ライフサイエンスコーパス: vinflunine

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1 1200 mg or chemotherapy (physician's choice: vinflunine 320 mg/m(2), paclitaxel 175 mg/m(2), or 75 mg

2 Vinflunine 320 mg/m2 by 10-minute intravenous infusion w

3 at the mitotic IC(50) value was highest for vinflunine (4.2 +/- 0.2 microM), intermediate for vinore

4 study reports the clinical efficacy data for vinflunine, a novel microtubule inhibitor, in MPM.

5 Vinflunine, a novel vinca alkaloid, showed some activity

6 -generation Vinca alkaloids, vinorelbine and vinflunine, affect microtubule dynamics very differently

7 Thus the unique constellation of effects of vinflunine and vinorelbine on dynamic instability and tr

8 The major effects of vinflunine and vinorelbine on dynamic instability were a

9 Here we have analyzed the effects of vinflunine and vinorelbine on microtubule dynamic instab

10 latively less powerful inhibitory effects of vinflunine and vinorelbine on microtubule dynamics bette

11 In addition, vinflunine and vinorelbine suppressed treadmilling, but

12 ifluoro-3',4'-dihydrovinorelbine (F12158, or vinflunine) and the parent compound, vinorelbine.

13 Vinflunine can be delivered with high-dose intensity in

14 axation times for polymer redistribution for vinflunine consistent with induction of the shortest spi

15 Vinflunine demonstrates 3-16-fold lower overall affinity

16 ntation velocity to compare vinorelbine- and vinflunine-induced self-association of porcine brain tub

17 Vinflunine is a novel Vinca alkaloid presently in Phase

18 ovides the only direct evidence to date that vinflunine is a tubulin-binding drug.

19 entirely consistent with our hypothesis that vinflunine is likely to result in reduced clinical neuro

20 eservoir(s) may be partially responsible for vinflunine's high efficacy and minimal side effects.

21 These data suggest that vinflunine should be further evaluated in the management

22 shortening in vitro, whereas vinorelbine and vinflunine suppress the rate and extent of microtubule g

23 or inhibition of HeLa cell proliferation for vinflunine, vinorelbine, and vinblastine were 18, 1.25,

24 ng immune cells [IC2/3]), chemotherapy type (vinflunine vs taxanes), liver metastases (yes vs no), an

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