ライフサイエンスコーパス: viral assembly

1 tegument proteins remains a key question in viral assembly.

2 fold provides new constraints for models of viral assembly.

3 ane vesicular transport pathway important in viral assembly.

4 a model in which NS2 provides the matrix for viral assembly.

5 two homologous strands of genomic RNA during viral assembly.

6 on of the large HDV antigen is essential for viral assembly.

7 ch character have potential use as probes of viral assembly.

8 responsible for initiation of this aspect of viral assembly.

9 (ds) RNA, a process that occurs at sites of viral assembly.

10 lyprotein, from which it is cleaved prior to viral assembly.

11 capsid proteins principally interfered with viral assembly.

12 ons in the virus-producing cells and affects viral assembly.

13 ions related to viral replication, including viral assembly.

14 rs at the level of replication instead of at viral assembly.

15 th specific lipid environments formed during viral assembly.

16 These interaction domains may play roles in viral assembly.

17 e of unusual hydrophobic environments in the viral assembly.

18 31)] is required for capsid dimerization and viral assembly.

19 ional roles in the replication cycle such as viral assembly.

20 heir synthesis was found to be essential for viral assembly.

21 large HDAg (HDAg-L), which is essential for viral assembly.

22 which includes the late domain required for viral assembly.

23 g to facilitate lipid droplet biogenesis and viral assembly.

24 alpha and cellular lipogenesis to facilitate viral assembly.

25 and molecular interactions that occur during viral assembly.

26 rms state-of-the-art methods for genome-wide viral assembly.

27 unter dimerized GagPol in the cytosol during viral assembly.

28 es its interaction with core protein and the viral assembly.

29 geted toward fatty acid synthesis to support viral assembly.

30 ciated lipid droplet formation to facilitate viral assembly.

31 fic capture of the genomic RNA genome during viral assembly.

32 hway to transport viral proteins to sites of viral assembly.

33 G-catalyzed fusion as well as study steps of viral assembly.

34 implicated in host-pathogen interaction and viral assembly.

35 The retroviral Gag polyprotein mediates viral assembly.

36 ntact amino acid residues is deleterious for viral assembly.

37 to the plasma membrane of host cells during viral assembly.

38 eraction between Gag and TRIM5alpharh during viral assembly.

39 le roles of pV and protein X/Mu precursor in viral assembly.

40 repulsion present a strong energy barrier in viral assembly.

41 orters for studying anaerobic biosystems and viral assemblies.

42 the virological synapse and by extracellular viral assemblies.

43 he important roles of ORF33 and ORF38 during viral assembly, a process critical for virus propagation

44 However, it differs as to viral assembly and budding, which take place on plasma m

45 urg viral proteins within lipid rafts during viral assembly and budding.

46 um-concentration state, which is relevant to viral assembly and disassembly inside host cells.

47 esidues in mediating the contacts needed for viral assembly and disassembly.

48 es of cell-cell contact to support polarized viral assembly and egress for efficient cell-cell spread

49 During viral assembly and egress, the late domain within the p1

50 llowing viral entry as well as for efficient viral assembly and egress.

51 nfection, where BiP performs unique roles in viral assembly and egress.

52 For many paramyxoviruses, M proteins drive viral assembly and egress; however, some paramyxoviral g

53 All stages in viral assembly and export therefore coexist, making it i

54 ablate the function of the ligand or disrupt viral assembly and function.

55 f influenza virus plays an essential role in viral assembly and has a variety of functions, including

56 ratifying and differentiating host tissue in viral assembly and has allowed for the rapid analysis of

57 of HCV-infected cells to daclatasvir reduced viral assembly and induced clustering of structural prot

58 racterized the effects of these mutations on viral assembly and infectivity by using a single-step in

59 complex is required early in replication for viral assembly and initiation of DNA synthesis through a

60 ocalization of nanoATV at endosomal sites of viral assembly and its slow release sped antiretroviral

61 as a prototypic retrovirus in order to study viral assembly and later to produce large amounts of rev

62 ene, tat, rev, and nef, eventually affecting viral assembly and leading to the overall inhibition of

63 e conformational flexibility observed during viral assembly and maturation.

64 p28, and pp65) known to be indispensable for viral assembly and maturation.

65 from the cytoplasm to the Golgi, the site of viral assembly and maturation.

66 dant virion protein and the key component in viral assembly and morphogenesis.

67 ntains all of the determinants important for viral assembly and must move around in the cell in order

68 nfirmed that there was a correlation between viral assembly and NS2B-NS2A interaction.

69 the one hand segregate molecules needed for viral assembly and on the other hand furnish peptides th

70 endra virus F protein is required for proper viral assembly and particle release.

71 actions of three Nipah virus proteins during viral assembly and particularly on the role of one of th

72 ced, thus the molecular interactions driving viral assembly and production are still unclear.

73 In general, the requirements on Gag for viral assembly and propagation are more stringent than o

74 ractions and also examined the efficiency of viral assembly and release in vivo.

75 CD81, are actively recruited by HIV-1 Gag to viral assembly and release sites.

76 us type 1 (HIV-1) Gag protein, which directs viral assembly and release, accumulates at surface TEMs

77 dentified 3 that were severely defective for viral assembly and release.

78 oxes are likely to be required for efficient viral assembly and release.

79 y in mouse cells, with a resulting defect in viral assembly and release.

80 the role of the RNP-binding domain of M1 in viral assembly and replication, mutations in the coding

81 he zinc finger motif and the RKLKR domain in viral assembly and replication, we introduced multiple m

82 y virus type 1 (HIV-1) is a critical step in viral assembly and replication.

83 packaging provides significant insights into viral assembly and replication.

84 onal protein critical for several aspects of viral assembly and replication.

85 cell cycle regulation, gene regulation, and viral assembly and replication.

86 To further define its role in viral assembly and to identify host cell proteins that i

87 s a useful tool for dissecting mechanisms of viral assembly and transmission.

88 s may possess antiviral effects against both viral assembly and uncoating.

89 We also showed that FQ has no effect on viral assembly and virion secretion.

90 teins relocalize to lipid droplets, sites of viral assembly, and their depletion increases infectious

91 Viral assembly appears directed toward a relatively smal

92 is paralleled, at the subcellular level, by viral assembly at different microsegments of the plasma

93 (Gag) structural protein, a critical step in viral assembly at the plasma membrane, is mediated by th

94 toichiometry of functional units involved in viral assembly, be they single molecules or oligomers.

95 Viral assembly begins with the packaging of the pgRNA in

96 s at these positions cause severe defects in viral assembly, budding and Gag processing.

97 of MV spread between neurons at the level of viral assembly but allows an alternate, CD46-independent

98 16 is important for the efficiency/timing of viral assembly but is not essential for HSV-1 replicatio

99 e not in preformed membrane patches prior to viral assembly but rather that glycoproteins are activel

100 al capsids, and 5 mutations supported normal viral assembly but were nevertheless reduced more than 2

101 Gag proteins perform important functions in viral assembly, but are also involved in other steps in

102 and matrix (M) protein are key mediators of viral assembly, but the underlying mechanisms are poorly

103 ion complex biogenesis, daclatasvir prevents viral assembly by blocking transfer of the viral genome

104 These domains drive viral assembly by mediating multiple interactions betwee

105 Substitutions for G61 may inhibit viral assembly by preventing the protein from achieving

106 gnitude, indicating that factors involved in viral assembly can be targets for efficient and specific

107 t in trafficking of pp150 to the cytoplasmic viral assembly compartment (AC), without altering traffi

108 Formation of the cytoplasmic viral assembly compartment (cVAC) is an important step f

109 ed ECs, Golgi stacks were disrupted, and the viral assembly compartment characteristic of HCMV infect

110 ous virions, takes places in the cytoplasmic viral assembly compartment.

111 with true-late kinetics and localizes to the viral assembly complex during infection.

112 ble deficiency in late-phase replication and viral assembly during VZV infection of neurons in cultur

113 rmation, we improve our understanding of the viral assembly/egress process and point to potential int

114 onent of the viral RNA polymerase complex, a viral assembly factor, and an inhibitor of host interfer

115 lication and capsid assembly, functioning as viral assembly factories.

116 ement of viruses, and as such, understanding viral assembly has great potential in the development of

117 ring structure dynamics and heterogeneity of viral assemblies have revealed important insights into g

118 pid rafts and point to a role for rafts as a viral assembly hub.

119 findings suggest that E protein facilitates viral assembly in a manner that does not require E prote

120 Increased efficiency of viral assembly in murine cells was observed from MHIV co

121 We localized the defect for viral assembly in the first two-thirds of the gag gene b

122 NS2B and NS2A may participate in modulating viral assembly in the flavivirus life cycle.

123 bility of Vpu to displace BST2 from sites of viral assembly in the plane of the plasma membrane.

124 To study viral assembly in vivo, we inoculated wild-type and repl

125 studies that help clarify the mechanisms of viral assembly, infection, and replication.

126 rgely unknown because it is not required for viral assembly, infection, or replication.

127 This domain has been implicated in viral assembly, infectivity, and cytopathogenicity.

128 ate, thus offering an explanation underlying viral assembly initiation by an AAG motif.

129 the intracellular localization of these two viral assembly intermediate complexes was investigated b

130 ly identified two distinct forms of putative viral assembly intermediate complexes, a detergent-resis

131 e propose that these complexes may represent viral assembly intermediates and that Vif is appropriate

132 Viral assembly is an ideal system in which to investigat

133 cription from the major late promoter and in viral assembly is discussed.

134 Human immunodeficiency virus type 1 (HIV-1) viral assembly is mediated by multiple protein-protein a

135 A role for AP-2 complex in viral assembly is supported by immunofluorescence analys

136 terminal acetylation of Gag is essential for viral assembly, it is completely dispensable for functio

137 This mutation enhances viral assembly, leading to an increase in viral producti

138 viruses, reverse transcription occurs during viral assembly, leading to DNA-containing virions.

139 folding and to ensure proper function during viral assembly, maturation, and infection.

140 ved across retroviruses and is essential for viral assembly, maturation, and infectivity.

141 o virions in vivo, suggesting that defective viral assembly may be associated with the induction of s

142 ant degree of stability, and the kinetics of viral assembly may dominate the folding process.

143 Furthermore, our method is the first viral assembly method that scales to millions of sequenc

144 ure block, DNA packaging and later events in viral assembly nevertheless occurred at near-normal leve

145 to the plasma membrane where, subsequently, viral assembly occurs.

146 Since replication and viral assembly of Ad5-dV/TSB could still occur in the ab

147 e transcription [RT]-PCR product) as well as viral assembly on the cell membrane.

148 termine whether the A9L protein functions in viral assembly or infectivity, we made a conditional-let

149 e exclusively in VP2 had a minimal effect on viral assembly or infectivity.

150 could promote biomedical efforts to prevent viral assembly or nanomaterials applications that exploi

151 the wild type, suggesting a defect in early viral assembly or trafficking.

152 chanism by which LysRS is recruited into the viral assembly pathway can be exploited for the developm

153 a few seconds, thus demonstrating a distinct viral assembly pathway.

154 of replication-defective mutants with normal viral assembly phenotypes indicates that CA also perform

155 and (ii) that one or more components of the viral assembly pool decay in the absence of drug.

156 The conclusion suggests that some viral assembly principles are limited paradigms for prot

157 NMR spectroscopy, provides insight into the viral assembly process.

158 e fusions, into the virion during the normal viral assembly process.

159 o as to aid its encapsidation and assist the viral assembly process.

160 the IVa2 protein plays multiple roles in the viral assembly process.

161 ng near the carboxy terminus (M-site) of the viral assembly protein precursor.

162 incorporation and had a minor effect on the viral assembly rate.

163 d on IE62/CDK1/cyclin B1 colocalization near viral assembly regions, we hypothesized that these cellu

164 Gag structural protein is a critical step in viral assembly, relying in part on interaction between t

165 rgely unknown because it is not required for viral assembly, replication, or infection.

166 establishment of the infecting provirus and viral assembly, respectively.

167 h specific lipid-protein interactions at the viral assembly site.

168 cleus to the cytoplasm prior to transport to viral assembly sites on the cellular plasma membrane.

169 mical reconstitution of ESCRT recruitment to viral assembly sites, using purified proteins and giant

170 he recruitment of MxA protein to perinuclear viral assembly sites, where the protein surrounded the v

171 ing the movement of Vpu-bound BST2 away from viral assembly sites.

172 coproteins are actively recruited to certain viral assembly sites.

173 Unlike most viral assembly systems, two scaffolding proteins, B and

174 rions and the determination of parameters of viral assembly that are inaccessible with conventional t

175 otein interactions during the final stage of viral assembly that result in the incorporation of the v

176 the most abundant viral protein, and during viral assembly, the N protein forms trimers and packages

177 During viral assembly, the p17MA domain of Pr55gag promotes mem

178 tios of mutant to wild-type pRNA in in vitro viral assembly, the percent mutant pRNA versus the yield

179 Besides being a key step in viral assembly, this process is of interest as a model f

180 for ATP binding caused both ATP binding and viral assembly to cease, suggesting that the ATP binding

181 en viral envelope (Env) and receptor directs viral assembly to cell-cell contact sites to promote eff

182 e-specific host factors may aid in directing viral assembly to distinct destinations.

183 ct was assayed for dependence on Ubc9 during viral assembly, trafficking, and Env incorporation.

184 aphy with electron microscopy to investigate viral assembly, viral infection of cells, and neutraliza

185 ecific role of the envelope glycoproteins in viral assembly, we created chimeric SeVs whose HN (rSeVh

186 egions in the fusion glycoprotein that drive viral assembly, we further our understanding of how thes

187 Because this matrix function is integral to viral assembly, we reasoned that this would be reflected

188 ell proteins that interact with pp150 during viral assembly, we utilized yeast two-hybrid analyses to

189 eiotropic effects: Mutation of Gln287 blocks viral assembly while mutation of Arg299 permits assembly

190 he Sulfolobus ESCRT machinery is involved in viral assembly within the cytoplasm and in escape from t

191 the relocation of SNAP-23 to the cytoplasmic viral assembly zone, and knockdown of SNAP-23 inhibited