ライフサイエンスコーパス: virally

1 hereas knockdown of AIP by siRNA potentiates virally activated IFN production.

2 ntral to the efficient immune recognition of virally and malignantly transformed cells.

3 munotherapy has clinical activity in certain virally associated cancers.

4 geting nonviral antigens in immunotherapy of virally associated cancers.

5 ers' diarrhea and in tear fluid derived from virally associated corneal disease.

6 ults argued that the antitumor efficacy of a virally based transgene therapeutic relied strongly on a

7 Virally based transsynaptic tracing technologies are pow

8 of viruses and underscores the importance of virally-coded suppressors of gene silencing in virus inf

9 phoproliferative disorder (PTLD) to discover virally controlled therapeutic targets involved in lymph

10 amate release ex vivo in BNST from mice with virally delivered channelrhodopsin2 (ChR2) expression in

11 Using virally delivered designer receptors to specifically con

12 Here, we used virally delivered fluorescent probes and in vivo time-la

13 ed to enter trials in the next 1-2 years and virally delivered RNA interference and zinc finger trans

14 Virally delivered short interfering RNA (siRNA) ensured

15 Two model systems were utilized: virally delivered shRNA-mediated knockdown of Pink1 and

16 olinergic drugs, we infused physostigmine or virally delivered shRNAs targeting AChE into the hippoca

17 ype I interferons (IFN-I) in the efficacy of virally delivered therapeutic genes.

18 d yellow fluorescent protein (ChR2-eYFP) was virally delivered to this region in SOM-Cre mice.

19 hybrid gene delivery agents comprising both virally derived and synthetic materials (nanobiovectors)

20 We hypothesize that a virally-derived SBF may have initially hijacked cell cyc

21 ype of diffuse large B-cell lymphoma and the virally driven lymphomas.

22 Several viruses, including SARS-CoV, utilize virally encoded 2'-O-MTases to camouflage and obscure th

23 adenovirus virions must be processed by the virally encoded adenovirus proteinase (AVP) before the v

24 Key to both activities is the virally encoded alkaline exonuclease KSHV SOX.

25 Key to this destruction is the virally encoded alkaline exonuclease SOX.

26 fter dsDNA binding, or in complex with three virally encoded anti-CRISPR suppressors that inhibit dsD

27 We previously showed that the virally encoded BPLF1 protein interacts with and regulat

28 The phosphoprotein (P) is virally encoded by the Rhabdoviridae and Paramyxoviridae

29 abundant tegument protein, as being the only virally encoded component responsible for these cytoskel

30 be common features of DNA transport through virally encoded conduits.

31 nts the first high-resolution structure of a virally encoded DNA-translocating conduit.

32 Viruses are known to use virally encoded envelope proteins for cell attachment, w

33 ed ribonuclease H (RNase H) remains the only virally encoded enzymatic function not targeted by curre

34 ed ribonuclease H (RNase H) remains the only virally encoded enzymatic function yet to be exploited a

35 This reaction is catalysed by the virally encoded enzyme integrase (IN) and is facilitated

36 he human herpesviruses because it requires a virally encoded enzyme to phosphorylate it to acyclovir

37 rus type 1 (HIV-1) integrase is one of three virally encoded enzymes essential for replication and, t

38 The glycans on fibrils are produced by virally encoded enzymes, organized in gene clusters.

39 al of a C-terminal tag that destabilizes the virally encoded form of the repressor.

40 ion of surface HLA class I expression by the virally encoded G protein-coupled receptor BILF1, thereb

41 virus genome is packaged with protein VII, a virally encoded histone-like core protein that is sugges

42 ontext of virus infection that NSs acts as a virally encoded IFN antagonist and that NSs is dispensab

43 V disease pathology is the interplay between virally encoded immune antagonists and host components t

44 MCV lesions persist because of virally encoded immune evasion molecules that inhibit an

45 Stable expression of the virally encoded latency-associated nuclear antigen (LANA

46 The virally encoded latency-related RNA (LR-RNA) is expresse

47 least in part explained by modulation of the virally encoded LTA.

48 strains are proteolytically processed by the virally encoded main protease.

49 into virions through an interaction with the virally encoded matrix protein.

50 easurements demonstrate that expression of a virally encoded melanopsin lacking all C-terminal phosph

51 ighly regulated spatiotemporal exposure of a virally encoded membrane lytic factor, resulting in the

52 Here we show that the virally encoded miR-K10a miRNA, whose precursor overlaps

53 In addition, it is now clear that virally encoded miRNAs play a key role in inhibiting ant

54 Since the identification of virally encoded miRNAs, various mRNAs have been identifi

55 a precisely mediated process fulfilled by a virally encoded molecular machine called terminase that

56 rototypic member of herpesviruses, employs a virally encoded molecular machine called terminase to pa

57 sed on reversion to fluorescence in a set of virally encoded mutant green fluorescent proteins, which

58 re landscape of RNA stability in cells using virally encoded nucleases.

59 A) genome of the virus is wrapped around the virally encoded nucleoprotein N to form the ribonucleopr

60 The virally encoded oncoprotein Tax activates the transcript

61 ISVP* formation releases two virally encoded peptides, myristoylated mu1N (myr-mu1N)

62 The virally encoded poly(A) polymerase, which polyadenylates

63 Our study suggests that as the first virally encoded polyamine acetyltransferase, vPAT plays

64 ect the T cells and remain latent due to the virally encoded product Tax inhibiting a key host defens

65 When the virally encoded protease (gp4) is coexpressed with gp5,

66 this proteolytic cleavage is mediated by the virally encoded protease AVP.

67 enes involved in latency, UL133-UL138, and a virally encoded protein kinase, UL97, which plays crucia

68 counterparts, although they do not express a virally encoded protein on their surface, thus distingui

69 e processivity factor (PF), one of the eight virally encoded proteins necessary for origin-dependent

70 Virally encoded proteins therefore exist to limit, inhib

71 Potato virus X (PVX) requires three virally encoded proteins, the triple gene block (TGB), f

72 KSHV), is comprised of at least 33 different virally encoded proteins.

73 in the nucleus prior to genome packaging by virally encoded Rep proteins.

74 ZIKV replicates its RNA genome using virally encoded replication proteins.

75 on, at least partly through retention of the virally encoded repressor pVII on this promoter.

76 Positive strand RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that

77 A key component of the VRC is the virally encoded RNA-dependent RNA polymerase (RdRp), whi

78 These viruses replicate by using a virally encoded RNA-dependent RNA polymerase enzyme that

79 The virally encoded site-specific recombinase Int collaborat

80 fe cycle of several viruses involves host or virally encoded small noncoding RNAs, which play importa

81 This study represents the first report of a virally encoded sugar acetyltransferase.

82 A virally encoded superfamily-2 (SF2) helicase (NS3h) is e

83 Utilizing expression of a virally encoded synaptic anterograde tracer, AAV-Synapto

84 The virally encoded Tat protein hijacks positive transcripti

85 fied a suppressor mutation (F86C) in NS4B, a virally encoded transmembrane protein with loops on both

86 ght/dark cycle compared with mice expressing virally encoded WT melanopsin; however, the phase angle

87 The retroviral integrases are virally encoded, specialized recombinases that catalyze

88 changes, and how this program is altered by virally-encoded immune antagonists, is a fundamental cha

89 virus families in that they express multiple virally-encoded microRNAs in latently and/or lytically i

90 ellular antiviral response involving vMIA, a virally-encoded protein that is not only able to prevent

91 istochemistry showed that the combination of virally enhanced VTA BDNF, stress, and AMPH resulted in

92 fined murine models of atopic, nonatopic and virally exacerbated forms of pulmonary inflammation, we

93 mice to visualize the dynamic behavior of a virally expanded, diabetogenic CTL population in the pan

94 d neurons, to examinations of the effects of virally expressed alpha-synuclein introduced into the mo

95 nsitivity to mu opioid receptor agonists, we virally expressed channel rhodopsin (ChR2) in rat VP neu

96 s established the expression and function of virally expressed Channelrhodopsin (ChR2) in CST cell bo

97 ed context) and long lasting (observed after virally expressed CRTC1 dissipated).

98 GCaMP3 signals were rapid, compared with virally expressed GCaMP3 and synthetic calcium indicator

99 We virally expressed inhibitory hM4Di DREADD (designer rece

100 Activation of virally expressed KORD in several neuronal contexts robu

101 In hearing animals, virally expressed PKCgamma overrides PKCbeta to produce

102 he glycoproteins of filoviruses are the only virally expressed proteins on the virion surface and are

103 of mutant ataxin-1 (ATXN1) expression, using virally expressed RNAi triggers, could prevent disease s

104 large premotor CbN cells over development by virally expressing channelrhodopsin in the inferior oliv

105 By virally expressing the isoforms in dopamine neurons of D

106 Conversely, virally guided overexpression of Sept5 in the hippocampu

107 ations of host interactome may underlie such virally implicated disease relationships.

108 Expression changes in virally implicated disease tissues and comorbidity patte

109 , are also associated with viral infections (virally implicated diseases), either in a directly causa

110 Tranexamic acid or virally inactivated fresh frozen plasma can be used for

111 Virally increasing Crem levels decreased impulsive actio

112 These long-lived, virally induced adhesive contacts greatly enhance the ra

113 for neuropeptide Y before, during, and after virally induced autoimmune attack of the islet.

114 Castleman disease (MCD), a life-threatening, virally induced B-cell lymphoproliferative disorder.

115 Submucosal regions with high virally induced BMP4 expression had high innervation den

116 However, the molecular mechanisms leading to virally induced cancer development have yet to be fully

117 ation of the autophagosome is sufficient for virally induced cell lysis.

118 Viral factors and host barriers influence virally induced disease, and asymptomatic versus symptom

119 lead to better treatments and preventions of virally induced disease.

120 s crucial to understanding the mechanisms of virally induced disease.

121 in response to Ad5 infection depends on the virally induced endosomal membrane rupture to release ly

122 Unlike genetic alterations, these virally induced epigenetic changes can be reversed pharm

123 In contrast to virally induced exhaustion, CLL T cells showed increased

124 Thus, transcriptional pausing primes virally induced genes to facilitate rapid gene induction

125 ful approach to control lesion severity in a virally induced immunopathological disease.

126 show that TGB1 organizes the PVX "X-body," a virally induced inclusion structure, by remodeling host

127 This work further defines the mechanisms of virally induced inflammasome activation.

128 In accord with the survival studies, virally induced levels of Mcl-1 expression dissipated to

129 at ACLY is not essential for HCMV growth and virally induced lipogenesis.

130 The virally induced mechanism counteracted defects in the pr

131 However, it is clear that virally induced metabolic reprogramming can substantiall

132 This work characterizes a virally induced modulation of the innate immune response

133 r promotes or inhibits viral replication and virally induced pathogenesis.

134 ated that this immunization strategy against virally induced pneumococcal disease can be conferred wi

135 teral lung transplantation in a patient with virally induced refractory respiratory failure supported

136 The mechanisms of virally induced ROS are poorly defined, however.

137 tudies, phenylmethimazole markedly decreased virally induced Toll-like receptor-3 expression and sign

138 s through exposure to tobacco and alcohol or virally induced tumorigenesis.

139 We have shown that virally induced upregulation of cellular Mcl-1 promotes

140 ells exhibit E1B 19K-dependent repression of virally induced, NF-kappaB-dependent macrophage cytokine

141 egress of HSV-1 in Vero cells is directed to virally induced, specialized egress sites that form alon

142 gnaling cascades by RVFV infection and found virally inducted phosphorylation of the classical DNA da

143 fective serial killers capable of destroying virally infected and cancerous targets by polarized rele

144 ic protein substrates to induce apoptosis in virally infected and neoplastic cells.

145 as chosen as a marker to follow secretion in virally infected and noninfected strains.

146 ocytes that provide critical defense against virally infected and transformed cells.

147 ) use polarized secretion to rapidly destroy virally infected and tumor cells.

148 oy a variety of activating receptors to kill virally infected and tumor cells.

149 to explain the full extent of the disease in virally infected animals.

150 lls in the lungs and draining lymph nodes of virally infected animals.

151 ovel mechanism of viral persistence in which virally infected B cells become hyper-responsive to coin

152 nes involved in leukocyte recruitment to the virally infected brain and demonstrate that simultaneous

153 ve microglial activation and astrogliosis in virally infected brains.

154 an individual, understanding the dynamics of virally infected CD4(+) TSCM during suppressive ART is i

155 FLIP) K13 was originally believed to protect virally infected cells against death receptor-induced ap

156 rus-encoded vFLIP K13 is believed to protect virally infected cells against death receptor-induced ap

157 e immune signaling, eliciting effects within virally infected cells and after release from dying cell

158 CD8(+) CTLs are adept at killing virally infected cells and cancer cells and releasing cy

159 lls protect from viral infections by killing virally infected cells and secreting interferon-gamma.

160 perforin/granzyme cytotoxic pathway to kill virally infected cells and tumors.

161 e immune inflammation during accumulation of virally infected cells at sites of infection and suggest

162 ol of HIV-1 infection through recognition of virally infected cells by both activating and inhibitory

163 g to IAV infection are believed to eliminate virally infected cells by direct cytolysis but may also

164 host immune molecules that kill bacteria and virally infected cells by pore formation, and mutations

165 Effective clearance of virally infected cells requires the sequential activity

166 Interestingly, many virally infected cells secrete microvesicles that differ

167 ght induce greater inflammatory responses to virally infected cells than E1B 19K-positive vectors, be

168 the control of viral infections, recognizing virally infected cells through a variety of activating a

169 (+) cytotoxic T lymphocytes (CTLs) eliminate virally infected cells through directed secretion of spe

170 ed to induce apoptosis of tumor cells and/or virally infected cells, although sparing normal cells, a

171 s: ongoing viral replication, persistence of virally infected cells, and cross-presentation of Ag.

172 to their direct cytotoxicity toward tumors, virally infected cells, and stressed cells, and they als

173 While interferons help kill virally infected cells, they can also promote systemic i

174 d worked cooperatively in the elimination of virally infected cells.

175 idered to cause apoptosis in tumor cells and virally infected cells.

176 V-1 replication but does not fully eliminate virally infected cells.

177 tic, immunorepressive cell death activity of virally infected cells.

178 ptosis functions as a trap door to eliminate virally infected cells.

179 how the host signaling pathways function in virally infected cells.

180 that prevents antibody-mediated clearance of virally infected cells.

181 l for tumor surveillance and defense against virally infected cells.

182 av1.6 and Nav1.7 mRNA but not Nav 1.8 in PHN virally infected cells.

183 ough the cross-presentation of antigens from virally infected cells.

184 adaptive immune system to target cancer and virally infected cells.

185 cular cellular needs or blocked in cancer or virally infected cells.

186 Immune cell entry into the virally infected CNS is vital for promoting viral cleara

187 activity depended upon direct contact of the virally infected corpses with responder macrophages.

188 ion of vascular endothelial growth factor by virally infected epithelial cells.

189 relevance for redirecting T cells to target virally infected hepatoma cells.IMPORTANCE Due to the pr

190 nd calcium imaging were used to characterize virally infected hiPSC-CMs for alterations in cellular m

191 imilarly, the CXCR4 antagonist released from virally infected human CAOV2 ovarian carcinoma cells inh

192 is the first ex vivo demonstration that non-virally infected human T cells can express NKG2DL, with

193 ge of PRRSV nsp2 was further investigated in virally infected MARC-145 cells by using two recombinant

194 Virally infected mice with a very low minute volume did

195 continuous surveillance for the presence of virally infected or cancerous cells.

196 ense by surveying for and ultimately killing virally infected or malignant target cells.

197 n immediate and direct cytolytic response to virally infected or malignantly transformed cells.

198 Cytotoxic lymphocytes eliminate virally infected or neoplastic cells through the action

199 (NK) cells discriminate between healthy and virally infected or transformed cells using diverse surf

200 rapidly produce effector cytokines and kill virally infected or transformed cells, NK cells also exh

201 e innate lymphocytes that recognize and lyse virally infected or transformed cells.

202 in promoting survival and transformation of virally infected T cells.

203 estricted cytotoxicity toward transformed or virally infected target cells.

204 for immune cell-mediated lysis of tumors or virally infected targets rely on average responses of pe

205 es for miRNA families in cell culture and in virally infected tissue and transgenic animals.

206 ells that have been malignantly transformed, virally infected, or stressed by chemotherapy or other f

207 Natural killer (NK) cells kill virally infected/transformed cells via degranulation of

208 and represents an RNA that activates MDA5 in virally-infected cells.

209 A virally introduced tandem fluorophore protein reporter o

210 We validate optical actuation by virally introducing optogenetic drivers in rat and human

211 All virally labeled brain regions contained neurons projecti

212 Synaptic connectivity of pairs of virally labeled cells was demonstrated by using slice cu

213 For the latter, laser capture of individual virally labeled neurons was used.

214 Conversely, virally mediated activation of NF-kappaB signaling decre

215 Additionally, pharmacological blockade or virally mediated conditional deletion of mGluR5 in the C

216 005 documenting hair cell regeneration using virally mediated delivery of the mouse atonal 1 gene, ge

217 These data reveal that virally mediated ectopic expression of human rod opsin c

218 al and morphological changes in vivo because virally mediated expression of a dominant-negative Kir2

219 Virally mediated expression of GIRK3 in the ventral tegm

220 Here we use virally mediated GABAergic-specific GCaMP6f expression t

221 Thus our findings indicate that virally mediated HDAC inhibition can act as a signal for

222 gh central pharmacological administration or virally mediated hypothalamic overexpression converts th

223 We used a virally mediated knockdown strategy (short hairpin RNA t

224 Virally mediated overexpression of HDAC2 in frontal cort

225 sing a selective neocortical knockout mouse, virally mediated prelimbic cortical-specific gene deleti

226 reasing dopaminergic neurotransmission using virally mediated RNA interference of tyrosine hydroxylas

227 We used virally mediated RNA interference to locally downregulat

228 Finally, virally mediated silencing of DGL-alpha, but not DGL-bet

229 g Cre recombinase-dependent adeno-associated virally mediated transfection.

230 me pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and

231 to trigger adaptive immune responses against virally or malignantly transformed cells.

232 AP uses an anti-GFP ribosomal tag (expressed virally or using transgenesis) to immunoprecipitate tran

233 To test this hypothesis, we virally overexpressed CREB in CA1 of dorsal hippocampus.

234 ing potassium (GIRK2; Kir 3.2) channels were virally overexpressed in the striatum, and the resulting

235 -receptor synaptic activity was assessed via virally overexpressed potassium channels (GIRK2) in medi

236 gs from CHIs and medium spiny neurons (MSNs) virally overexpressing G-protein-activated inwardly rect

237 488-induced reinstatement of cocaine CPP, we virally re-expressed KORs in the LC of KOR knockout mice

238 RT; and (4) proportion of stage 3 who became virally suppressed (</=200 copies/mL).

239 l {CI}, 3.21-3.87]) but still elevated among virally suppressed (<400 copies/mL) persons (adjusted RR

240 be prescribed ART (52% vs 94%; P < .01) and virally suppressed (39% vs 77%; P < .01) than uninsured

241 respectively), and participants who were not virally suppressed (6.3 vs 4.7 per 1000 person-years for

242 tage were 84% diagnosed, 84% on ART, and 85% virally suppressed (60% of people living with HIV).

243 Participants were virally suppressed (HIV-1 RNA <50 copies per mL) on efav

244 Participants were virally suppressed (HIV-1 RNA <50 copies per mL) on rilp

245 5% and 12% less likely, respectively, to be virally suppressed (P </= .02) than those with RWHAP onl

246 s with viral load measurements (n=3066) were virally suppressed (translating to 106,371 individuals o

247 patients (64%) initiated treatment and were virally suppressed at 10 mo, compared to 96/190 (51%) in

248 itiated ART, and of those more than 80% were virally suppressed at 9 months.

249 We followed 2584 virally suppressed HIV patients for 13 369 person-years

250 diovascular disease, cancer, and death among virally suppressed HIV patients.

251 D163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22);

252 Peripheral blood was collected from 70 virally suppressed HIV-1-infected individuals from Rakai

253 ribute to progressive neurological damage in virally suppressed HIV-infected individuals.

254 Virally suppressed HIV-positive individuals on cART who

255 -term clinical and immunological outcomes of virally suppressed HIV-positive individuals.

256 ART reduced %CD28(-) levels at week 96 among virally suppressed individuals.

257 (LN; n = 9), and rectal tissue (n = 17) from virally suppressed individuals.

258 sistence of latently HIV-1 infected cells in virally suppressed infected patients, a number of in vit

259 h HIV (PLHIV) who are diagnosed, on ART, and virally suppressed out of the estimated number of PLHIV.

260 useful as independent prognostic markers in virally suppressed patients on ART.

261 scription (Tat) continues to be expressed in virally suppressed patients on cART.

262 time from initiation of cART to start of the virally suppressed period were risk factors for not achi

263 ral particle release from CD4(+)T cells from virally suppressed subjects on highly active antiretrovi

264 When administered to virally suppressed subjects, IL-7 led to the rapid proli

265 In virally suppressed subjects, the approach identified lat

266 ce were more likely to be prescribed ART and virally suppressed than those with other types of health

267 AP were more likely to be prescribed ART and virally suppressed than those without RWHAP supplementat

268 have a high CD4 count, adhere to cART, or be virally suppressed than were other US HIV-positive MSM.

269 Virally suppressed Ugandans had a 3-fold lower frequency

270 as 48%, and the proportion of PLHIV who were virally suppressed was 40%.

271 rehensive care for >6 months (whether or not virally suppressed) is <13:100 000.

272 ms for 72% (90% diagnosed times 80% of those virally suppressed) viral suppression among persons with

273 artum; with 39% and 31% retained in care and virally suppressed, respectively, at 1 year postpartum,

274 partum, and 25% and 34% retained in care and virally suppressed, respectively, at 2 years postpartum.

275 s applied whether or not index partners were virally suppressed.

276 t (ART), and 90% of those taking ART will be virally suppressed.

277 erall, 91% were prescribed ART, and 75% were virally suppressed.

278 ransmission from HIV-positive people who are virally suppressed; however, coverage of these intervent

279 ART initiation, and (3) 179 samples from 20 virally-suppressed adults who had evidence of viral brea

280 activity with an HIV-positive partner taking virally suppressive ART.

281 nfer IFN-mediated anti-Fv3 protection to the virally susceptible X. laevis kidney (A6) cell line.

282 us, Megavirus glycans are mainly composed of virally synthesized N-acetylglucosamine (GlcNAc).

283 cuit integration in the adult brain, we have virally traced local corticotropin-releasing hormone (CR

284 Phlebovirus proteins are translated from virally transcribed mRNAs that, like host mRNA, are capp

285 hanism for microglia-mediated elimination of virally transduced cells in the central nervous system.

286 on with IL-4 or IL-13, HR(-) ETPs expressing virally transduced HR also exhibit STAT6 phosphorylation

287 sensitivity approaching that of in utero or virally transduced neurons.

288 We have characterized the usage of virally transduced or transgenically expressed extracell

289 ic imaging, we demonstrate rapid kinetics of virally transduced or transgenically expressed glutamate

290 Htr3a-Cre mice were then virally transduced to express halorhodopsin to allow act

291 individuals and Alzheimer's patients, using virally transduced transcription regulators and extrinsi

292 in the same preparation were obtained using virally transfected fluorescent labeling or by immunolab

293 axons independent of transmitter status, we virally transfected VTA neurons with channelrhodopsin-2

294 of HSUR 1 alters levels of these proteins in virally transformed cells.

295 ng being adenomas or adenocarcinomas [4, 5], virally transformed fish cells [6-8], or products of coa

296 ifferent clinical presentations of viral and virally triggered ("paraviral") exanthems is necessary f

297 d exaggerated cell death in animal models of virally triggered IBD and allogeneic hematopoietic stem

298 RIPK1 inhibition ameliorated disease in the virally triggered IBD model.

299 r NOD2-RIPK2 signaling in protection against virally triggered immunopathology by negatively regulati

300 individuals who were HIV seroconcordant but virally unlinked from their spouses were then tested by