ライフサイエンスコーパス: viral titer

1 a sensitivity, it also resulted in decreased viral titer.

2 controls in the TG based on measurements of viral titer.

3 mph node responses and a lesser reduction in viral titer.

4 ed syncytia despite no significant change in viral titer.

5 the collected supernatant is higher than the viral titer.

6 ty of basal gene expression and the yield of viral titer.

7 d illness and later-time-point (day 6 to 10) viral titer.

8 (P < .05) that correlated with a decrease in viral titer.

9 s, infiltration of leukocytes, or changes in viral titer.

10 ed in delayed reovirus infection and reduced viral titers.

11 treatment that ultimately leads to increased viral titers.

12 VZV glycoprotein biosynthesis and diminished viral titers.

13 gain weight, and 10- to 100-fold higher lung viral titers.

14 neutralizing antibody responses, and reduced viral titers.

15 gen in cigarette smoke, resulted in enhanced viral titers.

16 e of CXCL10(-/-) mice, despite increased CNS viral titers.

17 t loss and clinical signs in the presence of viral titers.

18 istence enhances T-cell function and reduces viral titers.

19 ng failed to enhance TCD8 function or reduce viral titers.

20 BaP exposure also increased HPV16 and HPV18 viral titers.

21 ors, these mutants had drastically decreased viral titers.

22 ed apoptosis resulting in a dramatic drop in viral titers.

23 e CNS, leading to significantly higher brain viral titers.

24 ortality and showed drastically reduced lung viral titers.

25 ase activity that correlated with changes in viral titers.

26 immediate-early gene expression and lowered viral titers.

27 ery of beta-galactosidase and for neoplastic viral titers.

28 kinase activity, caused a 4-log decrease in viral titers.

29 ls by 48 h despite the continued presence of viral titers.

30 l vectors and have no detrimental effects on viral titers.

31 ction led to a 2.5- to 5.5-log10 decrease in viral titers.

32 enged animals, coinciding with reductions in viral titers.

33 nated animals also showed reduced nasal wash viral titers.

34 e of the virus or a significant reduction of viral titers.

35 cretion, which was associated with increased viral titers.

36 CD8(+) T cells into foci, modestly reducing viral titers.

37 d viral translation and, ultimately, overall viral titers.

38 les by 48 h postinfection, despite identical viral titers.

39 ginal HPV prime/boost reduced cervicovaginal viral titers 1,000-fold after intravaginal challenge wit

40 ic MCMV challenge, as evidenced by decreased viral titers (10(5) plaque-forming units to undetectable

41 effect was associated with a reduction in 1) viral titer, 2) viral gene expression, 3) IFN-gamma leve

42 o compared well to an additional data set on viral titer after experimental infection and treatment w

43 hose of other groups and had the lowest lung viral titers after challenge.

44 AS1411 results in a significant reduction of viral titers after DENV infection.

45 nization significantly reduced morbidity and viral titers after influenza challenge.

46 was accompanied by a millionfold increase in viral titer and a massive reduction in DWV diversity, le

47 Viral titer and bacterial load were compared following i

48 PD also had more severe infection (increased viral titer and pulmonary inflammation, and compromised

49 W) and basic (K and H) residues critical for viral titer and suggest that AII, BV2, and CP internal c

50 amivir to be efficient in reducing influenza viral titer and symptom intensity.

51 strate that these differences correlate with viral titer and that both the titer and expression diffe

52 ress gM, produced a 3- to 4-fold decrease in viral titers and a 50% reduction in average plaque sizes

53 ic effects were achieved with relatively low viral titers and correlated with a reduced proliferative

54 ovir were both equally effective in reducing viral titers and decreasing the duration of viral sheddi

55 agglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all

56 and CCR2-deficient mice exhibited increased viral titers and elevated expression of the liver enzyme

57 luenza virus infection led to decreased lung viral titers and enhanced survival.

58 pidly fatal disease associated with high CNS viral titers and extensive CNS apoptosis, whereas in 4-w

59 +) T cells had significantly lower pulmonary viral titers and greatly improved pulmonary function as

60 eassortant virus also significantly improved viral titers and HA protein yield in eggs.

61 S and 2009 H1N1 viruses exhibited comparable viral titers and histopathologies following virus infect

62 , B6-lpr mice had decreased liver and spleen viral titers and increased numbers of and increased gamm

63 Ifnlr1(-/-) mice of higher intestinal tissue viral titers and increased viral shedding in the stool.

64 ture infectious dose [TCID50]) in nasal wash viral titers and inflammation response.

65 Despite similar initial viral titers and inflammatory responses between wild-typ

66 fected Bax(-/-) mice had significantly lower viral titers and levels of activated caspase 3 in the br

67 species that belong to the same virus clade, viral titers and particle morphologies and compositions

68 imulation of autophagy resulted in increased viral titers and pathogenicity in the mouse.

69 their lungs were collected for evaluation of viral titers and pathological findings.

70 hich included prolonged viremia and elevated viral titers and persistence in the muscle, resulting in

71 Viral titers and RNA analyses revealed that mutant viral

72 ceiving a single dose (25 mg/kg) had reduced viral titers and showed less lung tissue injury, despite

73 However, deleting ORF10 reduced viral titers and the extent of cutaneous lesions signifi

74 The depletion of iNKT cells increased both viral titers and the frequency of EBV-infected B cells.

75 Ocular viral titers and vaccinia-specific antibody titers were

76 Ocular viral titers and vaccinia-specific antibody titers were

77 In mice, nalmefene treatment increased viral titers and was associated with more pronounced wei

78 in the lung associated with markedly reduced viral titers and weight loss after challenge with H1 and

79 istic regression (P = 0.04) along with race, viral titer, and genotype.

80 FN-lambda reduced the disease severity, lung viral titer, and inflammatory response in the lung.

81 lpr) mice had decreased morbidity, decreased viral titers, and an increased percentage and number of

82 uced type I interferon production, increased viral titers, and enhanced cell sensitivity to viral inf

83 subsets increases mortality, sustains higher viral titers, and impairs pulmonary CD8 T cell responses

84 yed reduced viral gene expression, decreased viral titers, and improved survival compared to the untr

85 ng antibodies, morbidity postchallenge, lung viral titers, and inflammatory cytokines.

86 served only one nucleotide change, low heart viral titers, and no heart and liver pathology in adult

87 ed with rIL-33 developed significantly lower viral titers, and pancreatitis was attenuated.

88 infection, they do reduce weight loss, lower viral titers, and promote recovery of mice challenged wi

89 a virus infection enhanced survival, lowered viral titers, and reduced clinical disease.

90 Myocardial inflammation, viral titers, and viral RNA levels were also reduced sig

91 Viral structural gene expression, viral titers, and viral spread are also enhanced in endo

92 rus-shedding rates than IHNV or where higher viral titers are required to initiate infection of naive

93 3-methyladenine (3-MA) markedly reduced the viral titer, as determined by assays measuring both cell

94 ive RT-PCR has an excellent correlation with viral titers, as measured by culture, and should be a us

95 At present, monitoring viral titer at sites of replication requires biopsy.

96 an indicator of successful vaccination), the viral titer at the time of peak lesion formation, antivi

97 spite there being no difference in mean lung viral titers between the groups.

98 dies, however, eliminated the differences in viral titers between the two groups, suggesting that the

99 6-lpr mice and eliminated the differences in viral titers between them.

100 after RSV infection) effectively reduced the viral titer but had a minimal effect on pulmonary inflam

101 n of unlicensed NK cells impaired control of viral titers, but depletion of licensed NK cells did not

102 SCP-null mutation decreased viral titer by 1,000 times and impaired but did not full

103 ty (CC(5)(0) = 30.9 +/- 1.1 muM) and reduced viral titer by 100-fold.

104 0 with 2.5 mM NVC-422 for 1 hour reduced the viral titer by 4 logs and 4.5 logs, respectively.

105 to a greater than 300-fold reduction in the viral titer by 48 h but had little effect on the number

106 n (r = 0.84) between quantitative RT-PCR and viral titer by cell culture.

107 , were highly efficacious, each reducing the viral titer by greater than 5.7 log10 compared to contro

108 cid changes (N133D/G198E) in the HA improved viral titer by more than 10-fold (reached a titer of 10(

109 .0 and bDNA-3.0 assays, a bias toward higher viral titer by the bDNA-2.0 assay was noted (P = 0.001).

110 .0 and bDNA-3.0 assays, a bias toward higher viral titer by the bDNA-3.0 assay was noted (P < or = 0.

111 ith defects in 3' RNA processing and reduces viral titers by >10-fold.

112 Wortmannin (WM) and LY294002 (LY) increased viral titers by 3-16 folds in primary mouse macrophages,

113 ced death in infected flies and increases in viral titers compared to those in WT flies.

114 in; however, it showed significantly reduced viral titers compared to those of the parental RABV stra

115 d by no loss in body weight and reduced lung viral titers compared to WT mice.

116 CVB3/0, had significantly higher mean heart viral titers compared with CVB3/0-infected adult mice.

117 .5% cidofovir significantly (P<0.05) reduced viral titers compared with tobramycin/dexamethasone or b

118 G(+) and CD8(+) cells dramatically increased viral titers, consistent with their synergistic but spat

119 ect viral replication, and respiratory tract viral titers correlate with both symptoms and measures o

120 onpermissive high temperatures, whereas high viral titers could be obtained at permissive low tempera

121 ng NAI drug efficacy using only the observed viral titer decay rates seen in patients.

122 viral replication than wild-type MEFs, with viral titers decreased at least 10-fold.

123 In contrast, the viral titers detected in the central nervous systems of

124 virus, tissues and tumor were harvested for viral titer determination.

125 recipients, which correlated with increased viral titers, diminished macrophage accumulation, and li

126 al [18F]-FHBG accumulation was identified at viral titers down to 1x10(7) pfu.

127 The reduction in viral titer downstream of PLD2 inhibition was dependent

128 g, (P = 0.008), and the mean combined ocular viral titer during the early (days 1-5; P = 0.0001) and

129 blockade prevented TCD8 impairment, reduced viral titers during primary infection, and enhanced prot

130 etrovirus-infected CD8-deficient I/LnJ mice, viral titers exceed the neutralizing capability of antiv

131 All mutant genomes tested showed reduced viral titers following growth in organotypic raft cultur

132 as well as increased and sustained pulmonary viral titers following influenza virus infection.

133 , decreased splenic pathology, and decreased viral titers from 10(6) pfu to undetectable levels.

134 pe were not significantly affected; however, viral titers generated from vectors with only 3- or 6-nt

135 Viral titers generated from vectors with R lengths reduc

136 Further, obese mice had elevated viral titers, greater lung inflammation and lung damage,

137 muM, SI > 100), which significantly reduced viral titer (>400,000-fold), and several analogs were sh

138 l E1A 10S and E1B 19k mRNA but not IIIa, and viral titers had fallen two logs by day 4 after injectio

139 of cellular responses by rapid reduction of viral titer, have been proposed.

140 d the cellular targets of infection, maximal viral titers, immune response to the viral infection, an

141 irus more rapidly, and increased the overall viral titer in multiple cell types.

142 BAL response correlated with a reduction in viral titer in nasal swabs and lungs, following challeng

143 has similar sensitivity as the corresponding viral titer in phosphate buffer despite the presence of

144 that succumbed to infection, including high viral titers in all organs, increased levels of liver fu

145 uced NS3 and E proteins and generated higher viral titers in amniotic epithelial cells from mid-gesta

146 ultimately resulted in significantly reduced viral titers in both A549 and differentiated normal huma

147 ral clearance in the periphery and increased viral titers in brain.

148 mportantly, WNV grew to significantly higher viral titers in chop(-)(/)(-) mouse embryonic fibroblast

149 for IFN-beta in control of WNV replication, viral titers in ex vivo cultures of macrophages, dendrit

150 result of failure in viral clearance because viral titers in granzyme B-deficient mice were similar t

151 itinib in WT mice resulted in 10-fold higher viral titers in heart tissues while suppressing by about

152 and reduced expression of viral proteins and viral titers in influenza virus-infected human lung aden

153 ring the primary infection did not influence viral titers in lung tissue.

154 Moreover, BST2(-/-) mice had lower viral titers in lungs following intranasal infection wit

155 the HBV enhancer I that contribute to higher viral titers in men.

156 In contrast, sunitinib had no effect on viral titers in mice deficient in both RNase L and PKR.

157 onstructs, were able to significantly reduce viral titers in nasal turbinates, lungs, and olfactory b

158 The observed increases in viral titers in NLRC5-deficient mice correlated with imp

159 Viral titers in sera were determined by plaque assay in

160 ntrast, HSV-2-infected GT KO mice had higher viral titers in spleen and liver and exhibited significa

161 ponse correlated with an improved control of viral titers in target organs after the development of t

162 5TERM P-PMO treatment reduced viral titers in target organs and protected mice against

163 Later, others reported decreased AD169 viral titers in the absence of ATM.

164 Concordantly, viral titers in the blood were higher following infectio

165 control the virus, exhibited persisting high viral titers in the brain after day 6, and died of viral

166 nstrate that death correlates with increased viral titers in the brain and that this loss of virus co

167 Importantly, the decreased viral titers in the brains of mice infected with the mut

168 Infectious viral titers in the CNS (brain and spinal cord combined)

169 matory response, leading to the reduction of viral titers in the CNS and survival of animals.

170 XCL10-/- mice possessed significantly higher viral titers in the CNS in comparison to WT mice consist

171 ted WT and CXCL1(-/-) mice possessed similar viral titers in the cornea during late acute infection.

172 RV-Ravn caused uncontrolled viremia and high viral titers in the liver, spleen, lymph node, and other

173 novel H1N1 influenza virus and assessed for viral titers in the nasal wash, morbidity, and mortality

174 ce at the time of infection modestly reduced viral titers in the nervous system suggesting in additio

175 Viral titers in the spleens, livers, lungs, and salivary

176 levels, and corneal pathology but increased viral titers in the stroma and trigeminal ganglion.

177 Viral titers in the tear film were determined by plaque

178 Viral titers in the tear film were determined by plaque

179 challenged with wild-type RSV A, DB1 reduced viral titers in the upper and lower airways by 3.8 log10

180 Correspondingly, viral titers in the upper-and lower-respiratory tract we

181 ptible to SeV than Ifit2(-/-) mice, although viral titers in their lungs were even higher.

182 UL24-betagluc replicated to wild-type viral titers in three different cell lines.

183 tment with favipiravir significantly reduced viral titers in tissue samples and reduced mortality rat

184 ) infection and regulates fecal shedding and viral titers in tissue.

185 and IFN-lambda, which resulted in decreased viral titers in vitro and in vivo.

186 rence of PLD delayed viral entry and reduced viral titers in vitro.

187 om mice that had been exposed to the highest viral titers in vivo induced the lowest levels of T cell

188 cells cultured with DC exposed to increasing viral titers in vivo resulted in a gradually decreased T

189 mice caused a significant reduction in lung viral titers, in contrast to those from control CII(-/-)

190 8+ cells from brain slices, and intratumoral viral titers increased 10-fold.

191 Intratumoral viral titers increased 5-fold.

192 By day 3 p.i., viral protein expression and viral titers increased dramatically in NPSCs with result

193 he percentage of DV-infected K562 cells, and viral titer (infected K562 cell supernatants) was measur

194 IFN-alpha showed significantly reduced lung viral titers, inflammation, and clinical disease than un

195 ding evidence that the observed reduction in viral titers is ISG15 dependent.

196 l challenge, as demonstrated by undetectable viral titers, lack of body weight loss, and a significan

197 d not alter resistance to viral infection or viral titer levels, suggesting that the main antiviral r

198 se of disease, as determined by weight loss, viral titers, levels of neutralizing Ab, and lung pathol

199 Viral titers measured from MG132-treated cells were repr

200 atment for at least 3 weeks during declining viral titers mitigated the programmed contraction of CD8

201 enhanced virion production nearly 5-fold and viral titers more than 10-fold.

202 mong all the vectors, the differences in the viral titers most likely reflected the impact of the hom

203 A two-log reduction in viral titers occurred despite blocking the cytotoxicity

204 ected in single living cells infected with a viral titer of 2 x 10(3.6) 50% tissue culture infective

205 orylated motif of MLV p12 and can rescue the viral titer of a strain with the lethal p12-PM14 mutatio

206 NVC-422 reduced the viral titer of HAdV-5, HAdV-8, HAdV-19, HAdV-37, and HSV

207 ne silencing and knockout events can enhance viral titers of both attenuated (Sabin strain) and wild-

208 dependent and sequence-specific reduction in viral titers of greater than 5 log(10), with a concomita

209 in vivo prolonged survival and reduced lung viral titers of mice challenged with influenza virus, as

210 K cells, macrophages, or microglia increased viral titers of oHSV in cocultures with glioblastoma cel

211 Following virus infection, the survival and viral titers of Piwi, Aubergine, Argonaute-3, and Zucchi

212 Viral titers of these chimeras indicate that exchange wi

213 ifs into the AAV capsid without compromising viral titer or infectivity.

214 ment to the infected brain have no effect on viral titer or survival following infection with a virul

215 educed c-Jun activation without altering the viral titer or viral antigen distribution.

216 deletions in HIV-based vectors do not alter viral titers or the in vitro and in vivo properties of t

217 in ferrets, delayed 81.39a treatment reduced viral titers, particularly in the lower respiratory trac

218 0(Old)) exhibited significantly higher heart viral titers, pathology, and weight loss than adult mice

219 (-/-)7(-/-) mice 24 hpi, at which time point viral titers peaked and started to be cleared.

220 Viral titers peaked at approximately 1 x 10(6) PFU on da

221 h and that inhibiting p53 leads to increased viral titers, potentially through modulation of the inte

222 ted in reductions in lethality, weight loss, viral titers, proinflammatory cytokine and chemokine exp

223 ies, which were found to correlate well with viral titer (r2=0.96, P<0.001 for D2R80A; r2=0.98, P<0.0

224 can explain differential phenotypes such as viral titer, receptor binding, and tissue tropism exhibi

225 ansgene showed a modest inhibitory effect in viral titers recovered from the supernatants of transfec

226 repressed by the six-finger peptide with the viral titer reduced by 90%.

227 to additional evaluation using an authentic viral titer reduction assay employing an epidemic strain

228 y was confirmed through a plaque assay where viral titer reduction was observed in the presence of se

229 th influenza A exhibited 2.75-log-fold lower viral titer relative to control mice.

230 malian cell types, although at the same time viral titers remain relatively low.

231 because even infections associated with high viral titers responded to reduction in immunosuppression

232 supernatant but had nearly 1,000-fold-higher viral titers, resulting in an increased specific infecti

233 Administration of PF-04178903 did not alter viral titers, severity of secondary bacteria infections

234 lian isolate demonstrated tissue tropism and viral titers similar to those of historical Lassa virus

235 type Con1 genome was infectious and produced viral titers similar to those produced by other infectio

236 vealed that all recombinant viruses produced viral titers similar to those produced by the wild-type

237 r PP2 demonstrated a 2- to 4-log decrease in viral titers, suggesting that SFK activity is required f

238 cific CD8(+) T cells, in the absence of high viral titers, sustained proinflammatory cytokine product

239 I molecules, are more efficient at reducing viral titers than are low-avidity CTL, thus establishing

240 -7.5 cells to produce nearly 100-fold-higher viral titers than the parental strain.

241 ated by conventional methods for determining viral titer that high concentrations of BaP increase HPV

242 ation of NK cells resulted in a reduction in viral titers that was dependent on gamma interferon secr

243 , the viruses lacking the G protein produced viral titers that were at least 10-fold lower than titer

244 In 24 rats with various viral titers, the %ID was correlated with ex vivo well c

245 n spite of a slight advantage of wt virus in viral titer, there were no differences in the severities

246 cytokine expression concomitant with reduced viral titers, thereby protecting mice from lethal infect

247 Males transmit lower viral titers through sperm than females transmit through

248 There was little difference in viral titer throughout the infection between the line 19

249 oth a delay in growth and a decrease in peak viral titer to approximately 10(4) PFU/ml.

250 ghly active antiretroviral therapy can lower viral titers to an undetectable level.

251 B plus PD-L1 blockade resulted in rebound of viral titers to original levels, the low dose of anti-4-

252 AV articular cartilage gene therapy with low viral titers to prevent and/or treat arthritis.

253 aches the brain stem) reduced nervous system viral titers to undetectable levels but did not alter br

254 nduced weight loss and mortality by reducing viral titers to undetectable levels throughout the cours

255 d that depending on the viral entity and the viral titer used for stimulation, induction of IFN-alpha

256 For about 50% of patients, the curve of viral titer versus time has two peaks.

257 y activation to the BaP-mediated increase in viral titer was determined by Erk pathway inhibition wit

258 ve mechanism for explaining this increase in viral titer was lacking.

259 he supernatant, but the observed increase in viral titer was not mirrored by an increase in infectivi

260 findings reveal that the early (day 0 to 5) viral titer was not the determining factor in the outcom

261 The reduction in viral titer was observed even when Roscovitine was first

262 Mean viral titer was similar in older and younger children.

263 A small reduction of viral titers was detected on day 5 in ferrets infected w

264 a IFNR-deficient (CD118(-/-)) mice, although viral titers were 2- to 3-fold higher in cornea and TG c

265 Peak viral titers were 46-fold higher in Hep3B transfected wi

266 To measure effectiveness, viral titers were analyzed in cornea and trigeminal gang

267 Survival, weight loss, and viral titers were assessed over a 14-day study period.

268 various doses of GCV and ACV, and infectious viral titers were determined by a green Raji cell assay.

269 ction were determined immunohistochemically, viral titers were determined by plaque assay, and pathol

270 Following corneal infection, HSV-1 viral titers were elevated in the nervous system of CXCL

271 rarectal challenge with pathogenic SHIV-Ku2, viral titers were eliminated more completely (to undetec

272 When viral titers were examined, high levels were initially o

273 sion and protein production were reduced and viral titers were increased in IRF-7(-/-) primary macrop

274 By day 7 posttreatment, viral titers were lower in both of the combined regimens

275 However, lung viral titers were markedly elevated in COX-2-/- mice rel

276 ed ferret nasal turbinate cells, and similar viral titers were measured in the nasal turbinates of in

277 Pulmonary viral titers were not different between strains and path

278 High viral titers were obtained from nasal turbinates and lun

279 different outcomes were observed after peak viral titers were reached: sustained viral clearance, tr

280 h disease was also significantly reduced and viral titers were reduced by 1 log at 24 hours postinfec

281 Lung viral titers were reduced by 50% in mice receiving D-4F.

282 cation proceeded through the late phase, but viral titers were reduced.

283 herpesvirus 68 (MHV-68), although early lung viral titers were significantly increased.

284 DWV viral titers were significantly negatively correlated wi

285 Viral titers were significantly reduced on some days aft

286 Since viral titers were too low, complete serotyping was not p

287 onger and had significantly higher peak mean viral titers when compared with the non-naive participan

288 ses; influenza cross-reactive T cells reduce viral titers, whereas Abs to nucleoprotein suppress indu

289 f JMJD2A, an H3K9me3 demethylase, attenuates viral titers, whereas its overexpression increases KSHV

290 in a 10-fold increase in HPV type 31 (HPV31) viral titers, whereas treatment with low concentrations

291 g adaptive immunity as manifest by increased viral titers, with an associated loss of its protective

292 tors, namely, CXCR3 and CCR2, does not alter viral titers within the brain but markedly reduces infla

293 by reduced T cell infiltration and increased viral titers within the brain suggesting that CXCL10 fun

294 and associated with a dramatic reduction in viral titers within the CNS, followed by viral persisten

295 sed mortality that correlated with increased viral titers within the CNS.

296 However, NKG2D neutralization increased viral titers within the liver, suggesting a protective r

297 fficiency (at least a 4-log reduction in the viral titer) within minutes, as well as the airborne hum

298 m(6)A in one viral genomic region increases viral titer without affecting RNA replication.

299 unrestricted in HUHEP mice resulting in high viral titers without pathologic effects.

300 le dramatically enhancing Ad replication and viral titer yields, characteristics indistinguishable fr