ライフサイエンスコーパス: virulence determinant

1 racis growth, making it a potentially unique virulence determinant.

2 ew genes and increased the expression of one virulence determinant.

3 (GlcNAc) side chains, which is an essential virulence determinant.

4 y of the heat-labile toxin, a principal ETEC virulence determinant.

5 lysaccharide capsule, a primary cryptococcal virulence determinant.

6 o is consistent with its role as a bona fide virulence determinant.

7 ein of H5N1 viruses has been identified as a virulence determinant.

8 nd it was speculated that it may represent a virulence determinant.

9 gesting that exoU is a horizontally acquired virulence determinant.

10 pes, compensatory mutations, and a potential virulence determinant.

11 ene regulatory mechanisms for this essential virulence determinant.

12 in has evolved to serve as an iNOS-dependent virulence determinant.

13 dle ear infection demonstrated that VP1 is a virulence determinant.

14 rally occurring H5N1 viruses as an important virulence determinant.

15 ema denticola (TDE) and one of its principal virulence determinants.

16 tem, which is a major regulator of S. aureus virulence determinants.

17 nt pathogen that synthesizes a wide range of virulence determinants.

18 -1) U(S)1 gene encodes host-range and ocular virulence determinants.

19 eems to correlate with altered expression of virulence determinants.

20 ms to coordinately control the expression of virulence determinants.

21 on of RhoG by multiple Y. pseudotuberculosis virulence determinants.

22 th an emphasis on genome-wide approaches and virulence determinants.

23 isolates for the presence of these putative virulence determinants.

24 (PFGE) and PCR for pvl and 31 other putative virulence determinants.

25 nding protein that regulates these important virulence determinants.

26 identifying pathogenicity islands and novel virulence determinants.

27 ug development efforts targeted toward those virulence determinants.

28 orts experimentally demonstrating E. faecium virulence determinants.

29 ons within hantavirus G1 tails are potential virulence determinants.

30 s exotic lipids that have been implicated as virulence determinants.

31 buting to the complex regulation of Shigella virulence determinants.

32 pounds that enhance the production of fungal virulence determinants.

33 s to control co-ordinately the expression of virulence determinants.

34 elated with resistance patterns but not with virulence determinants.

35 0 kb pathogenicity island (PAI) that carries virulence determinants.

36 ngoing analysis of nontypeable H. influenzae virulence determinants.

37 nism of how taurocholate affects V. cholerae virulence determinants.

38 expression of a battery of colonization and virulence determinants.

39 ntly correlated with resistance patterns and virulence determinants.

40 ensus clones of SFV strains were used to map virulence determinants.

41 sulted in the dysregulation of several known virulence determinants.

42 d dissemination of antibiotic resistance and virulence determinants.

43 positively regulates numerous P. aeruginosa virulence determinants.

44 al pathogens via horizontal gene transfer of virulence determinants.

45 ial host and can influence the expression of virulence determinants.

46 er iron limitation often in conjunction with virulence determinants.

47 ortant for the regulation of proteobacterial virulence determinants.

48 envelope-localized proteins, including many virulence determinants.

49 oup 1 capsular polysaccharides, which act as virulence determinants.

50 of its targets, including seven established virulence determinants.

51 atase in vitro to maintain the expression of virulence determinants.

52 c gene deletion mutants of important CA-MRSA virulence determinants (alpha-toxin, PSM alpha, Agr) in

53 genesis and compare it with well-established virulence determinants: alpha-hemolysin (Hla), phenol-so

54 porter) secretion system and is considered a virulence determinant among the bacteria expressing the

55 Lipopolysaccharide is both a virulence determinant and a target for host immune respo

56 injected parasite factor, ROP16, to be a key virulence determinant and regulator of host cell transcr

57 SLS is a key virulence determinant and responsible for the beta-hemol

58 s constructed with a marker that is itself a virulence determinant and therefore complicates their in

59 p, and DksA, which control the expression of virulence determinants and adaptation to a variety of st

60 y causes dysregulated expression of multiple virulence determinants and cripples the ability of the o

61 rtunistic pathogens, it is unclear why their virulence determinants and expression of pathogenic beha

62 identify antibiotic resistance and specific virulence determinants and indicate the appropriate trea

63 t CsrRS regulates expression of multiple GBS virulence determinants and is likely to play an importan

64 duction was specifically due to the unneeded virulence determinants and not to pleiotropic regulatory

65 an important platform from which to identify virulence determinants and the principle mechanisms of a

66 an be used as a surrogate model to determine virulence determinants and their regulation in APEC stra

67 y, essentially deficient in the secretion of virulence determinants, and avirulent in infection model

68 esis that AggR is a global regulator of EAEC virulence determinants, and builds on the hypothesis tha

69 riate cyclic (c)-di-GMP levels, induction of virulence determinants, and various nutritional requirem

70 infecting a wide range of hosts, many of its virulence determinants are host specific.

71 Shared virulence determinants are limited to the virulence plas

72 ad to metabolic streamlining and the loss of virulence determinants are more frequently found in pers

73 However, the virulence determinants are not established.

74 2), indicating that these putative borrelial virulence determinants are regulated at the transcriptio

75 lel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively

76 firmed the presence of previously identified virulence determinants, as well as a contiguous 54-kb fl

77 Other virulence determinants, as well as vaccines and therapeu

78 aluronic acid capsular polysaccharide, a key virulence determinant associated with severe GAS infecti

79 tial of animal EPEC strains and the need for virulence determinant-based screening of E. coli isolate

80 cretome HT signals, including those of major virulence determinants, bind PI(3)P with nanomolar affin

81 cterium has been extensively studied for its virulence determinants, biofilm growth, and immune evasi

82 Here we demonstrate that CcpE also regulates virulence determinant biosynthesis and pathogenesis.

83 aureus, metabolism is intimately linked with virulence determinant biosynthesis, and several metaboli

84 the carboxyl terminus that can function as a virulence determinant by targeting cellular PDZ proteins

85 Finally, sequence analyses of the virulence determinant CagA reveal three main groups stri

86 expected, the deduced sequences of two known virulence determinants (CagA and VacA) are highly diverg

87 Bacterial virulence determinants can be identified, according to t

88 asmids that encode antibiotic resistance and virulence determinants can be induced by peptide sex phe

89 gued that the likely existence of additional virulence determinants can be investigated in vivo by us

90 letions in genes encoding three of its major virulence determinants: capsular polysaccharide (cps), p

91 Potential virulence determinants carried by the genome include sys

92 secretome' of hundreds of proteins including virulence determinants containing a host (cell) targetin

93 Shiga toxins (Stx) are the key EHEC virulence determinant contributing to severe disease.

94 lating evidence indicates that the H. pylori virulence determinant cytotoxin-associated gene A (CagA)

95 s approach was used to identify 3 additional virulence determinants dependent on VAD1: PCK1, TUF1, an

96 n of mutacins are considered to be important virulence determinants displayed by this organism.

97 onocytogenes is considered to be its primary virulence determinant during mammalian infection; howeve

98 henotypic heterogeneity in the expression of virulence determinants during colonization of a non-mamm

99 expression of the important multifunctional virulence determinants eap and emp.

100 tional profiling of differentially expressed virulence determinants (eg, cytotoxicity and invasivenes

101 he first of its kind to figure out potential virulence determinants encoded by SPI for therapeutic ta

102 We report here that three virulence determinants encoded by Y. pseudotuberculosis

103 view recent discoveries related to bacterial virulence determinants, epithelial hyperplasia, innate a

104 Furthermore, 2 prominent mycobacterial virulence determinants, Erp and ESX-1, do not affect thi

105 nd that the acquisition of a large number of virulence determinants featuring numerous cell membrane

106 ridium perfringens enterotoxin) is the major virulence determinant for C. perfringens type-A food poi

107 nesis in sheep, indicating that ORFV121 is a virulence determinant for ORFV in the natural host.

108 extracellular matrix proteins is a critical virulence determinant for skin pathogens.

109 ulator previously identified as an important virulence determinant for systemic infection of Streptoc

110 The hemagglutinin (HA) protein is a major virulence determinant for the 1918 pandemic influenza vi

111 alpha C protein of group B streptococcus, a virulence determinant for this neonatal human pathogen,

112 C. perfringens beta toxin (CPB) is the major virulence determinant for type C infections and is also

113 his study represent an exciting new class of virulence determinants for further mechanistic study to

114 srupted genes identified a list of potential virulence determinants for further testing with animals.

115 The virulence determinants for highly pathogenic avian influ

116 the continuing need to better understand the virulence determinants for IAV in intermediate hosts, su

117 Listeriolysin O (LLO) and ActA are essential virulence determinants for Listeria monocytogenes pathog

118 from the oomycete Phytophthora infestans and virulence determinants from the human malaria parasite P

119 the native sequences of the FopA and FTT1525 virulence determinants from the select agent Francisella

120 tructure of VacA and CagA, and each of these virulence determinants has evolved separately from the c

121 The effects of this mutation on specific GAS virulence determinants have been assessed, with emphasis

122 A number of virulence determinants have been identified in S. epider

123 While multiple virulence determinants have been identified, the combina

124 in coregulated pilus, the Vibrio cholerae O1 virulence determinants having the largest contribution t

125 the role of H. ducreyi CpxRA in controlling virulence determinants, here we defined genes potentiall

126 urprisingly, expression of the Type I ROP-18 virulence determinant in an avirulent strain did not con

127 the identification and confirmation of a new virulence determinant in an important pathogen.

128 ystem is an important Pseudomonas aeruginosa-virulence determinant in animal models of infection and

129 e Panton-Valentine leukocidin (PVL) is a key virulence determinant in CA-MRSA necrotizing pneumonia.

130 as historically been regarded as the primary virulence determinant in Clostridium difficile infection

131 over, the expression of SraP appears to be a virulence determinant in endovascular infection.

132 to cellular PDZ proteins and functions as a virulence determinant in infected mice.

133 he use of siderophores is a well-established virulence determinant in mammalian pathogenesis.

134 ESAT-6 is a virulence determinant in Mycobacterium tuberculosis and

135 the synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Ty

136 indicate that SPPV-019 is a significant SPPV virulence determinant in sheep.

137 We conclude that Scl-1 is a virulence determinant in the M1T1 GAS clone, allowing GA

138 ding a nonribosomal peptide synthetase, is a virulence determinant in the maize (Zea mays) pathogen C

139 ajor outer sheath protein (Msp) is a primary virulence determinant in Treponema denticola, as well as

140 s supporting a role for InlF as a functional virulence determinant in vivo under specific conditions.

141 in tyrosine phosphatase YopH is an essential virulence determinant in Yersinia spp., causing gastroin

142 c-di-GMP regulates the expression of various virulence determinants in a wide range of bacterial path

143 Capsular polysaccharides are important virulence determinants in a wide range of invasive infec

144 identification of additional Rrp2-dependent virulence determinants in B. burgdorferi.

145 rphisms, including antibiotic resistance and virulence determinants in carbapenem-resistant Enterobac

146 ts RNAIII transcription and the synthesis of virulence determinants in concert with sigma(B), SarA, a

147 on of the horizontal transfer of PAI-encoded virulence determinants in E. faecalis and has implicatio

148 t AggR also controls the expression of other virulence determinants in EAEC 042.

149 is molecule an almost universal regulator of virulence determinants in enteric bacteria.

150 STa and heat-labile toxin (LT) are virulence determinants in ETEC diarrhea.

151 sis is a proximal regulator of cell envelope virulence determinants in M. tuberculosis.

152 ious studies have identified lipoproteins as virulence determinants in other streptococcal species.

153 Bacteria coordinate expression of virulence determinants in response to localized microenv

154 Analysis of virulence determinants in strain Ea1189Deltahfq showed t

155 Studies of virulence determinants in the bacterial phytopathogen Er

156 system implicated in the control of multiple virulence determinants in the important human pathogen,

157 igated temporal and spatial requirements for virulence determinants in the intracellular life cycle,

158 hat both the hgp genes and the hxuC gene are virulence determinants in the rat model of human invasiv

159 Further, virulence determinants in the SCD context were distinct

160 oteins of Borrelia spirochetes are important virulence determinants in the transmission and pathogene

161 cascade of regulators controls expression of virulence determinants in V. cholerae at both transcript

162 d by one of these sRNAs, revealing potential virulence determinants in Y. pseudotuberculosis that are

163 y uncharacterized CDSs that may encode novel virulence determinants including a hemolysin, a metallop

164 contains an even larger set of host-specific virulence determinants, including proteins involved in t

165 both known and previously unknown Salmonella virulence determinants, including Salmonella Pathogenici

166 lator (agr), which governs the expression of virulence determinants, including surface and exoprotein

167 We identified seven putative virulence determinants, including two putative type III

168 Thus, the 1918 hemagglutinin contains murine virulence determinants independent of receptor binding s

169 reonine protein kinase YpkA, is an essential virulence determinant involved in host actin cytoskeleta

170 zation of DCs and impairs DC maturation, the virulence determinants involved are still controversial.

171 nd cag pathogenicity island as the bacterial virulence determinants involved.

172 A major GBS virulence determinant is its sialic acid (Sia)-capped ca

173 Its major virulence determinant is the polysaccharide (PS) capsule

174 The likely more deeply studied P. aeruginosa virulence determinant is the type III secretion system (

175 A critical virulence determinant is the Yersinia protein kinase A,

176 local environment for optimal expression of virulence determinants is a continued area of research.

177 Interfering with crucial virulence determinants is considered a promising new app

178 plant cell wall degrading enzymes and other virulence determinants is controlled in a cell density-d

179 The identification of virulence determinants is of considerable importance, be

180 The synthesis of many staphylococcal virulence determinants is regulated in part by stress-in

181 lipid biosynthesis and expression of unknown virulence determinants, is composed of an N-terminal rec

182 tured macrophages, and mycobacteria have the virulence determinant MarP, which confers acid resistanc

183 mucoid conversion and inhibition of invasive virulence determinants may both confer a selective advan

184 on and characterization of influenza A virus virulence determinants may provide insight into genotypi

185 These effectors are the major virulence determinants mediating the transformation of n

186 ncern remains whether experimentally evolved virulence determinants mimic those that have evolved nat

187 ponses, selective packaging and secretion of virulence determinants, modulation of the host immune re

188 tified by this approach included established virulence determinants, more recently identified putativ

189 confirm bacterial-encoded S1PL as a critical virulence determinant of B. pseudomallei and B. thailand

190 t A. baumannii inhibits filamentation, a key virulence determinant of C. albicans.

191 rains, we conclude that PVL is not the major virulence determinant of CA-MRSA.

192 Serum opacity factor (SOF) is a virulence determinant of group A streptococci that opaci

193 in-mediated phagocytosis may be an important virulence determinant of infective endocarditis.

194 he influenza virus RNA polymerase is a major virulence determinant of influenza viruses.

195 -6, Early Secreted Antigen, 6kDa) is a major virulence determinant of Mycobacterium tuberculosis, the

196 As such, it is a major virulence determinant of P. gingivalis.

197 NanA is a virulence determinant of pneumococci which is important

198 The zinc protease AmpDh2 is a virulence determinant of Pseudomonas aeruginosa, a probl

199 type III secretion system (TTSS) is a major virulence determinant of Pseudomonas aeruginosa.

200 Previous studies determined that the major virulence determinant of R. equi is the surface bound vi

201 ic ablation of serum opacity factor (SOF), a virulence determinant of S. pyogenes, reduced binding by

202 the target of serum opacity factor (SOF), a virulence determinant of Streptococcus pyogenes that tur

203 ested that the adhesin is likely a potential virulence determinant of the bacterium in the initiation

204 A Carbohydrate, the molecular signature and virulence determinant of the human pathogen Group A Stre

205 nstrates a strict temporal requirement for a virulence determinant of the Lyme disease spirochete Bor

206 K-antigen capsule synthesis is an important virulence determinant of the oral anaerobe Porphyromonas

207 lbicans to invade mucosal tissues is a major virulence determinant of this organism; however, the mec

208 yer of regulation to this tightly controlled virulence determinant of Y. pestis.

209 l evolutionary approach to identify relevant virulence determinants of an RNA virus.

210 ination and biofilm formation are recognized virulence determinants of Candida albicans.

211 Crucial virulence determinants of disease causing Neisseria meni

212 olates suggested adherence/invasion were key virulence determinants of epithelial chemokine secretion

213 ) have recently been recognized as potential virulence determinants of many Gram-negative bacterial p

214 III secretion systems (T3SSs) are essential virulence determinants of many Gram-negative bacterial p

215 These proteins share features with virulence determinants of other pathogens, and we provid

216 gh this trafficking pathway that the primary virulence determinants of P. falciparum infections are t

217 The virulence determinants of pathogenic bacteria include th

218 Crucial virulence determinants of pathogenic Nm strains are the

219 breakthrough allows us to investigate other virulence determinants of PEDV strains and will provide

220 emonstrating for the first time that protein virulence determinants of pneumococci have, as identifie

221 Most known virulence determinants of Pseudomonas aeruginosa are rem

222 transcriptional regulator PrfA controls key virulence determinants of the facultative intracellular

223 To identify virulence determinants of this economically important pa

224 ellular cysteine proteases and are important virulence determinants of this periodontal bacterium.

225 Identification of virulence determinants of viruses is of critical importa

226 els to facilitate en masse identification of virulence determinants or explore host-pathogen interact

227 ited than macaques for the identification of virulence determinants or the evaluation of therapeutics

228 These studies demonstrate that virulence determinants, other than capsule loci, vary am

229 Together with the virulence determinants, PAPI-1 plays an important role i

230 ll genomic islands, including those carrying virulence determinants (pathogenicity islands).

231 These data indicate that a key virulence determinant plays a critical role in downregul

232 lled with pneumococci; and (3) the bacterial virulence determinants, pneumolysin and hydrogen peroxid

233 Among the multitude of virulence determinants possessed by P. aeruginosa, the t

234 Cys-phosphorylation is crucial in regulating virulence determinant production and bacterial resistanc

235 Carbon metabolism and virulence determinant production are often linked in pat

236 ed that the fusion glycoprotein is the major virulence determinant regardless of the identical virule

237 The collagen adhesin Acm was the first virulence determinant reported to be important for the p

238 The identified potential virulence determinants represent novel functional classe

239 losis exported repetitive protein (Erp) is a virulence determinant required for growth in cultured ma

240 uctan hydrolase (fructanase), an established virulence determinant required for releasing D-fructose

241 i infection and to identify and characterize virulence determinants required for colonization.

242 nes (hgbA, flp-tad, and lspB-lspA2) encoding virulence determinants required for human infection.

243 Importantly, we demonstrate that the virulence determinants responsible for bacterial persist

244 of the supershedder phenotype depends on the virulence determinants Salmonella pathogenicity islands

245 E. coli K1 require at least two of the known virulence determinants shown for mammals.

246 ntire genotype rather than a single putative virulence determinant such as PVL.

247 increased expression of core-genome-encoded virulence determinants, such as alpha-toxin and phenol-s

248 LE-inducible candidal virulence determinants, such as germination and enhanced

249 fferential expression of core genome-encoded virulence determinants, such as phenol-soluble modulins

250 A number of virulence determinants, such as the abilities to adhere,

251 Pseudogenes in virulence determinants suggest that the pathogenic respo

252 the close linkage of central metabolism and virulence determinant synthesis, and they establish a me

253 hese RpiR homologues affect PPP activity and virulence determinant synthesis, the rpiR homologues wer

254 the agr quorum-sensing system that controls virulence determinant synthesis.

255 It contains the virulence determinants tdh and trh but appears to infect

256 Thus, rhsT encodes a virulence determinant that activates the inflammasome.

257 ggest that VP24 is likely to be an important virulence determinant that allows EBOV to evade the anti

258 his study provides an example of a microbial virulence determinant that alters the requirements for h

259 We conclude that optimal RdRp fidelity is a virulence determinant that can be targeted for viral att

260 tein from EIAV is an example of a retroviral virulence determinant that independently evolved SERINC5

261 2 serves as a regulator for a B. burgdorferi virulence determinant that is required for productive in

262 ccessory regulator A locus (sarA) is a major virulence determinant that may potentially impact methic

263 ntracellular multiplication (icm) genes is a virulence determinant that remains highly conserved in b

264 so a valuable tool for the identification of virulence determinants that can serve as potential antim

265 genetic elements that encode resistance and virulence determinants that could enhance fitness and pa

266 asticity zone (PZ) may encode niche-specific virulence determinants that dictate pathogenic diversity

267 Among the many P. aeruginosa virulence determinants that impact infections, type III

268 The results suggested that BipC possesses virulence determinants that play significant roles in ho

269 utilize fibronectin binding as an important virulence determinant, the borrelial fibronectin-BBK32 i

270 hough phagocytosis is considered to be a key virulence determinant, the mechanism is not very well un

271 the expression of a quorum-sensing dependent virulence determinant, the PA-I lectin.

272 e to demonstrate that a major S. Typhimurium virulence determinant, the Salmonella pathogenicity isla

273 We show here that two H. pylori virulence determinants, the gamma-glutamyl transpeptidas

274 nome that temporally regulate its arsenal of virulence determinants throughout its virulence lifestyl

275 gest that GAS deploys SP-STP as an important virulence determinant to exploit host cell machinery for

276 at OMV can function as a vehicle to transfer virulence determinants to the cytoplasm of the infected

277 ing infection, C. difficile produces two key virulence determinants, toxin A and toxin B.

278 lerated rate in multiple replicates, whereas virulence determinants, transposons, and chromosome stru

279 Various virulence determinants unique to CA-MRSA have been uncov

280 ter membrane homeostasis and is an important virulence determinant upon host infection in Escherichia

281 faceted life histories and deploy stratified virulence determinants via complex, global regulation ne

282 However, the molecular function of this virulence determinant was unclear.

283 umolysin, a pore-forming cytotoxin and major virulence determinant, was both necessary and sufficient

284 To examine additional virulence determinants, we performed a genetic screen in

285 Sites previously implicated as virulence determinants were examined for association wit

286 Several of the experimentally evolved virulence determinants were identical to those discovere

287 omponents of AcrAB-TolC, expression of known virulence determinants were significantly altered.

288 EC strains harboring mutations in known EAEC virulence determinants were tested in an in vitro model

289 FN regulation, hantaviruses contain discrete virulence determinants which permit them to be human pat

290 GAS expresses a large number of virulence determinants whose expression is under the con

291 Understanding virulence determinants will aid in the design of vaccine

292 tion and characterization of this organism's virulence determinants will facilitate the development o

293 porate MLST and take into account additional virulence determinants will provide a greater understand

294 co-ordinating production of colonization and virulence determinants with flagella, which together are

295 ternal-fetal interface, we hypothesized that virulence determinants with placental tropism are requir

296 These findings define a potential virulence determinant within the NY-1V GnT that may perm

297 rum-sensing alleles to variant expression of virulence determinants within a bacterial species.

298 horylation and IFN-beta induction and define virulence determinants within GnTs that may permit the a

299 In order to identify the virulence determinants within the PICV genome, we develo

300 microbes, functional amyloids are often key virulence determinants, yet the structural basis for the