ライフサイエンスコーパス: virus titer

1 of protection (>1,500-fold reduction in lung virus titer).

2 There was no effect of carrageenan on virus titer.

3 rrespond to the 1- to 2-log-unit decrease in virus titer.

4 onsible for an early rapid decrease in HSV-2 virus titer.

5 ndent upon the duration of APC infection and virus titer.

6 n nasal-lavage specimens, or on quantitative-virus titer.

7 n the G tract had little or no effect on the virus titer.

8 d of the PPT and determined their effects on virus titer.

9 re complex mutations had stronger effects on virus titer.

10 V-activated CD4(+) T-cell blasts reduced the virus titer.

11 ent resulting in > or =100-fold reduction in virus titer.

12 (10- to 50-fold) in viral RNA packaging and virus titer.

13 gnal mutants has defects in RNA packaging or virus titer.

14 the 627K mutant, but it did enhance the lung virus titer.

15 xpression of IFIT3 resulted in a decrease of virus titer.

16 ectedly, anti-IL-22-treated mice had reduced virus titers.

17 lung tissue correlated with the reduction of virus titers.

18 , including a drastic reduction in challenge virus titers.

19 ut do not ultimately control cell-associated virus titers.

20 n-deficient mice contained similar influenza virus titers.

21 ducing a 10- to 1,000-fold reduction in peak virus titers.

22 matic increase in viral RNA accumulation and virus titers.

23 .0 +/- 0.3 days; p < 0.02) despite increased virus titers.

24 and were positively correlated with tracheal virus titers.

25 eter and a 51-fold decrease in extracellular virus titers.

26 ated with severe illness and higher vaccinia virus titers.

27 ection domain generally had small effects on virus titers.

28 the R-peptide yet does not adversely affect virus titers.

29 nes, while anti-F antibody treatment reduced virus titers.

30 rus production onset, and (iii) reduced peak virus titers.

31 s virus (WHV) induces a transient decline in virus titers.

32 nt reduction of viral protein expression and virus titers.

33 g but altered neither antibody responses nor virus titers.

34 alpha-globin mRNA per copy) without reducing virus titers.

35 rotein levels in viral pellets or infectious virus titers.

36 ttC or dptB showed a significant increase in virus titers.

37 lded at least a 1 log decrease in infectious virus titers.

38 Lesion expression did not correlate with virus titers.

39 ologic changes, reflecting reduced levels of virus titers.

40 t a 12-fold increase in encephalomyocarditis virus titers.

41 related to preexisting antibody or to higher virus titers.

42 howed relatively little suppression of DEN-2 virus titer (0.1 and 0.9 log10, respectively).

43 inhibiting the spread of Mo-MLV and reducing virus titers 1,500- to 2,500-fold.

44 I1 and HI8), (ii) particles with a decreased virus titer (1 log) but normal infectivity (HI4), and (i

45 was delivered to >80% of cells and inhibited virus titers 10- to 100-fold in a sequence-specific and

46 Treatment on day 0 reduced peak pulmonary virus titers 10- to 100-fold, reduced the severity of vi

47 In contrast, the peak virus titers (10(3.6) to 10(4.3) TCID(50)/ml) for Mal08

48 n (>10 h postinfection [p.i.]) after maximal virus titers (150 to 200 PFU/cell) have been reached, wi

49 RNA displayed widespread eGFP expression and virus titers 16-fold higher than dsbetagal controls afte

50 ces a massive recall response, which reduces virus titers 2-3 days earlier than in nave controls.

51 e vaginal mucosa; 2) had significantly lower virus titers; 3) had decreased overt signs of genital he

52 nes, the hemolytic complement gene, affected virus titer 7 days after infection.

53 As a result of the higher virus titer, 80% of BALB/cLA females developed mammary g

54 ment of IRF-3(-/-) BMDCs resulted in reduced virus titers, a far greater reduction was seen after IFN

55 l result in a drastic decrease in infectious virus titers, a reduction in the amount of packaged vira

56 uced EHV-1 production by 23-fold compared to virus titers achieved in cells transfected with the empt

57 ions at Y501 have been shown to decrease the virus titer and affect the specificity of RNase H cleava

58 In vivo, PLD2 inhibition reduced virus titer and correlated with significant increases in

59 Consequently, increased lung virus titer and higher mortality were observed.

60 gs, rather than with traditional measures of virus titer and host responses.

61 ed mice exhibited a significant reduction in virus titer and improvement in survival that is associat

62 revealed an inverse linear relationship with virus titer and MOI.

63 RSHZ19 reduced virus titer and protected against illness when used in p

64 th a approximately 10-fold reduction in lung virus titer and protection against weight loss when comp

65 sed vector and determined the effects on the virus titer and RNase H cleavage specificity.

66 n using 2-bromopalmitate (2-BP) affected the virus titer and the interaction of UL20 and gK but did n

67 virus replication, as judged both by maximum virus titer and time of viral clearance.

68 ve CD8 T cells failed to clear the pulmonary virus titer and to promote host survival.

69 s could be a major factor in determining the virus titer and, by extension, viral fitness, which coul

70 ulted in a 6-fold reduction of extracellular virus titers and a 13% reduction of plaque diameters, wh

71 selected until after the initial decrease in virus titers and after the development of immune respons

72 e severe pulmonary inflammation, higher lung virus titers and greater weight loss compared with mice

73 assessed by the quantification of infectious virus titers and HCMV genome copies and the detection of

74 vival rates associated with markedly reduced virus titers and immune pathology in the brain but norma

75 l NSV-induced encephalomyelitis, we compared virus titers and immune responses in adult B6 and Bc mic

76 ed with higher virus load because equivalent virus titers and immunohistochemical staining were obser

77 and blockade of PD-L1 in vivo led to reduced virus titers and increased CD8(+) T cell numbers in high

78 able Mcl-1-knockdown cells led to restricted virus titers and increased physical to infectious partic

79 accination decreased postchallenge tear film virus titers and ocular disease incidence and severity w

80 virus, resulted in significant reductions in virus titers and pathological lesions in the liver compa

81 d systemic infection in the ducks, with high virus titers and pathology in multiple organs, particula

82 d virus increased the reproducibility of the virus titers and PRN titers.

83 llowing RSV inoculation despite similar lung virus titers and rates of virus clearance.

84 Although virus titers and release of spherical particles were not

85 at this stimulatory effect is independent of virus titers and RSV-induced inflammation; that it is as

86 ted in asymptomatic infection with lower CNS virus titers and undetectable CNS apoptosis.

87 High virus titers and viral replication in many tissues were

88 creased survival, lowered the peak of ocular virus titer, and cleared the ocular disease.

89 sms, including direct cytotoxicity, elevated virus titer, and reduced tumor neovascularization.

90 lted in a significant reduction in pulmonary virus titers, and largely reduced virus-induced lung pat

91 lence in vivo as measured by disease scores, virus titers, and mortality.

92 C-CX3CR1 binding and chemotaxis, reduce lung virus titers, and prevent body weight loss and pulmonary

93 influenza-associated morbidity and influenza virus titers, and that these changes in disease severity

94 V-1 can replicate without UL21, although the virus titers are greatly reduced.

95 to no discernible cytopathic effect, and low virus titers are produced.

96 strategies for retroviral transduction, the virus titers are relatively high and stable and can be f

97 s difference in inflammatory damage, cardiac virus titers are similar between C57BL/6 and Bl.Tg.Ealph

98 corneal infection were found to have ocular virus titers as much as 10(5)-fold higher than that seen

99 Infectious virus titers at day 8 postinfection in liver, spleen, an

100 However, within 6 to 12 months, virus titers begin to increase towards pretreatment leve

101 o a glycine resulted in a modest decrease in virus titer but a substantial decrease (1 log order) in

102 tible tomato Moneymaker (MM) revealed higher virus titers but lower amounts of siRNAs.

103 wn of IFITMs by RNA interference reduced the virus titer by about 100-fold on day 8 postinfection, ac

104 ed a smaller plaque diameter and reduced the virus titer by approximately 1 log.

105 he adjacent region caused a reduction in the virus titer by blocking virus release, and some affected

106 yping contributed to the elevated polytropic virus titer by increasing the efficiency of packaging an

107 diately, evidenced by a 30-fold reduction in virus titer by week 2, declining to a nonquantifiable le

108 inhibitors that block HSP70 function reduces virus titers by up to 1,000-fold, suggesting that this i

109 at 14 days postinfection, a period when the virus titer comes primarily from reactivated latent geno

110 on shutoff (100-fold or greater reduction in virus titer compared to that at 37 degrees C) at 39 degr

111 tantial (5-12 log(10)) reduction in vaccinia virus titer compared with mock-immunized controls.

112 NP show approximately 100-fold reductions in virus titers compared to controls, while mice immunized

113 mice showed a complete reduction in vaccinia virus titers compared to HCV DNA prime/boost- and mock-i

114 otent antiretroviral therapy and that plasma virus titers correlate, albeit in a nonlinear fashion, w

115 T cells and remained unmethylated even when virus titers decreased.

116 These mutations increased infectious virus titers, demonstrated a strong positive impact on v

117 guinea pigs by both viruses, as measured by virus titer determination and seroconversion.

118 h we have demonstrated clearly that absolute virus titer does not predict clinical outcome.

119 Normalized virus titers dramatically increased after adult emergenc

120 in a significant decrease in the normalized virus titer during larval and pupal development.

121 ced morbidity but had no effect on pulmonary virus titers during primary H1N1 infection compared to p

122 RDR, and it had no significant influence on virus titers during systemic infection.

123 and not Tc2 effectors reduced the pulmonary virus titer early during infection.

124 ice to SARS-CoV was associated with elevated virus titers, enhanced vascular leakage, and alveolar ed

125 ons caused an initial increase of infectious virus titer followed by a decrease with a longer duratio

126 crease in sarcolemmal disruption and cardiac virus titer following CV infection.

127 51g rescued virus (51gR) but yielded reduced virus titers following infection of permissive bovine ce

128 Virus titers from nasal swabs peaked on day 2, and low t

129 In contrast, virus titers from the PBMC of morphine-naive SIVmac239-i

130 ic relief in addition to reducing infectious virus titers, FST-100 should be a valuable addition to t

131 els in HuH-7 cells significantly affects HCV virus titers, further demonstrating the requirement for

132 Virus titers, genome copies, and lesion size were decrea

133 SERCA virus titers >5 to 6 plaque-forming units per cell produ

134 No difference in virus titers, HRV species, and inflammatory or allergic

135 The peak virus titer in cotton rat lungs occurred on day 4 postin

136 tigen, the virus genome copy number, and the virus titer in IHH culture fluid.

137 verse transcriptase PCR (RT-PCR) analysis of virus titer in L1 thrips revealed a significant increase

138 Pneumonic consolidation and mean virus titer in lung 7 days after challenge were signific

139 of mice with 100 PFU of group 1 viruses, the virus titer in lungs was 10(7) PFU/g or 3 log units high

140 that eosinophil deficiency had no impact on virus titer in PVM Ag-vaccinated mice, nor on weight los

141 o achieve a 2000-fold reduction in pulmonary virus titer in RSV-infected mice.

142 t there is a significant correlation between virus titer in the bloodstream of infected individuals a

143 packaging by studying the RNA packaging and virus titer in the context of proviruses.

144 e is no absolute correlation between primary virus titer in the eye and TG and the level of viral DNA

145 with CX4C had a 0.7 to 1.2 log10-fold lower virus titer in the lung at 5 days postinfection (p.i.) a

146 Average virus titer in the patient specimens was 1.05 e4 copies/

147 tion mutant in terms of disease severity and virus titer in vaginal swabs and central nervous system

148 vitro and that cyclopamine is able to reduce virus titers in a mouse model of hRSV infection.

149 Virus titers in all four woodchucks were only transientl

150 It may be reasonable to obtain West Nile Virus titers in any patient presenting with the above fi

151 ignificant reduction of dengue and West Nile virus titers in cell-based assays of virus replication,

152 that overlapped with transient increases in virus titers in CXCR3-deficient mice.

153 Virus titers in heart and spleen were dramatically lower

154 No significant differences in virus titers in heart or pancreas were observed between

155 y of these siRNAs significantly reduced lung virus titers in infected mice and protected animals from

156 the CNS of infected mice, it does not affect virus titers in infected mice thymi, spleens or infected

157 na, and this delay correlated with decreased virus titers in infected tissues, compared with mice inf

158 In contrast, mean virus titers in liver, spleen, and lung tissues from pla

159 ic reductions in weight loss, mortality, and virus titers in lung and bronchoalveolar lavage fluid af

160 Virus titers in lymph nodes were significantly lower, an

161 ction, and a 100- to 1,000-fold reduction in virus titers in lymphoid tissue and bone marrow were obs

162 o doses of MVA prevented illness and reduced virus titers in mice who were challenged with either vSC

163 ociated with a broad tissue tropism and high virus titers in multiple organs, including the brain.

164 cation kinetics were assessed by determining virus titers in nasal swabs and respiratory tissues, whi

165 In contrast, although virus titers in neural tissues of p55-/- N13 mice were e

166 n only day 5, but E caused more reduction of virus titers in old than in young mice (25-fold vs. 15-f

167 of 1 and 10 mg/kg/day significantly reduced virus titers in organs and provided 60% and 80% survival

168 characterized by high levels of viremia and virus titers in peripheral organs.

169 against lethal challenge and displayed high virus titers in respiratory tissues.

170 Virus titers in serum, peripheral organs, and the brain

171 absence of NK cells has a profound effect on virus titers in spleen and liver.

172 at 5 days postinfection (peak of infectious virus titers in the central nervous system) compared to

173 peripheral organs, which resulted in higher virus titers in the central nervous system.

174 Although minocycline reduces virus titers in the CNS of infected mice, it does not af

175 delayed until 2 and 4 days after infection, virus titers in the eye were analogous to those in the c

176 even after corneal scarification, had lower virus titers in the eye, had less latency in the TG, and

177 avirulent (KOS and RE) strains of HSV-1, and virus titers in the eyes and TG during primary infection

178 s, (ii) virus antigen shedding or infectious virus titers in the feces or intestinal contents measure

179 the liver, there was no correlation between virus titers in the gut and detection of virus in the li

180 / SA11-Cl4 reassortants and determination of virus titers in the gut and liver revealed that the extr

181 CVB3 resulted in approximately 50-fold-lower virus titers in the heart and approximately 6-fold-lower

182 Virus titers in the heart were equivalent at days 3 and

183 tion with RSV showed substantially decreased virus titers in the lung and decreased inflammation and

184 nza virus resulted in dramatically increased virus titers in the lung and intranasal cavity of mutant

185 or BALB/c mice enhanced survival and reduced virus titers in the lung.

186 ein gene and PEI87 resulted in a 94% drop of virus titers in the lungs of influenza-infected animals.

187 Virus titers in the lungs of KyA-immunized mice were 1,0

188 Virus titers in the lungs of mice unable to respond to I

189 d lower at 2 days post-RacL11 challenge than virus titers in the lungs of nonimmunized mice, indicati

190 A comparison of virus titers in the mouse respiratory tract versus MDCK

191 gher virus excretion via the nose and higher virus titers in the nasal turbinates than intratracheal

192 in the heart and approximately 6-fold-lower virus titers in the pancreas.

193 ociated with lethality, significantly higher virus titers in the respiratory tract, virus disseminati

194 but can reduce disease severity, deaths, and virus titers in the respiratory tract.

195 Virus titers in the serum of vaccinated mice were signif

196 Topical drug treatment markedly reduced virus titers in the skin and snout, whereas parenteral t

197 Immunized ferrets had significantly lower virus titers in the upper respiratory tract and less-sev

198 Virus titers in these tissues reached 10(9) pfu/g.

199 Virus titers in these tissues reached 10(9) pfu/g.

200 Pr4Delta3-C2 virus titers in ticks were significantly reduced 100- to

201 yet retained growth dynamics, stability, and virus titers in vitro that were similar to those of the

202 n the target cell surface does not influence virus titers in vitro.

203 Significant effects of E on lung virus titers in young mice were observed on only day 5,

204 irus initially replicated to low titers, but virus titer increased significantly after mutations appe

205 Furthermore, virus titer increased with apoptosis progression, sugges

206 l of intravenous JEV infection, we show that virus titers increased exponentially in the brain from 2

207 However, DC480 mutant virus titers increased nearly 20-fold when the virus was

208 ion of mouse cells with 16/L leads to higher virus titers, increased production of RNA, and total cyt

209 s among healthy, full-term infants; however, virus titers, inflammation, and Th2 bias are proposed ex

210 In contrast to the 30-fold increase in virus titers, intracellular levels of viral RNA were inc

211 ce were euthanized 5 days postinfection, and virus titers, levels of neutralizing antibodies, and num

212 e non-1 (75% vs. 56%) and in patients with a virus titer < 2 x 10(6) copies/mL (93% vs. 43%).

213 and had no significant reductions in tissue virus titers observed on day 5 post-H5N1 virus challenge

214 erefore, based on the analysis of CIT50, the virus titer of a given sample can be determined from the

215 ized by early appearance of viremia and peak virus titers of 10(5)-10(6) genome equivalents/mL.

216 were similar for Ncal99 and Sw30, with peak virus titers of 10(5.1) 50% tissue culture infectious do

217 Virus titers of targeting vectors obtained from stable p

218 Virus titers on chicken embryo cells were reduced by app

219 eutralizing-antibody titers and reduced lung virus titers on day 3 postchallenge.

220 ed 30 ppm of E had significantly higher lung virus titers on days 2 and 7 after infection than young

221 SV-2 strain resulted in significantly higher virus titers on days 3 to 7 but only slightly delayed re

222 8 U/ml) of cells reduced 40% E2-G pseudotype virus titer only.

223 in apoptosis at 10 h p.i., with no effect on virus titers (only SB203580 tested).

224 here were no differences among the groups in virus titers or the route and timing of virus spread in

225 progression, hematology, serum biochemistry, virus titers, or lethality in nonhuman primates infected

226 IFN-I remains detectable until after virus titers peak, but early IFN-I administration amelio

227 Laryngeal virus titers peaked at 10(5.0)-10(6.0) plaque-forming un

228 In all guinea pigs, virus titers peaked in nasal secretions at day 2 after i

229 Virus titers peaked in the CNS between postnatal days 10

230 revealed that cycling cells generated higher virus titers per cell.

231 l cell shedding accelerated the reduction of virus titers, presumably by clearing virus-infected cell

232 ssembly is largely responsible for increased virus titers produced during S-phase.

233 A linear relationship was found in the virus titer range of 2(-10)-2(2)HAU.

234 ical serum specimens (genotypes 1 to 6, with virus titers ranging from 15.1 to 2.1 x 10(7) IU/ml) sho

235 Despite the high virus titers, rCVB3 infection of naive mice failed to in

236 Virus titers reached 10(8) TCID50/ml in the blood and be

237 e observed a log-linear relationship between virus titer reduction and the number of rPMP molecules i

238 eases in morbidity, mortality, and pulmonary virus titers relative to controls.

239 edia of infected cells has demonstrated that virus titers released from the apical surface are about

240 In no case was the peak virus titer substantially reduced following infection of

241 different methods available for determining virus titers such as plaque assays end-point dilution, q

242 although this mutation significantly reduced virus titer, suggesting that removing three nucleotides

243 Loss of P58(IPK) leads to reduced virus titer, suggesting that wild-type P58(IPK) protein

244 cided with a 100- to 1,000-fold reduction in virus titer, supporting the hypothesis that the HPIV1 C

245 fectious progeny for weeks, producing higher virus titers than late-gestation cells that varied by do

246 tro and the SSTT mutation resulted in higher virus titers than were observed for the parental rOka st

247 negligible T-cell-mediated injury, and high virus titers that persist.

248 replicate in primary fibroblasts, attaining virus titers that were 2 to 3 orders of magnitude lower

249 ated in all animals with a 2-log decrease in virus titer, the timing occurred approximately 2 weeks l

250 ere characterized by a continual decrease in virus titer, the titers in the persistent infections rea

251 000-fold and also caused the cell-associated virus titer to increase.

252 virulent HSV-2 strain resulted in a rise in virus titers to levels comparable to those of nonimmune

253 erienced less morbidity but had similar lung virus titers to placebo-treated females.

254 These mutations reduced virus titers to widely varying extents that ranged from

255 us stocks resulted in a 200-fold increase in virus titers (up to 10(6) CFU/ml).

256 iameter change data were used to compute the virus titer using a statistical method called the method

257 mosquito pools could be detected when the WN virus titer was 10(2.1) to 10(3.7) PFU/0.1 ml.

258 The reduction in B virus titer was attributed to the complete growth of typ

259 inoculation with poliovirus, no increase in virus titer was detected in the feces of TgFABP-PVR mice

260 Virus titer was maximal 96 hpi in CaCo-2 cells, and viru

261 was competent for virion formation, but the virus titer was reduced 4.5-fold relative to that of the

262 on and binding to the receptor; however, the virus titer was reduced 5- to 45-fold, indicating a post

263 amples and challenged with HSV-2(G), and the virus titer was then determined.

264 lenge, although significant reduction of the virus titers was noted.

265 Serum antibodies, lung virus titers, weight loss, and pulmonary pathology were

266 ished R-region homology on DNA synthesis and virus titer were examined.

267 mal cell damage in rat myocytes if the SERCA virus titer were maintained within 1 to 4 plaque-forming

268 Lower virus titers were also detected in other tissues, includ

269 Further, 22/n199 virus titers were below the level of detection in trigem

270 f resistant lines carrying Ty-1 or Ty-3, low virus titers were detected concomitant with the producti

271 High virus titers were detected in the lungs and brains of tr

272 ected monkeys secreted virus, while marginal virus titers were detected in tracheal lavage fluid cell

273 Virus titers were determined by plaque assay.

274 cells, whereas lymphocytic choriomeningitis virus titers were dramatically increased.

275 Virus titers were elevated in the trigeminal ganglia and

276 The resulting virus titers were greatly reduced from those of JFH1, an

277 At all times and in all organs analyzed, virus titers were higher in CAST than in BALB/c mice.

278 the heart; in the absence of such signaling, virus titers were markedly elevated by day 3 postinfecti

279 In the absence of an intact ISG15 system, virus titers were markedly elevated by postinfection day

280 Surprisingly, virus titers were not elevated in MAVS-deficient mice, d

281 with the parental virus (pH1N1/NS1-wt), yet virus titers were not significantly increased in cell cu

282 Increased virus titers were observed among 1:7 viruses containing

283 However, lower virus titers were observed in all corresponding tissues

284 High virus titers were present in lung and brain tissues 2 an

285 Infectious virus titers were present in the blood and most tissues

286 us were treated with the 5'End or 3'CSI PMO, virus titers were reduced by approximately 5 to 6 logs a

287 Consistent with antibody responses, lung virus titers were significantly higher in obese mice tha

288 n the lungs of both Nu/Nu and Nu/+ mice, but virus titers were significantly higher in T cell-deficie

289 erforin and Fas or neither perforin nor Fas, virus titers were significantly lower than in control mi

290 Nasal wash virus titers were similar for Ncal99 and Sw30, with peak

291 an Ifit2(-/-) mice, although their pulmonary virus titers were similarly high.

292 ry steps of the virus life cycle because the virus titers were similarly inhibited from infected cell

293 induces apoptosis in cells containing dsRNA, virus titers were strongly reduced.

294 gs of dual-infected mice, although influenza virus titers were unaffected.

295 Mean (+/-SD) log10 virus titers were, in study 1, group A, 2.3 +/- 0.8 pfu/

296 ions in lung pathology without reductions in virus titer when treated with two intranasal doses of RT

297 geny production (a reduction of 95 to 99% in virus titer), which correlated with the phosphorylation

298 s were not exhausted by the presence of high virus titers, which persisted in the SMG despite the str

299 Addition of monocytes restored the virus titer, while addition of resting T cells or EBV-ac

300 egulation decreases extracellular infectious virus titers with little effect on intracellular RNA con