ライフサイエンスコーパス: virulence factor

1 polysaccharide of the Legionella pneumophila virulence factor.

2 nisms, suggesting that pGP3 is a key in vivo virulence factor.

3 isms that control the growth of this crucial virulence factor.

4 lactopyranose (UDP-Galp) and is an important virulence factor.

5 rectly regulates the two primary V. cholerae virulence factors.

6 assembly of a poorly characterized class of virulence factors.

7 n S. aureus, that controls expression of key virulence factors.

8 harbors both MDR and a deadly complement of virulence factors.

9 ne responses, and Mycobacterium tuberculosis virulence factors.

10 a small set of targets, many of which encode virulence factors.

11 ponses to infection through the secretion of virulence factors.

12 to control the expression of membrane bound virulence factors.

13 dentification and strategies that neutralize virulence factors.

14 ic human infections due to a wide variety of virulence factors.

15 accines to target the multitude of S. aureus virulence factors.

16 produces a variety of adhesins and delivers virulence factors.

17 pathogenic lineages I or I/II and encode key virulence factors.

18 s the presence of potentially horse-specific virulence factors.

19 icating that CsrA is a positive regulator of virulence factors.

20 lated to its ability to secrete a variety of virulence factors.

21 logical relationships and identify potential virulence factors.

22 -IX secretion system (T9SS) for secretion of virulence factors.

23 ch deter attachment and induce expression of virulence factors.

24 indicate that microbial GHs are undiscovered virulence factors.

25 ein CodY, the BCAAs are key co-regulators of virulence factors.

26 y for trophozoite attachment, while inducing virulence factors.

27 ngle-chain toxins TcdA and TcdB are the main virulence factors.

28 on compared to strains lacking known E. coli virulence factors.

29 operate may represent a target for bacterial virulence factors.

30 on the expression and production of several virulence factors.

31 genes of foreign DNA elements and bacterial virulence factors.

32 addition, cell wall lipids are mycobacterial virulence factors.

33 ntibiotics and also to trigger production of virulence factors.

34 eumoniae produces pneumolysin toxin as a key virulence factor against host cells.

35 s (AMs) through the activity of the secreted virulence factor alpha toxin (AT), which has been implic

36 -specific response to the S. aureus-secreted virulence factor alpha-hemolysin (Hla).

37 ons and cell destruction through its primary virulence factor, alpha toxin.

38 teine peptidase of T. cruzi, is an important virulence factor and a chemotherapeutic target with exce

39 bacterium tuberculosis (Mtb) is an essential virulence factor and macrophages are critical for tuberc

40 Candida albicans excretes E,E-farnesol as a virulence factor and quorum sensing molecule that preven

41 study demonstrates that OxyR is an important virulence factor and transcriptional regulator of the ox

42 We conclude that Salmonella virulence factors and antibiotic treatment promote patho

43 population structure and the distribution of virulence factors and antibiotic-resistance determinants

44 Finally, pre-computed predictions including virulence factors and antimicrobial resistance are now a

45 pathogenicity islands, and the expression of virulence factors and bacteriocins are all controlled by

46 they are also involved in the production of virulence factors and conferring resistance to various a

47 ignalling molecules, including autoinducers, virulence factors and morphogenic substances.

48 ess of the microbe within a niche, including virulence factors and other medically or environmentally

49 lycoside hydrolase 12 (GH12) proteins act as virulence factors and pathogen-associated molecular patt

50 ClpAS-P system to regulate the expression of virulence factors and pathogenicity.

51 tween clinical and environmental isolates in virulence factors and stress response genes.

52 nsporter proteins, which represent important virulence factors and targets for developing countermeas

53 Knowledge of Acinetobacter virulence factors and their role in pathogenesis is scar

54 Although several virulence factors and their roles in pathogenesis are we

55 lated to its ability to secrete a variety of virulence factors and to promote biofilm formation.

56 new pathogenic function for this classic GAS virulence factor, and highlights a potential innate immu

57 by enhancing expression of immunomodulatory virulence factors, and examples that promote asymptomati

58 translocation products, targets of oncogenic virulence factors, and genomic mutations that hijack ang

59 istributions of antibiotic-resistance genes, virulence factors, and phage sequences in microbial comm

60 henotypes, including the production of major virulence factors, and suggest a link between c-di-GMP s

61 P. gingivalis colonization and expression of virulence factor are therefore attractive approaches for

62 Several bacterial virulence factors are deamidases that manipulate the act

63 Bacterial virulence factors are increasingly recognized as importa

64 This method of regulation suggests that virulence factors are only utilized in early infection t

65 Type 1 fimbriae, a major UPEC virulence factor, are essential for ST131 bladder coloni

66 irus disease severity is influenced by viral virulence factors as well as individual differences in h

67 t encode 80 genes, including novel and known virulence factors associated with adherence and autoaggr

68 y, B. pertussis maintained the production of virulence factors at 24 degrees C, whereas B. bronchisep

69 is membranes ensures sustained production of virulence factors at suboptimal temperatures and may pla

70 es four major proteases that are emerging as virulence factors: aureolysin (Aur), V8 protease (SspA),

71 Besides being a virulence factor, Avr2 triggers immunity in I-2 carrying

72 In addition to multiple virulence factors, Bacillus cereus a pathogen that cause

73 ial (PE) growth phase, the pathogens express virulence factors, become flagellated, and leave the Leg

74 Toxins A and B are its major virulence factors, but expression of a third toxin, know

75 The virus-encoded NSs protein acts as a virulence factor by impairing host cell transcription.

76 la pertussis regulates the production of its virulence factors by the BvgA/S system.

77 e of Lenisia stimulates expression of known 'virulence' factors by Arcobacter.

78 virulence is induced with release of various virulence factors, by N-3-oxododecanolyl homoserine lact

79 AM1 interaction enables translocation of the virulence factor CagA into host cells and enhances the r

80 onella pathogenicity is mediated by specific virulence factors, called bacterial effectors, which are

81 These results show how a virulence factor can hijack host kinases to inhibit effe

82 appaB pathway was identified as the key UPEC virulence factor causing a significant increase (P < 0.0

83 rcuit coordinates the induction of two major virulence factors: cholera toxin and a toxin-coregulated

84 e first time, which of several well-studied "virulence factors" common to classical Bordetella specie

85 d DNA damage, and therefore induced ATM in a virulence factor-dependent manner.

86 cleaves porcine IgM and represents the first virulence factor described, linkingS. suisto pigs as the

87 n complex dedicated to the export of several virulence factors during host infection.

88 cular microbiome on host damage and pathogen virulence factors during infection.

89 uring coexistence with other microorganisms, virulence factors during pathogenic interactions with pl

90 us aureus (MRSA) via regulation of principal virulence factors (eg, adhesins and toxins) and biofilm

91 e compounds were able to reduce QS-regulated virulence factors (elastase, rhamnolipid, and pyocyanin)

92 TCS controls expression of all known protein virulence factor-encoding genes and is considered the "m

93 icida as a model organism, a bacterial lipid virulence factor (endotoxin) was imaged and identified a

94 The ESX-1 system secretes virulence factor ESAT-6 that plays a critical role in mo

95 rus (IAV) nonstructural protein 1 (NS1) is a virulence factor essential for counteracting the innate

96 says revealed that production of a number of virulence factors essential for dissemination and surviv

97 order to assess which PKs are also potential virulence factors essential in vivo, lines were pooled,

98 ce regulon, controls the expression of many "virulence factors" expressed in the Bvg positive (Bvg+)

99 armacological hydroxylase inhibition reduces virulence factor expression and pathogenicity in a murin

100 that AtxA1 is the primary regulator of G9241 virulence factor expression and that AtxA1 and AtxA2 are

101 eumonia in which invasive infection requires virulence factor expression controlled by the accessory

102 Activation of agr and subsequent virulence factor expression is inhibited by apolipoprote

103 n bacterial oxygen sensing, displays reduced virulence factor expression.

104 nt system has a major role in regulating GAS virulence factor expression.

105 In addition, we show that NS4 is a virulence factor for BTV by favoring viral replication i

106 ase is now emerging as a potential auxiliary virulence factor for C. perfringens enteritis and entero

107 InlP is a novel virulence factor for listeriosis with a strong tropism f

108 odents, whereas VP40 appears to be the major virulence factor for marburgviruses.

109 The most significant virulence factor for S. epidermidis is its ability to fo

110 These findings establish CPS as a key virulence factor for the induction of systemic infection

111 ate that the derived diterpenoid serves as a virulence factor for this rice leaf streak pathogen, ser

112 cteria by leveraging the natural affinity of virulence factors for cellular membranes is reported.

113 covered here may facilitate targeting of GAS virulence factors for disease management.

114 4) and nucleoprotein (NP) appear to be major virulence factors for ebolaviruses in rodents, whereas V

115 Type IV pili are important virulence factors for many pathogens, including Pseudomo

116 Type 1 pili (T1P) are major virulence factors for uropathogenic Escherichia coli (UP

117 The ESX-1 secretion defect prevents several virulence factors from being functional during infection

118 hemical entities designed to target exotoxin virulence factors from important human bacterial pathoge

119 cause current pathways have shown that major virulence factors from microorganisms have the potential

120 A family of virulence factors from the bacterial pathogen Legionella

121 e that HpnN is capable of shuttling hopanoid virulence factors from the outer leaflet of the inner me

122 hand, differential presence or expression of virulence factors has been shown to significantly impact

123 ng unique combinations of multiple canonical virulence factors have also been described.

124 To date, however, only a few virulence factors have been described for Leishmania maj

125 Host-targeted virulence factors have evolved repeatedly out of this po

126 rades viral oncoproteins and other microbial virulence factors; however, the role of endolysosomal de

127 nt on the surface-exposed, membrane-embedded virulence factor IcsA, which recruits the host actin reg

128 ococcus pyogenes (GAS) are surface-expressed virulence factors implicated in processes that contribut

129 ion system 5 (T6SS-5), which is an essential virulence factor in both species.

130 heep abortion." These results identify a key virulence factor in Campylobacter and a potential target

131 the molecular basis of assembly of this key virulence factor in cell nuclei.

132 y is to evaluate the role of Pg capsule as a virulence factor in coaggregated mixed infection with Fu

133 st potential in vivo functions for HsvA as a virulence factor in fire blight and may also provide a b

134 n quality control, has been reported to be a virulence factor in many pathogens.

135 Pg capsule was found to serve as a unique virulence factor in mixed infection with Fn.

136 anscriptional regulator PhoP is an essential virulence factor in Mycobacterium tuberculosis, and it p

137 c-like serine/threonine protein kinase, is a virulence factor in Mycobacterium tuberculosis, required

138 ualifies ClpG as a potential persistence and virulence factor in P. aeruginosa.

139 The CPS1 gene was identified as a virulence factor in the maize pathogen Cochliobolus hete

140 between temperature-dependent expression of virulence factors in a pathogen and infection of its cor

141 Here, we analyzed parasite virulence factors in an infected adult population in Ind

142 orming toxins, which often represent crucial virulence factors in bacteria.

143 iofilms, which could be one of the important virulence factors in determining the pathogenic potentia

144 toxins, TcdA and TcdB, which are the primary virulence factors in disease.

145 Type IV pili (Tfp), which are key virulence factors in many bacterial pathogens, define a

146 s, and other steps of infection, require two virulence factors in particular: urease and MR/P fimbria

147 lication allowed the stepwise acquisition of virulence factors in pathogenic Leptospira evolved from

148 of the multilaminate cell wall and essential virulence factors in pathogenic species.

149 Although streptococcal SAgs are known virulence factors in scarlet fever and toxic shock syndr

150 eby suggesting the involvement of additional virulence factors in such strains that remain to be iden

151 e expression of key quorum sensing regulated virulence factors in the opportunistic pathogen Pseudomo

152 porting the consideration of these traits as virulence factors in this system.

153 Quorum sensing controlled virulence factors include secreted toxins responsible fo

154 oduction of several well-known P. gingivalis virulence factors including fimbrial proteins and gingip

155 GAS controls the expression of several major virulence factors including secreted protease SpeB durin

156 ause different diseases, they share multiple virulence factors, including bacterial secretion systems

157 enes in S. agalactiae 874391 that encode key virulence factors, including beta-h/c and HvgA, but not

158 at insect killing occurs as a consequence of virulence factors, including insecticidal toxins and enz

159 rotein strains that upregulate expression of virulence factors, including the IL-8 proteaseStreptococ

160 A. baumannii expresses a variety of virulence factors, including type IV pili, bacterial ext

161 ealed hypoxia-induced repression of multiple virulence factors independent of altered bacterial growt

162 Leishmania lipophosphoglycan (LPG) is a key virulence factor, initiating inflammation resulting in c

163 ction, and demonstrate that heterogeneity in virulence factor injection and cellular responses play a

164 nic infection inside the stomach and how its virulence factors interact with the epithelial target ce

165 us influenzae protein F (PF) is an important virulence factor interacting with laminin, an extracellu

166 called a type III secretion system to inject virulence factors into host cells.

167 tisomes of gram-negative pathogens to export virulence factors into host cells.

168 tems that breach immune barriers and deliver virulence factors into mammalian cells.

169 rete Sec-dependent effectors (SDEs) or other virulence factors into the phloem elements or companion

170 cus aureus protein A, an important S. aureus virulence factor involved in immune evasion and biofilm

171 The pneumococcal autolysin LytA is a key virulence factor involved in several important functions

172 s a guanine auxotroph, the production of key virulence factors is compromised, and the ability to inf

173 r, a critical analysis of the most promising virulence factors is presented, highlighting their poten

174 The nonstructural protein NSs is a major virulence factor known to suppress the type I interferon

175 Secreted virulence factors like bacterial collagenases are concep

176 finding that numerous skin strain-associated virulence factors make slight but significant contributi

177 ies by 18- to 210-fold, including the silent virulence factor malleilactone.

178 n exciting strategy, since the modulation of virulence factors might lead to a milder evolutionary pr

179 The GAS CpsY regulon includes known virulence factors (mntE, speB, spd, nga [spn], prtS [Spy

180 comparable in degree to classical listerial virulence factor mutants.

181 a protein with homology to the pneumococcal virulence factor, NanA, which has neuraminidase (sialida

182 because M.tb DK9897 cannot secrete the EsxA virulence factor nor induce a host response against it.

183 We also showed that diversification of virulence factors occurred within each lineage, most lik

184 between growth morphologies is an important virulence factor of C. albicans.

185 he M protein is the major surface-associated virulence factor of group A Streptococcus (GAS) and an a

186 The viral protein R (Vpr) is an accessory virulence factor of HIV-1 that facilitates infection in

187 e report that the gamma134.5 gene product, a virulence factor of HSV-1, facilitates nuclear egress co

188 PB1-F2 is a virulence factor of influenza A virus (IAV) whose functi

189 Exotoxin A (ETA) is the most toxic virulence factor of Pseudomonas aeruginosa.

190 Typhoid toxin, a unique virulence factor of Salmonella Typhi (the cause of typho

191 Typhoid toxin is an essential virulence factor of Salmonella Typhi, the cause of typho

192 onstructural protein, termed NSs, is a major virulence factor of SBV, and it is known to promote the

193 .2 MDa pore complex of pneumolysin, the main virulence factor of Streptococcus pneumoniae, by cryoEM.

194 terol-dependent cytolysin pneumolysin, a key virulence factor of Streptococcus pneumoniae, using sing

195 Shiga toxin (Stx) is the primary virulence factor of Stx-producing Escherichia coli (STEC

196 h as the yeast-to-hyphae transition is a key virulence factor of the human fungal pathogen Candida al

197 Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen

198 Shiga toxins are the major virulence factor of these pathogens, however adhesion an

199 The lipopolysaccharide is a virulence factor of this pathogen, although there are ga

200 Among the virulence factors of B. anthracis is the S-layer-associa

201 glycan cell wall, housekeeping proteins, and virulence factors of bacteria.

202 ment of nonantibiotic agents that target the virulence factors of bacterial pathogens is one way to b

203 tudies to characterize isolates that contain virulence factors of both EPEC and ETEC.

204 necrotizing fasciitis outcome by modulating virulence factors of CLI-susceptible and CLI-resistant G

205 genes or proteins targeted by SDEs or other virulence factors of Liberibacters serve as susceptibili

206 y, alleviated gut lesions, and decreased the virulence factors of pathogenic bacteria (VF 0073-ClpE,

207 toxins form a family of proteins that act as virulence factors of pathogenic bacteria, but similar pr

208 The virulence factors of pathogenic microbes often have sing

209 ic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which d

210 By examining secreted virulence factors of Staphylococcus aureus, we determine

211 forsythia will be valuable in investigating virulence factors of the latter and possible health bene

212 of M proteins, the major surface-associated virulence factors of the widespread bacterial pathogen g

213 APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania sp

214 Type IV pili are important virulence factors on the surface of many pathogenic bact

215 we demonstrate that Listeriolysin S (LLS), a virulence factor only present in a subset of lineage I s

216 Many pathogens deliver virulence factors or effectors into host cells in order

217 are limited examples of direct regulation of virulence factors, PASTA kinases are critical for virule

218 substrates, including macrolide antibiotics, virulence factors, peptides and cell envelope precursors

219 For both viruses, interactions between viral virulence factors, personal risk factors (eg, genetics),

220 s (STs) and for host specific resistance and virulence factors previously associated with LA-MRSA.

221 Pyocyanin is a virulence factor produced as a secondary metabolite by t

222 PYO is one of the most important virulence factors produced by nearly all P. aeruginosa s

223 ription activator-like effectors (TALEs) are virulence factors, produced by the bacterial plant-patho

224 triggers repression of genes responsible for virulence factor production and biofilm formation.

225 ing metabolic reorganization and controlling virulence factor production in vitro.

226 scriptional regulators coordinately silences virulence factor production is proposed.

227 rature-associated differential modulation of virulence factor production was linked to the phosphoryl

228 g-controlled target promoters and suppresses virulence factor production, confirming their potential

229 y bacterial species, quorum sensing controls virulence factor production.

230 lation between the genomic sequence type and virulence factor profiles based on prevalence of the iso

231 reptococcus (GAS) has acquired an arsenal of virulence factors, promoting life-threatening invasive i

232 The bacterial virulence factor PSMalpha, but not alpha-toxin or delta-

233 res and activity against the major bacterial virulence factors: quorum sensing, bacterial biofilms, b

234 In an effort to disentangle hypha-associated virulence factor regulation from morphological transitio

235 These transporters are critical virulence factors, relying on specific and high-affinity

236 hogen, as well as the complexity of the EPEC virulence factor repertoire.

237 This virulence factor represents a tool for the development o

238 We identified two virulence factors required for cluster development: urea

239 tor (agr) operon to coordinate expression of virulence factors required for invasive infection.

240 d cotton, VdEG1 and VdEG3 acted as PAMPs and virulence factors, respectively indicative of host-depen

241 e proteins have evaded selection in previous virulence factor screens in animals.

242 nowledge, the first characterized, bona fide virulence factor secreted by Acinetobacter species.

243 hmania donovani gp63 (Ldgp63)) is a critical virulence factor secreted by Leishmania However, how new

244 the quantification of relevant and specific virulence factors secreted by this microorganism.

245 um, interact with secreted SDEs and/or other virulence factors secreted or located on the Liberibacte

246 orchestrate collective behaviours, including virulence factor secretion and biofilm formation.

247 y essential homeostatic processes as well as virulence factor secretion and the elimination of drugs.

248 A activation and the subsequent induction of virulence factor secretion.

249 Knowledge on the virulence factors specific to hvKP is limited.

250 with a mutation in the gamma134.5 protein, a virulence factor, stimulates dendritic cell (DC) maturat

251 of enterocyte effacement (LEE), but lack the virulence factors (stx, bfpA) that characterize enteroha

252 stomata that are less responsive to pathogen virulence factors such as coronatine (phytotoxin produce

253 pression of many QS regulated genes encoding virulence factors such as hemolysins and proteases were

254 electron transport chain and cannot produce virulence factors such as leukocidins, hemolysins, or th

255 ylation, derepressed multiple CovR-regulated virulence factors (such as SPN and SLO), and increased v

256 They possess virulence factors, such as cytolethal distending toxin (

257 inosa genome, including major regulators and virulence factors, such as the quorum sensing (QS) regul

258 argo analysis of EVs shows that they contain virulence factors suggesting a role in the pathogenesis

259 cins, NBs specific for Escherichia coli, and virulence factors, suggesting NBs play a role in infecti

260 ates interconnectivity between inhibition of virulence factor synthesis and growth.

261 e activity of 112 virulence-linked genes and virulence factor synthesis pathways that produce 17 uniq

262 ropathogenic E. coli use the multifunctional virulence factor TcpC to attenuate innate immune respons

263 the role of pore-forming alpha-toxin (AT), a virulence factor that causes host cell lysis and elicits

264 l (PQS) compound is a secreted P. aeruginosa virulence factor that contributes to the pathogenicity o

265 ococcal pyrogenic exotoxin B (SpeB) is a key virulence factor that is produced abundantly during infe

266 mycetemcomitans leukotoxin (LtxA) is a major virulence factor that kills leukocytes permitting it's e

267 ns of S. pyogenes have evolved a plethora of virulence factors that aid in disease-by promoting bacte

268 background containing several VAPs acquires virulence factors that allow for its emergence as a path

269 resence of BvgAS-independent, PlrS-dependent virulence factors that are critical for bacterial surviv

270 ally important pathogen with an abundance of virulence factors that are necessary for survival within

271 coded proteases are an important category of virulence factors that cause robust changes on the host

272 ogies associated with H7N9 infection and the virulence factors that contribute to these pathologies.

273 pathogens exploit ubiquitin signalling using virulence factors that function as E3 ligases, deubiquit

274 sms of drug resistance are well studied, the virulence factors that govern Acinetobacter pathogenesis

275 ureus is an AD-associated pathogen producing virulence factors that induce skin barrier disruption in

276 in the inability of P. aeruginosa to produce virulence factors that kill S. aureus These data could p

277 duction and/or accumulation of extracellular virulence factors that limit osteoblast and osteoclast v

278 mic strains, and novel roles for several key virulence factors that may allow the field to better und

279 indicate the existence of previously unknown virulence factors that may serve as new vaccine componen

280 Microbial pathogens have evolved virulence factors that reprogram these host signaling re

281 Our approaches reveal key virulence factors that respond to restricted oxygen avai

282 readth and evolutionary novelty of candidate virulence factors that we discover underscores the urgen

283 Streptococcus mutans employs a key virulence factor, three glucosyltransferase (GtfBCD) enz

284 hips between strains to be reconstructed and virulence factors to be identified.

285 Bacteria often coordinate virulence factors to fine-tune the host response during

286 lular cargo between cells as well as package virulence factors to infect host cells by secreting oute

287 toxin or though regulating the stability of virulence factors to remove their function once it is no

288 valent nanotoxoids are capable of delivering virulence factors together, are safe both in vitro and i

289 ococcus aureus, Fak is a global regulator of virulence factor transcription and is essential for the

290 EVs are organelles mediating non-hereditary virulence factor transfer and causing host erythrocyte r

291 s (CF) lung, including reduced production of virulence factors, transition to a biofilm-associated li

292 ce they expand our limited knowledge base on virulence factors unique to hvKP, which is needed to lay

293 Type IV pili (T4P) are among the key virulence factors used by P. aeruginosa for host cell at

294 his area, such as the targeting of bacterial virulence factors, utilization of bacteriophages to kill

295 urface-expressed M1 protein, a classical GAS virulence factor, was required for high-level histone re

296 estingly, while the M segment of SBVp32 is a virulence factor, we found that the S segment of the sam

297 They belong to the AB5 virulence factors, which bind to glycans on host cell me

298 transcriptional regulation for an important virulence factor with IHF playing a role in regulating g

299 xpression of many genes, which include known virulence factors, yet the influence of phasevarion-medi

300 NF-kappaB and MAPK signaling by the Yersinia virulence factor YopJ inhibits cytokine production by in