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1 ls for investigating the biological roles of vitamin B12 .
2 materials, potential new dietary sources of vitamin B12.
3 ssociated with reduced levels of circulating vitamin B12.
4 c acid and thus may lead to malabsorption of vitamin B12.
5 bdate, is approximately 10-fold smaller than vitamin B12.
6 ansporters for diverse iron siderophores and vitamin B12.
7 activated CORM) to the 5'-OH ribose group of vitamin B12.
8 N2O can be rescued by addition of exogenous vitamin B12.
9 B6 while FUT2 interferes with absorption of vitamin B12.
10 e intakes of dietary folate, vitamin B6, and vitamin B12.
11 folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12.
12 e of Gram-negative bacteria which transports vitamin B12.
13 ented with oral folic acid and intramuscular vitamin B12.
14 ein and the absorption of iron, calcium, and vitamin B12.
15 or studies of catalysis analogous to that of vitamin B12.
16 ral density, serum creatinine, magnesium, or vitamin B12.
17 riority to the MBA in determining the active vitamin B12.
18 atment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain
19 y for choline, 10.5 (SD, 5.1) microg/day for vitamin B12, 240 (SD, 104) mg/day for betaine, and 1,268
20 n the ABC transporter BtuCD-F, which imports vitamin B12 across the inner membrane of Escherichia col
21 binding and transport of cobalamin (CBL), or vitamin B12, across the asymmetric outer membrane (OM) o
22 de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and
31 [SD] age, 70.9 [9.1] years), higher baseline vitamin B12 and holotranscobalamin levels were associate
34 epsilonC/epsilonCl values of 4.6 and 5.0 for vitamin B12 and norvitamin B12 were significantly differ
35 antifying physiologically relevant levels of vitamin B12 and performing human trials where it was use
37 These results expand the biological role of vitamin B12 and provide fundamental insight into a new m
39 ed that EutR expression is induced by EA and vitamin B12 and that EutR promotes expression of the eut
41 many reasons for reviewing the neurology of vitamin-B12 and folic-acid deficiencies together, includ
44 ctive intestinal malabsorption of cobalamin (vitamin B12) and urinary loss of several specific low-mo
46 erfere with the absorption of iron, calcium, vitamin B12, and certain drugs as well as predispose the
47 erfere with the absorption of iron, calcium, vitamin B12, and certain drugs as well as predispose to
48 as well as the absorption of iron, calcium, vitamin B12, and certain medications as well as prevents
51 boflavin, pyridoxal phosphate (PLP), folate, vitamin B12, and flavin mononucleotide (FMN) were measur
52 ating form is pyridoxal-5'-phosphate (PLP)], vitamin B12, and homocysteine in relationship to pancrea
54 he vitamin cofactors folate, vitamin B6, and vitamin B12; and 3) adjustment for the presence of risk
58 ntake of B vitamins (folate, vitamin B6, and vitamin B12) as ascertained by repeated administration o
59 solving a long-standing problem in anaerobic vitamin B12 assembly and reveal an unanticipated interse
60 oped, reduction-free, direct alkynylation of vitamin B12 at the central cobalt ion proved to be versa
63 in a bacterial-diatom model system based on vitamin B12 auxotrophy as a sensitive assay for metaboli
64 perature (-13.3 +/- 0.9 per thousand), trace vitamin B12 availability (-12.7 +/- 1.0 per thousand), l
65 ntary experimental approaches, the impact of vitamin B12 availability and methotrexate exposure on Da
66 In the present study, we have shown that vitamin B12 (B12) deficiency in a murine genetic model r
67 the associations between intakes of choline, vitamin B12, betaine, and folate during the first and se
69 y mutations in genes encoding enzymes of the vitamin B12 biosynthesis pathway and the vitamin B12-dep
73 ater-soluble vitamins folic acid, cobalamin (vitamin B12), biotin, pantothenic acid, and thiamine (vi
74 and follow-up levels of plasma Hcy, folate, vitamin B12, blood pressure and other pertinent covariab
76 reflects nutritional status with regards to vitamin B12, but at these low concentration current Cbl
77 pendent degradation of ethanolamine if given vitamin B12, but it can make B12 from exogenous Cbi only
83 editary juvenile megaloblastic anemia due to vitamin B12 (cobalamin) deficiency is caused by intestin
84 onas rostrata requires an external supply of vitamin B12 (cobalamin) for growth, which it can obtain
91 uct of propionic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl C
95 320 binds transcobalamin (TC) saturated with vitamin B12 [cobalamin (Cbl)] and mediates cellular upta
96 ibition during development, and an excess of vitamin B12 coenzyme, which is essential for class II ac
99 orted associations between total circulating vitamin B12 concentrations and a common null variant in
101 absorption is associated with reduced serum vitamin B12 concentrations, mild macrocytic anemia, and
103 s of strict vegetarians, an investigation of vitamin B12 content in plant sources, was carried out.
105 the addition of cobalt or cobalt-containing vitamin B12 could further enhance chlorophyll a yields b
106 nvestigate the excited-state photophysics of vitamin B12 (cyanocobalamin, CNCbl) and the related cob(
108 new diagnoses were prediabetes (28 [6.1%]), vitamin B12 deficiency (20 [4.4%]), diabetes mellitus (8
109 I pills/d were more strongly associated with vitamin B12 deficiency (OR, 1.95 [95% CI, 1.77-2.15]) th
110 tests for diabetes, thyroid dysfunction, and vitamin B12 deficiency allowed neurologists to identify
112 TIENTS: We evaluated the association between vitamin B12 deficiency and prior use of acid-suppressing
113 25,956 patients having incident diagnoses of vitamin B12 deficiency between January 1997 and June 201
117 long-term exposure to these medications and vitamin B12 deficiency in large population-based studies
123 Among patients with incident diagnoses of vitamin B12 deficiency, 3120 (12.0%) were dispensed a 2
127 shunt that is transcriptionally activated on vitamin B12 deficient diets, or under genetic conditions
128 tal homocysteine are sensitive indicators of vitamin B12-deficient diets and correlate with clinical
130 een proposed for such different processes as Vitamin B12-dependent biodegradation and zerovalent meta
132 In the present study, we have found that vitamin B12-dependent methionine metabolism is dysregula
133 al metabolism is primarily as a cofactor for vitamin B12-dependent methionine synthase, and that coba
134 the vitamin B12 biosynthesis pathway and the vitamin B12-dependent methylmalonyl-CoA-mutase MutAB.
136 ctivity lead to the bacterium switching from vitamin B12-dependent to vitamin B12-independent biosynt
139 f DNA double-strand breaks, was increased in vitamin B12 depletion, and this effect was exacerbated b
140 te that a nuclear 5-methylTHF trap occurs in vitamin B12 depletion, which suppresses de novo dTMP bio
141 ly discovered CarH-type photoreceptors use a vitamin B12 derivative, adenosylcobalamin, as the light-
143 (ACATs) exist that are capable of converting vitamin B12 derivatives into coenzyme B12 by catalyzing
144 crucial step involved the synthesis of new, vitamin B12 derived cobryketone via palladium-catalyzed
145 bination pill of folic acid, vitamin B6, and vitamin B12 did not reduce a combined end point of total
149 factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a genome-wide asso
151 s, we estimated the production of vitamin A, vitamin B12, folate, iron, zinc, calcium, calories, and
152 2 intravenously on day 1 every 21 days, with vitamin B12, folic acid, and dexamethasone prophylaxis.
153 robial compounds; dietary factors, including vitamin B12, folic acid, and fish oil; obesity; and stre
154 h on propanediol plus Cbi and can use pseudo-vitamin B12 for all of their corrinoid-dependent enzymes
155 revealed that 171 species require exogenous vitamin B12 for growth, implying that more than half of
160 delian randomization estimated that maternal vitamin B12 had a small causal effect on DNA methylation
164 nsporters (importers of trace elements, e.g. vitamin B12, heme, and iron-siderophores) the role of AT
167 ntify additional loci associated with plasma vitamin B12, homocysteine, folate and vitamin B6 (active
175 idated for the determination of human active vitamin B12 in cell extracts of Propionibacterium freude
176 method is needed to analyse in situ produced vitamin B12 in plant-based materials, potential new diet
178 lasma total homocysteine (tHcy), folate, and vitamin B12 in plasma and liver, as well as biliary tHcy
179 an milk and serum show that past analyses of vitamin B12 in samples with high HC content might have b
183 rium switching from vitamin B12-dependent to vitamin B12-independent biosynthetic pathways, through t
185 ntification and carbon tracing, we uncover a vitamin B12-independent propionate breakdown shunt that
186 n incubations with reduced cobalamins (e.g., vitamin B12) indicating that biomolecules can transform
189 mortality, and between multivitamin use and vitamin B12 intake on CVD mortality and total mortality.
191 dies (GWAS) in which we resolved total serum vitamin B12 into the fractions bound to transcobalamin a
192 to malabsorption of iron, folic acid, and/or vitamin B12 is a common complication of celiac disease a
193 clinical penetrance of <60%, elevated serum vitamin B12 is a reliable and accurate biomarker of ALPS
202 ylcobalamin or the two-electron reduction of vitamin B12, is one of the most powerful nucleophiles kn
205 chromosome 19q13 were associated with plasma vitamin B12 levels among women in a genome-wide associat
206 hionine concurrent with decreased folate and vitamin B12 levels and Hcy transsulfuration to cysteine.
207 There was no association between folate and vitamin B12 levels and likelihood of a successful pregna
209 d rs1047781:A > T as proxies for circulating vitamin B12 levels in the Avon Longitudinal Study of Par
212 , we estimated the causal effect of maternal vitamin B12 levels on cord blood DNA methylation using t
213 findings support a causal effect of maternal vitamin B12 levels on cord blood DNA methylation, and a
214 Neonatal cord blood folate, homocysteine and vitamin B12 levels were measured, and MTHFR C677T and A1
215 ictive of HFS, including baseline folate and vitamin B12 levels, as well as genetic polymorphisms wit
223 d cell count, comprehensive metabolic panel, vitamin B12 measurement, serum protein electrophoresis w
225 order characterized by defects in cobalamin (vitamin B12) metabolism and other developmental defects.
229 onal genome-wide significant loci for plasma vitamin B12 on chromosomes 6p21 (P = 4.05 x 10(-08)), 10
232 pill containing folic acid, vitamin B6, and vitamin B12 or a matching placebo, and were treated for
239 observed no association between folate, PLP, vitamin B12, or homocysteine and pancreatic cancer risk.
240 not routinely raise their intake of calcium, vitamin B12, or magnesium beyond the Recommended Dietary
241 ection of sub-nmol/L physiological levels of vitamin B12, our assay incorporates an innovative "space
242 ase of 1 SD, beta (SE) was 0.048 (0.013) for vitamin B12 (P < .001) and 0.040 (0.013) for holotransco
243 alysis indicated that serum folate (P=0.01), vitamin B12 (P=0.05), creatinine (P=0.03), and BUN (P=0.
245 or the preparation of cobinamide (CN)2Cbi, a vitamin B12 precursor, that should allow its broader uti
246 wed previously that cobinamide, a cobalamin (vitamin B12) precursor, binds NO with high affinity, and
248 ved in macronutrient metabolism; and folate, vitamin B12, pyridoxine, and riboflavin play important r
249 coli outer membrane proteins-the cobalamin (vitamin B12) receptor (BtuB) and the OmpF porin, which a
253 lood DNA methylation, and a causal effect of vitamin B12-responsive DNA methylation changes on childr
259 ia, the MTHFR C677T mutation, and folate and vitamin B12 status are not important risk factors for RV
261 ere it was used to accurately evaluate blood vitamin B12 status of 12 participants from just a drop (
262 were analyzed for tHcy level and folate and vitamin B12 status, and extracted DNA was assessed for t
263 reductase (MTHFR) C677T genotype, folate and vitamin B12 status, and retinal vein occlusion (RVO).
265 herichia coli TonB-dependent transporter for vitamin B12, substrate binding to the extracellular surf
266 Areas for research include intermittent vitamin B12 supplement dosing and better measurements of
269 ls are needed to determine the importance of vitamin B12 supplementation on slowing brain aging in ol
273 t nitrosylcobalamin (NO-Cbl), an analogue of vitamin B12 that delivers nitric oxide (NO), had potent
274 t using 5'-deoxyadenosylcobalamin, a form of vitamin B12 that is best known as an enzyme cofactor, ha
275 f DMB provides clarification of an aspect of vitamin B12 that was otherwise incomplete, and may contr
276 evolution of higher eukaryotes that utilize vitamin B12, the high reactivity of the cofactor coupled
277 litates the absorption of iron, calcium, and vitamin B12; thwarts enteric infection; and prevents bac
279 dose (n=2054) of folic acid, vitamin B6, and vitamin B12 to determine whether decreasing total homocy
282 utes on the extracellular loops in BtuB, the vitamin B12 transporter, and FecA, the ferric citrate tr
283 (2014) establish the importance of different vitamin B12 transporters that help a Bacteroides species
286 gen-doped carbon (C-N-Fe), was prepared from vitamin B12 (VB12) and the polyaniline-Fe (PANI-Fe) comp
288 de scavenger, we tested whether cobalamin, a vitamin B12 vitamer, would be neuroprotective in vitro a
294 A nutritionally relevant amount of active vitamin B12 was produced by P. freudenreichii in cereal
295 ains of life require the cofactor cobalamin (vitamin B12), which is produced only by a subset of bact
298 19q13, we confirm the association of plasma vitamin B12 with rs602662 and rs492602 (P-value = 1.83 x
300 nts (vitamin A, vitamin D, iron, folic acid, vitamin B12, zinc, and glucose) in the control of cell c
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