ライフサイエンスコーパス: virus

1 nucleic acid material (Nipah and chikungunya viruses).

2 structure indicating their importance to the virus.

3 bust correlates of protection against dengue virus.

4 CD163 is the receptor for the virus.

5 e amplification and subsequent spread of the virus.

6 ainst respiratory reinfection with influenza virus.

7 and greater pathogenicity than the parental virus.

8 us, measles virus, and respiratory syncytial virus.

9 ed to generate an effective vaccine for this virus.

10 observe prevalence and incidence of Sabin 2 virus.

11 we generated a ToV-PLP knockout recombinant virus.

12 the further spread of clade 2.2.1 or 2.3.4.4 viruses.

13 that govern assembly of other segmented RNA viruses.

14 ilitate studies of HSV and other neurotropic viruses.

15 are enveloped negative-sense tripartite RNA viruses.

16 useholds and surrounding areas for influenza viruses.

17 at the disposal of prokaryotes against their viruses.

18 al of these fungi have been shown to contain viruses.

19 fraction represented by eukaryotic cells and viruses.

20 when pdm2009 displaced previous seasonal H1 viruses.

21 nd genomic comparisons with previously known viruses.

22 ivity and biogeochemical influence of marine viruses.

23 from two alphaherpesviruses, herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV), have sugge

24 o RIG-I during infection with herpes simplex virus 1 (HSV-1).

25 gic fever virus (SHFV) or Kibale red colobus virus 1 (KRCV-1) and assessed within-host viral evolutio

26 We tested the recombinant parainfluenza virus 5 (PIV5) vectors expressing RSV glycoproteins for

27 nc80L65 from a set of other adeno-associated virus (AAV) vectors as a potent vector for the cochlear

28 Adeno-associated virus (AAV) vectors have made great progress in their us

29 e editing approach in which adeno-associated virus (AAV)-mediated CRISPR/Cas9 delivery to postmitotic

30 ogether with the serial passages favour H9N2 virus adaptation to pigs.

31 Patients with human immunodeficiency virus/AIDS-associated cryptococcal meningitis (CM) frequ

32 Many RNA viruses also encode helicases, which are sometimes coval

33 that mediate alpharetroviral avian leukosis virus (ALV) integration are unknown.

34 To combat this virus, an effective vaccine would have distinct advantag

35 The study of hepatitis B virus and development of curative antivirals are hampere

36 We analyzed changes in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) d

37 t both 2009 pandemic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) vir

38 nome and functions as an adapter between the virus and the host cell machinery.

39 raction between positive-strand RNA [(+)RNA] viruses and cellular membranes that contribute to the bi

40 ring 2012-2013 and 2013-2014, when influenza viruses and vaccines were similar.

41 2.3.2.1c viruses remained related to earlier viruses and WHO-recommended prepandemic vaccine strains

42 s, which also includes rabies virus, measles virus, and respiratory syncytial virus.

43 acute respiratory syndrome (SARS), coxsackie viruses, and rhinoviruses.

44 r autophagy-mediated restriction of multiple viruses, and this activity was dependent on both its RIN

45 To mitigate the decline in measles virus antibody titers in IVIGs and to ensure consistent

46 However, not every virus-antibody combination results in complete neutraliz

47 ndings indicate that LP avian H7 influenza A viruses are able to infect and cause disease in mammals

48 esent evolutionary evidence that minor-group viruses are also more immunogenic in humans.

49 Viruses are incapable of autonomous energy production.

50 These data indicate that transmitted viruses are phenotypically distinct, and that increased

51 s known at the molecular level as to how the viruses are recognized and transmitted.

52 Olpidium bornovanus While a number of plant viruses are transmitted via insect vectors, little is kn

53 bility of minor gallinaceous species to HPAI virus, as this poultry sector also suffers from HPAI epi

54 The nucleocapsid acts as a scaffold for virus assembly and as a template for genome transcriptio

55 s M1 and M2 proteins play important roles in virus assembly and in the morphology of virus particles.

56 ctive study of 226 patients with hepatitis C virus-associated cirrhosis and CSPH who had SVR to inter

57 th microtubules facilitates the formation of virus-associated replication complexes, which are requir

58 ants in the combination group had detectable virus at day 3 compared with 97 (50.0%) of 194 (mean dif

59 py structure of mature Japanese encephalitis virus at near-atomic resolution, which reveals an unusua

60 of highly pathogenic avian influenza A(H5N1) viruses at the animal-human interface remain a major con

61 myristoylated and plays an important role in virus budding.

62 Viruses build icosahedral capsids of specific size and s

63 are arrested in cells infected with vaccinia virus, but mass fluctuations continue until cell death.

64 to highly pathogenic avian influenza (HPAI) viruses, but such viruses' origins are often unclear.

65 standing of key anatomic sanctuaries for the virus can inform future experiments aimed at further cla

66 Ebola virus causes devastating hemorrhagic fever outbreaks for

67 s cleavage by host cell proteases to mediate virus-cell and cell-cell fusion.

68 ore transmission.IMPORTANCECucumber necrosis virus (CNV), a member of the genus Tombusvirus, is trans

69 were detected in the consensus sequences of viruses collected from the bronchoalveolar lavage (BAL)

70 Thus, vDeltaK1L is the first vaccinia virus construct reported that caused a muted innate immu

71 c approach for the selective inactivation of virus contaminations in biological samples.

72 with a similar modest change in hepatitis B virus core antigen polypeptide (HBcAg/p21) synthesis, it

73 ion of latently infected cells by productive virus could similarly remove those cells through active

74 iomarkers toward better defining hepatitis B virus cure should occur in parallel with development of

75 tivity, and specificity by using either live viruses (dengue, mumps, and measles viruses) or nucleic

76 Although dengue virus (DENV) antibodies can neutralize or enhance Zika v

77 g virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodi

78 The four dengue virus (DENV) serotypes are mosquito-borne flaviviruses r

79 s including yellow fever virus (YFV), dengue virus (DENV), and Zika virus (ZKV), all of which are glo

80 (IHNV) as a model to study aquatic enveloped virus diseases and their inhibition.

81 each containing >/=105 copies herpes simplex virus DNA/ml collected a median of 5 months apart (IQR:

82 Here, we show that adeno-associated virus-driven expression of progranulin in the medial pre

83 of infection in infants with confirmed Zika virus during pregnancy.

84 Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infecti

85 membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV)-encoded oncoprotein that is packaged into sm

86 These viruses encode only four proteins to accomplish the vira

87 Infection with a recombinant pH1N1 virus encoding these 6 amino acid changes (pH1N1/NSs-6mu

88 in a cell.IMPORTANCE The pathways by which a virus enters a cell transform its packaged genome into a

89 The biological characteristics of these viruses, especially their interplay with the host innate

90 After initial infection, the virus establishes latent reservoirs in sensory neurons a

91 Thus, understanding how viruses evade or exploit macrophage function will provid

92 Here we characterize how these viruses evolved during replication in cell culture and i

93 to the immediate selection pressures that a virus experiences in its current host.

94 The detection of active macrophage-tropic virus expression, and probably replication, indicates th

95 monstrate that isolated TM domains of Hendra virus F protein associate in a monomer-trimer equilibriu

96 This Ebola virus was the Zaire strain of the virus family Filoviridae.

97 lation, both animal species shed the vaccine viruses for a limited time but without noticeable clinic

98 that can aid in global surveillance of such viruses for potential spread and emerging threat to the

99 By comparing the genetic sequence of viruses from vaccine and placebo recipients to the seque

100 tive highly pathogenic avian influenza A(H5) viruses from Vietnam were generated, comprising samples

101 the first 19 nucleotides (nt) of the rabies virus genome, we demonstrate that L alone initiates synt

102 argeted processing of persistently infecting virus genomes.

103 to correlate with protection against dengue virus have highlighted the need for a human DENV challen

104 Foamy viruses have the largest genomes among mammalian retrovi

105 The management of hepatitis B virus (HBV) e antigen-positive viremic patients with nor

106 ), often associated with chronic hepatitis B virus (HBV) infection.

107 s by either hepatitis A virus or hepatitis B virus (HBV), or a noninfectious cause for their ALF.

108 Hepatitis B virus (HBV)-encoded X protein (HBx) plays a critical rol

109 ith acute, resolved, and chronic hepatitis B virus (HBV)infection but might also signify occult HBV i

110 Hepatitis B viruses (HBVs), which are enveloped viruses with reverse

111 Chronic infections with hepatitis C virus (HCV) and HIV are highly prevalent in the USA and

112 ho are chronically infected with hepatitis C virus (HCV) and who do not have a sustained virologic re

113 Hepatitis C virus (HCV) has dominated the field of hepatology for th

114 Hepatitis C virus (HCV) infection is the most common chronic blood-b

115 s AP1 and AP2, are essential for hepatitis C virus (HCV) infection, but the underlying mechanism and

116 Chronic infection with hepatitis C virus (HCV) is one of the main causes of hepatocellular

117 There is a need for hepatitis C virus (HCV) therapies with excellent efficacy across gen

118 iruses including human pathogens hepatitis C virus (HCV), Severe acute respiratory syndrome (SARS), c

119 man immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients treated with interferon

120 ges in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) during tenofovir-containing

121 al treatment options for chronic Hepatitis E Virus (HEV) infections are limited and immunological det

122 Although hepatitis E virus (HEV) is regarded as a self-limiting infection and

123 Moreover, the virus hijacks the autophagic vacuoles to mature in an ac

124 tality during treated human immunodeficiency virus (HIV) disease in Ugandans as compared to US-based

125 During human immunodeficiency virus (HIV) disease, chronic immune activation leads to

126 target for novel anti-human immunodeficiency virus (HIV) drug development.IMPORTANCE The Vpr and its

127 osis in patients with human immunodeficiency virus (HIV) infection.

128 ical epicenter of the human immunodeficiency virus (HIV) pandemic, the Democratic Republic of the Con

129 ted to modulate local human immunodeficiency virus (HIV) RNA levels and the risk of sexual HIV transm

130 rition, or an unknown human immunodeficiency virus (HIV) status in an HIV-endemic setting.

131 dividuals living with human immunodeficiency virus (HIV) worldwide.

132 patterns of TDR among human immunodeficiency virus (HIV)-infected PWUD, and assessed its impacts on f

133 tality in a cohort of human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients

134 encoded by different human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) lentivir

135 the postfusion (post-F) state at the time of virus-host cell membrane fusion.

136 howed in a proof-of-principle study how this virus-host interaction can be employed to enhance effica

137 tudy viral diversity, viral metagenomics and virus-host interactions in natural ecosystems.

138 pseudorabies virus (PRV) and herpes simplex virus (HSV) particles in living cells.

139 In this study, infectious bursal disease virus (IBDV) was used to investigate the role of autopha

140 habdovirus infectious hematopoietic necrosis virus (IHNV) as a model to study aquatic enveloped virus

141 del virus, infectious hematopoietic necrosis virus (IHNV), infectivity was significantly inhibited in

142 l organoids to show that infection with Zika virus impairs cortical growth and folding.

143 After passage of the B/Brisbane/60/2008 virus in the presence of 46B8, we isolated three resista

144 revent reproduction and spread of the mutant viruses in human cells.

145 Risk factors for detection of multiple viruses included cord blood or HLA-mismatched HCT, myelo

146 ny positive-sense single-stranded RNA (+RNA) viruses including human pathogens hepatitis C virus (HCV

147 d highly pathogenic avian influenza A (H5N1) virus induce expression of tumor necrosis factor alpha,

148 HLA-E by high-risk HPV E7 may contribute to virus-induced immune evasion during HPV persistence.

149 mbranes that contribute to the biogenesis of virus-induced membrane organelles.

150 Rabies virus induces drastic behaviour modifications in infecte

151 To counter premature death of a virus-infected cell, poxviruses use a range of different

152 e in B cell survival mechanisms is unique to virus-infected cells and relies on regulation of MCL-1 m

153 High titers of ADCC-Abs against H7N9 virus-infected cells were detected in sera from adults a

154 ohort (representative of Italian hepatitis C virus-infected patients in care).

155 but a minority are nonpermissive because the virus infection aborts before its completion.

156 spitalized infants were tested for influenza virus infection and 1 tested positive.

157 wn of La in HEK 293 T cells increased Sendai virus infection efficiency, decreased IFN-beta, IFN-lamb

158 Zika virus infection induced detectable Dengue cross-reactive

159 utic, and a tool for exploring mechanisms of virus infection inhibition by antibodies.

160 Dengue virus infection typically causes mild dengue fever, but,

161 of highly pathogenic avian influenza A(H5N1) virus infection, detected through population-based activ

162 ron-based treatments for chronic hepatitis C virus infection, whereas Asian race was associated with

163 nd reduce the rate of reactivation of latent virus infection.

164 that significantly amplified after Dengue-2 virus infection.

165 enicity and low incidence of avian influenza virus infections in humans, the immune correlates of pro

166 When LJ001 was preincubated with our model virus, infectious hematopoietic necrosis virus (IHNV), i

167 eexisting antibodies to historical influenza viruses influenced HAI-specific antibodies and protectiv

168 tively, this study offers insights into host-virus interaction in tomato and provides valuable inform

169 ion of SV40 from the ER and transport of the virus into the cytosol.

170 ainst various toxins and pathogens including viruses, intracellular bacteria and parasite.

171 protein from the 2009 pandemic H1N1 (pH1N1) virus is not able to inhibit general gene expression.

172 uch orthomyxovirus, infectious salmon anemia virus (ISAV), spreads easily throughout farmed and wild

173 dy, we show that the replication capacity of viruses isolated during acute infection predicts subsequ

174 e of sequence conservation among GP of Ebola viruses, it would be challenging to determine the propen

175 Both viruses lack vaccines.

176 However, viruses lacking vp3 have abnormal shapes, indicating tha

177 A fuller understanding of the virus life cycle is important to aid control strategies.

178 ntibodies elicited by immunization via Pfs25 virus-like particles in human immunoglobulin loci transg

179 persons currently infected with hepatitis C virus lived >10 miles from a syringe services program.

180 The influenza A virus M1 and M2 proteins play important roles in virus a

181 fy the universal biomarker for the influenza virus, M1 protein.

182 Mononegavirales, which also includes rabies virus, measles virus, and respiratory syncytial virus.

183 Although polyoma virus middle T-driven tumors showed altered primary and

184 point-of-care testing (POCT) for respiratory viruses might improve clinical care by reducing unnecess

185 All viruses must antagonize antiviral signaling events for s

186 f MCCs are not driven by MCPyV and that such virus-negative MCCs, which can be quite reliably identif

187 y 20% (6/33) displayed cross-reactive tier 2 virus neutralization, which recapitulated the serum neut

188 long-lived PCs, it also generated prolonged virus-neutralizing antibodies (VNAs), resulting in bette

189 LnJ H2-Ob allele supported the production of virus-neutralizing antibodies independently of the class

190 The influenza A virus nucleoprotein (NP) is an essential multifunctional

191 ons of low-pathogenic avian influenza (LPAI) viruses of subtypes H5 and H7 into poultry from wild bir

192 on of the viral particle.IMPORTANCE Tailless viruses of the family Tectiviridae can infect commensal

193 strikingly similar to that observed in dsDNA viruses of the PRD1-adenovirus lineage, characterized by

194 maintains similar antigenicity to wild-type virus, opening the possibility for its use as a live-att

195 trols, with infections by either hepatitis A virus or hepatitis B virus (HBV), or a noninfectious cau

196 underlying mechanism and relevance to other viruses or in vivo infections remained unknown.

197 strong, T cell-dependent protection against viruses or tumors.

198 her live viruses (dengue, mumps, and measles viruses) or nucleic acid material (Nipah and chikungunya

199 rtant in immunity to cytosolic bacteria, DNA viruses, or HIV.

200 nic avian influenza (HPAI) viruses, but such viruses' origins are often unclear.

201 st to results from previous studies on other viruses, our results showed that filtration and nuclease

202 tion, management, and control in future HPAI virus outbreaks.

203 By using a virus overlay assay, it was previously shown that the ma

204 each other in some, but not all, aspects of virus particle assembly.

205 e input virus, suggesting that a fraction of virus particles are resistant to antibody neutralization

206 lamentous and branched respiratory syncytial virus particles, and assembly with genomic ribonucleopro

207 pating in budding or being incorporated into virus particles.

208 s in virus assembly and in the morphology of virus particles.

209 ols and viremic KTR were stimulated using BK virus peptide libraries loaded or not on monocytes-deriv

210 lysis of the interactions between the dengue virus polymerase NS5 and SLA in solution has not been pe

211 ly understood, and previous studies analyzed viruses produced by transformed lymphocytic cell lines c

212 (Gag) interaction could potentially suppress virus proliferation, this approach could offer a new str

213 Here, we report that the fowlpox virus prosurvival protein FPV039 promiscuously binds to

214 widely used method to visualize pseudorabies virus (PRV) and herpes simplex virus (HSV) particles in

215 pes simplex virus 1 (HSV-1) and pseudorabies virus (PRV), have suggested that UL37 plays an essential

216 Recombinant virus (rAAV) leptin antagonism in the VTA decreased whee

217 ADD (rAAV5-hSyn-hM3(Gq)-mCherry) and control virus (rAAV5-hSyn-EGFP) were stereotactically administer

218 Internalized virus remained capable of expressing reporter genes whil

219 lade 1.1.2, 2.3.2.1a, 2.3.2.1b, and 2.3.2.1c viruses remained related to earlier viruses and WHO-reco

220 The virus replicates to high titers in the liver of these an

221 rrogate the functions of NoV proteins during virus replication and highlight the conserved properties

222 similarly remove those cells through active virus replication and resulting cytopathicity.

223 , these proteins were required for efficient virus replication and the ability of NS5A to spread thro

224 rtant roles of co-opted host proteins in RNA virus replication have been appreciated for a decade, th

225 ly important functions of cellular lipids in virus replication have been gaining full attention only

226 tion, while respiratory infection results in virus replication in the lung.

227 R), is critical for the initiation of dengue virus replication, but quantitative analysis of the inte

228 tein kinase R (PKR), which potently inhibits virus replication.

229 Viruses represent the most abundant life forms on the pl

230 plant death, thus extending the lifespan of virus reservoirs and particle production.

231 from the host transcriptomic, epigenetic and virus response also has the potential to provide deeper

232 t of which included detection of hepatitis D virus RNA among anti-hepatitis D virus seropositive part

233 e replication and transcription of influenza virus RNA.

234 regulated on APC after respiratory syncytial virus (RSV) infection, and its inhibition leads to exagg

235 HIV-1 Gag, as well as purified Rous sarcoma virus (RSV) MA and Gag, depends strongly on the presence

236 ed rhinovirus (RV) and respiratory syncytial virus (RSV) replication.

237 me orthoretroviruses, including Rous Sarcoma Virus (RSV), CA carries a short and hydrophobic spacer p

238 Respiratory virus (RV) has been suggested to play a role in the path

239 been successful to date, due in part to the virus's high sequence variability leading to immune esca

240 antibodies elicited by the wild-type HA from viruses selected as the vaccine candidates.

241 hepatitis D virus RNA among anti-hepatitis D virus seropositive participants.

242 In vivo, AAV9 (adeno-associated virus serotype 9)-mediated cardiac overexpression of Qki

243 acaques with either simian hemorrhagic fever virus (SHFV) or Kibale red colobus virus 1 (KRCV-1) and

244 tion of CRISPR-Cas systems against different viruses should vary.

245 ficiency virus (HIV)/simian immunodeficiency virus (SIV) lentiviruses.

246 vere asthma and wheezing, including airborne viruses, smoke, indoor dampness, cockroaches, and poor a

247 T cells engineered to express a hepatitis B virus-specific (HBV-specific) T cell receptor (TCR) may

248 pamycin treatment resulted in suppression of virus-specific B cell responses by inhibiting proliferat

249 Virus-specific CD8 T cells home to the site of recurrent

250 n of the memory-precursor effector subset of virus-specific CD8 T cells transferred into antigen-free

251 preserves functional lymphocytes, including virus-specific T cells.

252 ndicating that the vp3 gene is important for virus structure.

253 DNA tumor viruses such as Kaposi's sarcoma-associated herpesvirus

254 ults in complete neutralization of the input virus, suggesting that a fraction of virus particles are

255 r Disease Control and Prevention respiratory virus surveillance data.

256 xpression and to increased resistance to all viruses tested to date.

257 we delivered Cre-inducible adeno-associated virus that drives the expression of fluorescent marker i

258 Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV)

259 vovirinae are small nonenveloped icosahedral viruses that are important pathogens in many animal spec

260 rotein fold found in several plus-strand RNA viruses that binds to the small molecule ADP-ribose.

261 Further, using recombinant viruses that establish a nonreactivating, latent-like or

262 Mycobacteriophages are viruses that infect mycobacterial hosts including Mycoba

263 ion protein is responsible for attaching the virus to an F-pilus and delivering the viral genome into

264 This might represent an adaptation of pH1N1 virus to humans.

265 port the further development of both vaccine viruses to optimally prepare for the further spread of c

266 d by a variety of pathogens, from persistent viruses to parasites.

267 properties, efforts are underway to engineer viruses to respond to endogenous stimuli in new ways as

268 ically the transmission of human respiratory viruses to wild great apes, causing high morbidity and,

269 suggest that introduction of the pdm2009 H1 virus, to which most of the broadly prevalent, neutraliz

270 h c-Src-mediated tyrosine phosphorylation in virus-transformed cells.

271 Human immunodeficiency virus type 1 (HIV-1) drug resistance genotyping is recom

272 icipants with chronic human immunodeficiency virus type 1 (HIV-1) infection.

273 Minority variant human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase

274 antibody may improve human immunodeficiency virus type 1 (HIV-1)-specific immunity and increase clea

275 oach to genome engineering of herpes simplex virus type 1 (HSV-1), which has a large DNA genome, usin

276 Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult

277 tenuated chimeric bovine/human parainfluenza virus type 3 (rB/HPIV3) was developed previously as a ve

278 protective immunity.IMPORTANCE The vaccinia virus (VACV) K1 protein inhibits NF-kappaB activation am

279 functional studies, generation of oncolytic virus vectors, development of delivery platforms of gene

280 t oligomeric states of the Marburg and Ebola virus VP35 proteins may explain differences between them

281 This Ebola virus was the Zaire strain of the virus family Filovirid

282 ahedral) and nonspherical (tailed) bacterial viruses were experimentally determined by measuring thei

283 As viruses were found in over a quarter of isolates tested,

284 term cross-protection against H3N2 influenza virus when compared to other vaccination groups.

285 EBV is a common gammaherpes virus with tropism for B lymphocytes and infection in im

286 ification studies and for quantitating other viruses with high sequence diversity.

287 uthern African, clade C envelope-pseudotyped viruses with neutralization titers against 16 broadly ne

288 face remain a major concern for emergence of viruses with pandemic potential.

289 All viruses with positive-sense RNA genomes replicate on mem

290 atitis B viruses (HBVs), which are enveloped viruses with reverse-transcribed DNA genomes, constitute

291 e spread and the unique pathogenesis of this virus; with the intent to rapidly develop vaccines and t

292 ing is critical for the control of West Nile virus (WNV) infection by regulating type I IFN (IFN-I) r

293 rtant human pathogens including yellow fever virus (YFV), dengue virus (DENV), and Zika virus (ZKV),

294 ealth agencies have declared the recent Zika virus (ZIKV) infection an epidemic and a public health e

295 V) antibodies can neutralize or enhance Zika virus (ZIKV) infection in vitro, their contribution to Z

296 case series of virologically confirmed Zika virus (ZIKV) infections from Southeast Asia, ZIKV infect

297 Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged

298 Zika virus (ZIKV) is a re-emerging virus that has recently sp

299 Zika virus (ZIKV) is an emerging pathogen causally associated

300 r virus (YFV), dengue virus (DENV), and Zika virus (ZKV), all of which are global public health conce