ライフサイエンスコーパス: viroid

1 of the loop E motif of Potato spindle tuber viroid.

2 nd replication cycle resemble those of plant viroids.

3 dulate the hammerhead cleavage properties in viroids.

4 utations in loop E motifs of PSTVd and other viroids.

5 cally favored for the vast majority of these viroids.

6 me is structurally related to those of plant viroids.

7 ion of AGO1, AGO2, AGO4, and AGO5 attenuated viroid accumulation, supporting their role in antiviroid

8 usly were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of ne

9 ion regarding the pathogenesis mechanisms of viroids and perhaps other infectious RNAs.IMPORTANCE Num

10 ne extended hammerheads derived from natural viroids and satellite RNAs were constructed with the goa

11 d, information for all sequences of viruses, viroids and satellites of plants, fungi and protozoa tha

12 central source of information about viruses, viroids and satellites of plants, fungi and protozoa.

13 This CCC RNA is the smallest among all known viroids and virusoids and the only one that codes protei

14 Viroids are a unique class of noncoding RNAs: composed o

15 Viroids are non-translatable, autonomously replicating c

16 Viroids are noncoding RNAs that can cause disease in pla

17 Viroids are single-stranded, circular, and noncoding RNA

18 Viroids are small noncoding and infectious RNAs that rep

19 Viroids are the simplest noncoding eukaryotic RNA pathog

20 e tuber viroid (PSTVd) and avocado sunblotch viroid (ASBVd) were only 0.5% cleaved.

21 ch is a new concept that helps to understand viroid-based pathogenesis.

22 s) supports the notion that DCLs also target viroids but does not clarify whether vd-sRNAs activate o

23 small RNAs in infected plants suggests that viroids can trigger RNA silencing in a host, raising the

24 case, pathogenic noncoding RNAs alone (i.e., viroids) can cause disease in plants.

25 treme case, pathogenic ncRNAs alone (such as viroids) can infect eukaryotic organisms, leading to dis

26 based on complementary Coconut Cadang-Cadang Viroid (CCCVd) RNA sequence, was covalently bonded onto

27 model system to investigate the mechanism of viroid cell-to-cell transport.

28 The identification of viroid-derived small RNAs (vd-sRNAs) of 21 to 24 nucleot

29 accumulation in these plants of 21- to 24-nt viroid-derived small RNAs (vd-sRNAs) supports the notion

30 Viroids, despite their minimal genomes (non-protein-codi

31 ng specific hot spot distributions along the viroid genome.

32 However, viroid genomes contain no open reading frames, whereas H

33 It is likely that viroids hijack critical host RNA pathways for processing

34 eover, a specific role of DNA methylation in viroid-host interactions is not yet confirmed.

35 ystem, resemble the plant pathogens known as viroids in their structure, mode of generation and funct

36 processes, and developmental patterns makes viroid infection a valuable system in which to investiga

37 Using Potato spindle tuber viroid infection of Nicotiana benthamiana as the experim

38 An important component of the viroid infection process is cell-to-cell movement; howev

39 ar activities underlying nuclear-replicating viroid infection processes in plants, including effects

40 ed RNA replication is essential for viral or viroid infection, as well as for regulation of cellular

41 to 24 nucleotides (nt) in plants infected by viroids (infectious non-protein-coding RNAs of just 250

42 comprehensive genome-wide analyses of plant-viroid interactions and discover several novel molecular

43 n to a possible evolutionary relationship to viroids is discussed.

44 f rolling circle replication for HDV RNA and viroids is not clear.

45 However, whether viroids, like RNA viruses, are also targeted by the RNA-

46 Hepatitis delta virus (HDV) contains a viroid-like circular RNA that is presumed to replicate v

47 Hepatitis delta virus (HDV) contains a viroid-like circular RNA that replicates via a double ro

48 l principles and offer perspectives on using viroid models to continue advancing some frontiers of li

49 A viroid most likely has evolved structural motifs that mi

50 A vast number of plant pathogens from viroids of a few hundred nucleotides to higher plants ca

51 Viroids of the Pospiviroidae family, as represented by t

52 mechanistic link with the antagonism of the viroid on the virus in co-infected tomato plants.

53 /paperclip ribozyme model proposed for plant viroid or virusoid RNAs, have been proposed.

54 oorganisms such as fungi, bacteria, viruses, viroids, phytoplasma and nematodes.

55 report that the CCR of Potato spindle tuber viroid (PSTVd) also plays a role in pathogenicity.

56 larly, rod-like RNAs of potato spindle tuber viroid (PSTVd) and avocado sunblotch viroid (ASBVd) were

57 presumably cleavage of Potato spindle tuber viroid (PSTVd) and closely related members of the family

58 folding pathways of the potato spindle tuber viroid (PSTVd) and the host killing mechanism of Escheri

59 We used Potato spindle tuber viroid (PSTVd) as a model to investigate the direct role

60 omain (T(L)) of the potato spindle tuber RNA viroid (PSTVd) constitutes one of its five structural el

61 In this study, potato spindle tuber viroid (PSTVd) has been used as a model system to invest

62 Here, we employ potato spindle tuber viroid (PSTVd) infecting tomato as a system to dissect h

63 Potato spindle tuber viroid (PSTVd) is a circular, single-stranded, noncoding

64 Potato spindle tuber viroid (PSTVd) is a pathogenic RNA that does not encode

65 tion of an RNA motif in Potato spindle tuber viroid (PSTVd) required for trafficking from palisade me

66 benthamiana infected by potato spindle tuber viroid (PSTVd) were agroinfiltrated with plasmids expres

67 nstrated that like with Potato spindle tuber viroid (PSTVd), a satRNA associated with Cucumber Mosaic

68 inia virus (TYLCSV) and potato spindle tuber viroid (PSTVd), co-infect their common host tomato, we o

69 , as represented by the Potato spindle tuber viroid (PSTVd), replicate in the nucleus by utilizing DN

70 ed from the replicating Potato spindle tuber viroid (PSTVd).

71 Viroids replicate through an RNA-to-RNA rolling-circle m

72 ional mechanisms of RNA motifs that regulate viroid replication and trafficking.

73 ulatory elements necessary for initiation of viroid replication.

74 a remarkable example of parasitic strategy, viroids reprogram for their replication the template and

75 examples of groundbreaking contributions of viroid research to the development of new biological pri

76 le-stranded (ss) DNA geminiviruses and ssRNA viroids, respectively, but both pathogens can counteract

77 RNAs, the predicted secondary structure of a viroid RNA contains many loops and bulges flanked by dou

78 otif that the noncoding Potato spindle tuber viroid RNA evolved to potentiate its efficient trafficki

79 The viroid RNA genome must interact directly with cellular f

80 All functions are mediated directly by the viroid RNA genome or genome-derived RNAs.

81 sm consisting of transcription of oligomeric viroid RNA intermediates, cleavage to unit-length strand

82 The structures of viral and viroid RNA motifs are studied commonly by in vitro, comp

83 Our results led to a genomic map of viroid RNA motifs that mediate single-cell replication a

84 The feasibility of correlating viroid RNA sequence/structure with the altered expressio

85 genetic evidence for the essential role of a viroid RNA three-dimensional motif in rolling-circle rep

86 assays with an analogous tomato planta macho viroid (-)RNA resulted in a much larger fraction of infe

87 During replication, (+)- and (-)-strand viroid RNAs are produced.

88 f a complex mixture of coconut cadang-cadang viroid RNAs revealed the presence of relatively large am

89 cally the infectivity of monomeric (-)strand viroid RNAs, we have developed a ribozyme-based expressi

90 rived mostly from the secondary structure of viroid RNAs.

91 rod-shaped structures, similar to the plant viroid RNAs.

92 The occurrence of viroid-specific small RNAs in infected plants suggests t

93 uction of small RNAs of Potato spindle tuber viroid (srPSTVds) and investigating how PSTVd responds t

94 rize recent advances in the understanding of viroid structures and cellular factors enabling these fu

95 RNA transcripts of the potato spindle tuber viroid, suggesting that RIPs may target invading nucleic

96 The properties of viroids that make them candidates for being survivors of

97 ests a possible evolutionary relationship to viroids that replicate in the nucleus.

98 benthamiana infected by potato spindle tuber viroid, the endogenous AGO1 and distinct AGOs from Arabi

99 For potato spindle tuber (PSTVd) and related viroids, the possible role of a circular (-)strand RNA a

100 ve evolved to vary widely, from 250 bases in viroids to 670 billion bases in some amoebas.

101 Selected endogenous RNAs, viral RNAs, and viroids traffic between specific cells or organs via thi

102 ated upon infection of a nuclear-replicating viroid, which is a new concept that helps to understand