cycle of progressive myocardial dysfunction in c

80 in (ETC) function has been implicated in the vicious cycle of reactive oxygen species (ROS) productio

81 onomic] symptom responses) and thus causes a vicious cycle of recurrent hypoglycemia.

82 sociated autonomic failure and the resultant vicious cycle of recurrent iatrogenic hypoglycemia.

83 tnatal life of the 1-HC female rat sets up a vicious cycle of spontaneous transfer of the HC phenotyp

84 ns can foster negative thinking and create a vicious cycle of stress and disability.

85 y challenges are truly daunting because of a vicious cycle of three synergistic factors: the social d

86 n attractive therapeutic target to block the vicious cycle of tumor-stromal interactions that plagues

87 sts that, during AD onset and progression, a vicious cycle revolves around amyloid beta (Abeta) produ

88 ous alphaS compromise this ability, likely a vicious cycle scenario faced by microglia in Parkinson's

89 on of a single prostate cancer cell yields a vicious cycle similar in cellular composition and pathop

90 s highlight the possibility of a feedforward vicious cycle such that the Hh pathway might be turned o

91 itivity (elevated lipogenesis) establishes a vicious cycle that aggravates hyperinsulinemia and insul

92 s, and it has been argued that they create a vicious cycle that amplifies the dominance of establishe

93 cancer cells and their microenvironment is a vicious cycle that enhances the survival and progression

94 lease initiated and sustained by c-Met fed a vicious cycle that generated a favorable microenvironmen

95 It is perhaps the nature of such a vicious cycle that is the key pathophysiologic concept.

96 Together these pathways can create a vicious cycle that leads to fibrosis or keloid formation

97 r decline of insulin sensitivity, creating a vicious cycle that may contribute to the development of

98 d excessive expansive remodeling establish a vicious cycle which leads to the formation of severe pla

99 Insights into mechanisms underlying the vicious cycle will help to design rational therapies to

100 el of cryptosporidial disease, including its vicious cycle with body weight loss and heavier infectio

101 east cancer cells and the initiation of the "vicious cycle" of bone destruction induced by these cell

102 results provide compelling evidence for the "vicious cycle" of mitochondrial ROS production and lead

103 he effect of Runx2 on key components of the "vicious cycle" of transforming growth factor beta (TGFbe

104 void extreme pathophysiology and the "bloody vicious cycle".

105 These observations support a 'vicious cycle' theory which states that there is a feedb

106 fore, autoimmunity to HIP/PAP might create a vicious cycle, accelerating the immune process leading t

107 XNIP induction plays a critical role in this vicious cycle, and suggest that inhibition of TXNIP may

108 hysiology are altered in ways that can, in a vicious cycle, lead to further allostatic load.

109 ionship among the components of the putative vicious cycle, with particular emphasis on the role of m

110 is required to prevent continuation of this vicious cycle.

111 large artery stiffness and thus perpetuate a vicious cycle.

112 te each of their activations in a pernicious vicious cycle.

113 get simultaneously the three partners of the vicious cycle.

114 ear film, amplify inflammation, and create a vicious cycle.

115 cially powerful for local factors, given the vicious cycles set in motion by these factors and the ef

116 ile age-related insults initiate interacting vicious cycles that increase vulnerability to Alzheimer'

117 vil society will be necessary to break these vicious cycles.

118 IV-1 generates in ex vivo lymphoid tissues a vicious destructive circle of activation and infection.

119 s to identify mechanisms responsible for the vicious feed-forward loop between systemic and oral dise

120 tabolic conditions sustains and propagates a vicious feedback cycle of chronic inflammation and metab

121 /WHSC1/mTORC2 signaling cascade represents a vicious feedback loop that elicits unrestrained AKT sign

122 human AD and believed to serve as part of a vicious inflammatory cycle that drives AD pathology.

123 effects in the vasculature are enhanced by a vicious loop and cross-talk with the IL-18 signaling pat

124 t toward another pathway to MPE formation: a vicious loop of interactions between pleural-based tumor

125 In this setting, Na(+) loading fuels a vicious loop whereby increased CaMKII activation perturb

126 hibition may block TGF-beta propagation of a vicious osteolytic cycle in this MDA-MB-231 model of bon

127 reduced metabolic adaptability may lead to a vicious pathogenic cycle leading to the co-morbidities o

128 sregulated, overactivated microglia create a vicious self-propagating cycle causing uncontrolled, pro

129 cG and miRNA deregulations often establish a vicious signal-amplification loop in lymphoma associated

130 were altered, triggering a transition from a vicious to a virtuous cycle.

131 he computer-based health-education tool 'The Vicious Worm' was developed to create awareness and prov