ライフサイエンスコーパス: viral factor

1 (F) protein of RSV 2-20 is a mucus-inducing viral factor.

2 ch bacterial transcription is regulated by a viral factor.

3 ach case initiated predominantly by a single viral factor.

4 rge extent with a limited number of host and viral factors.

5 roduction is limited by cellular rather than viral factors.

6 er is RTA responsive in the absence of other viral factors.

7 on the contribution of immunosuppression and viral factors.

8 ough the association with these cellular and viral factors.

9 come is affected by identifiable clinical or viral factors.

10 he ER when expressed in the absence of other viral factors.

11 splant factors remained significant, but not viral factors.

12 s driven by the interaction between host and viral factors.

13 This process is influenced by many host and viral factors.

14 stigated their association with clinical and viral factors.

15 lpha produced by NK cells are important anti-viral factors.

16 ized infection stage across diverse host and viral factors.

17 Host adaptation likely involves multiple viral factors.

18 ility of influenza is determined by host and viral factors.

19 quires lifelong adherence and mostly targets viral factors.

20 hat this class of proteins acted as positive viral factors.

21 n expressed in vitro in the absence of other viral factors.

22 ine the risk of progression to LRD more than viral factors.

23 the intricate relationship between host and viral factors.

24 otype, indicating a likely role for multiple viral factors.

25 ase progression is associated with host, not viral, factors.

26 ne how the ISG IFIT3 is used by IAV as a pro-viral factor, advancing our understanding of IFIT3 funct

27 Identification of cellular and viral factors affecting the formation of the membrane-bo

28 Although viral factors almost certainly play a role in limiting h

29 These viral factors alone, however, could not account for the

30 Additional viral factors also contribute to this balance.

31 ow genetic perturbation of critical host and viral factors alters the timing, course and progression

32 were consistent with HO-1 acting as an anti-viral factor and these findings suggested that induction

33 between baseline patient characteristics and viral factors and baseline plasma antigen levels were as

34 is in the absence of other de novo-expressed viral factors and can act in synergy with the Fas recept

35 Viral factors and host barriers influence virally induce

36 pe 1 (HIV-1) and other lentiviruses, but the viral factors and mechanism of nuclear entry have not be

37 Our results reveal the roles of host and viral factors and provide a roadmap for the dissection o

38 The relationships among host immune and viral factors and the severity of liver disease due to h

39 sed treatment are dependent on both host and viral factors and vary markedly among patients infected

40 n and assess the impact of cellular factors, viral factors, and antivirals.

41 criptional repression of p21 by cellular and viral factors, and delve in detail into its possible bio

42 ssociation between atherosclerosis, host and viral factors, and liver histological features.

43 However, it is likely that other host and viral factors are also involved in determining the outco

44 Multiple clinical and viral factors are associated with plasma antigen level a

45 Host anti-viral factors are essential for controlling SARS-CoV-2 i

46 It is not entirely clear which host and viral factors are responsible for the viral set point.

47 luminates the collaboration between host and viral factors as an essential interaction for viral reac

48 Studies have identified both host and viral factors associated with disease progression.

49 nd generalized linear models were tested for viral factors associated with dispersal.RESULTSAcross pa

50 HIV-1 clade-C infected infants and identify viral factors associated with early bnAb responses.

51 A better understanding of the host and viral factors associated with human immunodeficiency vir

52 Here we evaluated host demographic and viral factors associated with RSV disease severity in 32

53 e used whole-genome HCMV data to investigate viral factors associated with the clinical outcome.

54 d the demographic, behavioral, metabolic and viral factors associated with transient elastography-mea

55 aks of respiratory tract infections, but the viral factors associated with virulence remain unknown.

56 Pieces of the puzzle as they relate to viral factors-both human herpes virus 8 (HHV-8) and huma

57 Environmental, host genetic, and viral factors can affect the risk of HCC in individuals

58 Conversely, perturbation of viral factors can create distinct, abortive trajectories

59 ls are infected with EBV, latency-associated viral factors confer resistance to various inducers of a

60 latency, how viral genomes persist or which viral factors contribute to genome maintenance and/or re

61 l function in viremic condition, and several viral factors contribute to these defects.

62 These observations suggest that additional viral factors contribute to virulence.

63 tems are enabling identification of host and viral factors contributing to breakdown of the unique BB

64 vides critical insight into the cellular and viral factors contributing to the establishment of laten

65 However, little is known about the viral factors contributing to the high virulence of MERS

66 To investigate the viral factors contributing to these phenotypes, we gener

67 However, the viral factors contributing to these specific clinical di

68 Little is known about viral factors contributing to virulence, and there are c

69 al nonstructural protein 1 (NS1) is the main viral factor counteracting the host antiviral response.

70 In this study, we aimed to determine the viral factors critical for aerosol transmission of the 2

71 Multidimensional host and viral factors determine the clinical course of COVID-19.

72 identified the glycoprotein to be the major viral factor determining JUNV attenuation.

73 Viral factors (e.g. transmitted cytotoxic T- lymphocyte

74 an papillomavirus (HPV) DNA genome relies on viral factors E1 and E2 and the cellular replication mac

75 that is activated by early and intermediate viral factors: E1A, E4 Orf3, and IVa2.

76 The viral factor E2 restores specificity through a physical

77 es, implicated IFN-gamma as the primary anti viral factor early in infection.

78 ed by this host cell gene in addition to the viral factor, EBNA2, and may help to explain how LMP1 is

79 om its own promoter in the presence of other viral factors, either by coexpression with ICP0 or by in

80 l neurological impairment worldwide, but the viral factors enabling vertical spread across the placen

81 ously unknown function of HCPro in which the viral factor enhances the stability of its cognate capsi

82 However, little is known about the viral factor/event which triggers the apoptotic process.

83 to identify host proteins down-regulated by viral factors expressed during the latest phases of vira

84 e of the mRNA but most likely on one or more viral factors expressed in the infected cell.

85 ified the PRV US9/gE/gI protein complex as a viral factor facilitating the proteasomal degradation of

86 IMPORTANCE Serving as a key viral factor for chronic hepatitis B virus (HBV) infecti

87 ur research is in identifying pUL25 as a key viral factor for genome uncoating.

88 biological properties and is implicated as a viral factor for HCV mediated pathogenesis.

89 e requisite information and require no other viral factors for appropriately polarized trafficking.

90 ng the portal proteins pUL6 and pUL17 as key viral factors for engaging the terminase complex with th

91 e of the hidden open-reading frames encoding viral factors for pathogenicity.

92 d with HIV-1 integrase and nucleocapsid, key viral factors for reverse transcription and integration.

93 the potential utility of detecting host and viral factors for the diagnosis and prognosis of NPC is

94 The role of viral factors has been studied extensively and has been

95 to the EC status; instead, several host and viral factors have been discussed as playing a role.

96 With the advance of HBV virology, several viral factors have been found to be associated with the

97 Viral factors have long been the subject of intense rese

98 linical (ALT, use of antiviral therapy), and viral factors (HBV DNA), which had acceptable-excellent

99 tion is performed by the extensively studied viral factor HCPro, which seems to use an unknown mechan

100 erived factors (IFN-gamma and endotoxin) and viral factors (HCV core protein) act in tandem to induce

101 sis stage, interleukin 28B polymorphism) and viral factors (hepatitis C virus [HCV] genotype, viral l

102 Our genome-wide screen for pro-viral factors identifies the cytoplasmic DNA exonuclease

103 ar targeting of VP22 is independent of other viral factors, (ii) the carboxyl terminus of VP22 is req

104 E1 deleted and for the study of cellular or viral factors important for viral replication.

105 A key viral factor in Ebola virus IB formation is the nucleopr

106 One key viral factor in this process is latent membrane protein

107 xamine the relative significance of host and viral factors in activating early gene expression of the

108 modification occurs in the absence of other viral factors in cell lines which stably express its gen

109 cular, supports the idea of the relevance of viral factors in contributing to this rare HIV-1 phenoty

110 vestigated the role of cis- and trans-acting viral factors in EV IRES translation in living cells.

111 conditional approach to dissect the role of viral factors in HCMV biology.

112 for assessing the interplay of host cell and viral factors in pathogenesis and for screening for inhi

113 ng, demonstrating the need for both host and viral factors in the curtailment of viral replication wi

114 The role of viral factors in the pathogenesis of chronic hepatitis C

115 mouse models, providing an expanded role for viral factors in the pathogenesis of metabolic disorders

116 nterstitial pneumonia, the roles of host and viral factors in the pathogenesis of pneumonia are not w

117 e same cell line points to the importance of viral factors in the switch from latency to lytic cycle.

118 Two key viral factors in this process are the latent membrane pr

119 irulence of SIVsmPBj, implicating additional viral factors in this unique virus pathogenesis.

120 ts highlight a potentially important role of viral factors-in particular, HIV subtype and accessory p

121 00/mm3, HCT comorbidity index score >=3, and viral factors including symptomatic infection, human rhi

122 titis C correlates with several clinical and viral factors, including age, viral genotype and initial

123 Viral factors, including rotavirus gene 4, are important

124 how HIV-1 Tat protein, an immunosuppressive viral factor, induces the PD-1/PD-L1 coinhibitory pathwa

125 Evidence suggests that both host and viral factors influence disease severity after infection

126 Host and viral factors influence the HIV-1 infection course.

127 However, the viral factors influencing the clinical outcome of RSV in

128 1-kDa protein encoded by UL138 (pUL138) as a viral factor inherent to low-passage strains of human cy

129 clin A leads to apoptosis, suggesting that a viral factor inhibits the deleterious effects of cyclin

130 st models in which to study the cellular and viral factors involved in acute corneal infection.

131 The specific viral factors involved in such HCMV-mediated modulation,

132 The study of viral factors involved in the production of severe dengu

133 Still, the viral factors involved in these events remain largely ob

134 nflammatory lipoxin A4 in host cells and the viral factors involved in this process using in vitro KS

135 This viral factor is directly involved in diverse steps of vi

136 Extracellular HCV core is a viral factor known to cause HCV-induced T cell impairmen

137 of genetically inactivating highly conserved viral factors known to limit the host innate immune resp

138 The opposing goals of host and viral factors lead to evolutionary arms races that can b

139 e autocrine/paracrine production of cellular/viral factors leading to a metabolic encephalopathy.

140 Many viral factors manipulate the host post-translational mod

141 is common and RRP is rare, other host and/or viral factors may contribute to pathogenesis.

142 Integration of these viral factors may help to determine the disease state of

143 uses dysregulate bone homeostasis, detailing viral factors, molecular mechanisms, host immune respons

144 ed cell motility, indicating that additional viral factors must be involved.

145 fibroblasts and identified the cellular and viral factors needed.

146 Host and/or viral factors not accounted for by viral load or mutatio

147 nflammatory environment and upregulated anti-viral factors notably APOBEC3A.

148 ohort analysis of the effects of hepatitis B viral factors on risk for HCC, based on metabolic factor

149 nguishing between the influences of host and viral factors on viremia.

150 loss of Ser-2 RNAP II does not require other viral factors or the context of the infected cell.

151 ogenous and may involve host immune factors, viral factors, or both.

152 Cellular and viral factors participate in the replication cycle of ro

153 ses appear to underlie Long COVID, including viral factors (persistence, reactivation, and bacterioph

154 Viral factors play a minor role.

155 ar factors, previous evidence indicates that viral factors play a role in the initiation of viral DNA

156 the viral genome are needed to identify such viral factors, polymorphisms at the UL4 gene locus were

157 viral RdRP (NS5) from that of other host or viral factors present in the cytoplasmic extracts, the N

158 Different viral factors probe different aspects of CHB.

159 Here, we sought to determine how viral factors regulate cell death.

160 Here, we sought to determine how viral factors regulate these processes.

161 Although several viral factors regulating airborne transmission (AT) have

162 Cellular and viral factors regulating LTR activity contribute to HIV-

163 it, it is surprising that specific heritable viral factors remain mostly elusive.

164 nucleocapsid protein (NC), the trans-acting viral factor required for genome packaging, disrupts the

165 polymerase (L protein), the two trans-acting viral factors required for both virus RNA replication an

166 esvirus infection and pathogenesis; however, viral factors required for transport have yet to be iden

167 e been identified, little is known about the viral factors required to alter metabolism.

168 B19V nonstructural protein 1 (NS1) was a key viral factor responsible for altering E2F1-E2F5 expressi

169 regulator of the viral life cycle and a main viral factor responsible for cytopathic effects and subv

170 Influenza NS1 is the main viral factor responsible for the control of host innate

171 leted virus (DeltaSH) to show that SH is the viral factor responsible for the inhibition of IL-6 sign

172 ovirus evolution and will help elucidate the viral factors responsible for the broad host range of pa

173 at the entry level and further explored the viral factors responsible for the lack of genomic RNA re

174 The viral factors responsible for the reduction in Ser-2 CTD

175 tral importance to identify the cellular and viral factors responsible for this trafficking event.

176 elocalization mechanism utilizes a different viral factor(s) and available evidence suggests the invo

177 To identify the viral factor(s) involved, we infected cells with several

178 This second step depends on an early viral factor(s) that has eluded identification for over

179 In this study, we aimed to identify the viral factor(s) that mediate monocyte-to-MPhi differenti

180 fection, suggesting the involvement of other viral factor(s).

181 susceptibility such as mitochondrial DNA and viral factors such as Chlamydia pneumoniae are reviewed.

182 Additionally, viral factors such as the HIV-1 accessory protein Nef ca

183 teraction in the presence of other important viral factors, such as the HPV16 E1 protein and the vira

184 enylation is triggered by multiple divergent viral factors, suggesting that altering the subcellular

185 Various cellular and viral factors target p300/CBP to modulate transcription

186 While the viral factor Tat is known for its transcriptional transa

187 cription factors, such as NF-kappaB, and the viral factor Tat, which through the recruitment of P-TEF

188 ECs from the same donor and identified a key viral factor that affected host susceptibility, the domi

189 ore, we conclude that soluble Vpr is a major viral factor that causes a disturbance in neuronal commu

190 We identify mutation PB2-627V as an emerging viral factor that confers dual ability to the virus to i

191 that capsid, not integrase, is the dominant viral factor that dictates transportin 3 dependency duri

192 encoded growth factor (VGF) as an essential viral factor that induces cellular EGFR-Akt signaling to

193 ls infected with wild-type virus, Nef is the viral factor that interferes with the immune mechanisms

194 he infant's host environment, as well as the viral factors that affect disease outcome, is important

195 infection in mice was used to define host or viral factors that affect rotavirus viremia.

196 will introduce the conventional and emerging viral factors that are associated with clinical outcomes

197 at failure to form condensates or to recruit viral factors that are critical for assembly results in

198 rvoir or intermediate hosts, but the host or viral factors that are important for OPXV host range in

199 A number of viral factors that are present in HIV-1 preintegration c

200 During reactivation, other viral factors that are required for lytic replication ar

201 The constellation of viral factors that contribute to developing enteric dise

202 A better understanding of viral factors that contribute to influenza A virus (IAV)

203 otropic virus infection to identify host and viral factors that contribute to invasion of the brain,

204 Understanding the host and viral factors that contribute to the controller phenotyp

205 his review explores the human, mosquito, and viral factors that contribute to the global spread and p

206 cell culture, and little is known about the viral factors that determine HCMV epithelial cell tropis

207 o poultry is selective and likely depends on viral factors that determine host range restriction.

208 oads among individuals, and why searches for viral factors that determine viral load have had limited

209 Our understanding of the cellular and viral factors that dictate this switch from silenced to

210 eful background in which to identify certain viral factors that enhance transmissibility.

211 of HIV reservoir size, we hypothesized that viral factors that facilitate the evasion of such respon

212 Here, we discuss cellular and viral factors that impact on antiviral RNAi and the cont

213 The host and viral factors that impact the gammaherpesvirus-driven ge

214 iral infections are associated with host and viral factors that impair effective antiviral immunity.

215 ppears to be closely correlated with unknown viral factors that increase intracellular lipid levels.

216 One of the viral factors that is expressed during reactivation is o

217 We studied host and viral factors that may contribute to the control of vira

218 s, innate and adaptive immune responses, and viral factors that may contribute to this phenotype.

219 isms involving the interplay of cellular and viral factors that may depend on the cell type.

220 pproaches might be used to identify host and viral factors that mediate roseolovirus pathogenesis.

221 Here we discuss a variety of cellular and viral factors that modulate the outcome of virus infecti

222 e systems can be used to define cellular and viral factors that play a role in HHV-6A/B integration.

223 Understanding viral factors that promote cross-species transmission is

224 lymphomagenesis, identification of host and viral factors that promote germinal center responses dur

225 animal model with which to identify host and viral factors that regulate gammaherpesvirus latency.

226 in the cytoplasm in these cells, but also by viral factors that repress transcription from this locus

227 Importantly, host and viral factors that selectively affect the gammaherpesvir

228 phase of infection are more associated with viral factors, that is set point VL, than with host fact

229 h cellular membranes in the absence of other viral factors, the pol domain of gene 1 was cloned and e

230 e for other viruses, HCV depends on host and viral factors to complete its life cycle.

231 The mechanisms that link viral factors to defective adipose tissue function and a

232 tudy addresses the potential contribution of viral factors to HIV disease progression in eight infant

233 RB and p53 families and an ability of these viral factors to induce S-phase in quiescent cells.

234 Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx viru

235 ransiently expressed in the absence of other viral factors, U(L)31 protein localized diffusely in the

236 tiply infected cells, the saturation of anti-viral factors upon infection of cells, and rate limiting

237 No specific viral factors were identified that are associated with h

238 ral responses are governed to some extent by viral factors, whereas sustained responses may be more i

239 We conclude that LC may be a viral factor which promotes the replication of NV in cel

240 The environmental milieu and innate anti-viral factors which are modulated during macrophage diff

241 We propose that PE38 is one of at least two viral factors which collectively evoke a cellular apopto

242 fluenced by interactions with other host and viral factors will help to elucidate a mechanistic role

243 pathogenicity depends on the interference of viral factors with components of the host defense system

244 We generated chimeric viruses and found that viral factors within the structural and nonstructural re

245 Host and viral factors work together to affect a variety of molec

246 This suggests the involvement of other viral factors yet to be identified.