ライフサイエンスコーパス: vinca alkaloid

1 erently from vinblastine, a first generation Vinca alkaloid.

2 grafted tumors as effectively as taxanes and vinca alkaloids.

3 rarely has been applied to studies involving vinca alkaloids.

4 umor activities of the two second-generation Vinca alkaloids.

5 e efficacy of paclitaxel, docetaxel, and the vinca alkaloids.

6 , including platinum compounds, taxanes, and vinca alkaloids.

7 nding of paclitaxel and increased binding of Vinca alkaloids.

8 y to paclitaxel and decreased sensitivity to vinca alkaloids.

9 s using anthracyclines, glucocorticoids, and Vinca alkaloids.

10 r 6 mutants were cross-resistant only to the Vinca alkaloids.

11 ivative, vinorelbine (Navelbine), with other vinca alkaloids.

12 f the energetics of spiral formation for two vinca alkaloids: a novel difluorinated vinorelbine deriv

13 e binding site on tubulin differing from the vinca alkaloid and dolastatin 10 binding sites, or that

14 the massive stable structures observed with vinca alkaloids and antimitotic peptides.

15 with Dx5, with decreased cross-resistance to Vinca alkaloids and no resistance to dactinomycin.

16 ive inhibition of the tubulin binding of the Vinca alkaloids and other antimitotic agents, (2) proxim

17 Hybrids of vinca alkaloids and phomopsin A have been elaborated wit

18 ent antimitotic cancer chemotherapy based on vinca alkaloids and taxanes target tubulin, a protein re

19 Some of the drugs, such as Vinca alkaloids and taxol, are routinely used for cancer

20 ubulin that is distinct from the colchicine, vinca alkaloid, and paclitaxel binding sites and some, i

21 nclude liposomal anthracyclines, paclitaxel, vinca alkaloids, and bleomycin.

22 ance to anthracyclines, epipodophyllotoxins, vinca alkaloids, and some alkylating agents.

23 e to killing by MDR-sensitive drugs, such as vinca alkaloids, anthracyclines, podophyllins, and pacli

24 Vinca alkaloids appear to inhibit cell proliferation by

25 Taxanes and Vinca alkaloids are among the most active classes of dru

26 Vinca alkaloids are antimitotic drugs that inhibit micro

27 Vinca alkaloids are antineoplastic agents that halt cell

28 Taxanes and vinca alkaloids are in widespread use and have demonstra

29 residues that are crucial to the binding of vinca alkaloids are shown to be strongly involved in lon

30 775), KSP (ispinesib), and tubulin (taxanes, vinca alkaloids), are presented.

31 geting agents (MTA), such as the taxanes and vinca alkaloids, are used to treat a variety of cancers

32 AB-5, like taxanes and vinca alkaloids, blocks cell division during mitosis.

33 often used in combination with bleomycin and vinca alkaloids, can lead to vascular events including a

34 agents in clinical use, the taxanes and the vinca alkaloids, come from terrestrial sources, the sea

35 The ability of a class of C-20' modified vinca alkaloid congeners to induce tubulin spiral format

36 e studies comparing the interaction of a new vinca alkaloid derivative, vinorelbine (Navelbine), with

37 ategy has allowed fast access to a family of vinca alkaloid derivatives with an enlarged and function

38 tafolide), a conjugate of folic acid and the vinca alkaloid desacetylvinblastine hydrazide (DAVLBH),

39 or the response of breast cancer patients to Vinca alkaloid drug treatment.

40 Because RALBP1 transports anthracycline and Vinca alkaloid drugs, as well as GS-E, and because it co

41 ide was accompanied by cell sensitization to Vinca alkaloids, gramicidin D, and Taxol with no effect

42 ne (Navelbine), an amphiphilic semisynthetic Vinca alkaloid, has displayed superior activity and decr

43 e role of single-agent vinblastine and other vinca alkaloid in the management of pediatric LGGs deser

44 active route to the tetracyclic core of some vinca alkaloids, including the tetrahydroisoquinocarbazo

45 Cross-resistance was observed to Vinca alkaloids, including vincristine, vinorelbine, and

46 superior antitumor activity to that of other Vinca alkaloids, including vinorelbine from which it was

47 nucleotides are allosteric effectors of the vinca alkaloid-induced self-association of tubulin.

48 ed by the observation that the energetics of vinca alkaloid-induced tubulin spiral polymers, or spira

49 of the initial interaction between P-gp and Vinca alkaloids occurs in the cytoplasm.

50 Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is

51 y developed a new group of folate-conjugated Vinca alkaloids, one of which, EC145, emerged as a candi

52 xic agents such as liposomal anthracyclines, vinca alkaloids, or paclitaxel.

53 ntered by cancer patients receiving taxane-, vinca alkaloid- or platin-based chemotherapy.

54 Vinflunine is a novel Vinca alkaloid presently in Phase I clinical trials.

55 ty (many-fold greater than paclitaxel or the vinca alkaloids) raises important questions about its me

56 otherapeutic drugs (e.g., anthracyclines and vinca alkaloids) should concentrate in acidic organelles

57 Vinflunine, a novel vinca alkaloid, showed some activity and was recently ap

58 ults indicate that cryptophycin disrupts the Vinca alkaloid site of tubulin; however, the molecular d

59 Drugs such as taxanes and vinca alkaloids specifically target microtubules and cau

60 Since chemical modifications of the vinca alkaloid structure are known to modulate the overa

61 ored cellular sensitivity to anthracyclines, Vinca alkaloids, taxanes, and other anticancer drugs.

62 hmin expression on the action of taxanes and Vinca alkaloids using a panel of human breast cancer cel

63 kg, intravenous methylprednisolone 30 mg/kg, Vinca alkaloids (VCR 0.03 mg/kg), and/or intravenous ant

64 o other groups of anticancer drugs including vinca alkaloids (vinblastine and vincristine) and anthra

65 ffer significantly from those of the classic Vinca alkaloid, vinblastine.

66 lls created by continuous selection with the vinca alkaloid vincristine (HL60 RV+) or by retroviral i

67 itors sodium azide/2-deoxyglucose and by the vinca alkaloid, vincristine, but not by the chemotherape

68 The two second-generation Vinca alkaloids, vinorelbine and vinflunine, affect micr

69 eases microtubule binding and sensitivity to Vinca alkaloids, which promotes microtubule depolymeriza