ライフサイエンスコーパス: vitamin B6

1 5'-phosphate (PLP), the major active form of vitamin B6 .

2 hesis of thiamin (vitamin B1) and pyridoxal (vitamin B6).

3 in the catabolism of pyridoxal 5'-phosphate (Vitamin B6).

4 ated dementia (HAD) as well as deficiency of vitamin B6.

5 of pyridoxal-5-phosphate, an active form of vitamin B6.

6 e rehydration, prostaglandin inhibitors, and vitamin B6.

7 luences, including low intakes of folate and vitamin B6.

8 se with higher dietary intakes of folate and vitamin B6.

9 e those of red cell folate, vitamin B12, and vitamin B6.

10 cysteine are related to levels of folate and vitamin B6.

11 dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage o

12 Pyridoxal 5'-phosphate (PLP, vitamin B6), a cofactor in many enzymatic reactions, has

13 se results suggest that intake of folate and vitamin B6 above the current recommended dietary allowan

14 plasma vitamin B12, homocysteine, folate and vitamin B6 (active form pyridoxal 5'-phosphate, PLP), we

15 er, upon prompt treatment with high doses of vitamin B6, affected patients can have a normal developm

16 increased K(m) for succinyl-CoA, and reduced vitamin B6 affinity.

17 PdxK), an enzyme required for the salvage of vitamin B6, an essential enzymatic cofactor.

18 5'-phosphate (PLP) is the active vitamer of vitamin B6 and acts as an essential cofactor in many asp

19 In contrast, the relationship between vitamin B6 and atherosclerosis was independent of homocy

20 In contrast, use of vitamin B6 and B12 from individual supplement sources, b

21 For vitamin B6 and B12, the risk was even higher among men w

22 48, p = 8.30 x 10(-18)) were associated with vitamin B6 and FUT2 (rs602662, [corrected] p = 2.83 x 10

23 ate (PLP) is the biologically active form of vitamin B6 and is an important cofactor for several of t

24 gest that one-carbon nutrients, particularly vitamin B6 and methionine, may be protective against NHL

25 g of its metabolism and of the importance of vitamins B6 and B12 and folate as well as enzyme levels

26 B vitamins, including folic acid and vitamins B6 and B12 are the mainstay of treatment of pat

27 by daily supplementation with folic acid and vitamins B6 and B12 did not reduce the risk of developin

28 hed in methionine but depleted in folate and vitamins B6 and B12 increased atherosclerotic lesion are

29 Intakes of choline, folate, methionine, and vitamins B6 and B12 were assessed using a food frequency

30 Homocysteine, folate, and vitamins B6 and B12 were measured in preconception plasm

31 tHcy plasma levels are influenced by folate, vitamins B6 and B12, as well as by hereditary factors.

32 aining the recommended dietary allowances of vitamins B6 and B12, in a randomized, double-blind, plac

33 cysteine and concomitantly reduced levels of vitamins B6 and B12, in plasma of AVNFH patients.

34 amine the association between the intakes of vitamins B6 and C and risk of kidney stone formation in

35 The relation between the intake of vitamins B6 and C and the risk of symptomatic kidney sto

36 homocysteine-lowering trials with folate and vitamins B6 and/or B12 tested as protective agents again

37 ic acid, 100 mg of pyridoxine hydrochloride (vitamin B6), and 2 mg of cyanocobalamin (vitamin B12) or

38 TR received 2.4 mg/day of FA, 50.0 mg/day of vitamin B6, and 0.4 mg/day of vitamin B12, while the HD

39 ation pill of 2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12.

40 combination pill of 2.5 mg folic acid, 50 mg vitamin B6, and 1 mg vitamin B12) or to the placebo grou

41 upplementation (2.5 mg/d folic acid, 50 mg/d vitamin B6, and 1 mg/d vitamin B12), respectively.

42 rahydrofolate, in addition to 50.0 mg/day of vitamin B6, and 1.0 mg/day of vitamin B12.

43 , 0.65-0.90), the major source of folate and vitamin B6, and after excluding multiple vitamin users,

44 were concentrations of folate, vitamin B12, vitamin B6, and creatinine.

45 ciency include aging, deficiency of iron and vitamin B6, and exposure to toxic metals such as aluminu

46 d risks of antioxidant vitamins, folic acid, vitamin B6, and vitamin B12 among women with CVD or > or

47 follow-up, a combination pill of folic acid, vitamin B6, and vitamin B12 did not reduce a combined en

48 ve a combination pill containing folic acid, vitamin B6, and vitamin B12 or a matching placebo, and w

49 (n=2056) or low dose (n=2054) of folic acid, vitamin B6, and vitamin B12 to determine whether decreas

50 tively updated intake of B vitamins (folate, vitamin B6, and vitamin B12) as ascertained by repeated

51 tions by baseline intakes of dietary folate, vitamin B6, and vitamin B12.

52 or the role of the vitamin cofactors folate, vitamin B6, and vitamin B12; and 3) adjustment for the p

53 s at low risk of bias indicated that ginger, vitamin B6, antihistamines, metoclopramide (for mild sym

54 homocysteine and deficiencies of folate and vitamin B6 are common in transplant recipients.

55 in part dependent upon enzymes that require vitamin B6 as a cofactor, we tested the hypothesis that

56 of homocysteine and lower concentrations of vitamins B6, B12, and folate increase the risk for cogni

57 We examined the relation between vitamins B6, B12, and folate intake on cortical volume u

58 rthermore, there was no relationship between vitamins B6, B12, or folate intake on global brain volum

59 upon dietary supplementation with folate and vitamins B6/B12.

60 lic drug interconversion involving bacterial vitamin B6, B9, and ribonucleotide metabolism.

61 ver, intakes of fruit and vegetables, fiber, vitamins B6, B9, C, D, and E, iron, and magnesium were h

62 rcentile (<513 nmol/L) and concentrations of vitamin B6 below the lowest 20th percentile (<23.3 nmol/

63 fundamental differences in the regulation of vitamin B6 biosynthesis across the two lineages.

64 me (PDX1.2), which is involved in regulating vitamin B6 biosynthesis de novo under stress conditions.

65 pseudoenzyme acts as a positive regulator of vitamin B6 biosynthesis during such stress conditions in

66 catalytic homolog of the PDX1 subunit of the vitamin B6 biosynthesis protein machinery, PYRIDOXINE BI

67 s rescued by elevated levels of the cofactor vitamin B6, but also alleles rescued by elevated heme, a

68 d how well the foetus has been supplied with vitamin B6 by the mother.

69 nutrition as partially available sources of vitamin B6, (c) undergo partial hydrolysis by a novel ma

70 c acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation.

71 tudy provides robust evidence that increased vitamin B6 catabolism is independently associated with a

72 We hypothesized that pyridoxal phosphate (vitamin B6 coenzyme) was de-activated by L-Delta(1)-pyrr

73 The vitamin B6 cofactor pyridoxal was conjugated with the lu

74 sent work reports the interaction of various vitamin B6 cofactors with the red emitting glutathione s

75 Vitamin B6 comprises a family of compounds that is essen

76 Folate and vitamin B6 concentrations were lower (5.9+/-4.2 vs. 7.9+

77 Lower levels of folate and vitamin B6 confer an increased risk of atherosclerosis.

78 The results show that the level of the vitamin B6 conjugate in the circulation of control subje

79 2 knockdown lines demonstrates that boosting vitamin B6 content is dependent on PDX1.2, revealing tha

80 ts showed little change in expression of the vitamin B6 de novo pathway genes, but significant increa

81 Vitamin B6 de-activation may contribute to seizures in h

82 Folate and vitamin B6 deficiencies were seen in 10.8% and 17.91% of

83 We previously identified vitamin B6 deficiency in a child presenting with seizure

84 Vitamin B6 deficiency was more frequent in patients than

85 o=0.7, 95% CI: 0.4, 1.1) than did women with vitamin B6 deficiency.

86 X1.1 expression, accounting for the stronger vitamin B6 deficit in pdx1.3 compared with pdx1.1.

87 series of novel polyglycosylated fluorinated vitamin B6 derivatives as 19F NMR-sensitive aglycons for

88 Results Use of supplemental vitamins B6, folate, and B12 was not associated with lun

89 Plants are the major source of vitamin B6 for animals, yet the biosynthesis pathway and

90 doxal 5'-phosphate (PLP), the active form of vitamin B6, functions as a cofactor in humans for more t

91 risk among men in the highest categories of vitamin B6 (> 20 mg/d; hazard ratio, 1.82; 95% CI, 1.25

92 Women with sufficient vitamin B6 had a higher adjusted hazard ratio of concept

93 with a lower risk of NHL, but that for only vitamin B6 (highest vs. lowest quartile: odds ratio = 0.

94 alyses demonstrate an important link between vitamin B6 homeostasis and nitrogen metabolism.

95 bution of these various pathways to cellular vitamin B6 homeostasis in plants is not fully understood

96 ss conditions, which would serve to maintain vitamin B6 homeostasis in times of need in eudicots that

97 for the detection of two major components of vitamin B6 i.e. pyridoxine (Py) and pyridoxal-5'-phospha

98 e successfully exploited for the analysis of vitamin B6 in food supplements.

99 rological disorders as well as deficiency of vitamin B6 in human being.

100 rological disorders as well as deficiency of vitamin B6 in human being.

101 mbranes, implying a potential involvement of vitamin B6 in membrane function.

102 Our study establishes a critical role of vitamin B6 in plant development and stress tolerance and

103 the biosynthesis pathway and the function of vitamin B6 in plants are not well elucidated.

104 idoxine 5'-beta-D-glucoside, a major form of vitamin B6 in plants, we detected two cytosolic beta-glu

105 Vitamin B6 in the form of pyridoxine (PN) is one of the

106 Major differences in the metabolism of vitamin B6 in various cancers compared to their normal c

107 Other forms of vitamin B6 include pyridoxamine 5'-phosphate (PMP), pyri

108 n in the highest quintile of both folate and vitamin B6 intake compared with the opposite extreme.

109 analysis, we found that adults with greater vitamin B6 intake had greater gray matter volume along t

110 s were observed between multivitamin use and vitamin B6 intake on myocardial infarction, between mult

111 A diet poor in folic acid and vitamin B6 is also associated with a higher risk of deve

112 Vitamin B6 is an indispensable compound for survival, we

113 the phosphorylated and the oxidized form of vitamin B6 is an organic cofactor.

114 Vitamin B6 is indispensible for all organisms, notably a

115 Vitamin B6 is involved in a variety of enzymatic transfo

116 Pyridoxine (vitamin B6) is a cofactor required by numerous enzymes i

117 some essential nutrients (Inulin, DHA & EPA, vitamins B6, K1, and D3) as enhancers of calcium bioavai

118 tablishes an association between an index of vitamin B6 levels with lung cancer risk.

119 entrations may be caused by lower folate and vitamin B6 levels.

120 ate, B12, and pyridoxal 5'-phosphate (active vitamin B6) levels, along with other potential determina

121 High doses of vitamin B6 may decrease oxalate production, whereas vita

122 Large doses of vitamin B6 may reduce the risk of kidney stone formation

123 pment and stress tolerance and suggests that vitamin B6 may represent a new class of antioxidant in p

124 8 microg/d) and 0.67 (95% CI, 0.53-0.85) for vitamin B6 (median intake, 4.6 mg/d vs 1.1 mg/d).

125 ins that have been implicated in pyridoxine (vitamin B6) metabolism in the filamentous fungi Cercospo

126 Studies addressing the role of vitamin B6 nutrition in regulating the activity and its

127 point more strongly to the possibility that vitamin B6 offers independent protection.

128 f dietary folate (OR, 0.7; 95% CI, 0.4-1.3), vitamin B6 (OR, 0.5; 95% CI, 0.3-1.0), vitamin B12 (OR,

129 idoxal 5'-phosphate (PLP, the active form of vitamin B6) perform a myriad of diverse chemical transfo

130 tin can be improved by combining it with the vitamin B6 precursor pyridoxine.

131 for 2-3 weeks with high doses of pyridoxine (vitamin B6) produced a profound proprioceptive loss, sim

132 a impacts microbiota composition, decreasing vitamin B6 production and promoting sustained colonizati

133 n stress, concomitant with an enhancement of vitamin B6 production.

134 oamines and their cofactors (the pterins and vitamin B6 (pyridoxal phosphate (PLP))) in human cerebro

135 Vitamin B6 (pyridoxal phosphate) is an essential cofacto

136 and the observation that the active form of vitamin B6 (pyridoxal phosphate, P5P) modulates the self

137 ential enzymes and the intake of folic acid, vitamin B6 (pyridoxine), and vitamin B12 (cobalamin).

138 s, which are involved in the biosynthesis of vitamins B6 (pyridoxine) and B1 (thiamin).

139 001), vitamin B12 (r = -0.21; P = .001), and vitamin B6 (r = -0.18; P = .001).

140 upplements, including vitamin D, folate, and vitamin B6, remains uncertain, calcium supplementation i

141 In contrast, vitamin B6-responsive XLSA mutations p.Arg452Cys and p.A

142 es, the epimerase homolog being fused to the vitamin B6 salvage enzyme pyridoxine 5'-phosphate oxidas

143 pimerase (NNRE), the latter being fused to a vitamin B6 salvage enzyme.

144 first report of a pyridoxal reductase in the vitamin B6 salvage pathway in plants.

145 Poor vitamin B6 status appears to decrease the probability of

146 Vitamin B6 status is best assessed by using a combinatio

147 , but they may be preventable with long term vitamin B6 supplementation.

148 e show that SOR1 is essential in pyridoxine (vitamin B6) synthesis in C. nicotianae and Aspergillus f

149 ngle fixed-dose pill, along with pyridoxine (vitamin B6), that would be taken once per day to help wi

150 for remethylation; low intake (<2.1 mg/d) of vitamin B6, the cofactor in the catabolic pathway of hom

151 Relative to women in the lowest quartile of vitamin B6, those in the third and fourth quartiles had

152 subset of patients manages the disease with vitamin B6 treatments, the only effective treatment for

153 e pathway that interconverts between the six vitamin B6 vitamers.

154 se findings highlight mechanisms that affect vitamin B6, vitamin B12 and homocysteine serum levels.

155 gate genetic factors that affect circulating vitamin B6, vitamin B12, folate and homocysteine, a geno

156 A high intake of vitamin B6 was inversely associated with risk of stone f

157 d from the formulation in 1976), pyridoxine (vitamin B6)), was associated with a lower risk for conge

158 Here, using the example of vitamin B6, we investigate the regulation of biosynthesi

159 f pyridoxal 5'-phosphate (the active form of Vitamin B6), which we validate experimentally via multic

160 concentrations and low levels of folate and vitamin B6, which could contribute to the development of

161 LPL gene likely influences the catabolism of vitamin B6 while FUT2 interferes with absorption of vita

162 to examine plasma concentrations of folate, vitamin B6 [whose main circulating form is pyridoxal-5'-

163 both plr1 mutants had lower levels of total vitamin B6, with significantly decreased levels of pyrid