ライフサイエンスコーパス: viral tropism

1 fines the host range of the virus, known as 'viral tropism'.

2 on of human cervical tissue independently of viral tropism.

3 ntiviral agents as well as for understanding viral tropism.

4 f various protein complexes that enable wide viral tropism.

5 tor (CAR) and is thus a major determinant of viral tropism.

6 3 beta-repeats in human Ads, also influences viral tropism.

7 ontrol a unique molecular switch restricting viral tropism.

8 by the translational apparatus can determine viral tropism.

9 linical stage of HIV disease correlates with viral tropism.

10 permissive for HIV-1 infection regardless of viral tropism.

11 es or dendritic cells resulted in restricted viral tropism.

12 these strains play a major role in mediating viral tropism.

13 in the developing brain and their impact on viral tropism.

14 y stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary H

15 s, although a causative relationship between viral tropism and CD4+ T cell depletion has not yet been

16 the immune system is a major determinant of viral tropism and damage during visceral HSV infections.

17 tachment to cells plays an essential role in viral tropism and disease.

18 To ablate native viral tropism and facilitate binding of the pIX-incorpor

19 However, viral tropism and mechanism of spread in the CNS have no

20 virus strain is an important determinant of viral tropism and pathogenesis, and virus-receptor inter

21 has become a valuable tool for investigating viral tropism and pathogenesis.

22 correlate Env-receptor binding constants to viral tropism and pathogenesis.

23 Changes in coreceptor use strongly influence viral tropism and pathogenesis.

24 es derived from 3 subjects were analyzed for viral tropism and phylogeny.

25 t may have implications for the selection of viral tropism and the access of drugs to protease for sp

26 ty of binding of LCMV to alpha-DG determines viral tropism and the outcome of infection in mice.

27 the molecular mechanisms of host-restricted viral tropism and the potential for transmission of viru

28 iated deaths suggested marked differences in viral tropism and tissue damage compared with seasonal i

29 herefore necessary both to ablate endogenous viral tropism and to introduce novel tropism.

30 tal status of the retina profoundly affected viral tropism and transgene distribution.

31 dase (HN) protein plays an important role in viral tropism and virulence.

32 netics, virion association, and influence on viral tropism and/or dissemination.

33 , dependence on this protein for cell entry, viral tropism, and disease course.

34 d their use by HIV-1 strains largely explain viral tropism at the level of entry.

35 rophage tropic, and in chronic infection the viral tropism broadens to include B cells and CD8+ T cel

36 gp120 determines viral tropism by binding to target-cell receptors, while

37 routinely exploit the ability to manipulate viral tropism by swapping viral surface proteins.

38 Here we show that viral tropisms can also be regulated by tissue-specific

39 Addition of the 6xHis tag did not alter the viral tropism compared to wild-type AAV.

40 Although viral tropism could be altered, the chimeric envelope pr

41 es of glycans incorporated, thus controlling viral tropism for CD209-expressing cells.

42 ncreased HIV-1 expression is irrespective of viral tropism for chemokine receptors as previously sugg

43 coreceptors for HIV-1 entry which determine viral tropism for different cell types.

44 the small RNA profile could be used to infer viral tropism for ovaries among other aspects of virus b

45 born infants to coxsackievirus infection and viral tropism for the CNS, few studies have been aimed a

46 Viral tropism for the decidua and placenta is then depen

47 important in understanding the mechanism of viral tropism for the salivary glands and shedding in sa

48 Viral tropism for this particular cell type (which has b

49 a mutated form of JCV, leading to a shift in viral tropism from the glia to cerebellar granule cells.

50 batches, and was subsequently used to assess viral tropism in nonhuman primates.

51 responsible for strain-specific patterns of viral tropism in the murine central nervous system and r

52 Our results suggest that viral tropism may be influenced not only by the corecept

53 erminants of resistance and their effects on viral tropism on primary CD4(+) T cells.

54 tions can be made to its C terminus to alter viral tropism or add molecular tags and/or reporter prot

55 ccelerated mortality was not due to expanded viral tropism or increased replication.

56 a mechanism which does not influence either viral tropism or viral burden in the brain.

57 amino acid difference in VP1 known to shift viral tropism profoundly affects the quantity and qualit

58 e of gD-retargeted HSVs to determine whether viral tropism remained dependent on the interaction of g

59 ersistence, suggesting that NS1/2 determines viral tropism that is necessary for persistence.

60 nces disease processes through its effect on viral tropism, the emergence of viruses resistant to the

61 V particles that have expanded or retargeted viral tropism, the inserted sequences have been relative

62 ovirus (Ad) fiber protein largely determines viral tropism through interaction with specific cell sur

63 herapy applications, methods to alter native viral tropism to achieve cell-specific transduction woul

64 ions could be improved by restricting native viral tropism to selected cell types.

65 present on a flavivirus virion can influence viral tropism under certain circumstances.

66 In addition to expanding the viral tropism, V2 loop glycosylation at the three sites

67 ortant contexts, we proposed modification of viral tropism via genetic alterations to the viral fiber

68 ding chimerism analysis, CCR5 genotyping and viral tropism, viral isolation and sequence, viral reser

69 ince receptors are important determinants of viral tropism, we set out to map the CV-A24 receptor rep

70 Fetal tissues exhibiting the highest viral tropism were blood mononuclear cells and brain (ea

71 distribution pattern corresponded to broader viral tropism with neuronal infection in 14 (66.7%) of 2

72 vivo could provide a mechanism for expanded viral tropism with potential effects on the pathogenesis

73 boost virus infection in cis and can expand viral tropism without affecting coreceptor preference.