ライフサイエンスコーパス: viral genome

1 ls of exceptional stability that protect the viral genome.

2 lution at multiple loci dispersed across the viral genome.

3 acers) that target specific sequences in the viral genome.

4 ult in A3G signature G-to-A mutations in the viral genome.

5 ore efficiently transcribe and replicate the viral genome.

6 tein and a deletion within the 3'-UTR of the viral genome.

7 to form the convex shell that surrounds the viral genome.

8 L1 at the terminal repeat (TR) region of the viral genome.

9 ulence associated with rearrangements of the viral genome.

10 ds in the terminal repeat (TR) region of the viral genome.

11 d transcriptional output from the integrated viral genome.

12 pecifically to the 3' untranslated region of viral genome.

13 d to a reduced nucleosome positioning on the viral genome.

14 The primary role of capsid is to package the viral genome.

15 logenetic classification based on the entire viral genome.

16 sible because of the segmented nature of the viral genome.

17 vide a stable, genetically defined source of viral genome.

18 that encase the double-stranded DNA (dsDNA) viral genome.

19 functions and requires interaction with the viral genome.

20 by the first open reading frame (ORF) of the viral genome.

21 mal membrane, and permits the release of the viral genome.

22 em for UUKV that permits manipulation of the viral genome.

23 izes stem-loop sequences engineered into the viral genome.

24 n exonuclease-inactivating mutation into the viral genome.

25 y of a complex that is able to replicate the viral genome.

26 ognizes a poly-uridine/cytosine motif in the viral genome.

27 irus-like particle that does not contain the viral genome.

28 ecognition because of characteristics of the viral genome.

29 G2 phase is independent of the nature of the viral genome.

30 activity of cellular enzymes that mutate the viral genome.

31 ies, whose codons are overrepresented in the viral genome.

32 CTCF peaks relative to the Ser5P form in the viral genome.

33 hich are noninfectious because they lack the viral genome.

34 role during the strategic mutagenesis of the viral genome.

35 II and preventing silenced chromatin on the viral genome.

36 as found in the 2C/3A junction region of the viral genome.

37 some L1 protein remains associated with the viral genome.

38 to efficiently replicate and transcribe the viral genome.

39 L1, from the minor capsid protein L2 and the viral genome.

40 e reconstruction across large regions of the viral genome.

41 r model of infection, and sequenced the full viral genomes.

42 e-specific integration and excision of their viral genomes.

43 recapitulating RSE-mediated recoding within viral genomes.

44 nes may be important modulators of infecting viral genomes.

45 ber of CD4(+) T cells that harbor infectious viral genomes.

46 e decoding of mobile chromosomal element and viral genomes.

47 HPV) through epigenetic modifications of the viral genomes.

48 opulations of both viral particles and naked viral genomes.

49 recombination is an important factor shaping viral genomes.

50 cted cell lines containing highly methylated viral genomes.

51 offers direct and experimental annotation of viral genomes.

52 ion whereas other designs create chimeras of viral genomes.

53 nome similar to vAc(P35), while in the other viral genome, a 24.4 kbp-fragment containing 10 essentia

54 RNA replication observed for the 5'-deleted viral genomes-a less stable ribonucleoprotein complex fo

55 , we identified 10 complete or near complete viral genomes allowing, for the first time, an assessmen

56 addition, neutralization of IL-8 diminished viral genome amplification in differentiating HPV-positi

57 Viral genome analysis indicates unusually low CpG dinucl

58 It inhibits reverse transcription of the viral genome and can also synthesize unanchored polyubiq

59 proteins that leads to amplification of the viral genome and expression of late viral genes.

60 s, VP35, is essential for replication of the viral genome and for evasion of host immune responses.

61 or significant accumulation of mutations per viral genome and for intracellular selection.

62 ultifunctional protein that encapsidates the viral genome and functions as an adapter between the vir

63 leus, thereby promoting nuclear entry of the viral genome and infection.

64 vaccine platform, due to the absence of the viral genome and its high protein density.

65 Variation in the viral genome and negative effects of serial vaccination

66 SPR/Cas9 system disrupts latently integrated viral genome and provides long-term adaptive defense aga

67 These capsids help to organize the viral genome and replicative complex(es).

68 iced viral RNA transcripts, which encode the viral genome and the genes encoding viral structural pro

69 s tethering by binding simultaneously to the viral genome and to chromatin during mitosis.

70 We have characterized the viral genome and used this information to take steps tow

71 virus in cell culture before search for the viral genome and viral antigens.

72 rocess ensures rapid copying of the parental viral genome and will enable protein factors involved in

73 RE11-RAD50-NBS1 (MRN) DSB-sensing complex to viral genomes and activation of the ATM kinase can promo

74 lopment of novel antiviral drugs that target viral genomes and block viral replication.

75 ries to search for the presence of all known viral genomes and discover human T-lymphotropic virus 1

76 the history of virus dispersal from sampled viral genomes and infer the locations of ancestral infec

77 onal HSV-2 low-passage-number and laboratory viral genomes and initiated analysis of the genetic dive

78 virus capsids, which encapsidate and protect viral genomes and mediate entry into host cells.

79 identification of transmitted/founder (T/F) viral genomes and their progeny.

80 nome synthesis, methylation of the 5'-cap of viral genome, and polyprotein processing among other act

81 on of Tax, which drives transcription of the viral genome, and Rex, which favors expression of incomp

82 ed with antiviral signaling, the presence of viral genome, and the absence of HSV protein expression

83 ral protein expression, encapsidation of the viral genome, and the release of mature virions were imp

84 How chromatin is initially assembled on viral genomes, and which variant forms of the core histo

85 Furthermore, viral genomes are highly diverse, and using only the cur

86 escent infection resembling latency in which viral genomes are retained in a low number of neurons, v

87 , is critical for function, probably to wrap viral genome around the ring during packaging initiation

88 DNA to the host cell nucleus to maintain the viral genome as nuclear episomes, which are the basis fo

89 pparently coats but does not encapsidate the viral genome as visualized by atomic force microscopy.

90 viruses observed, suggesting that both core viral genomes as well as viral community structure were

91 sid proteins and secondary structures in the viral genome, as exemplified by the RNA bacteriophage MS

92 anism by which the viral core containing the viral genome associates with dynein and induces its peri

93 res for a large-scale comparison of complete viral genomes available in RefSeq.

94 ost for 1 year demonstrated mutations in the viral genome become fixed over time.

95 ggest that some L1 protein may accompany the viral genome beyond the endosomal compartment.

96 HIRA co-localizes with viral genomes, binds to incoming viral and plasmid DNAs

97 SET also allows ATM to localize to incoming viral genomes bound by protein VII during infection with

98 ced approximately 80% of the backbone of the viral genome, built atomic models for 16 RNA stem-loops,

99 orm this shell must be stable to protect the viral genome but also sufficiently flexible to disassemb

100 isolated HPAI H5N1 viruses that had similar viral genomes but differed substantially in their lethal

101 t a DNA damage response (DDR) is directed to viral genomes but is distinct from the response to cellu

102 infection, KAP1 is still associated with the viral genome, but its heterochromatin-inducing activity

103 not in cDCs, indicating that sensing of the viral genome by pDCs activates cDCs in trans to cross-pr

104 cological reagents, specific mutation in the viral genome by reverse genetics and confocal microscopy

105 Using differential staining of an incoming viral genome by small molecular dyes in selectively perm

106 NA replication complex and is brought to the viral genome by the viral proteins E1 and E2.

107 ane perturbation and recognition of incoming viral genomes by cytosolic nucleic acid receptors are re

108 Recoding viral genomes by numerous synonymous but suboptimal subs

109 ich the structure, function, and fate of the viral genome can be modulated by the transcriptionally c

110 Rapidly evolving viral genomes can adapt to this pressure by acquiring ge

111 se results, the alanine substitutions in the viral genome caused exaggerated syncytium formation, red

112 Once at the viral genome, CDK11 phosphorylated serines at position 2

113 rstones toward viral sequence annotation and viral genome classification.

114 Analysis of complete viral genomes collected from patients in western Africa

115 re, using deep genome sequencing 13 distinct viral genome constellations were differentiated.

116 70.8-kb circular double-stranded DNA (dsDNA) viral genome content, and identification of its cellular

117 cell transmission, only a minute fraction of viral genomes contribute to the progeny.

118 eveloped markedly larger lesions with higher viral genome copies in skin than did wild-type mice.

119 lts in the reduction of viral transcription, viral genome copy number and virus yield.

120 n human neurons than in MRC-5 cells, and the viral genome copy number-to-PFU ratio for VZV in human n

121 fluorescence microscopy, indicating a higher viral genome copy number.

122 for amplification of two large fragments of viral genome covering about 80% of the unique HIV-1 geno

123 DNA), which is a stable episomal form of the viral genome decorated with host histones and nonhistone

124 Here we provide evidence that the incoming viral genome dissociates from the TGN and associates wit

125 separation of reverse transcriptase from the viral genome during early steps of infection.IMPORTANCE

126 ributed to mutations that accumulated in the viral genome during its derivation.

127 ssures exist to maintain the fidelity of the viral genome during repeated reactivations from its late

128 cells are programmed to retain the incoming viral genomes during primary infection.

129 therwise acute viruses.Replication defective viral genomes (DVGs) can facilitate persistence of param

130 Replication defective viral genomes (DVGs) generated during virus replication

131 step of genome recognition is mediated by a viral genome-encoded RNA rather than a protein.

132 dditionally, miR-122 reduces the fraction of viral genomes engaged in protein translation.

133 s recruited to nuclear sites associated with viral genome entry in a SIM-dependent manner, consistent

134 act of A3B on productive BKPyV infection and viral genome evolution.

135 cumulated at nuclear pores that retained the viral genome for at least 4 h postinfection.

136 H motifs enables specific recognition of the viral genome for initiation of DNA packaging during viru

137 he palindromic structures at the ends of the viral genome for their replication.

138 ified infectious virus for up to 185 dpi and viral genomes for up to 400 dpi in lymphoid tissues of t

139 nces of integration for the evolution of the viral genome, for the telomere, and for the risk of dise

140 pUL25 protein is required for releasing the viral genome from capsids docked at nuclear pores.

141 system with a spacer that matched a partial viral genome from the metagenome.

142 a of (i) archaeal, bacterial, eukaryotic and viral genomes from cultured organisms, (ii) single cell

143 rotein that is suggested to protect incoming viral genomes from detection by the cellular DNA damage

144 on multiplex PCR for targeted enrichment of viral genomes from samples containing as few as 50 genom

145 equences in their respective donors and that viral genomes generally evolved early in infection accor

146 fluenced by events that occur soon after the viral genome has entered the host cell nucleus.

147 to suppress viral gene expression after the viral genome has integrated into the host cell genome, w

148 and breaks (DSBs) targeted to the integrated viral genome have been shown to decrease production of p

149 While many of those viral genomes have become inactivated, some copies of th

150 icular, the protein containers encapsulating viral genomes have been determined to high resolution us

151 Colinear alignments of the viral genomes identified segmental homologies to ERVs of

152 lay between the innate immune system and the viral genome in HCV control.

153 f EBV lytic promoters and helps maintain the viral genome in its latent state.

154 been linked to reverse transcription of the viral genome in target cells, the mechanism by which unc

155 te was observed, along with the detection of viral genome in the air at low copy numbers.

156 virus (IAV) life cycle is replication of the viral genome in the host cell nucleus.

157 d L1 proteolysis and retention of L2 and the viral genome in the late endosome/lysosome.

158 e proteins can accumulate on or close to the viral genomes in a sequential manner which may lead to t

159 and suggests that the exchange of RNA among viral genomes in an infected host occurs in multiple loc

160 ripts, we visualized active transcription of viral genomes in naturally infected cells.

161 n of PML NB proteins, which are recruited to viral genomes in order to repress viral transcription.

162 s used to determine k for all 3,905 complete viral genomes in RefSeq.

163 the MRN complex consistently colocalize with viral genomes in replication compartments (RCs), whereas

164 ent targeting results in a sharp increase of viral genomes in the host cell when the target is locate

165 sviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes.

166 r sites [serine (S)220 and S239] in the full viral genome increase LT levels and promote MCV virion p

167 tion of nucleotide substitution rates in the viral genome indicated an increase in the frequency of t

168 ction, with the detection of negative strand viral genome, indicating viral replication.

169 s the recruitment process, the newly formed, viral-genome-induced PML NB-like foci can fuse with exis

170 Packaging of viral genomes inside empty procapsids is driven by a pow

171 ion of the minor capsid protein, L2, and the viral genome instead of trafficking into the nucleus.

172 n of complex genomic rearrangements, such as viral genome integration, in paired-end sequence data.

173 To maximize the coding potential of viral genomes, internal ribosome entry sites (IRES) can

174 This process involves packaging of the viral genome into chromatin, which is often assumed to o

175 e intricate machinery that delivers a single viral genome into empty preformed capsids (encapsidation

176 in is responsible for the integration of the viral genome into the host cell chromosome.

177 HIV-1 integrates its viral genome into the host cell, leading to persistent i

178 g the virus to an F-pilus and delivering the viral genome into the host during infection, but how the

179 retroviruses must direct the movement of the viral genome into the nucleus to complete their replicat

180 ges the NPC and what triggers release of the viral genome into the nucleus.

181 lex (NPC), a key step during delivery of the viral genome into the nucleus.

182 e of the NPC, a key step for delivery of the viral genome into the nucleus.

183 capsid at a nuclear pore, and release of the viral genome into the nucleus.

184 ranscription initiation and packaging of the viral genome into viral nucleocapsids.

185 To identify the regions of the viral genome involved in this process, we used SELEX (sy

186 Terminal deletions at the 5' end of the viral genome involving an RNA secondary structure requir

187 to naive cells, it is not clear whether the viral genome is also transferred via this mechanism and

188 transcriptional activity across most of the viral genome is associated with high viral loads in infe

189 Replication of the hepatitis C viral genome is catalyzed by the NS5B (nonstructural pro

190 As a result, expression of the incoming viral genome is delayed.

191 After one viral genome is encapsidated, the internal pressure sign

192 In papillomavirus infections, the viral genome is established as a double-stranded DNA epi

193 us infection, a histone-free DNA copy of the viral genome is synthesized that must be loaded with nuc

194 The complete viral genome is transcriptionally active during infectio

195 Upon host cell entry, the viral genome is translated on endoplasmic reticulum (ER)

196 Characterization of unknown viral genomes is hindered by the many genomes populating

197 This property of viral genomes is unexplained.

198 pon viral injection, a small sequence of the viral genome, known as a spacer, is integrated into the

199 the determinants of SBVp32 virulence to the viral genome M segment.

200 the structural and functional features of a viral genome maturation complex, an essential intermedia

201 As part of its viral genome, MERS-CoV encodes a papain-like protease (P

202 onstrate detection of a soluble nucleic acid viral genome mimic.

203 ustering affects both viral partitioning and viral genome numbers of KSHV.

204 Propagation of the viral genome occurs within replication complexes, and un

205 egion (nucleotides [nt] 5199 to 5338) of the viral genome of positive sense.

206 The specific infectivities (PFU per viral genome) of HSV(chol) and HSV(des) were similar, su

207 Viral genomes often encode genes derived from their host

208 th the detection of serum viremia and plasma viral genomes on day 4 p.e.

209 ata sets than published metagenome-assembled viral genomes or isolates.

210 icate within the lungs or generate defective viral genomes or to differences in levels of costimulato

211 n is replication-competent with no change in viral genome over time.

212 ed in this paper reveals a new mechanism for viral genome packaging and will provide a tractable syst

213 ay be excluded as an essential mechanism for viral genome packaging.

214 ein controls replication, transcription, and viral genome partitioning during the viral infectious li

215 proteins expressed from the L4 region of the viral genome perform essential roles in moving the infec

216 of B cells is predominantly latent, with the viral genome persisting as a multicopy episome and expre

217 In this quiescent state, the viral genome persists as a circular, histone-associated

218 A packaging signals mapping along the entire viral genome" play the critical role in poliovirus packa

219 C3H preferentially binds to sequences in the viral genome predicted to contain duplexes, a property t

220 either the reverse transcription step of the viral genome prior to HK2 viral particle formation and/o

221 miRNAs, the interactions of miR-122 with the viral genome promote viral RNA accumulation in cultured

222 fections were also identified, and assembled viral genomes provided additional information on genotyp

223 d progenitors was not associated with robust viral genome replication and progeny production, while m

224 knockdown of NAP1L1, Bin1 or VAP-A impaired viral genome replication and recapitulated the perinucle

225 essing of MVC mRNAs at (pA)p is critical for viral genome replication and the optimal expression of N

226 protein during latency and is important for viral genome replication and transcription.

227 sis and glutaminolysis, but not FAS, inhibit viral genome replication and, interestingly, are require

228 demonstrate that SUMO2/3 is recruited to E2A viral genome replication domains through noncovalent int

229 duce sumoylation and the assembly of SUMO2/3 viral genome replication domains.

230 and will enable protein factors involved in viral genome replication to be specifically localised in

231 stimulate cellular proliferation to support viral genome replication with minimal activation of the

232 Deleting ORF7 did not affect viral entry, viral genome replication, or the expression of typical v

233 els of KSHV lytic transcripts, proteins, and viral genome replication.

234 ns in inactivating MRN and ATM to facilitate viral genome replication.

235 of hepatitis C virus (HCV) is essential for viral genome replication.

236 -acting function of 3D that is essential for viral-genome replication.

237 Streptococcus pyogenes Cas9 cleavage of the viral genome requires the presence of a 5'-NGG-3' protos

238 nomic coverage between different loci in the viral genome, respectively, due to large deletions in th

239 ne expression and excision of the integrated viral genome resulting in reactivation.

240 At least some of the quiescent viral genomes retain the capacity to reactivate, resulti

241 Sequencing of plasma and CSF viral genome revealed only two non-coding changes compar

242 opens unprecedented opportunities to analyse viral genomes, revealing conserved structural features a

243 rmation (NCBI) database contained >2 million viral genome sequences and a reference set of 4000 vira

244 By analysing 92 newly generated viral genome sequences from blood donors and recipients,

245 Two novel influenza A-like viral genome sequences have recently been identified in

246 led to a dramatic increase in the number of viral genome sequences identified primarily from metagen

247 enome sequences and a reference set of 4000 viral genome sequences that cover a wide range of known

248 Partial or full-length viral genome sequences were generated in 86% of RNA-seq-

249 We report the first use of whole viral genome sequencing to identify nosocomial transmiss

250 e data are consistent with a model involving viral genome sequestration into such structures, thereby

251 The viral genome shares 75.4% nucleotide identity with a pro

252 Phylogenetic analysis of the viral genome showed that SFTS virus represents a new lin

253 cting viral genomes to cooperatively promote viral genome silencing.

254 is a complex event where the latent episomal viral genome springs back to active transcription of lyt

255 ever, transgenic CRISPR/Cas9 system-mediated viral genome targeting has not been reported as an antiv

256 is also involved in the transcription of the viral genome that it delivers to the nucleus.

257 formation and excision to release a circular viral genome that was subsequently lost.

258 ow us to quantitate myeloid cells containing viral genomes that lead to productive infection in SIV-i

259 o release the contained reverse-transcribing viral genome, the capsid must disassemble in a process t

260 Lassa virus protects its viral genome through the formation of a ribonucleoprotei

261 omeres, remains associated with the incoming viral genome throughout mitosis and transiently resides

262 s viral assembly by blocking transfer of the viral genome to assembly sites.

263 hingolipid biosynthesis, not reported in any viral genome to date.

264 oncert to convert single-stranded RNA of the viral genome to double-stranded DNA that is then integra

265 Some designs merely modify a single viral genome to improve on the age-old method of attenua

266 suggesting strong selective pressure on the viral genome to maintain sequence fidelity during reacti

267 structure that associates with the condensed viral genome to produce the mature infectious conical co

268 evolved a unique strategy for delivering the viral genome to the nucleus of dividing cells.

269 rt that some L1 protein traffics with L2 and viral genome to the nucleus.

270 a pH of ~5 to clear a physical path for the viral genome to transit from the viral interior to the c

271 sm to translate viral proteins and replicate viral genomes to avoid or disable the host defense mecha

272 ed to nuclear domains that contain infecting viral genomes to cooperatively promote viral genome sile

273 of biologically important RNAs, ranging from viral genomes to long noncoding regulatory RNAs.

274 V requires the viral protein, LANA1, to bind viral genomes to nucleosomes arrayed on both cellular an

275 the MTOC, potentially aiding in the delivery viral genomes to the nucleus.

276 Daclatasvir greatly reduced delivery of viral genomes to these core clusters without altering HC

277 Some host factors are diverted for the viral genome translation, some are recruited to improvis

278 gic degradation, whereas PLA2G16 facilitates viral genome translocation and prevents clearance.

279 volutionary rate estimates across almost all viral genome types and replication strategies, and we ex

280 ng on newly incorporated genetic elements in viral genomes, under conditions of energy limitation.

281 rus RNA in CSF and plasma, and sequenced the viral genome using an unbiased metagenomic approach.

282 The protocol can be used to sequence other viral genomes using the online Primal Scheme primer desi

283 P) is known to mediate the nuclear import of viral genome via its nuclear localization signals.

284 to 24 months after infection, from which the viral genome was also sequenced; (ii) we compared 2 mode

285 otiorum, a full-length cDNA of the 14,538-nt viral genome was cloned.

286 Viral genome was detected in 21 (2.3%) samples from 9 he

287 ng a conserved 3' untranslated region of the viral genome was evaluated.

288 Ultra-deep sequencing of the viral genome was performed on 11 entecavir-treated and p

289 The full viral genome was sequenced by primer walking.

290 ns, while low numbers of copies of influenza viral genome were detected in the air, predominantly at

291 Complete and partial viral genomes were assembled and used to measure the num

292 Rep-encoding single-stranded DNA (CRESS DNA) viral genomes, were identified.

293 data for cytidine deaminase activity on the viral genome, which causes an asymmetric increase in G t

294 enriched on the nontranscribed stand of the viral genome, which is also the lagging strand during vi

295 mary role is to promote transcription of the viral genome, which persists as an extrachromosomal DNA

296 in these factories and served to transcribe viral genomes, which coincided with an overall decrease

297 MCC tumors contain integrated copies of the viral genome with persistent expression of the MCPyV lar

298 Analyses of viral genomes with ecological and epidemiological data y

299 ikely arranged as capsomeres, stabilizes the viral genome within the subviral complex during intracel

300 r class, which appear to directly target the viral genome without affecting cell viability.IMPORTANCE