ライフサイエンスコーパス: vitro

1 illating with distinct phases in vivo and in vitro.

2 sis of M1 macrophages previously observed in vitro.

3 pecimens in vivo and in cancer cell lines in vitro.

4 ne release of bone marrow dendritic cells in vitro.

5 cava, and diminished platelet activation in vitro.

6 tigated the interaction of FtsZ with ZipA in vitro.

7 ins contribute to cellular transformation in vitro.

8 ng activity of post-AIT sera was assessed in vitro.

9 ly reconstituted the underlying processes in vitro.

10 ed differences in lipin phosphoregulation in vitro.

11 8 beads and gave rise to CD161(-) progeny in vitro.

12 increased platelet yield in vivo, but not in vitro.

13 ions are particularly good AID substrates in vitro.

14 LDH-positive cancer stem cell population, in vitro.

15 e microtubule growth rate by several-fold in vitro.

16 n is also spatially regulated in vivo and in vitro.

17 rogel containing naringin, were evaluated in vitro.

18 e modeled ICC desmoplasia and progression in vitro.

19 hat Pol epsilon can act in eukaryotic MMR in vitro.

20 differentiation of DPSCs both in vivo and in vitro.

21 US28 facilitates HCMV spreading in VSMCs in vitro.

22 bly is stimulated by Plk1 phosphorylation in vitro.

23 knockdown in differentiated human neurons in vitro.

24 xpression compared to 3R4F smoke exposure in vitro.

25 nce the mineralization potential of DPSCs in vitro.

26 enchymal stem cells (hMSCs) was evaluated in vitro.

27 by their ability to inhibit Ab responses in vitro.

28 cells, a previously unrecognized target, in vitro.

29 d to investigate single molecule dynamics in vitro.

30 eria during at least 4 hours of infection in vitro.

31 unity and Th17-skewing human cell culture in vitro.

32 ably all the cell types of the human body in vitro.

33 ating the generation of prion infectivity in vitro.

34 n binding and decreased thermal stability in vitro.

35 was decreased upon methylation treatment in vitro.

36 also potentiated oncogenic transformation in vitro.

37 additional functions for RbpA not evident in vitro.

38 al electrical resistance in an all-human, in vitro, 3-dimensional, blood-brain barrier model exemplif

39 rived mesenchymal stromal cells (MSC) and in vitro 3T3-L1 preadipocytes significantly increases their

40 In vitro activation revealed that patients with CVID behave

41 ells derived from alcohol users and after in vitro acute alcohol treatment of human MDDCs.

42 **)-22e, in particular, exhibited optimal in vitro ADME and pharmacokinetics properties and dose-depe

43 bortezomib and doxorubicin were observed in vitro against both multiple myeloma and ovarian cancer c

44 This identified a hit that subsequent in vitro analysis showed directly binds and inhibits purifi

45 In vitro analysis showed that PRN694 effectively inhibited

46 Taken together, by combining in vivo and in vitro analysis using TC10-deficient mice, we define the

47 roximately 100 colony-forming units (CFU) in vitro and <1000 CFU in the lungs of mice.

48 blocked netrin-1-promoted axon repulsion in vitro and caused defects in axon projection of DRG towar

49 In vitro and cell-based assays revealed that the CNAbeta1-c

50 In an in vitro and cell-based model of MMP-dependent breast cance

51 ins wild-type and Il7ra(-/-) ILC survival in vitro and compensates for IL-7R deficiency, as residual

52 AR T cell mediated killing of tumor cells in vitro and enhanced clearance of PD-L1+ tumor xenografts

53 sis of KIR3DL1/HLA-B subtype combinations in vitro and evaluated their impact in 1,328 patients with

54 n restored HLA class-I surface expression in vitro and in a mouse xenotransplantation model.

55 eened it for pyrazinamide resistance both in vitro and in an infected animal model.

56 ignificantly reduced drug resistance both in vitro and in computational model.

57 enes in undifferentiated progenitor cells in vitro and in embryonic mouse livers.

58 that CCAR2 is required for proliferation in vitro and in established SCC tumors in vivo.

59 h augmented activation of the ERK pathway in vitro and in hearts in vivo.

60 PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquitoes.

61 cancer or hepatocellular carcinoma cells in vitro and in mouse xenografts.

62 nces exhibited by both Leptosphaeria spp. in vitro and in planta.

63 yte proliferation and increased apoptosis in vitro and in skin grafts regenerated on mice, which was

64 tool to study infection with the pathogen in vitro and in vivo and the immune response to these bacte

65 strated to reduce amyloid deposition both in vitro and in vivo Because N-terminally truncated pyroglu

66 ts have the potential to be used for both in vitro and in vivo biomedical applications.

67 lso exerts a broad anti-leukemic activity in vitro and in vivo by inhibiting leukemia cell proliferat

68 This article describes the preclinical in vitro and in vivo characterization of 3 novel compounds-

69 Here, we report in vitro and in vivo effects of inhibiting PI3Kdelta in APD

70 vectors exhibited stable RSV F expression in vitro and in vivo In conclusion, an attenuated rHPIV1 ve

71 We confirmed these findings in vitro and in vivo in two murine tumor models, in primary

72 s, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 a

73 Using both in vitro and in vivo models, we go on to demonstrate that h

74 erts a powerful angiogenic effect in both in vitro and in vivo mouse studies.

75 AP/TAZ in mediating metastatic phenotypes in vitro and in vivo Notably, pharmacologic targeting of SP

76 xogenous expression of ACTRT1 reduced the in vitro and in vivo proliferation rates of cell lines with

77 Endothelial cell angiogenic responses in vitro and in vivo require ETS1-mediated transduction of

78 In this in vitro and in vivo study we hypothesized that the hepatok

79 matrix metalloproteinase-7), and cyclin D1in vitro and in vivo These data indicate that Gab2 mediates

80 fficient apoptotic cancer cell death both in vitro and in vivo through tumor-specific (1) O2 generati

81 d experimental models of immune responses in vitro and in vivo to quantify the spatial extent of cyto

82 SCs (93% accuracy) were employed for both in vitro and in vivo tumor phenotyping to identify the tumo

83 ells retain the capacity to differentiate in vitro and in vivo upon downregulation of OCT4 expression

84 -loaded nanoformulations are studied both in vitro and in vivo using animal disease models.

85 is regulated by parathyroid hormone both in vitro and in vivo, and protects osteocytes from oxidativ

86 Absence of CD200L signaling, both in vitro and in vivo, resulted in a higher inflammatory res

87 y site-directed mutagenesis and expressed in vitro and in vivo, the preparation of proteins phosphory

88 d TGF-beta1-mediated profibrotic pathways in vitro and in vivo, while esculetin significantly inhibit

89 sess biomaterial-tissue interactions both in vitro and in vivo.

90 omers that can act as a therapeutic agent in vitro and in vivo.

91 ical properties and Pab1 phase separation in vitro and in vivo.

92 XRN2 induced EMT and promoted metastasis in vitro and in vivo.

93 536) phosphorylation and c-Myc expression in vitro and in vivo.

94 he malignant phenotypes of SCC cells both in vitro and in vivo.

95 factor (TGF)-beta1 to -beta3 translation in vitro and in vivo.

96 olated HEV particles that were infectious in vitro and in vivo.

97 IRF8 is required for Th9 differentiation in vitro and in vivo.

98 , and characterized biochemical functions in vitro and in vivo.

99 -dependent anti-estrogen chemosensitivity in vitro and in vivo.

100 Os) in CYP1A1-positive cancer cells, both in vitro and in vivo.

101 lated with increased mast cell activation in vitro and in vivo.

102 lated under a high glucose condition both in vitro and in vivo.

103 optosis in MDA-MB-231 breast cancer cells in vitro and in vivo.

104 nvasive capabilities of lung cancer cells in vitro and in vivo.

105 e other compounds could suppress it, both in vitro and in vivo.

106 tance of AML cell lines and primary cells in vitro and in vivo.

107 cantly inhibited Wnt/beta-catenin pathway in vitro and in vivo.

108 ed by a decrease in hDBR1 expression both in vitro and in vivo.

109 of neurodegeneration-associated proteins in vitro and in vivo; however, the regulation of HSJ1 funct

110 the CXCR2(+) stem cells, as validated by in vitro and in-matrix migration assays.

111 olid is a new oxazolidinone with improved in vitro and intracellular potency against Mycobacterium tu

112 f the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds, such

113 s been shown to enhance viral replication in vitro and severe disease in animal models.

114 cysteine transport to trigger ferroptosis in vitro and slow tumour growth.

115 on, H9C2 rat cardiomyocytes were cultured in vitro and the phosphorylation of ERK1/2, AKT, GSK3beta a

116 utation confers enhanced FcRn interaction in vitro, and Abs harboring either the Q311R or TLQ mutatio

117 opoiesis in a non-cell-autonomous fashion in vitro, and depletion of the Hh effector Smoothened (Smo)

118 ations showed similar behaviors in yeast, in vitro, and in Drosophila, a few showed anomalous behavio

119 In sum, our complementary in silico, in vitro, and in vivo analysis argues that interface add-on

120 lizes microtubules using cell biological, in vitro, and structural approaches.

121 ently cleaved DSP into distinct fragments in vitro, and the deletion of Mmp9 caused improper processi

122 the MS-AFST assay performed at 3 h of the in vitro antifungal exposure failed to detect C. glabrata i

123 meability in the PAMPA-BBB model and high in vitro antioxidant activity, its conversion to AChEI 2r c

124 aving extraction-free procedure measuring in vitro antioxidant capacity which appears highly relevant

125 and analysis devices in a wide variety of in-vitro applications.

126 Here we combine in silico and in vitro approaches to characterize the SOS transcriptional

127 es and Gly-terminated nucleophiles occurs in vitro as well as in cellulo in the presence of Ca(2+) an

128 bearing endothelium under flow conditions in vitro as well as increased BM trafficking and extravasat

129 Using a visual in vitro assay we previously showed that efficient protein

130 question, we exploited a prion conversion in vitro assay, protein misfolding cyclic amplification (PM

131 asion of prostate cancer cell lines in 3D in vitro assays.

132 h highly responsive platelets to agonists in vitro assessed by flow cytometry (high-responder donors)

133 Importantly, through in vitro binding and activity assays, we showed that CML36

134 ) Intriguingly, coimmunoprecipitation and in vitro binding assays revealed that mortalin facilitates

135 exhibited low-affinity binding to LRP6 in in vitro binding assays, and inhibition of LRP6 or critical

136 In vitro binding studies showed that whereas mutation of Ar

137 CYP27A1 by >/=75% and were evaluated for in vitro binding to the enzyme active site and for inhibiti

138 ng alleles, live-cell spindle assays, and in vitro biochemical analyses, we show that She1 is require

139 on bursting that could not be obtained by in vitro biochemistry analysis.

140 In this study, in vitro biophysical and biochemical methods were utilized

141 well documented immunomodulatory effects in vitro, but not following oral administration in humans.

142 ifically degraded single-strand (ss) RNAs in vitro; but neither miRNAs nor miRNA*s in vivo.

143 hese altered responses could be corrected in vitro by treatment with NKH-477, a compound discovered a

144 In vitro, CD44TA-SMP accumulated in macrophages infected wi

145 el of gp120 proteins to alpha4beta7 in an in vitro cell binding assay.

146 Using in vitro cell culture and in vivo mouse models, we showed t

147 Further in vitro cell culture experiments and gene expression analy

148 e availability of large numbers of cells, in vitro cell expansion of tooth-inducing cell populations

149 FES binding was measured by using an in vitro cell uptake assay.

150 he severity of growth retardation and the in vitro cellular phenotype.

151 In silico and in vitro characterisation show that these mutations perturb

152 P. simiae genes to growth in 90 distinct in vitro conditions by RB-TnSeq, highlighting specific meta

153 The Ctk1 kinase complex binds RNA in vitro, consistent with direct EF-RNA interaction.

154 Using an in vitro culture model yielding human mo-DCs and mo-Macs cl

155 odels of IL-13-induced lung pathology and in vitro culture of murine fibroblast cell lines and primar

156 However, in vitro culture of neurons deprives them of their natural

157 Upon in vitro culture, compared to the GFP group, cells from BMP

158 fferences between these reticulocytes and in vitro-cultured adult reticulocytes functionally or at th

159 llected from infected individuals or from in vitro cultures of P. falciparum, making them prone to hi

160 Using in vitro cultures of several cell types found in the heart,

161 We find that this mAb can enhance the in vitro cytotoxic activity of venetoclcax for CLL cells wi

162 utilized high-throughput screening (HTS) in vitro data of PAHs to predict health risks associated wi

163 Comparatively few in vitro data on antimicrobial susceptibility are available

164 Adoptive transfer of in vitro differentiated MCs restored thrombosis.

165 that supports efficient and reproducible in vitro differentiation and positive selection of conventi

166 In vitro differentiation can trigger the development of the

167 otocol that describes how to initiate the in vitro differentiation of mouse and human PSCs into cardi

168 In vitro differentiation of progenitors transduced with a k

169 ty of blackberry purees through simulated in vitro digestion was also studied.

170 ined after their manufacturing and during in vitro digestion.

171 protein libraries, and should enable the in vitro directed evolution of proteins with designer singl

172 s) offers unprecedented opportunities for in vitro disease modeling and personalized cell replacement

173 rectly activated CTSB but not trypsinogen in vitro During pancreatitis in pancreas-specific CTSD(f/f)

174 Real-time impedance biosensing verified in vitro early, dose-dependent quantitative decreases in TJ

175 we confirm that HDAC6 inhibition augments in vitro efficacy of anti-CD20 mAbs and improves survival o

176 In vitro electrophysiological studies were conducted using

177 We show that decidualization (even in vitro) enhances the ability to communicate with the fetu

178 Temporal manipulation of the in vitro environment and growth factors can direct differen

179 The in vitro enzyme assays indicate that these distinct metabol

180 Although early in vitro enzyme assays showed that recombinant BAR and PAT

181 n-printed potentiometric immunosensor for in vitro evaluation of Trp consumption and Kyn production c

182 n kinetochores and microtubules, and some in vitro evidence indicates that the phosphorylation of Dam

183 Here, we report the use of an in vitro evolution approach involving systematic evolution

184 eology were rigorously investigated in an in vitro experimental setup that mimics the human circulati

185 A recent crystal structure and in vitro experiments highlighted potential residues mediati

186 In vitro experiments in human blood suggested that cavitati

187 In vitro exposure of human whole blood to PhNHOH and NOB de

188 patients with sPE, which dedifferentiated in vitro, failed to redecidualize in culture.

189 rentially expressed in vivo compared with in vitro (false discovery rate, </=0.001; 2-fold change) wi

190 cleavage and blastocyst development after in-vitro fertilization.

191 Consistent with the in vitro findings, DR6(-/-) animals displayed preserved axo

192 le cells from mouse tracheas were assayed in vitro for signaling pathways.

193 ifferences between microtubules assembled in vitro from mammalian or budding yeast tubulin.

194 both of which stimulated SRC-2 expression in vitro Furthermore, SRC-2 coactivated the transcription f

195 ns had wild-type-like fusion levels in an in vitro gB/gH-gL cell fusion assay.

196 decreased by about 50% at the end of the in vitro GID.

197 lusters were essential for fitness during in vitro growth in three C. jejuni strains, revealing that

198 Based on the in vitro growth study, MOS-III and MOS-IV was found to be e

199 ce autophagy at micromolar concentrations in vitro, have aggregate-clearing activity in a cellular mo

200 mplicated in the initiation of senescence in vitro Here we show that in a mouse model of prostate can

201 In vitro, hnRNP F overexpression stimulated Sirtuin-1 and F

202 When activated in vitro, however, IFN-gamma production by naive wild type

203 auP influenced FtsZ dynamics or bundling, in vitro, however.

204 In vitro, HpRppH converts RNA 5'-triphosphates and diphosph

205 o induce target tissue damage in a unique in vitro human graft-versus-host disease skin explant model

206 roduced using transglutaminase, and their in vitro IgE reactivity and digestibility under simulated g

207 In vitro, IL-17A enhanced IL-13-induced gene expression in

208 gonism modified PTH secretion in vivo and in vitro, implying roles for these specific miRNAs.

209 IAPP seeds accelerates Abeta aggregation in vitro in a seeding-like manner and the resulting fibrils

210 ated primary human airway epithelia (HAE) in vitro In human embryonic kidney HEK293 cells, the transf

211 oocytes autonomously synthesized betaine in vitro in the presence of choline, whereas this failed to

212 iation of oligodendrocyte precursor cells in vitro, in animal models, and in human cells.

213 imize the extracted biological data using in vitro-in vivo correlations.

214 In vitro-in vivo extrapolation (IVIVE) analyses translating

215 the presence of an antimicrobial peptide in vitro, inactivation of both phoP and Sant_4061 is necess

216 ix of many different monospecies biofilms in vitro, including some of those produced by oral bacteria

217 Sucrose, a tuber-promoting factor in vitro, increases StPP2Ac2b expression.

218 In vitro, increasing the hematocrit increased thrombin gene

219 By in vitro infection of gastric epithelial cells with wild-ty

220 In vitro interleukin-4-polarization of human primary monocy

221 The estimated in vitro intrinsic clearance (Clint) of TBECH mixture was s

222 olecular biology of ascovirus replication in vitro is lacking.

223 In vitro, ISG15 deficiency also leads to persistently high

224 essential for H3-H4 tetrasome deposition in vitro, it is required for efficient DNA synthesis-couple

225 In vitro laboratory study.

226 ribosome affinity purification (TRAP) and in vitro luciferase reporter assay indicate that mir-92a su

227 This protocol describes a unique in vitro method for the generation of a 3D human lymphatic

228 tLalpha ATPase, and MutLalpha function in in vitro mismatch repair.

229 and tumourigenesis, we have developed an in vitro model comprising human primary schwannoma cells, t

230 progresses the development of a suitable in vitro model to examine the effects of mechanical stress

231 siologically relevant cardiac tissue-like in vitro models for mechanistic biological research, diseas

232 Developing in vitro models of HIV-1 latency that recapitulate the char

233 e-base-pair precision, which allows novel in vitro models of human disease to be generated-e.g., in p

234 cofactors generating infectious prions in in vitro models.

235 , in the present study, we established an in vitro mouse brain slice preparation that retains connect

236 re have been increased calls for advanced in vitro multi-cellular models that provide reliable and va

237 e base triples reduce telomerase activity in vitro NMR studies also reveal that the pseudoknot does n

238 Using an in vitro optical trapping and fluorescence assay, we found

239 nd replication of SSPiM OCTA signal in an in vitro phantom.

240 re with free 9-cis-retinal from Rho in an in vitro phospholipid/detergent bicelle system.

241 There were lower levels of in vitro-polarized TH2 cells from Spi2A knockout mice (P <

242 Thiazole 27 showed excellent in vitro properties and a promising mouse PK profile, makin

243 In vitro, purified RPA directly enhances the association of

244 In vitro receptor autoradiography was performed with (125)I

245 Utilizing multi-color TIRF microscopy of in vitro reconstituted F-actin networks, we observed and ch

246 In vitro reconstitution and in vivo targeting assays show t

247 d characterized at functional level using in vitro reporter assays.

248 culture derived from timed pregnant rats in vitro, resulting in a much higher C99 level and C99/C89

249 reatment of the U251 glioma cells with NA in vitro results in reduced invasion, which is accompanied

250 Overall, our in vitro results propose a wide repertoire of potential bac

251 These in vitro results were confirmed in various cell line xenogr

252 , some specific applications ranging from in vitro sensing assays to cellular imaging are separated a

253 ry effects in the cellular assay, but not in vitro Sequencing analyses further demonstrated that Hsp9

254 CL photoactivation of Cy7 azide in vitro showed significantly higher fluorescence signal fr

255 on of this transporter gene revealed that in vitro SLC16A5-silencing altered cellular responses to ci

256 aim of this study was to investigate the in vitro starch digestibility of injera and porridge from s

257 oepithelial population and an increase in in vitro stem cell activity.

258 with micromolar affinity and is saturable in vitro Sterol binding by MpPR-1 requires the presence of

259 In vitro studies confirmed an increase in IL-17C mRNA and p

260 In vitro studies confirmed the platform's biocompatibility

261 In vitro studies demonstrate that Ct growth inhibition occu

262 In vitro studies demonstrate that Ofd1 directly binds Rps23

263 In vitro studies demonstrated that senescent-cell condition

264 In vitro studies have demonstrated the importance of apolip

265 In vitro studies here show that at the same shift motif HIV

266 at defined positions that can be used for in vitro studies is highly desirable.

267 In vitro studies of reconstituted E. coli replisomes have a

268 In vitro studies revealed that FTY720 also attenuated 6-OHD

269 is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calci

270 In vitro studies suggested OG would preferentially form in

271 Previous in vitro studies suggested that binding of SH2 and PTB doma

272 In vitro study showed more sustained drug release of CM-AL-

273 CHAF1A inhibits NEIL1 initiated repair in vitro Subsequent restoration of the chaperone-BER comple

274 at 1.65 A resolution, and we compare its in vitro substrate specificity with those of fungal Icp55 e

275 enzymes, and certain strains demonstrate in vitro susceptibility to these agents, potentially afford

276 Here, we show in a controlled in vitro system that phosphorylation of a membrane protein

277 In our in vitro T cell culture system, MART1-specific CD8 T cells

278 In vitro techniques at the molecular and cellular levels we

279 platelet function and thrombus formation in vitro than chrysin under physiologically relevant condit

280 We also showed in vitro that physiologic levels of OSM impair barrier func

281 In vitro, the compounds induce misfolding of chromatin fibr

282 Given the absence of external causes in vitro, the interplay of structurally differently conserv

283 ze or enhance Zika virus (ZIKV) infection in vitro, their contribution to ZIKV infection in vivo rema

284 elets, and cynomolgus platelet activation in vitro These experiments demonstrate that the SEFL modifi

285 When recapitulated with purified protein in vitro, this modification completely ablated the activity

286 FP reporter pluripotent stem cells (PSCs) in vitro to generate and isolate human primordial lung prog

287 fast and slow elongating VASP proteins by in vitro total internal reflection fluorescence microscopy

288 d its metabolites was then compared using in vitro transporter assays and in vivo microdialysis in ra

289 s greatly accelerated in vivo compared to in vitro using agitated phosphate buffered saline +0.02% Tw

290 , infectivity was significantly inhibited in vitro (using the epithelioma papulosum cyprini [EPC] fis

291 migration of fs120, but not fs188 cells, in vitro was inhibited by B20-4.1.1.

292 se using membrane potential sensitive dye in vitro was measured before and after RH.

293 model hydrostatic pressure-induced edema in vitro, we developed a method of applied pressure to the

294 ment with predictions from determinations in vitro, we discovered a decline of noradrenergic projecti

295 reatly reduced the synthesis of viral RNA in vitro, which was detected only for the 7- and 21-nucleot

296 c peptide inhibitor of C5 cleavage, using in vitro whole-blood assays and an in vivo baboon model of

297 CAT) tail elongation-can be recapitulated in vitro with a yeast cell-free system.

298 was less potent at inhibiting chemotaxis in vitro with an IC50 of 21 nm Furthermore, we observed tha

299 -terminal moiety of MF6p/FhHDM-1 interact in vitro with cell membranes in hemin-preconditioned erythr

300 ical neurons from slow excitotoxic injury in vitro, without influencing NMDA-induced intracellular ca