ライフサイエンスコーパス: virulent

1 a sulfite reductase mutant strain are fully virulent.

2 iremia and was efficiently neuroinvasive and virulent.

3 uction was inhibited, P. aeruginosa was less virulent.

4 (NA-WT) and NA-R292K virus seemed the least virulent.

5 interference made the treated nematodes less virulent.

6 quired for IAV of the H9N2 subtype to become virulent.

7 bicans and P. aeruginosa are synergistically virulent.

8 RBC generalist and RBC specialist are highly virulent; (3) and the presence of an RBC generalist in a

9 a murine SSTI challenge model with a highly virulent agr type I S. aureus isolate, PP7-AIP1S vaccina

10 umors, which develop upon infection with the virulent Agrobacterium tumefaciens strain C58, highly ex

11 Here we show that the genomes of a virulent and an attenuated strain of CMV are maintained

12 The first is E. coli PI-7, a virulent and antibiotic-resistant strain that was isolat

13 infectious conditions, with numerous highly virulent and antibiotic-resistant strains.

14 the full-length GPs of Rom and Can exhibited virulent and attenuated phenotypes, respectively, in gui

15 ere the only major variance detected between virulent and avirulent isolates, implicating its role in

16 ive whole-blood transcriptomics profiling of virulent and avirulent malaria shows the validity of thi

17 Inoculation with virulent and avirulent strains of the bacterial pathogen

18 ons indicate that these novel H3 viruses are virulent and can sustain onward transmission in pigs, an

19 y initiate or establish an infection, become virulent and cause pathogenicity within a host.

20 emergence and secondary adaptation of a new virulent and drug-resistant pneumococcal epidemic clone.

21 Mycoplasma gallisepticum is the most virulent and economically important Mycoplasma species f

22 This mutant was more virulent and exhibited increased toxin gene expression i

23 at results in the stable co-existence of non-virulent and hyper-virulent subpopulations, even after m

24 nella The modified Nissle strain became more virulent and less able to protect against Salmonella in

25 The evolution and fast spread of virulent and more aggressive race lineages of rust fungi

26 iments involving 3 types of DNA (attenuated, virulent and plasmid) at 3 concentrations.

27 e to a broad range of phages, including both virulent and temperate ones.

28 ith T. cruzi TcI isolates, SylvioX10/4 (SYL, virulent) and TCC (nonpathogenic), which represent mphi

29 Llo is immunologically silent, highly virulent, and lethal.

30 pecies that are unable to form hyphae are as virulent as C. albicans during polymicrobial IAI.

31 We demonstrate that low-binding virus is as virulent as higher binding counterparts, suggesting that

32 pseudotuberculosis yopJ mutant was as virulent as the wild type, while the yopJ yopM mutant wa

33 subtype D, with both subtypes becoming less virulent, as observed in the data.

34 The virulent ASFV Armenia/07, E70 or the naturally attenuate

35 us (ASFV-G-DeltaMGF) derived from the highly virulent ASFV Georgia 2007 isolate (ASFV-G) by specifica

36 SFV vaccine that protects against the highly virulent ASFV Georgia 2007 isolate as early as 2 weeks p

37 letion of the 9GL (B119L) gene in the highly virulent ASFV isolates Malawi Lil-20/1 (Mal) and Pretori

38 enuated recombinant ASFV derived from highly virulent ASFV strain Georgia (ASFV-G) lacking only six o

39 e regulation of viral transcripts.IMPORTANCE Virulent ASFV strains cause a highly infectious and leth

40 ntal vaccine that induces protection against virulent ASFV-G.

41 asonal virus, but significantly lower than a virulent Asian-lineage H5N1 (A/Thailand/16/2004) virus.

42 were challenged with a high dose of a highly virulent B. pertussis isolate, they were fully protected

43 by proteases, even by those secreted by non-virulent bacteria such as B. subtilis, can shift the del

44 ction recognized virulence factors and bound virulent bacteria within the intestinal lumen, leading t

45 vive for up to 30 d following challenge with virulent bacteria.

46 Total postchallenge nasopharyngeal virulent bacterial burden of vaccinated animals was subs

47 ue is initiated by Yersinia pestis, a highly virulent bacterial pathogen.

48 Infections due to clonal expansion of highly virulent bacterial strains are clear and present threats

49 Here, we focus efforts on the highly virulent bacterium Francisella tularensis tularensis.

50 ed PAMP responses and resistance against the virulent bacterium Pseudomonas syringae pv tomato DC3000

51 sensed or transported in order to induce the virulent behavior of S. scabies?

52 nistration of E. coli K1 strain A192PP and a virulent bioluminescent derivative, E. coli A192PP-lux2.

53 but the mechanisms by which the host senses virulent, but not commensal, S. aureus to trigger inflam

54 ses tested, EBOV-Makona may be slightly more virulent by the aerosol route than by the injected route

55 nto the complex immune response triggered by virulent C. carbonum.

56 ibodies against the pathogen, phenotypically virulent C. rodentium, accumulated and infected the epit

57 y was observed in those infected with a more virulent CagA+ strain of H. pylori.

58 pisthorchiasis exhibited higher frequency of virulent cagA-positive H. pylori than those free of fluk

59 We demonstrate that the highly virulent CEA10 strain is able to rapidly germinate withi

60 ted with FPII.2 virus were protected against virulent challenge with Brescia virus at 21 days postvac

61 hey were more probably colonized by the most virulent clone, CC17.

62 acterial populations before the emergence of virulent clones.

63 Our recent study demonstrated that virulent Coxiella burnetii Nine Mile phase I (NMI) is ca

64 derived exoenzyme effectively modulates this virulent cross-kingdom interaction.

65 a full-length infectious clone of the highly virulent CSFV strain Brescia (BICv) was used to evaluate

66 rol strategies; however, such mechanisms and virulent determinants for H5N1 influenza viruses have no

67 ance factors confirmed the unique and highly virulent determinants of the MRSA strain of poultry orig

68 son distribution, which is strongest for the virulent DNA sample.

69 1st cycle efficiency are much lower for the virulent DNA, moderately lower for the attenuated DNA an

70 0% of Bhutanese strains possessed the highly virulent East Asian-type CagA and all strains had the mo

71 The binding of biotinylated virulent EAV strain Bucyrus at 4 degrees C was significa

72 tivity and protective efficacy against three virulent ebolaviruses.

73 toms, or act prophylactically to prevent the virulent effects of a cholera infection.

74 Virulent ehrlichiae induce inflammasome activation leadi

75 SF-deficient mice infected with a moderately virulent encapsulated strain of C. neoformans (strain 52

76 The highly virulent Escherichia coli O104:H4 that caused the large

77 Second, the more virulent EVOL20 strain, derived from Af293, is able to g

78 lated from sewage using strain 536, a highly virulent extraintestinal E. coli.

79 In this study, we demonstrate that virulent F. tularensis impairs production of inflammator

80 Unexpectedly, some virulent F1 progeny were recovered from selfing of an av

81 enes alone can completely attenuate a highly virulent field ASFV isolate.

82 genes, MGF360-13L and MGF360-14L, in highly virulent field isolate Georgia/2007, did not affect viru

83 ous conditions, to test whether diversity of virulent FIV in lymphoid tissues is altered in the prese

84 A virulent fluorescently tagged ASFV is a suitable tool to

85 ied in Fon races 0 and 1 but not in the more virulent Fon race 2.

86 for in vitro and in vivo growth of a highly virulent food-borne pathogen, suggesting that GpsB could

87 mutational changes may be required to become virulent for pigs.IMPORTANCE Swine play an important rol

88 protozoan parasite responsible for the most virulent form of malaria, Plasmodium falciparum, invade

89 A particularly virulent form of this disease is castration-resistant pr

90 changes associated with differentiation into virulent forms.

91 ls is also required for early replication of virulent Francisella Taken together, our data demonstrat

92 y intracellular bacterial pathogens, such as virulent Francisella tularensis spp. tularensis (Ftt).

93 of a 17-kb O-PS gene cluster from the highly virulent Francisella tularensis subsp. tularensis (type

94 To discern virulent from innocuous microbes, the innate immune syst

95 ificantly higher titers of the presumed more virulent FSS13025 Cambodia (ZIKV(C)).

96 3 signaling is instead functional during non-virulent GAS lifestyles.

97 The virulent gene island polyketide synthase (pks) produces

98 By CRISPR/Cas9 system, the virulent genes of the newly isolated strain were simulta

99 gated, including recent work focusing on the virulent, globally disseminated, multidrug-resistant lin

100 Francisella tularensis is a highly virulent Gram-negative intracellular pathogen capable of

101 ar VDV1-DWV recombinants constitute the most virulent honeybee viruses in the UK.

102 ged orally with 10(5) focus-forming-units of virulent HRV at 33 days of age.

103 our studies, we typically infect mice with a virulent HSV-1 strain (McKrae) that does not require cor

104 following corneal scarification or (ii) the virulent HSV-1 strain McKrae without corneal scarificati

105 of mice latently infected with avirulent or virulent HSV-1.

106 Plasmodium falciparum is the most virulent human malaria parasite because of its ability t

107 imination of Plasmodium falciparum, the most virulent human malaria parasite, effective tools for mon

108 blood stage multiplication rates of the most virulent human malaria parasite, Plasmodium falciparum.

109 hia coli Nissle [EcN]) probiotic bacteria on virulent human rotavirus (VirHRV) infection and immunity

110 cantly protected mice from severe and highly virulent IAV-induced disease.

111 virulent in cell culture and 1000-fold more virulent in a chicken model than other strains; accordin

112 olated from broilers, was found to be highly virulent in cell culture and 1000-fold more virulent in

113 The recombinant virus is virulent in established ZIKV mouse models, leading to ne

114 a rabbit-specific poxvirus, which is highly virulent in European rabbits.

115 bee paralysis virus (SBPV), which is highly virulent in honey bees but rarely detected.

116 VA1994, while moderately virulent in house finches, displayed significant virulen

117 ulent in adult mice, while the L10 strain is virulent in mice of all ages.

118 NA-I222K virus was the most virulent in mice, whereas virus lacking NA change (NA-WT

119 A. fumigatus DeltasakA and DeltampkC were virulent in mouse survival experiments, but they had a 4

120 lically distinct subpopulation, and are less virulent in the experimental models used here.

121 VA2013, while highly virulent in the house finch, was significantly attenuate

122 cally found in human virus isolates was more virulent in transgenic mice than parental virus, demonst

123 ated from chicken, was observed to be highly virulent, in cell culture and in mouse model, and exhibi

124 ranscriptomic signatures associated with the virulent infection, including signatures for platelet ag

125 , they are among the most important and most virulent invasive bacterial pathogens.

126 However, deletion of this gene from a virulent isolate, Benin 97/1, producing the BeninDeltaDP

127 phylogenetic analyses show that these recent virulent isolates are more closely related to virulent s

128 ial and complete genomic sequences of recent virulent isolates of genotypes II and IX from China, Egy

129 subjected to heterologous challenge with the virulent Kenya-128B-15 RVFV strain.

130 ow-virulence MGH 78578 strain and the highly virulent KPPR1 strain.

131 brain, within 1 h after inoculation of 10(8) virulent L. interrogans bacteria.

132 InlP is conserved in virulent L. monocytogenes strains but absent in Listeria

133 strains of HSV-1 was similar to that of the virulent LAT((-)) McKrae-derived mutant.

134 ) mice that failed to induce protection upon virulent Leishmania challenge suggesting that IL-23 play

135 ogens reside in humans is by shifting from a virulent lifestyle, (systemic infection), to a dormant c

136 ssociated with the emergence of particularly virulent lineages.

137 infection with recombinant SFB Ag-expressing virulent Listeria (but not wild-type virulent Listeria),

138 ressing virulent Listeria (but not wild-type virulent Listeria), suggesting the CLP-induced polymicro

139 e found that the loss of WhiB6 resulted in a virulent M. marinum strain with reduced ESX-1 secretion.

140 ermore, 80% of IRAK-4(-/-) mice succumbed to virulent M. tuberculosis within 100 d following low-dose

141 unized mice following aerosol challenge with virulent M. tuberculosis, consistent with a role for the

142 ues by feeding them single high doses of the virulent Mahoney strain of wild type 1 poliovirus.

143 asmodium falciparum, the most widespread and virulent malaria parasite, persistence within its human

144 Mice were infected with virulent (McKrae) or avirulent (KOS and RE) strains of H

145 rovide critical information about the highly virulent MDR E. coli strain of poultry origin and warran

146 can lead to vision loss when initiated by a virulent microbial pathogen.

147 with microbial evasion mechanisms unique to virulent microorganisms, is now shown to increase host s

148 Although (+) mating type appeared to be more virulent, most of our clinical isolates presented belong

149 The virulent Mtb H37Rv strain encodes 20 cytochrome P450 (CY

150 e in mice, green fluorescent protein-labeled virulent MTB-strain H37Rv was localized to pimonidazole

151 ed growing colonies of Escherichia coli to a virulent mutant of phage P1.

152 acteria, but did result in emergence of less-virulent mutants that were more susceptible to macrophag

153 Infections with weakly virulent mycobacteria are much rarer than TB, but the in

154 We developed a 3-D system incorporating virulent mycobacteria, primary human blood mononuclear c

155 erized by severe infections caused by weakly virulent mycobacteria.

156 tuberculosis infection limited the growth of virulent Mycobacterium tuberculosis more efficiently tha

157 se analogues have been evaluated in a highly virulent NAP1 strain using optical density and phase-con

158 single locus can control susceptibility to a virulent natural pathogen.

159 s, and conferred complete protection against virulent NDV challenge.

160 lete immunity against infection by otherwise virulent obligate biotrophic powdery mildew fungi such a

161 selection favors pathogen genotypes that are virulent on a broad range of host genotypes.

162 genome of V. dahliae Vd991, which is highly virulent on its original host, cotton, and performed com

163 We show that the origin of Pgt isolates virulent on Sr35 is associated with the nonfunctionaliza

164 Verticillium dahliae isolates are most virulent on the host from which they were originally iso

165 s within one LSR (G-LSR2) in Vd991 were less virulent only on cotton.

166 s in enhanced disease resistance against the virulent oomycete pathogen Hyaloperonospora arabidopsidi

167 (Arabidopsis thaliana), local infection with virulent or avirulent strains of Pseudomonas syringae pv

168 Although infections with either virulent or avirulent strains of the pathogens increase

169 tal DEGs at any time point of infection with virulent or defense-inducing DC3000 strains.

170 measure to eradicate additional potentially virulent organisms beyond C. difficile.

171 CI, 1.03-1.45 per 5-year increase), and more virulent organisms were important predictors of poor fin

172 that play a pivotal role in host response to virulent P. aeruginosa Here, we show that QS genes in P.

173 ol showed weak bacteriostatic effects toward virulent P. aeruginosa, which may explain the low RCL po

174 an pathogens like P. aeruginosa and the less virulent P. fluorescens.

175 molecular-clock analysis performed on three virulent PAI proteins (Fic; D-alanyl-D-alanine-carboxype

176 n rapidly fluctuates during coevolution with virulent parasites ('the Red Queen Hypothesis').

177 ycota, often referred to as chytrids, can be virulent parasites with the potential to inflict mass mo

178 cess in individuals infected by more or less virulent parasitoids.

179 rain, but the Deltahyc strains were like the virulent parent strain with respect to both mouse morbid

180 sis of HSV-1 0DeltaNLS relative to its fully virulent parental strain in C57BL/6 mice.

181 onstrating that, while it is comparable to a virulent parental strain in terms of immunogenicity, HSV

182 ed, raising the possibility that P. vivax, a virulent pathogen in other parts of the world, may expan

183 orrhagic fever virus (CCHFV) is an extremely virulent pathogen of humans.

184 (routes, timing, outbreak sizes) under which virulent pathogen strains such as 'Ug99' (5,6) pose a th

185 flora, opening the niche for entry of other virulent pathogens (e.g., Streptococcus pyogenes, Staphy

186 Filoviruses are highly virulent pathogens capable of causing severe disease.

187 form non-pathogenic P. syringae strains into virulent pathogens in immunodeficient Arabidopsis thalia

188 recurring trend in the zoonotic emergence of virulent pathogens likely to come from bat reservoirs th

189 Bats are natural reservoir hosts of highly virulent pathogens such as Marburg virus, Nipah virus, a

190 Unlike most studies of virulent pathogens that are conducted under controlled c

191 Infections with virulent pathogens, in contrast, may activate receptors

192 ced resistance against a diverse range of (a)virulent pathogens, including Pst-AvrRpt2, Dickeya dadan

193 in 3-D presents challenges, especially with virulent pathogens.

194 ld some vaccines drive the evolution of more virulent pathogens?

195 tinct U.S. PEDV strains (the original highly virulent PC22A, S indel Iowa106, and S 197del PC177), an

196 accines to protect swine from current highly virulent PEDV infections.

197 s-protection against challenge by the highly virulent PEDV PC21A, suggesting that the 197-aa region m

198 from an infectious cDNA clone of the highly virulent PEDV PC22A strain (infectious clone PC22A, icPC

199 pism but reduced the virulence of the highly virulent PEDV strain PC22A in neonatal piglets.

200 s-protection against challenge with a highly virulent PEDV strain, all the surviving piglets were cha

201 ive immunity.IMPORTANCE The emerging, highly virulent PEDV strains have caused substantial economic l

202 in the spike protein can attenuate a highly virulent PEDV, but the virus may lose important epitopes

203 cific for antibodies against the ROP16 mouse-virulent peptide was performed in 46 serum specimens fro

204 These data suggest that this virulent Perkinsea clade is an important pathogen of fro

205 ch, we have identified an unrelated Acr in a virulent phage of Streptococcus thermophilus.

206 Two therapeutic virulent phages and 4 reference antibiotics were studied

207 To this end, we test a cocktail of three virulent phages in two animal models of cholera pathogen

208 lus strain CRISPR-immunized against a set of virulent phages, we found one that evaded the CRISPR-enc

209 th 10(4) HAD50 of ASFV-G-Delta9GL produced a virulent phenotype that, unlike Malawi-Lil-20/1-Delta9GL

210 Existing data on the importance of nsP3 for virulent phenotypes were confirmed, another determinant

211 antibodies to IE surface antigens expressing virulent phenotypes were much better maintained (half-li

212 teins appear to revert attenuated mutants to virulent phenotypes.

213 c diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populat

214 sequences associated with the attenuation of virulent PRRSV in RVRp13 and MLV quickly reverted to wil

215 rectly tested the individual oxidants on the virulent Pseudomonas aeruginosa strain PA14.

216 JMJ27 is induced in response to virulent Pseudomonas syringae pathogens and is required

217 RPN12a support increased bacterial growth of virulent Pseudomonas syringae pv tomato DC3000 (Pst) and

218 nt, but not sim-1, was more susceptible to a virulent Pseudomonas syringae strain, and this susceptib

219 8 gene does not influence resistance against virulent Pst or P. syringae pv. maculicola (Psm) pathoge

220 nced plants display normal susceptibility to virulent (Pst DC3000) and avirulent (Pst DC3000 AvrRPM1)

221 dy (VNA) production and protection against a virulent RABV challenge.

222 diminished in response to inoculation with a virulent race, CYR31.

223 are often overcome owing to evolution of new virulent races of the pathogen.

224 ne Sr13 confers resistance to Ug99 and other virulent races, and is more effective at high temperatur

225 onfers immunity against this pathogen's most virulent races, including Ug99.

226 Notably, nearly all these highly virulent reassortants (all except Gt13) were characteriz

227 This is the first virulent rHRSV strain with the genetic composition of a

228 Conditioned medium from TECs exposed to the virulent Rlow strain induced macrophage chemotaxis to a

229 host defenses in mice infected with a highly virulent serotype A strain of C. neoformans (H99).

230 ged through declining prevalence of the most virulent serotypes as a result of vaccination.

231 ely protected from challenge with individual virulent serotypes, both in early challenge and after 5

232 se healthy individuals infected with certain virulent serotypes.

233 (cryo-ET) to visualize intact machines in a virulent Shigella flexneri strain genetically modified t

234 of vaccinated monkeys to clear a subsequent virulent simian immunodeficiency virus challenge.

235 as a mechanism to avoid suppression by more virulent species in mixed infections, thereby increasing

236 Aspergillus fumigatus is the most virulent species within the Aspergillus genus and causes

237 ce from transnasal challenge with the highly virulent ST2 strain NCTC 7466 by reducing the bacterial

238 irulence: an attenuated strain (NiggA) and a virulent strain (NiggV).

239 ment for WTA galactosylation in a mouse oral-virulent strain by first creating mutations in four gene

240 mammalian host and quickly evolve to a more virulent strain is cause for concern.

241 Studies using a virulent strain of C. neoformans engineered to produce g

242 sing C57BL/6 mice infected with a moderately virulent strain of Cryptococcus neoformans (52D), which

243 d genome and methylome variations in a fully virulent strain of H pylori during experimental infectio

244 We analyzed adaptation of a fully virulent strain of H pylori to 12 different volunteers t

245 eographic origin of an infection with a more virulent strain of H. pylori.

246 evelop a metabolic model for KPPR1, a highly virulent strain of K. pneumoniae.

247 ermonecrosis following skin challenge with a virulent strain of MRSA.

248 c plants showed enhanced resistance toward a virulent strain of the biotrophic oomycete pathogen Hyal

249 o and tracheal tissue ex vivo in response to virulent strain Rlow that contributes to the infiltratio

250 the resistance and virulence of this highly virulent strain.

251 OmpBs from virulent strains contain multiple trimethylated lysine r

252 Low-dose challenge with fully virulent strains in cynomolgus macaques result in the fu

253 irulent isolates are more closely related to virulent strains isolated during the 1940s, which have b

254 G, and took a longer time to reactivate than virulent strains of HSV-1.

255 Virulent strains of Newcastle disease virus (NDV) cause

256 ut it is unknown whether this is due to more virulent strains of virus or differences in host immune

257 Virulent strains were nonlethal at low inocula but letha

258 s disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic

259 bes the molecular events leading from OPV to virulent strains.

260 rd selectively identify and destroy only the virulent strains.

261 toxoplasmosis belonged to the group of mouse-virulent strains.

262 We show that the virulent strategy works best for phages with large diver

263 table co-existence of non-virulent and hyper-virulent subpopulations, even after many generations of

264 r reservoirs of S. aureus in mice comprise a virulent subset of bacteria that can establish infection

265 epithelial cells which is characteristic for virulent swine influenza viruses.

266 However, after highly virulent systemic challenge, T. cruzi immune mice lackin

267 he leading cause of death in young cats, and virulent, systemic feline calicivirus (vs-FCV) causes a

268 carbapenem-resistant ST258 strain, are less virulent than 43816.

269 variant was isolated, was significantly more virulent than any individual variant and its mean mortal

270 e both phenotypically distinct from and more virulent than many El Tor isolates.

271 Our findings suggest that CP-CRE may be more virulent than non-CP-CRE and are associated with poorer

272 We show that ST3081 is significantly more virulent than ST618 in models of invasive pneumonia, and

273 exual mating ability but appeared to be more virulent than the (-) mating type.

274 DWV that has recently been shown to be more virulent than the original DWV genotype-A.

275 t MERSMA bearing mutant S proteins were more virulent than the parental virus in hDPP4 KI mice.

276 y end product fumigaclavine C also were less virulent than the wild type (P < 0.0003).

277 Cytauxzoon felis is a virulent, tick-transmitted, protozoan parasite that infe

278 This functional adaption makes ZIKV more virulent to human NPCs, thus contributing to the increas

279 e threat remains of the emergence of strains virulent to humans from this reservoir.

280 tritici (Pgt) Ug99 race group is virulent to most stem rust resistance genes currently de

281 A spontaneous mutant of Pgt virulent to Sr50 contained a 2.5 mega-base pair loss-of-

282 Specifically, multiple virulent toxins from bacterial protein secretions are co

283 ved surface proteins highly expressed during virulent transition, the vaccine mounts an immune respon

284 Asian-type CagA and all strains had the most virulent type of vacA (s1 type).

285 Compared with the highly virulent U.S. PEDV strain PC21A, the tissue culture-adap

286 otect suckling mice from oral challenge with virulent V. cholerae O395.

287 evolved the necessary mutations to produce a virulent variant.

288 If the virulent variants dominate, then the individual is more

289 d to be highly protective against homologous virulent virus challenges in type I interferon receptor

290 ucosal immunity to reinfection with a highly virulent virus requires the accumulation and persistence

291 Following challenge with the parental virulent virus, all pigs immunized by the intramuscular

292 CNS cells survive acute infection with this virulent virus, we developed a recombinant JHMV that exp

293 otection against challenge with the parental virulent virus.

294 The low rates of change for these virulent viruses (7.05 x 10(-5) and 2.05 x 10(-5) per ye

295 ssible that the source of some of the recent virulent viruses isolated from poultry and wild birds mi

296 ith two copies of nsP3 from SFV6 resulted in virulent viruses.

297 lthough not lethal to animals, became highly virulent when combined with NF2, its virulence augmented

298 h harbors exotoxin A (exoA) gene, was highly virulent when injected alone, but its virulence was atte

299 ce were subcutaneously infected with a fully virulent Y. pestis strain and treated at progressive sta

300 oth the attenuated MP12 strain and the fully virulent ZH548 strain.