ライフサイエンスコーパス: vitamin K-dependent

1 The carboxylation process is vitamin K dependent, and current evidence suggests that

2 support by genetically engineered 3T3 is not vitamin K dependent, and soluble recombinant GAS6 does n

3 The Drosophila carboxylase is vitamin K-dependent, and it has a K(m) toward a model pe

4 Protein C, a secretory vitamin K-dependent anticoagulant serine protease, inact

5 The vitamin K-dependent biosynthesis of gamma-carboxyglutami

6 domain, a membrane-anchoring domain found on vitamin K-dependent blood coagulation and regulatory pro

7 Some recombinant vitamin K-dependent blood coagulation factors (factors V

8 the bloodstream, Ad vectors can bind several vitamin K-dependent blood coagulation factors, which con

9 d mechanism, which involves virus binding to vitamin K-dependent blood coagulation factors.

10 arboxylase gene, and hence the regulation of vitamin K-dependent blood coagulation protein synthesis.

11 Prothrombin is a vitamin K-dependent blood coagulation protein that under

12 ntial post-translational modification of the vitamin K-dependent blood coagulation proteins, the regu

13 n amino acid critical to the function of the vitamin K-dependent blood coagulation proteins.

14 Human factor X is a two-chain, 58-kDa, vitamin K-dependent blood coagulation zymogen.

15 This domain is strongly conserved among vitamin K-dependent blood proteins and, in addition to a

16 rboxyglutamic acid-containing regions of the vitamin K-dependent blood-clotting proteins.

17 properties of matrix Gla protein (MGP) as a vitamin K-dependent calcification inhibitor.

18 mma-carboxylases argue for conservation of a vitamin K-dependent carboxylase across animal species an

19 is cDNA in COS cells or insect cells yielded vitamin K-dependent carboxylase activity and vitamin K-d

20 Assay of hagfish liver demonstrated vitamin K-dependent carboxylase activity in this hemicho

21 The vitamin K-dependent carboxylase also catalyzes the epoxi

22 us is the sole invertebrate wherein both the vitamin K-dependent carboxylase and its product, gamma-c

23 Vitamin K-dependent carboxylase catalyzes the post-trans

24 The vitamin K-dependent carboxylase catalyzes the posttransl

25 g [(3)H]-N-ethylmaleimide indicated that the vitamin K-dependent carboxylase contains two or three fr

26 ian vitamin K-dependent carboxylases and the vitamin K-dependent carboxylase from Conus textile, a ma

27 ts demonstrate the broad distribution of the vitamin K-dependent carboxylase gene, including a highly

28 The vitamin K-dependent carboxylase is an integral membrane

29 The vitamin K-dependent carboxylase modifies and renders act

30 odendrocytes nor neurons possess significant vitamin K-dependent carboxylase or epoxidase activity.

31 The vitamin K-dependent carboxylase was located in the endop

32 Incubation of the vitamin K-dependent carboxylase with the sulfhydryl-reac

33 The vitamin K-dependent carboxylase, a constituent of the en

34 Using recombinant vitamin K-dependent carboxylase, purified in the absence

35 only known invertebrate with a demonstrated vitamin K-dependent carboxylase.

36 Given the functional similarity of mammalian vitamin K-dependent carboxylases and the vitamin K-depen

37 KORC1L1 reduces vitamin K epoxide to support vitamin K-dependent carboxylation as efficiently as does

38 he diversity of animal species that maintain vitamin K-dependent carboxylation to generate gamma-carb

39 ements beyond the Gla domain of factor IX in vitamin K-dependent carboxylation, we have examined the

40 reductase (VKOR) is an essential enzyme for vitamin K-dependent carboxylation, while the physiologic

41 rrhage and normal functional activity of the vitamin K-dependent clotting factors IX, X, and prothrom

42 ited capacity, and cell lines overexpressing vitamin K-dependent clotting factors produce only a frac

43 The propeptide sequences of the vitamin K-dependent clotting factors serve as a recognit

44 quired for posttranslational modification of vitamin K-dependent clotting factors.

45 gs have been encountered in association with vitamin K-dependent coagulation factor deficiency, an au

46 ings with characteristic features of PXE and vitamin K-dependent coagulation factor deficiency.

47 e novel insight into mechanisms by which the vitamin K-dependent coagulation factors are regulated.

48 Vitamin K-dependent coagulation factors deficiency is a

49 including the binding of Ad to platelets and vitamin K-dependent coagulation factors, but we found th

50 In this study, we examined whether other vitamin K-dependent coagulation protease zymogens can mo

51 structural features that distinguish it from vitamin K-dependent coagulation proteases.

52 yme complex formation with gla variants of a vitamin K-dependent coagulation protein and provides evi

53 Factor VII is a vitamin K-dependent coagulation protein essential for pr

54 evaluate Ca2+-specific adsorption of several vitamin K-dependent coagulation proteins to monolayers t

55 se of decreased biological activities of all vitamin K-dependent coagulation proteins.

56 nism confirmed by in vitro reconstitution of vitamin K-dependent disulphide bridge formation.

57 bit calcification requires the activity of a vitamin K-dependent enzyme, which mediates MGP carboxyla

58 vitamin K-dependent carboxylase activity and vitamin K-dependent epoxidase activity.

59 Analyses of vitamin K-dependent factors in 6 cancer patients with av

60 Vitamin K-dependent factors protect against vascular and

61 and < 1% on warfarin, at a point where other vitamin K-dependent factors were at 30-40% activity leve

62 ogical role for these two new members of the vitamin K-dependent family of proteins.

63 inhibit the overall activity of the complete vitamin K-dependent g-carboxylation system.

64 binding of the cationic PF4 to the anionic, vitamin K- dependent gamma-carboxyglutamic acid domain o

65 lanogaster cDNA clone encodes a protein with vitamin K-dependent gamma-carboxylase activity.

66 between the Conus carboxylase and vertebrate vitamin K-dependent gamma-carboxylases argue for conserv

67 anticoagulant factor protein S is a secreted vitamin K-dependent gamma-carboxylated protein that is m

68 ding has been shown to be dependent upon the vitamin K-dependent gamma-carboxylation modification of

69 The vitamin K-dependent gamma-carboxylation of glutamate to

70 The vitamin K-dependent gamma-carboxylation system in the en

71 The vitamin K-dependent gamma-carboxylation system is respon

72 The eukaryotic cell harbors a vitamin K-dependent gamma-carboxylation system that conv

73 ngineering of cells containing a recombinant vitamin K-dependent gamma-carboxylation system with enha

74 d vitamin K cofactor-producing enzyme of the vitamin K-dependent gamma-carboxylation system, produced

75 mental approaches aimed at understanding the vitamin K-dependent gamma-carboxylation system.

76 in place of Gla is a poor substrate for the vitamin K-dependent gamma-glutamyl carboxylase (apparent

77 s to gamma-carboxyglutamic acid (Gla) by the vitamin K-dependent gamma-glutamyl carboxylase (gamma-ca

78 The vitamin K-dependent gamma-glutamyl carboxylase binds an

79 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

80 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

81 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

82 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

83 The vitamin K-dependent gamma-glutamyl carboxylase catalyzes

84 Vitamin K-dependent gamma-glutamyl carboxylase catalyzes

85 xin epsilon-TxIX and used in assays with the vitamin K-dependent gamma-glutamyl carboxylase from C. t

86 The expression of the vitamin K-dependent gamma-glutamyl carboxylase gene in l

87 Vitamin K-dependent gamma-glutamyl carboxylase is a 758

88 (residues 1-345 and residues 346-758) of the vitamin K-dependent gamma-glutamyl carboxylase, a glycop

89 n K antagonists such as warfarin inhibit the vitamin K-dependent gamma-glutamyl carboxylation during

90 emonstrate the evolutionary emergence of the vitamin K-dependent Gla domain before the divergence of

91 Protein C is a vitamin K-dependent glycoprotein synthesized in the live

92 Protein S is a vitamin K-dependent glycoprotein, which, besides its ant

93 CDP is also related to disruption of vitamin K-dependent metabolism, causing secondary effect

94 inalis as a model organism for investigating vitamin K-dependent physiological phenomena, which may b

95 Protein Z (PZ) is a multidomain vitamin K-dependent plasma protein that functions as a c

96 Protein Z (PZ) is a vitamin K-dependent plasma protein whose function has be

97 Human protein Z (PZ) is a 62,000-Mr, vitamin K-dependent plasma protein whose structure is si

98 Activated protein C (APC) is a vitamin K-dependent plasma serine protease which down-re

99 and defines a novel precursor structure for vitamin K-dependent polypeptides.

100 Because of their vitamin K-dependent post-translational modification, the

101 in the endoplasmic reticulum (ER), catalyzes vitamin K-dependent posttranslational modification of gl

102 rowth, seen in osteoarthritis (OA), may be a vitamin K-dependent process.

103 ormation, expression, and propagation of the vitamin K-dependent procoagulant complexes and extends o

104 The affinities of the vitamin K-dependent propeptides for the gamma-carboxylas

105 rfarin resistance to rat chromosome 1 and of vitamin K-dependent protein deficiencies to the syntenic

106 utamic acid protein (MGP) is a member of the vitamin K-dependent protein family with unique structura

107 oduce functional forms of all members of the vitamin K-dependent protein family.

108 in K antagonists on the functionality of the vitamin K-dependent protein produced by extrahepatic tis

109 anin-A[rs9658644], Cystatin-C[rs2424577] and Vitamin K-Dependent Protein S[rs6123] in the schizophren

110 equired for carboxylase activity, called the vitamin K-dependent protein site of interaction (VKS).

111 Protein Z (PZ) is a plasma vitamin K-dependent protein that functions as a cofactor

112 Activation of Axl by its ligand Gas6, a vitamin K-dependent protein, is inhibited at doses of wa

113 his contrasts with bone Gla protein, another vitamin K-dependent protein, which appears not to requir

114 r for the membrane-binding conformation of a vitamin K-dependent protein.

115 at factor-X-encoding cDNA revealed that this vitamin-K-dependent protein has a dibasic Arg-Arg sequen

116 ilic ligand, Gas6, a member of the family of vitamin K dependent proteins that is preferentially expr

117 ults suggest features of membrane binding by vitamin K-dependent proteins and provide reagents that m

118 physiological consequences in the levels of vitamin K-dependent proteins and the biochemical mechani

119 Overall, membrane binding by vitamin K-dependent proteins appeared consistent with th

120 Propeptides of the vitamin K-dependent proteins bind to an exosite on gamma

121 ities of synthetic propeptides of nine human vitamin K-dependent proteins by determining the inhibiti

122 The propeptides of the vitamin K-dependent proteins contain a gamma-carboxylati

123 l implications for overproducing recombinant vitamin K-dependent proteins for therapeutic use.

124 TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S.

125 Comparison of naturally occurring vitamin K-dependent proteins has provided possible bases

126 in individuals with combined deficiencies of vitamin K-dependent proteins have a mutation, L394R, in

127 Two human cDNAs that encode novel vitamin K-dependent proteins have been cloned and sequen

128 Severe deficiency of vitamin K-dependent proteins in patients not maintained

129 presence of activation peptides (AP) of the vitamin K-dependent proteins in the phlebotomy blood of

130 r gamma-carboxyglutamic acid modification of vitamin K-dependent proteins includes gamma-carboxylase

131 dent carboxylase modifies and renders active vitamin K-dependent proteins involved in hemostasis, cel

132 Gamma-carboxylation of vitamin K-dependent proteins is dependent on formation o

133 modification of the membrane contact site of vitamin K-dependent proteins may enhance the membrane af

134 ic acid to gamma-carboxyglutamic acid in the vitamin K-dependent proteins of blood and bone.

135 All known vitamin K-dependent proteins possess a conserved eightee

136 gamma-Carboxylation of vitamin K-dependent proteins requires a functional vitam

137 The enzymatic activity of the vitamin K-dependent proteins requires the post-translati

138 peptide and the propeptides of the mammalian vitamin K-dependent proteins show no obvious sequence ho

139 The propeptides of vitamin K-dependent proteins stimulate gamma-carboxylase

140 istent with studies on prothrombin and other vitamin K-dependent proteins that have been modified or

141 and dissociation kinetics relative to other vitamin K-dependent proteins that have been tested.

142 Therefore, the five vitamin K-dependent proteins that were examined were equ

143 ropeptide is the primary binding site of the vitamin K-dependent proteins to carboxylase.

144 Binding of vitamin K-dependent proteins to cell membranes containin

145 tion is strongly dependent on the binding of vitamin K-dependent proteins to cell membranes containin

146 The vitamin K-dependent proteins undergo a conformational tr

147 hat the affinities of the propeptides of the vitamin K-dependent proteins vary over a considerable ra

148 No binding of PTX2 to other vitamin K-dependent proteins was observed.

149 raction by prothrombin, protein Z, and other vitamin K-dependent proteins were studied to determine t

150 tion of select glutamic acid residues of the vitamin K-dependent proteins which are important for coa

151 ated Glu (Gla) to activate a large number of vitamin K-dependent proteins with diverse functions, and

152 ding properties of human and bovine forms of vitamin K-dependent proteins Z, S, and C were characteri

153 ree new factors interpreted as inflammation, vitamin K-dependent proteins, and procoagulant activity.

154 s involved in the gamma-carboxylation of the vitamin K-dependent proteins, and vitamin K epoxide is a

155 e carboxylation and consequent activation of vitamin K-dependent proteins, but the mechanism of reduc

156 sible for post-translational modification of vitamin K-dependent proteins, converting them to Gla-con

157 shared to some degree by factor X and other vitamin K-dependent proteins, most notably prothrombin.

158 , a required cofactor for g-carboxylation of vitamin K-dependent proteins.

159 is not attributable to the Gla domain of all vitamin K-dependent proteins.

160 amino acid propeptide sequence found in all vitamin K-dependent proteins.

161 ed for the posttranslational modification of vitamin K-dependent proteins.

162 underlie membrane binding behaviors of other vitamin K-dependent proteins.

163 tamin K that is required for modification of vitamin K-dependent proteins.

164 n/phospholipid binding) for a Gla residue in vitamin K-dependent proteins.

165 ylation of certain glutamic acid residues in vitamin K-dependent proteins.

166 in post-translational gamma-carboxylation of vitamin K-dependent proteins.

167 t-translational modification of a variety of vitamin K-dependent proteins.

168 he sea squirt Ciona intestinalis that encode vitamin K-dependent proteins.

169 increased cellular production of recombinant vitamin K-dependent proteins.

170 ey regulatory protein in synthesis of active vitamin K-dependent proteins.

171 erent than in Gla domain structures of other vitamin K-dependent proteins.

172 cerning regulation of gamma-carboxylation of vitamin K-dependent proteins.

173 propeptide cleavage site, as occurs in other vitamin-K-dependent proteins.

174 activated by gamma-glutamyl carboxylation, a vitamin K-dependent reaction, to serve in an anti-minera

175 Central to this pathway is the vitamin K-dependent serine protease, APC, and its precur

176 nd 2 are the founding members of a family of vitamin K-dependent single-pass integral membrane protei

177 fication of select glutamate residues of its vitamin K-dependent substrates to gamma-carboxyglutamate

178 terrogans genome revealed an ortholog of the vitamin K-dependent (VKD) carboxylase as one of several

179 The vitamin K-dependent (VKD) carboxylase binds VKD proteins

180 The vitamin K-dependent (VKD) carboxylase converts clusters

181 The vitamin K-dependent (VKD) carboxylase converts Glu's to

182 The vitamin K-dependent (VKD) carboxylase uses the oxygenati

183 Vitamin K-dependent (VKD) proteins are modified by the V

184 Vitamin K-dependent (VKD) proteins become activated by t

185 nts governing the modification of individual vitamin K-dependent (VKD) proteins by the carboxylase ha

186 Carboxylation of vitamin K-dependent (VKD) proteins is required for their

187 Vitamin K and vitamin K-dependent (VKD) proteins may be involved in re

188 Vitamin K-dependent (VKD) proteins require carboxylation

189 Vitamin K-dependent (VKD) proteins require modification

190 For 16 known vitamin K-dependent (VKD) proteins, we evaluated the rel

191 ycles vitamin K to support the activation of vitamin K-dependent (VKD) proteins, which have diverse f

192 a-carboxylase for gamma-carboxylation of all vitamin K-dependent (VKD) proteins.

193 Factor VII is a vitamin K-dependent zymogen of a serine protease that pa