ライフサイエンスコーパス: virus particle

1 rimer set for bacteriophage MS2 (a model RNA virus particle).

2 nformations in the context of the infectious virus particle.

3 ral protease into the proteins that form the virus particle.

4 in expressed in the cell and packaged in the virus particle.

5 m the known hexagonal protein lattice in the virus particle.

6 ssed only when E proteins are assembled on a virus particle.

7 opy of each RNA segment is packaged into one virus particle.

8 epitope located at the surface of the dengue virus particle.

9 budding, which then constitutes part of the virus particle.

10 s in virus assembly and in the morphology of virus particles.

11 mental force-deformation spectra for several virus particles.

12 ered to be packaged efficiently into vaccine virus particles.

13 otein crucial for the optimal infectivity of virus particles.

14 ein lattices that drive assembly of immature virus particles.

15 e cells to recognize genomes within incoming virus particles.

16 mediated by exosomes rather than infectious virus particles.

17 host factors to optimally produce infectious virus particles.

18 , but there was very little C3 deposition on virus particles.

19 ermine the position of protein layers within virus particles.

20 s cells to recognize genomes within incoming virus particles.

21 significantly higher IFN responses than free virus particles.

22 and the A17 membrane protein for assembly of virus particles.

23 s to budding and release of progeny immature virus particles.

24 erely attenuated upon depletion of GSLs from virus particles.

25 een the nucleocapsid and the envelope within virus particles.

26 stponed and reduced production of infectious virus particles.

27 tes the properties of ApoE on the surface of virus particles.

28 FN-gamma resulted in a reduced production of virus particles.

29 sates from both infected cells and disrupted virus particles.

30 binds lipids, and regulates formation of new virus particles.

31 h in the isolated recombinant protein and in virus particles.

32 s (uncoating) as well as assembly of progeny virus particles.

33 excluded hundreds of superinfecting vaccinia virus particles.

34 preparations of both Sindbis and Chikungunya virus particles.

35 ates assembly and egress of infectious Ebola virus particles.

36 form for detection and diagnostics of intact virus particles.

37 s structures resembling native Env spikes on virus particles.

38 bilization and the intracellular motility of virus particles.

39 ch reduced amounts of often markedly smaller virus particles.

40 brane formation and the assembly of immature virus particles.

41 tructural protein Gag or its accumulation in virus particles.

42 tely 1 to 2% of BM cells produced infectious virus particles.

43 tries, and dimensions that match the size of virus particles.

44 tential for exposure to VEEV via aerosolized virus particles.

45 this often remains incomplete for infectious virus particles.

46 nt of BBLF1 to achieve optimal production of virus particles.

47 pating in budding or being incorporated into virus particles.

48 ull-length Gag protein was incorporated into virus particles.

49 erful tool to visualize and track individual virus particles.

50 assemble trimer-clustered T = 3 icosahedral virus particles.

51 down to attomole levels and as few as 10(6) virus particles.

52 r reminiscent of the cell-surface docking of virus particles.

53 ressive assembly, and packaging into progeny virus particles.

54 PD that result in intercellular movement of virus particles.

55 strates for RNA synthesis and packaging into virus particles.

56 g to HA on the surface of infected cells and virus particles.

57 oduction, thereby increasing the chances for virus particle acquisition by aphid vectors and CaMV tra

58 is required for complete budding of Sindbis virus particles although several different amino acids c

59 s, termed HK2, still is capable of producing virus particles, although these particles have been rega

60 n of RT and, in some cases, integrase in the virus particle and this abolishes infectivity.

61 ed cell culture supernatant was enriched for virus particles and a generic, PCR-based method was used

62 n between the glycosphingolipid (GSL) GM3 on virus particles and CD169/Siglec-1 on MDCs.

63 rafficking pathways to effect the release of virus particles and disrupts the structure of the Golgi

64 ucture, dynamics, and biological function in virus particles and other large protein cages.

65 Like Nef, S2 excludes SERINC5 from virus particles and requires an ExxxLL motif predicted t

66 led that the vaccine contained visible split-virus particles and retained the native conformation of

67 y blocked post-entry long-range transport of virus particles and suppressed infection approximately 5

68 vesicular compartments or surface-localized virus particles and that large fluorescent signals corre

69 h a thin layer of a composite containing M13 virus particles and the electronically conductive polyme

70 onstrated to be by both the direct action on virus particles and the interference on the host cells.

71 otein (Env) spike, located on the outside of virus particles and the only relevant protein for the in

72 antitative analysis of fluorescently labeled virus particles and virus neutralization assays, we show

73 hat it is in a higher-order structure in the virus particle, and provide the first direct evidence th

74 lamentous and branched respiratory syncytial virus particles, and assembly with genomic ribonucleopro

75 d incorporates more VP26 fusion protein into virus particles, and individual virus particles exhibit

76 racellular infectivity, thermal stability of virus particles, and NS2 interactions.

77 observed to impair Env protein assembly into virus particles, and several of these are suppressed by

78 the incorporation of IAV gene segments into virus particles, and this process is thought to be media

79 e mechanisms by which infectious hepatitis C virus particles are assembled and released from the cell

80 Efficient replication and assembly of virus particles are integral to the establishment of inf

81 e studies demonstrate that noncapped Sindbis virus particles are produced as a result of viral RNA sy

82 to changes in environmental conditions after virus particles are released from the host cells.

83 e input virus, suggesting that a fraction of virus particles are resistant to antibody neutralization

84 anterograde axonal transport, ensuring that virus particles are transported from the cytoplasm into

85 e contrast using ice-embedded tobacco mosaic virus particles as test samples at 20-80 keV electron en

86 luorescence microscopy can detect individual virus particles as they enter cells, allowing us to map

87 proteins have important roles in assembling virus particles as well as modifying host cells to promo

88 In all cases, the mutant virus particles, as well as the antibody-bound wild-type

89 ranules suggest that they may be sites where virus particles assemble.

90 However, the mechanisms involved in virus particle assembly and egress are still elusive.

91 ributions of MA-mediated membrane binding to virus particle assembly are not well understood.

92 Retroviral Gag proteins direct virus particle assembly from the plasma membrane (PM).

93 teins in virus assembly.IMPORTANCE Influenza virus particle assembly involves the careful coordinatio

94 hermore, defects in NS4A oligomerization and virus particle assembly of two mutants were rescued by N

95 ORTANCE A key aspect in virus replication is virus particle assembly, which is a poorly understood pr

96 nd provides new insights into the process of virus particle assembly.

97 main in coordinating HCV RNA replication and virus particle assembly.

98 each other in some, but not all, aspects of virus particle assembly.

99 the conformation and/or epitope exposure of virus particle-associated ApoE.

100 rental virion only, suggesting a cis-acting, virus particle-associated mechanism of control.

101 A) to a subsequent delay in uncoating of the virus particle at 33 degrees C during the next cycle of

102 of the A17 protein were packaged into mature virus particles at a reduced level, demonstrating that t

103 human immunodeficiency virus type 1 (HIV-1) virus particles at the plasma membrane (PM).

104 the first time direct detection of unlabeled virus particles based on the formation of antibody-virus

105 coded adenovirus proteinase (AVP) before the virus particle becomes infectious.

106 hypothesize that this antibody binds to the virus particle before internalization and endosomal proc

107 structural protein is the primary driver of virus particle biogenesis, and the CA CTD is the primary

108 ntrations of gB-GNP that coat the surface of virus particles block virus entry, whereas lower concent

109 To this end, individual, infectious virus particles bound by fluorescently labeled antibodie

110 tion by increasing the efficiency with which virus particles bud from infected cells and restoring fi

111 this mutant is grown at a lower temperature, virus particles bud from the host cell, but budding arre

112 mation while having limited effects on total virus particle budding.

113 step for immature Gag lattice formation and virus particle budding.

114 ntral role in the intracellular transport of virus particles but also regulate a wider range of proce

115 and the repetitive structure of the original virus particle, but lack infectious genomic material.

116 compensatory mutant strains showed complete virus particles, but these now formed paracrystalline ar

117 efficacy and altered tropism of these coated virus particles by (123)I scintigraphy and to evaluate t

118 RNA synthesis by even a single virus particle can initiate a productive infection.

119 The interiors of virus particles can encapsulate and protect sensitive co

120 ns resulted in up to 92 and 80% reduction of virus particle capture and trans-infection, respectively

121 ed nanolenses are rapidly formed around each virus particle captured on the substrate using a portabl

122 n retrovirus that assembles intracytoplasmic virus particles, commandeers the cellular factor YB-1, a

123 ing, suggesting that host damage signals and virus particles compete for retrograde transport.

124 Icosahedral virus particles constitute paradigms to study self-assem

125 n termination factor eRF1 produces defective virus particles containing 20 times more gRNA.

126 Here we show that inactivated rabies virus particles containing the MERS-CoV S1 protein induc

127 Virus particles containing those fusions maintained the

128 is evidently highly specific such that every virus particle contains a set of 10 RNA segments, the or

129 The resulting fluorescent virus particles could be visualized in virus entry studi

130 lytic replication reduces the production of virus particles, demonstrating the requirement of BBLF1

131 HCPs) were exposed to mainly small influenza virus particles (diameter, <4.7 microm), with concentrat

132 ions that prevented generation of infectious virus particles did not abolish acylation of expressed H

133 In a fraction of virus particles, EGFP fluorescence was recovered, presum

134 h beta-propiolactone-inactivated recombinant virus particles elicited protective RABV antibody titers

135 These virus particles, engineered to selectively bind HSA, ser

136 sponse to low-level stimuli and suggest that virus particle entry is sensed as a stress signal.

137 However, the mechanism by which enveloped virus particle entry mediates a stress response, leading

138 uring fusion, a necessary step for enveloped virus particle entry, appears sufficient to induce trans

139 protein into virus particles, and individual virus particles exhibit brighter red fluorescence.

140 d WSN viruses, scission failed, and emerging virus particles exhibited a "beads-on-a-string" morpholo

141 FEZ1 depletion blocks early infection, with virus particles exhibiting bi-directional motility but n

142 eation of plant-based expression systems and virus particles for use in nanotechnology.

143 s propagation; in its absence, GP-containing virus particles form but are noninfectious, due in part

144 ntiviral effect, since it may interfere with virus particle formation and virus production.

145 ally considered an absolute prerequisite for virus particle formation.

146 tating its interaction with the core for new virus particle formation.

147 three-dimensional reconstruction to analyze virus particles formed by mutants that do not express pa

148 BOR OF BRCA1 (NBR1) targets nonassembled and virus particle-forming capsid proteins to mediate their

149 complex proteins to promote scission of the virus particle from the plasma membrane.

150 Therefore, purified influenza A virus particles from adherent and suspension MDCK host c

151 ced fluorescent detection to separate intact virus particles from DNA and RNA impurities.

152 a corresponding inhibition of the release of virus particles from infected cells.

153 l cells: (i) anterograde axonal transport of virus particles from neuron bodies to axon tips and (ii)

154 ld be less hydrated at pH 5 (where influenza virus particles fuse with endosome membranes) than at pH

155 an at pH 7.4 (where synaptic vesicles or HIV virus particles fuse with plasma membrane).

156 The standard approach for purification of virus particles has been to use a multiple-step, complex

157 While virus particles have been observed in M cells, it is not

158 Virus particles have been observed within M cells.

159 (HCVcc), it is known that highly infectious virus particles have low to very low buoyant densities.

160 c hippocampal injections of adeno-associated virus particles in APP/PS1 mice, localized primarily to

161 E1 is detrimental to the assembly of Sindbis virus particles in baby hamster kidney cells.

162 The dynamic properties of virus particles in cells can be imaged by fluorescent pr

163 acellular HCV RNA and accumulates infectious virus particles in cells.

164 ia virus DNA, it can be recovered from these virus particles in enzymatically active form; it is stil

165 ogical entities on Earth, with the number of virus particles in many environments exceeding the numbe

166 c hippocampal injections of adeno-associated virus particles in mutant hAPP Tg mouse brains decreases

167 Intracellular transport of virus particles in neurons is important, as this process

168 (ORF14) and (ii) ultrastructural features of virus particles in neurons.

169 lar clones replicate better and produce more virus particles in PA28gamma-deficient cells.

170 rmed single-particle tracking of fluorescent virus particles in primary neurons to measure anterograd

171 Our structures solved from virus particles in solution are largely in agreement wit

172 of computer simulations and experiments with virus particles in tailor-made disk- and annulus-shaped

173 (MMTV) orchestrates the assembly of immature virus particles in the cytoplasm which are subsequently

174 and US9 fail to properly assemble enveloped virus particles in the cytoplasm, which blocks anterogra

175 The tc-VLPs resembled authentic virus particles in their protein composition and neutral

176 ectious virus and RNA-containing hepatitis C virus particles, indicating a block in virus assembly.

177 with JUNV attachment to the cell surface or virus particle internalization into host cells, it preve

178 as viral receptors has enabled insights into virus particle internalization, host and tissue tropism,

179 anisms involved in gE/gI-mediated sorting of virus particles into axons and extracellular spread to a

180 US9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an ef

181 c domains play important roles in sorting of virus particles into axons.

182 ing both gE and US9 that failed to transport virus particles into axons.

183 detectable SGH(+), or release of detectable virus particles into the blood meals during feeding even

184 measured by the release of newly synthesized virus particles into the cell supernatant.

185 on is dependent on the release of infectious virus particles into the virological synapse.

186 acilitate fluorescence microscopy studies of virus particle intracellular transport, as a brighter pa

187 the assembled lattice of Gag within immature virus particles is necessary to understand the interacti

188 The major product of this, the virus particle, is finding increasing roles in the emerg

189 on, linking viral metagenomic sequences to a virus particle, its sequenced genome, and its host direc

190 spumaviruses; (ii) within the extracellular virus particle itself, transitioning from an RNA-contain

191 siological conditions of one of the simplest virus particles known, the minute virus of mice (MVM) ca

192 ion (V165I) restored polyprotein processing, virus particle maturation, and significant levels of rep

193 Although multiple virus particles may enter a cell at the same time, mecha

194 HA is the most abundant protein in the virus particle membrane and represents the basis of most

195 lycosphingolipid (GSL) incorporated into the virus particle membrane, as the receptor and ligand for

196 displayed a very good detection limit of 30 virus particles/ml and a wide linear dynamic range of 10

197 und to be 10(4) bacterial cells/mL and 10(4) virus particles/mL, consistent with clinical utility.

198 , when the viremia level had reached 4 log10 virus particles/mL, rescued 100% of Lassa virus-infected

199 mportant in vitro function, which is to make virus particles more infectious, but the mechanism has b

200 Detection limits of 1 x 10(3) virus particles of Human adenovirus C (HAdV), Human astr

201 etection of individual fluorescently labeled virus particles of three influenza A subtypes in two imp

202 imiting HIV-1 endocytosis and in maintaining virus particles on dendrites, which is required for effi

203 interferon-inducible factor tetherin retains virus particles on the surfaces of cells infected with v

204 nts, suggesting that for the majority of the virus particles, only one copy of each RNA segment is pa

205 semen is present in different forms: as free virus particles or as cell-associated virus (ie, within

206 nd virus replication utilize either purified virus particles or deficient genomes that do not complet

207 uired for the efficient production of mature virus particles or serve as a marker for the process.

208 dministration of Ad5.hAC6 (3.2 x 109 to 1012 virus particles) or placebo.

209 rus-like particles, it is not known if these virus particles package and transmit HK2-related sequenc

210 ablish a detection limit of approximately 67 virus particles per milliliter (vp/ml) of EV71 in a Dulb

211 sal adenovirus vaccine doses as low as 10(8) virus particles per mouse induced complete protection ag

212 h HTLV-1 particle populations containing few virus particles possessing a complete capsid core struct

213 us resulted in production of huge amounts of virus particles presenting the peptides all over their s

214 regulating the intracellular trafficking of virus particles prior to nuclear delivery of the viral g

215 receptors recognize genomes within incoming virus particles prior to virus replication.

216 id sensors recognize genomes within incoming virus particles prior to virus replication.

217 In contrast, virus particles produced by HSV gE-277 spread poorly to

218 level of GP1,2 expression profoundly affects virus particle production and release and uncovers a new

219 mRNAs bearing tandem RREs (GP-2xRRE), rescue virus particle production in murine cells even in the ab

220 h virus RNA translation in the cytoplasm for virus particle production, and when translation is inhib

221 the actin cytoskeleton severely reduced net virus particle production.

222 ectors to modulate HCV genome replication or virus particle production.

223 s (RNPs), indicating a translational role in virus particle production.

224 relocates sites of assembly, and reduces net virus particle production.

225 y as a powerful and versatile tool to define virus particle profiles.

226 Hepatitis D virus particles pseudotyped with surface proteins of U.

227 cellulose particles reduced the influenza A virus particle purification time from 3.5 h to 30 min be

228 We employed virus particle purification, genome amplification, pyros

229 duce high titers of VZV, the number of total virus particles relative to the number of viral particle

230 rupting TF production leads to a decrease in virus particle release in both mammalian and insect cell

231 body neutralization of circulating oncolytic virus particles remains a formidable barrier.

232 mers, and incorporation of the proteins into virus particles requires an interaction of Env CT domain

233 Retroviruses first assemble into immature virus particles, requiring interactions between Gag prot

234 sence results in an accumulation of deformed virus particles retaining the scaffold protein and defic

235 electron microscopy analyses of the purified virus particles revealed three classes of particles base

236 nerated heat-sensitive, noninfectious dengue virus particles, revealing a large effect of components

237 neutralizing antibody titer against reporter virus particles (RVPs) representing AA, A1-160K, A1-160Q

238 struct of ZIKV was used to generate reporter virus particles (RVPs) that package a green fluorescent

239 We then generated the virus particle, self-complementary adeno-associated viru

240 plasma membrane of live cells, and on single virus particles, show the high potential of these dyes f

241 ase, yielding a DNA-containing extracellular virus particle similar to the spumaviruses; (ii) within

242 orly to epithelial cells, despite numbers of virus particles similar to those for HSV gE-348.

243 VP2 is shed from virions in early endosomes, virus particles still consisting of VP5 were trafficked

244 nsitivity of cellular responses to low-level virus particle stimulation, but provide important insigh

245 We found that virus particles strongly associate with the SM-rich regi

246 ddition, there are defects in the sorting of virus particles such that particles, when formed, do not

247 ppeared to decrease production of infectious virus particles, suggesting a block in virion assembly.

248 To do this, virus particles tether themselves to dyneins and kinesin

249 o hairy insects for pollination to nanoscale virus particles that are highly infectious toward host c

250 essfully genetically manipulated to generate virus particles that could be visualized in infected cel

251 ve cell imaging, we show that herpes simplex virus particles that have entered primary human cells ex

252 the envelope glycoprotein (Env) structure on virus particles that is targeted by neutralizing antibod

253 In addition, the virus particles that were released from cells had reduce

254 sing cryo-electron tomography, we identified virus particles that were spherical, filamentous, and as

255 ity of HIV-1 infections result from a single virus particle (the transmitted/founder) that makes it p

256 ncorporation of the transcription complex in virus particles, the transcriptional activity of A19-def

257 rium dissociation constants such that in the virus particle, they are predicted to be essentially irr

258 antigenically indistinguishable from mature virus particles, they are less stable and readily conver

259 As symmetry exists in many virus particles, this method may also be applied to 3D s

260 r the first time in any metazoan, infectious virus particles through self-assembly from transgenes.

261 ntous actin, which hints toward transport of virus particles through the use of a myosin motor.

262 Generation of influenza virus particles thus critically relies on a functional s

263 ividual virion with the capacity of the same virus particle to undergo membrane fusion.

264 on drives the conversion of stable, immature virus particles to a mature, metastable state primed for

265 contained the PM marker, and could transfer virus particles to noninfected cells.

266 apture HIV-1 particles and transfer captured virus particles to T cells without establishing producti

267 roteins that mediate virus attachment tether virus particles to the cell surface, initiating infectio

268 virus release by cross-linking newly formed virus particles to the producing cell.

269 ies of proteins on the surface of individual virus particles.To become infectious, HIV-1 particles un

270 Extracellular virus particles transmit infection between organisms, bu

271 have proven to be a valuable method to study virus particle transport in living cells.

272 Immature dengue virus particles undergo a dramatic conformational change

273 More interestingly, the virus particle underneath the MOF shell can be chemicall

274 IKV C-prM-E cell line that produces reporter virus particles upon transfection with a GFP replicon pl

275 Here we analyse the properties of Junin virus particles using a sensitive flow virometry assay a

276 A method for the purification of influenza virus particles using novel magnetic sulfated cellulose

277 cation of PEDOT nanowires that entrain these virus particles using the lithographically patterned nan

278 s sensing of the genomic RNA within incoming virus particles via cytoplasmic RNA sensors to produce t

279 n substrates in vitro and in vivo in nascent virus particles via one-dimensional diffusion along the

280 retic behavior of complexes between rod-like virus particles (virions) and bivalent antibodies.

281 he multivalent consensus vaccine (1 x 10(10) virus particles (vp)/mouse) induced protective HI titers

282 5 up to more than 2000 peptides on a single virus particle was obtained.

283 s that physical contact between nanorods and virus particles was not required for viral inactivation

284 he transcriptional activity of A19-deficient virus particles was severely reduced.

285 ylated and recruited to the endosomes, where virus particles were located.

286 e defects in assembly of gE(-) US9(-) mutant virus particles were novel because they were neuron spec

287 Observed cores were generally polygonal, and virus particles were on average 115 nm in diameter.

288 Late-domain mutant virus particles were seen at the uropod in form of buddi

289 om mycelia and RNA from samples enriched for virus particles were sequenced.

290 of total AAV capsid proteins (4.3 femtomole virus particles) were loaded to the autosampler vial.

291 as maintained within both infected cells and virus particles, where N is assembled as RNPs.

292 r infectious genomes, and are packaged as DI virus particles which can be transmitted to susceptible

293 yo-electron microscopy reconstruction of the virus particle, which demonstrated that most structural

294 s based on recombinant vaccine strain rabies virus particles, which concurrently display the protecti

295 t is important for packaging of genomes into virus particles, which constitutes a previously unknown

296 Encapsidated DI-RNAs were incorporated into virus particles, which reduced the infectivity of virus

297 Finally, virus particles with primary patient-derived E1-E2 prote

298 ripheral tissue, whereas the second delivers virus particles within nerve fibers to the neural gangli

299 4 colocalization with the newly internalized virus particles within target lymphocytes and found that

300 le additives to slow down the degradation of virus particles would address the problem.