ライフサイエンスコーパス: virus strain

1 rain, and a recently emerging H7N9 influenza virus strain.

2 ls more slowly than their parental wild-type virus strain.

3 edical conditions increased severity despite virus strain.

4 nes into the genome of an oncolytic vaccinia virus strain.

5 prevent human infection with any influenza A virus strain.

6 of a highly pathogenic avian H7N1 influenza virus strain.

7 elong humoral immunity against the homotypic virus strain.

8 MHC class II expression by RDC and with the virus strain.

9 to generate W7-791, a live attenuated mutant virus strain.

10 stic cats, with clinical course dependent on virus strain.

11 as cross-subtype protection against various virus strains.

12 to evade host immunity acquired to previous virus strains.

13 assessing the risks associated with emergent virus strains.

14 e limited by the emergence of drug-resistant virus strains.

15 tently found mutated in rodent-adapted Ebola virus strains.

16 e of pathogenicity across multiple influenza virus strains.

17 ruses and current human seasonal influenza A virus strains.

18 cross-protection against different influenza virus strains.

19 revent infection against genetically diverse virus strains.

20 n neutralize seasonal and pandemic influenza virus strains.

21 effective but highly specific for particular virus strains.

22 or identifying antigenically novel influenza virus strains.

23 stic recall of antibody to earlier influenza virus strains.

24 seasonal or pandemic circulating influenza A virus strains.

25 for distinguishing virus of various sizes or virus strains.

26 outside of Africa and to seasonal influenza virus strains.

27 ion compared to prototypic macrophage-tropic virus strains.

28 n with its host and genetic exchange between virus strains.

29 red to prototypic "highly macrophage-tropic" virus strains.

30 ently against homologous and closely matched virus strains.

31 selected group of genetically diverse mumps virus strains.

32 ), and potentially pandemic (H5N1) influenza virus strains.

33 ction or vaccination with seasonal influenza virus strains.

34 ng frame of the PB1 gene of most influenza A virus strains.

35 pearance of existing seasonal H1N1 influenza virus strains.

36 of such vaccines against emerging influenza virus strains.

37 erminants in seasonal and pandemic influenza virus strains.

38 nhibited wild-type and Enfuvirtide-resistant virus strains.

39 he hemagglutinin protein of circulating H3N2 virus strains.

40 ection and subtyping of avian influenza (AI) virus strains.

41 ontribute to viral pathogenesis of influenza virus strains.

42 ividuals can be superinfected with different virus strains.

43 sid-assembly events that are crucial to some virus strains.

44 t elicits broad protection against different virus strains.

45 to evaluate the prevalence and spread of new virus strains.

46 risks of inadvertent selection for damaging virus strains.

47 ion breadth and potency against most primary virus strains.

48 cine virus strains or with differing vaccine virus strains.

49 cosal, and cellular immunity against diverse virus strains.

50 nfection with a series of distinct influenza virus strains.

51 design of novel inhibitors against resistant virus strains.

52 PB2 of human from that of avian influenza A virus strains.

53 ponse modules under infections from multiple virus strains.

54 ss-reactivity with past and future influenza virus strains.

55 that prevent infection by diverse influenza virus strains.

56 tive immunity against heterologous influenza virus strains.

57 uish influenza virus fusion properties among virus strains.

58 t heterovariant and heterosubtypic influenza virus strains.

59 decay of RNA in cells infected with multiple virus strains.

60 ly mutated variant (var) thereof as parental virus strains.

61 n, including sieving effects on breakthrough virus strains.

62 e than the HAs from other seasonal influenza virus strains.

63 immunity that are protective against diverse virus strains.

64 igs but also in mice immunized with the same virus strains.

65 th a vaccine containing a mixture of diverse virus strains.

66 ion of A/J mice with the CoV mouse hepatitis virus strain 1 (MHV-1) induces an acute respiratory dise

67 on into the genetic basis of mouse hepatitis virus strain 1 (MHV-1) pneumovirulence.

68 ponse to CpG DNA or the yellow fever vaccine virus strain 17D.

69 nuated derivative of simian immunodeficiency virus strain 239 deleted of V1-V2 sequences in the envel

70 fat diet-caused obesity and murine hepatitis virus strain-3 (MHV-3)-induced fulminant hepatitis due t

71 in a sample of a virulent strain of dengue-2 virus (strain 44/2), which was recovered from a patient

72 ia/20/1999 and 2009 pandemic swine influenza virus strain A/California/04/2009.

73 14D is applicable in both seasonal influenza virus strain A/New Caledonia/20/1999 and 2009 pandemic s

74 ecombinant hemagglutinin (HA) from influenza virus strain A/New Caledonia/20/99 (H1N1) into NDs and i

75 rus engineering (SAVE) approach to influenza virus strain A/PR/8/34 to rationally design live attenua

76 and FluMist against challenge with influenza virus strain A/Puerto Rico/8/1934 (H1N1).

77 tranasal infection with a pandemic influenza virus strain (A/California/4/09 [CA09]), a human seasona

78 Using 6 influenza A virus strains (A/Puerto Rico/8/1934, A/Aichi/2/1968 x A/

79 (1%-1.5%) of 2009 pandemic influenza A/H1N1 virus strains (A[H1N1]pdm09) are oseltamivir resistant,

80 viruses, including a pandemic H1N1 influenza virus strain, a highly pathogenic H5N1 avian influenza v

81 Like all influenza A virus strains, A(H5N1) viruses evolve rapidly.

82 n response to infection with two influenza A virus strains, A/Udorn/72 and A/WSN/33.

83 ences or the NCR sequences of two other H1N1 virus strains, A/WSN/1933 and A/New York/312/2001, were

84 primary mouse astrocytes by mouse hepatitis virus strain A59 (MHV-A59) and MHV-2.

85 Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site

86 Mouse hepatitis virus strain A59 infection of mice is a useful tool for

87 nfection with the gliatropic mouse hepatitis virus strain A59.

88 The two virus strains achieved similar peak titers in IRF-3(+/+)

89 ntaining neutralizing epitopes from multiple virus strains across subgroups to reduce immune patholog

90 Influenza A virus strains adapt to achieve successful entry into hos

91 rtment of IAV gene segments from coinfecting virus strains adapted to different hosts in conjunction

92 to understand how past exposure to influenza virus strains affects the response to subsequent immuniz

93 ow that DRELFA can discriminate a particular virus strain against others of the same subtype or commo

94 genomics between a virulent and an avirulent virus strain and construct chimeras to map their locatio

95 tability of influenza viruses depends on the virus strain and host species and that HA stability can

96 ion and virulence are strongly influenced by virus strain and host species.

97 how acid-induced membrane fusion varies with virus strain and influences tropism.

98 isolates of CTV representing five different virus strains and a set of isolates originated from viru

99 agent was tested on 21 prototype influenza A virus strains and confirmed to be specific for its inten

100 tigenic similarity in foot-and-mouth disease virus strains and in influenza strains, where the struct

101 14 seasonal H1N1 or H3N2 prototype influenza virus strains and is also not reactive with seven other

102 f this system allows efficient generation of virus strains and presents an alternative approach for i

103 e been conducted on NS1 function using human virus strains and primary human cells.

104 A) could confer immunity to the diverse H5N1 virus strains and provide information for effective vacc

105 izing activity of Fab 3674 against resistant virus strains and renders a series of related nonneutral

106 s that neutralize a broad range of influenza virus strains and subtypes by binding to this domain has

107 ), which are conserved among all influenza A virus strains and subtypes, could be manufactured in adv

108 oteins conserved among all known influenza A virus strains and subtypes, so it could be used early in

109 adly neutralize a wide spectrum of influenza virus strains and subtypes.

110 neutralization to highly divergent influenza virus strains and subtypes.

111 uld provide broad coverage against different virus strains and subtypes.

112 Instead, interactions between individual virus strains and the cellular microenvironment of the i

113 Interactions between virus strains and the microenvironment of individual ATM

114 be shared by circulating, seasonal influenza virus strains and the novel pandemic H1N1 influenza infe

115 ties of previously uncharacterized West Nile virus strains and West Nile-like viruses.

116 A virus and influenza B virus (41 influenza virus strains) and 24 common respiratory pathogens showe

117 IV antibody D5 10-100-fold (depending on the virus strain), and (iv) increases synergy between 2F5 an

118 in, a highly pathogenic H5N1 avian influenza virus strain, and a recently emerging H7N9 influenza vir

119 thoviruses have been conducted with a single virus strain, and the effect of intragenus competition b

120 Mixed infections with seasonal influenza A virus strains are a common occurrence and an important s

121 respiratory influenza, and highly pathogenic virus strains are characterized by massive infiltration

122 Vaccines that match circulating virus strains are needed for optimal protection.

123 Influenza virus strains are often pleiomorphic, a characteristic t

124 New vaccine virus strains are selected, replacing older strains to b

125 eact with strains emerging after the vaccine virus strains are selected.

126 ary IgA to influenza A(H3N2) and influenza B virus strains as early as 14 days after vaccination but

127 vidence and support the suitability of these virus strains as the next-generation BTV vaccines.

128 upport and validate the suitability of these virus strains as the next-generation vaccines for BTV.

129 rgeted an essential gene to develop disabled virus strains as vaccine candidates.

130 uenza A virus binds TRIM25, although not all virus strains block the interferon response, suggesting

131 Differences in how virus strains "breathe" may affect epitope exposure and

132 suggests that JPV-BH and JPV-LW are the same virus strain but were obtained at different passages fro

133 This region varies not only among Zika virus strains but also in other flaviviruses, which sugg

134 Differential behavior of virus strains can be exploited to elucidate gene functio

135 za are limited, and drug-resistant influenza virus strains can emerge through minor genetic changes.

136 nderlying host range differences among plant virus strains can provide valuable insights into viral g

137 tive mutations 627K or 701N, pH1N1 influenza virus strains can replicate efficiently in the low tempe

138 tive interfering (DI) RNA produced by Sendai virus strain Cantell.

139 ts could be used as sentinels for monitoring virus strains circulating in specific segments of the po

140 ics can result when animal-derived influenza virus strains combine with seasonal strains.

141 finity to a previously encountered influenza virus strain compared with the virus strain present in t

142 Virus strains competent to enter ECs replicate with diff

143 ength NS1A proteins from different influenza virus strains, controversy remains over the actual biolo

144 logical antibody levels to a given influenza virus strain correlate with low production of antibody-s

145 ine that protects against multiple influenza virus strains could alleviate the continuing impact of t

146 example of how genetic reassortment between virus strains could produce phenotypes that are distinct

147 ighly pathogenic avian (HPAI) H5N1 influenza virus strains could productively replicate in murine mac

148 e was a worldwide replacement of the initial virus strain (CPV type 2) by a variant (CPV type 2a) cha

149 the genotypic characteristics of circulating virus strains, critical information for the programs.

150 ctious clone of the highly pathogenic rabies virus strain CVS-N2c and replaced its cognate glycoprote

151 s in mice infected with encephalomyocarditis virus strain D (EMCV-D), which has tropism for the insul

152 ion, and replication that were cell type and virus strain dependent.

153 Finally, we identified virus strain-dependent variability in type I interferon

154 were infected with a patient-derived dengue virus strain developed clinical symptoms of the disease

155 g frame in a recent, seasonal H3N2 influenza virus strain did not affect these parameters, suggesting

156 o detect, type and subtype influenza A and B virus strains directly from clinical samples in a single

157 Influenza virus strains diverge by 1 to 2% per year, and commercia

158 ully diagnosing and distinguishing different virus strains (DMV, PWMV and novel CeMVs) using FFPE sam

159 d to rapidly and reliably survey circulating virus strains down to the molecular level is ever presen

160 and where and how novel pathogenic influenza virus strains emerge.

161 Here, we assess the potential for West Nile virus strains encoding mutations in the hE16 epitope to

162 Phenotypically, the new T/F virus strains exhibited a range of neutralization sensit

163 We generated a mutant influenza virus strain expressing NS1-W187R to destabilize this se

164 didymal white fat in mice using pseudorabies virus strains expressing different reporters together wi

165 vivo, I constructed a novel murine leukemia virus strain (FMLV-IL-1beta) that encodes the mature for

166 s (except 3B) of the low-neurovirulence BeAn virus strain for cell death.

167 nt (disabled infectious single-cycle [DISC]) virus strains for a number of serotypes and reported pre

168 ise vaccine match with currently circulating virus strains for efficacy, requiring constant surveilla

169 Variant influenza virus strains generated through antigenic shift or drift

170 exposure to either of two seasonal influenza virus strains, H1N1 and H3N2.

171 rapid emergence of drug-resistant influenza virus strains has reduced its efficacy.

172 en sequence variations in seasonal influenza virus strains have affected regions responsible for prot

173 g their potential to reassort with wild-type virus strains have been voiced.

174 Different influenza virus strains have caused a number of recent outbreaks k

175 A lymphotropic hepatitis C virus strain (HCV, SB strain, hereafter "SB-HCV") has be

176 onomers and neutralized heterologous primary virus strains HIV-2(7312A) and HIV-2(ST).

177 Abs neutralized a third heterologous primary virus strain, HIV-2(UC1).

178 values of >20 to 200 for different influenza virus strains; (iii) inhibit a wide spectrum of influenz

179 investigated the N9 NA from a zoonotic H7N9 virus strain in order to determine its possible role in

180 (H1N1pdm) virus is the predominant influenza virus strain in the human population.

181 g confirmed the reappearance of pretreatment virus strains in all cases.

182 tween strains in pigs and seasonal influenza virus strains in humans is also important in assessing t

183 cation inhibitor of a variety of influenza A virus strains in Madin-Darby canine kidney (MDCK) cells,

184 ely against lethal avian and swine influenza virus strains in mice, and induced robust immunity again

185 to 3 copies/ml, (ii) about one-third of the virus strains in reservoirs are replication incompetent,

186 eneChips for the rapid sequencing of Variola virus strains in the WHO Repository of the Centers for D

187 Influenza B virus strains in trivalent influenza vaccines are freque

188 nd H5 subtypes) and 2 (H3 subtype) influenza virus strains in vitro.

189 o provide broad protection against divergent virus strains in vivo.

190 is study, we show across a range of vaccinia virus strains, including the current clonal smallpox vac

191 tes reassortment between different influenza virus strains infecting the same cell.

192 ction or vaccination with seasonal influenza virus strains influences the ability to mount a protecti

193 are related to genotypic differences in the virus strains involved.

194 Typing of influenza virus strains is an important aspect of global health su

195 re, the B cell response to variant influenza virus strains is not dictated by the composition of the

196 rent epidemiologically important influenza A virus strains is not known.

197 analyses showed highest identities with Zika virus strains isolated from Brazil during 2015.

198 Although virus strains isolated from herpetic lesions cause limit

199 ietic CD34+ stem cells with low-passage CCHF virus strains isolated from human patients.

200 and analyzed 441 wild-bird origin influenza virus strains isolated from wild birds inhabiting North

201 d with attenuated strains of mouse hepatitis virus, strain JHM, develop a chronic infection in the br

202 al infection of mice with two live influenza virus strains leads to almost exclusive Ab responses to

203 ost vaccination with simian immunodeficiency virus strain mac239 (SIVmac239) Gag-Pol and Env provided

204 viruses, raising concern that certain mumps virus strains may escape vaccine-induced immunity.

205 is isolates has suggested that more than one virus strain might concurrently infect the same parasite

206 cal studies, melanin overproducing oncolytic virus strains might be used in clinical trials in patien

207 upon the accurate prediction of circulating virus strains months in advance of the actual influenza

208 Rift Valley fever virus strain MP-12 was generated by serial plaque passag

209 ogma by constructing a recombinant influenza virus strain of A/PR8/34 (H1N1) in which expression of N

210 The assay successfully detected all 94 AI virus strains of 15 different hemagglutinin (HA) subtype

211 he trivalent vaccine strains and circulating virus strains of last 2007-2008 influenza season, the ef

212 dies that can bind but do not inhibit dengue virus strains of other serotypes.

213 infection is restricted to type A influenza virus strains of the H2N2 subtype.

214 in a background of multiple introductions of virus strains of the same genotype or genetic cluster.

215 pact of intrauterine infection with multiple virus strains on the pathogenesis and long-term outcome

216 that are not found in circulating influenza virus strains or have not been previously identified to

217 g activity (nAbs) against multiple influenza virus strains or subtypes have been reported to bind the

218 years in a row with either identical vaccine virus strains or with differing vaccine virus strains.

219 This effect is independent of cell line, virus strain, or batch of pooled human serum used.

220 m of interest regardless of cell type, HIV-1 virus strain, or experimental perturbation.

221 not dependent on a specific cell substrate, virus strain, or type of inoculum.

222 59,984-bp-long genome sequence of P. globosa virus strain PgV-16T, encoding 434 proteins and eight tR

223 eterologous mouse-adapted A/PR/8/1934 (H1N1) virus strain (PR8).

224 red influenza virus strain compared with the virus strain present in the vaccine.

225 and Sudan Ebolavirus and 4 different Marburg virus strains produced severe, but more slowly progressi

226 ged between 0.05 and 1.21%, depending on the virus strain, producer cell type and gp120 V1-V3 loop si

227 RNA (satRNA) associated with Cucumber mosaic virus strain Q (Q-satRNA) has a propensity to localize i

228 d), a satRNA associated with Cucumber Mosaic Virus strain Q (Q-satRNA) has the propensity to localize

229 The virulence of Soromba-R, a Lassa virus strain recently isolated from southern Mali, was a

230 So far, circulating virus strains remain similar under continuous monitoring

231 enza A(H5N1) virus and other avian influenza virus strains represent major pandemic threats.

232 Our data show that multiple different virus strains seeded and were maintained throughout the

233 76, which is conserved in >99% of influenza virus strains sequenced to date, was identified as being

234 upon inoculation with human H1N1 influenza A virus strains, several swine influenza viruses, and infl

235 gglutinins (HAs) from previously circulating virus strains; several of these antibodies, which were p

236 Results of genetic studies using recombinant virus strains show that reovirus tropism for MDCK cells

237 intervals to combat newly arising influenza virus strains, so that a universal vaccine is highly des

238 al subversion of the IFN response and couple virus strain-specific differences in IFN antagonism to t

239 ces in the IFN response, which are linked to virus strain-specific differences in induction of murine

240 acid difference between viruses can dictate virus strain-specific differences in suppression of the

241 The M1 gene is a determinant of virus strain-specific differences in the IFN response, w

242 Influenza virus strain-specific monoclonal antibodies (mAbs) provi

243 e emergence of highly contagious influenza A virus strains, such as the new H1N1 swine influenza, rep

244 in an acute infection with a closely related virus strain, suggesting that persistent TLR stimulation

245 A shift in circulating JE virus strains suggests that a genotype shift phenomenon

246 oncogenic retrovirus, reticuloendotheliosis virus strain T (REV-T), that upregulates miR-155 in chic

247 , which is comprised of an attenuated DENV-2 virus strain (TDV-2) and three chimeric viruses containi

248 ody titer of the sera was lower against some virus strains than others, all viruses were readily neut

249 We constructed a pseudorabies virus strain that expressed Us9-GFP and tested its sprea

250 emains a challenge to identify an attenuated virus strain that has an optimal balance between attenua

251 A Sindbis virus strain that in wild-type (WT) mice only causes dis

252 c response to VACV, especially against those virus strains that are most dependent on cross-presentat

253 by generating an immune response toward the virus strains that are predicted to circulate in the upc

254 ve used a collection of vesicular stomatitis virus strains that had been evolving either under positi

255 el810), which is representative of influenza virus strains that have caused severe morbidity and mort

256 L20 in the context of a highly neurovirulent virus strain, the HSV-1(McKrae) genome was cloned into a

257 For the recombinant A/WSN/33 (rWSN) virus strain, the inability to stimulate PI3K had minima

258 Using whole-virus strains, the analytical sensitivity for representa

259 athogenic A/Vietnam/1203/04 (H5N1) influenza virus strain; the vaccines encoded influenza A virus hem

260 seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual va

261 rotection limited to the infection with same virus strains; therefore, the composition of influenza v

262 ded their distinction from circulating human virus strains through linking receptor specificity to hu

263 and determine the lineage of human influenza virus strains through the detection of one or more signa

264 s vaccines protect mostly against homologous virus strains; thus, regular immunization with updated v

265 chain antibodies by using oncolytic vaccinia virus strains to enhance their therapeutic efficacy.

266 that recognize a broader number of influenza virus strains to prevent infection and transmission.

267 this may be the ability of certain influenza virus strains to productively replicate in macrophages.

268 logical processes, from the emergence of new virus strains to the effectiveness of vaccination progra

269 ated NS1 proteins encoded by two influenza A virus strains, Udorn/72/H3N2 (Ud) and Puerto Rico/8/34/H

270 The A(H1N1)pdm09 virus strain used in the live attenuated influenza vacci

271 family glycoproteins not encoded by vaccinia virus strains used as vaccines.

272 n the context of emergence of an influenza A virus strain via a host switch event, it is difficult to

273 virus, the glioma-adapted vesicular stomatis virus strain VSVrp30a, was used for in vivo tests with t

274 recombinant A/Puerto Rico/8/34 (rPR8) mutant virus strain was attenuated and caused reduced morbidity

275 The virus strain was genotype D9, which was circulating in t

276 While infection by most virus strains was completely blocked by AMD3100, we iden

277 For a panel of avian influenza A virus strains, we find evidence for a trade-off between

278 typically associated with virulent influenza virus strains were absent in this species.

279 Three influenza A virus strains were also compared.

280 1 seasonal, and H1N1 2009 pandemic influenza virus strains were compared by infecting human different

281 amino acid residues of a number of influenza virus strains were engineered into the A/WSN/33 virus NS

282 While the two virus strains were found to be cocirculating in a mixed-

283 The virus strains were genotyped, and their time origin was

284 A total of 189 virus strains were identified.

285 Four T/F virus strains were inoculated into rhesus macaques, and

286 In contrast, only two virus strains were pathogenic for C57BL/6 mice upon high

287 nged by intranasal inoculation with vaccinia virus strain Western Reserve.

288 ice against infection with the H1N1 and H3N2 virus strains when administered before or after challeng

289 directed against a neutralization-sensitive virus strain, whereas neutralizing activities emerging a

290 l cells limit replication of human influenza virus strains, whereas avian influenza viruses overcome

291 The virus strain, which was previously provided by the Onder

292 A neurovirulent Sindbis virus strain with neuroinvasive properties (SVNI) causes

293 Virus strains with a history of repeated genetic bottlen

294 nfectivity and cellular tropism of influenza virus strains with different receptor specificities.

295 Lymphocytic choriomeningitis virus strains with high or low alpha-DG affinity and Jun

296 reverse genetics system to rescue defective virus strains with large deletions in an essential BTV g

297 has been a widespread emergence of influenza virus strains with reduced susceptibility to neuraminida

298 ne segments from the 2009 pandemic influenza virus strain without prior adaptation.

299 C57BL/6 mice with 1 x 10(7) PFU of vaccinia virus strain WR results in blepharitis, corneal neovascu

300 3 x 10(6) PFUs of virulent Rift Valley fever virus strain ZH-501 (RVFV ZH-501) at 126 days after vacc