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1 in homeobox transcription factor Lhx1 in the visceral endoderm.
2 on early in embryonic development across the visceral endoderm.
3 ed to be the homologue of the mouse anterior visceral endoderm.
4 symmetric patterns of gene expression in its visceral endoderm.
5 l positioning and structure formation of the visceral endoderm.
6 embryonic mesodermal cells that underlie the visceral endoderm.
7 buting to the epithelial organization of the visceral endoderm.
8 y and its regulation in the formation of the visceral endoderm.
9 nd altered epithelial characteristics in the visceral endoderm.
10 tion to the extra-embryonic ectoderm and the visceral endoderm.
11 rm and anterior neuroectoderm but not in the visceral endoderm.
12 cascade that controls differentiation of the visceral endoderm.
13 plete gastrulation due to dysfunction of the visceral endoderm.
14 Dab2 is a downstream target of GATA-6 in the visceral endoderm.
15 and that the process depends on signals from visceral endoderm.
16 mesoderm, whereas it is nonessential in the visceral endoderm.
17 er cell mass cells into the postimplantation visceral endoderm.
18 opological equivalent of the murine anterior visceral endoderm.
19 ependent on amnionless gene functions in the visceral endoderm.
20 ascade that regulates differentiation of the visceral endoderm.
21 the initial anterior movement of the distal visceral endoderm.
22 etic manipulation and can be induced to form visceral endoderm.
23 proliferates at a much higher rate than the visceral endoderm.
24 ives rise to the extraembryonic parietal and visceral endoderm.
25 NM II-B or chimeric NM IIs restores a normal visceral endoderm.
26 ryo proper but rather in the extra-embryonic visceral endoderm.
27 thality at E5.5-E6.5, showing defects in the visceral endoderm.
28 This includes an epCam+Dpp4+ subtype of visceral endoderm.
29 opment of the first columnar epithelium, the visceral endoderm.
30 microarray analysis on E8.25 definitive and visceral endoderm.
31 ities and differences between definitive and visceral endoderm.
32 flow cytometric isolation of definitive and visceral endoderm.
33 as GATA6 is essential for development of the visceral endoderm.
34 d the epithelial defects observed in the cKO visceral endoderm.
35 entiated to an epithelium that resembled the visceral endoderm.
36 lopment of the cardiovascular system and the visceral endoderm.
38 of lacZ, the imprinted X inactivation in the visceral endoderm, a derivative of the extraembryonic li
40 Maspin was specifically expressed in the visceral endoderm after implantation; deletion of maspin
42 ) were recently shown to be expressed in the visceral endoderm and anterior endomesoderm, respectivel
43 sh a primitive streak, although the anterior visceral endoderm and anterior epiblast fates are specif
44 r Nodal and Cripto in the differentiation of visceral endoderm and AVE from XEN cells and provide new
46 moting, and required for differentiation of, visceral endoderm and cavitation of embryoid bodies.
47 ory enhancer eliminates transcription in the visceral endoderm and decreases Nodal expression in the
48 s nodal expression in the early epiblast and visceral endoderm and disrupts asymmetric expression in
50 ene expressed in the extraembryonic anterior visceral endoderm and in primitive streak-derived tissue
51 embryos, Cerr1 is expressed in the anterior visceral endoderm and in the anterior definitive endoder
52 hly expressed by the epithelial cells of the visceral endoderm and localized to the brush-border memb
56 GATA6(-/-) ES cells lack a covering layer of visceral endoderm and severely attenuate, or fail to exp
57 the primitive streak; first in the posterior visceral endoderm and soon after in the adjacent posteri
58 sterior proximal epiblast and its associated visceral endoderm and subsequently to the primitive stre
59 sible for maintaining VEGF in the developing visceral endoderm and that a VEGF-responsive paracrine s
60 SL is the functional equivalent of the mouse visceral endoderm and that extraembryonic structures may
61 ed for forebrain specification, the anterior visceral endoderm and the anterior definitive endoderm,
63 To understand the function of GATA-6 in the visceral endoderm and to identify genes regulated by GAT
64 tion of Nodal expression in the epiblast and visceral endoderm, and at later stages governs asymmetri
66 ate, early definitive endoderm, and anterior visceral endoderm appear to be expanded, likely due to d
67 r Nodal, display upregulation of markers for visceral endoderm as well as anterior visceral endoderm
68 at, while Smad1 is uniquely expressed in the visceral endoderm at 6.5 dpc, in other tissues Smad1 is
69 scripts are present only in a small patch of visceral endoderm at the distal tip of the egg cylinder.
70 characteristic localized outpocketing of the visceral endoderm at the posterior embryonic/extra-embry
72 meobox gene Hex is expressed in the anterior visceral endoderm (AVE) and rostral definitive endoderm
74 he head organizer is located in the anterior visceral endoderm (AVE) and the trunk organizer in the n
76 chanism regulating migration of the anterior visceral endoderm (AVE) by BMP signaling through BMPRIA.
77 drives the collective migration of anterior visceral endoderm (AVE) cells in the early mouse embryo.
78 oper morphogenetic movements of the anterior visceral endoderm (AVE) during pre-gastrulation stage.
79 thought to take place only when the anterior visceral endoderm (AVE) emerges and starts its asymmetri
87 maintain cell-cell contacts in the anterior visceral endoderm (AVE) signalling centre that normally
89 the mouse embryo, migration of the anterior visceral endoderm (AVE) to the prospective anterior esta
91 ation and migration of cells of the Anterior Visceral Endoderm (AVE), an early extraembryonic organiz
92 or normal migration of cells of the Anterior Visceral Endoderm (AVE), an extraembryonic organizer tha
93 rs for visceral endoderm as well as anterior visceral endoderm (AVE), and can contribute to visceral
94 LRT3 expression is activated in the anterior visceral endoderm (AVE), and during gastrulation appears
95 follow the step-wise development of anterior visceral endoderm (AVE), critical for establishing AP po
96 ments that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and defin
97 blast, extraembryonic ectoderm, and anterior visceral endoderm (AVE), resulting in phenotypes that ar
98 A-P) axis formation by inducing the anterior visceral endoderm (AVE), the extraembryonic signaling ce
100 is expressed primarily in the extraembryonic visceral endoderm before gastrulation and later in both
101 at Indian hedgehog (Ihh) is expressed in the visceral endoderm both in the visceral yolk sac in vivo
102 opment, showing that Dab2 is required in the visceral endoderm but dispensable in the embryo proper.
104 l signals from the epiblast also pattern the visceral endoderm by activating the Smad2-dependent path
106 ed that spatial distribution of cells in the visceral endoderm can be traced back to polarity present
107 mesoderm indicating that loss of YY1 in the visceral endoderm causes defects in the adjacent yolk sa
108 ds to a switch from AVE to an extraembryonic visceral endoderm cell identity, and second, by demonstr
110 for upregulation of MT-I gene expression in visceral endoderm cells and that optimal expression also
111 eformed primitive egg cylinder; however, the visceral endoderm cells are not organized, the cells of
112 nexpectedly that a significant population of visceral endoderm cells does contribute, along with epib
113 endoderm cells and the derived parietal and visceral endoderm cells gain the capacity to produce col
114 l surfaces of enterocytes, acinar cells, and visceral endoderm cells in mice fed a zinc-adequate diet
115 reduction in apical vacuoles in the columnar visceral endoderm cells in the extraembryonic region.
116 e of elevated levels of message in the outer visceral endoderm cells relative to the core cells in ma
118 ith the stereotyped shift in the position of visceral endoderm cells reveal similarities among amniot
119 cted a morphological and lineage analysis of visceral endoderm cells spanning pre- and postprimitive
120 g that is produced by distal (ectoplacental) visceral endoderm cells that migrate into the allantoic
126 ct4 expression stain positive for markers of visceral endoderm (DAB2, alpha-fetoprotein (AFP), HNF4).
127 r, FLK1, recapitulates both the mesoderm and visceral endoderm defects observed in the cKO yolk sac.
128 iblast, which does not occur in the adjacent visceral endoderm, depends on cells losing contact with
131 bryoid bodies and embryos at the stages when visceral endoderm differentiation and cavitation are occ
132 cell line, a model for retinoic acid-induced visceral endoderm differentiation in which we demonstrat
135 estigated the cell behaviors and fate of the visceral endoderm during gut endoderm formation in the m
138 ells of the wild-type AVE migrate within the visceral endoderm epithelium from the distal tip of the
139 ng the gastrulating embryo and indicate that visceral endoderm-expressed BMP2 coordinates morphogenet
140 meras developing in the context of wild-type visceral endoderm fail to undergo ventral closure, axial
141 in both primitive streak-derived tissues and visceral endoderm for head formation and that its inacti
144 he growth of the inner cell mass stopped, no visceral endoderm formed, and finally the egg cylinder d
145 that Dab2 is pleiotropic and regulates both visceral endoderm function and lipoprotein receptor traf
151 normally gives rise to the parietal and the visceral endoderm in vivo, but XEN cells do not contribu
153 ocessing occurs in vivo in the intestine and visceral endoderm, in mouse Hepa cells that express the
156 r Endothelial Growth Factor A (VEGFA) by the visceral endoderm is essential for normal growth and dev
157 sient nodal expression in the extraembryonic visceral endoderm is essential for patterning the rostra
158 ults suggest that regional patterning of the visceral endoderm is independent of primitive streak for
163 Inactivation of Aurora A in the epiblast or visceral endoderm layers of the conceptus leads to apopt
164 In contrast, mutation of Aurora A in the visceral endoderm, leads to posteriorization of the conc
165 ted protease activity is not observed in the visceral endoderm-like cell line, PSA-5E, or in the diff
167 embryoid bodies contained an outer layer of visceral endoderm-like cells surrounding an inner layer
168 and differentiation into primitive and then visceral endoderm-like cells, accompanied by a suppressi
169 f BMP receptor IB inhibits expression of the visceral endoderm marker, Hnf4, and prevents cavitation
171 or-posterior neural patterning, but anterior visceral endoderm markers are expressed and correctly po
172 mal layer is evident, as cells with positive visceral endoderm markers are scattered throughout the d
173 arly gastrulation stage, displaying abnormal visceral endoderm morphology and severe disruption of me
174 ression as well as a failure to displace the visceral endoderm occurs despite the formation of a norm
175 expression is evident first in the posterior visceral endoderm of 5.5 dpc embryos and later in the po
177 tially, Alk2 transcripts are detected in the visceral endoderm of gastrula stage mouse embryos, sugge
182 KO) strategy was used to delete YY1 from the visceral endoderm of the yolk sac and the definitive end
183 oth the livers of adult Mttp+/- mice and the visceral endoderm of the yolk sacs from Mttp+/- embryos
184 ith these findings, Dab2 is expressed in the visceral endoderm of wild-type embryos but not in the vi
185 have assessed the consequences of a lack of visceral endoderm on blood cell and vessel formation usi
186 for by an inhibitory effect of Nodal-induced visceral endoderm on pluripotent cell differentiation in
187 Immunohistochemical staining revealed a visceral endoderm pattern of Indian hedgehog (Ihh) in wi
188 Smad2 and not Smad3 mRNA is expressed in the visceral endoderm, potentially explaining why the primar
189 ented transient nodal.lacZ expression in the visceral endoderm prior to and during early streak forma
191 normally expressed in the anterior proximal visceral endoderm (PxVE), is downregulated in Bmpr-null
192 hydrogenase-2 (Raldh2), was expressed in the visceral endoderm, RA receptors alpha1 and alpha2 were e
194 s with a tetraploid embryo-derived wild-type visceral endoderm rescues this early developmental arres
196 Hex(-/-) cells developing within a wild-type visceral endoderm show forebrain defects indicating that
198 WNT antagonists Dkk1 and Sfrp5, although the visceral endoderm subtype has much higher cardiac-induci
199 artments in the Snx1(-/-);Snx2(-/-) yolk-sac visceral endoderm, suggesting SNX1 and SNX2 may be requi
200 alpha5, which was associated with decreased visceral endoderm survival and production of VEGF-A, Ind
201 embryo culture restored vascular remodeling, visceral endoderm survival, as well as integrin alpha5 e
202 initially covered by a layer of cells called visceral endoderm that despite its name (visceral means
205 gulated by dietary zinc in the intestine and visceral endoderm, tissues involved in nutrient absorpti
206 iew, our data reveal no mass displacement of visceral endoderm to extraembryonic regions concomitant
207 he middle streak by acting in the underlying visceral endoderm to modulate a BMP signaling pathway.
208 murine embryo consists of an outer layer of visceral endoderm (VE) and an inner layer of ectoderm.
215 ed exclusively in an extra-embryonic tissue, visceral endoderm (VE), during the early post-implantati
217 ryonic day 9.5 chimeric embryos in which the visceral endoderm was composed of predominantly Lim1(-)(
219 riptional differences between definitive and visceral endoderm, we performed microarray analysis on E
220 ras in which the extraembryonic ectoderm and visceral endoderm were derived from homozygous mutant bl
222 impairment of the nutritive functions of the visceral endoderm, which otherwise appears to differenti
223 essed, at least in part because the anterior visceral endoderm, which provides signals that regulate
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