ライフサイエンスコーパス: voltage gated K channel

1 le is unique in structure and function among voltage-gated K channels.

2 e crystallographic images of side windows in voltage-gated K channels.

3 K+ channel and the tetramerisation domain of voltage-gated K+ channel.

4 by which Hanatoxin (HaTx) inhibits the drk1 voltage-gated K+ channel.

5 naptic cells, most likely via alterations of voltage-gated K+ channels.

6 similarities and differences between HCN and voltage-gated K+ channels.

7 ulation alters the properties of endothelial voltage-gated K+ channels.

8 Shaker, Shab, Shaw, and Shal subfamilies of voltage-gated K+ channels.

9 nhibition have been limited to the family of voltage-gated K+ channels.

10 ting cone snail Conus striatus that inhibits voltage-gated K+ channels.

11 appears to belong to the Shaker subfamily of voltage-gated K+ channels.

12 imary structure and functional modulation of voltage-gated K+ channels.

13 from the central pore axis on the surface of voltage-gated K+ channels.

14 s also known to bind and cluster Shaker-type voltage-gated K+ channels.

15 jections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels.

16 ith the crystal structure of ChTx bound to a voltage-gated K(+) channel.

17 motif common to the S6 domain of most other voltage-gated K(+) channels.

18 assemble with and modulate the properties of voltage-gated K(+) channels.

19 a(2+)](i) were not caused by the blockade of voltage-gated K(+) channels.

20 distinct classes of structurally unrelated, voltage-gated K(+) channels.

21 transmembrane domain that closely resembles voltage-gated K(+) channels.

22 ntiates outward K(+) current through several voltage-gated K(+) channels.

23 rocessing and cell surface expression of Kv1 voltage-gated K(+) channels.

24 assemble with and modulate the properties of voltage-gated K(+) channels.

25 t is analogous to hanatoxin, an inhibitor of voltage-gated K(+) channels.

26 of that accompanying C-type inactivation of voltage-gated K(+) channels.

27 on process similar to C-type inactivation of voltage-gated K(+) channels.

28 e S6 domain in electromechanical coupling of voltage-gated K(+) channels.

29 nhibitors of ATP-sensitive K(+) channels and voltage-gated K(+) channels.

30 nd ion conducting properties of a variety of voltage-gated K(+) channels.

31 ied by Shaker cognate L (Shal; also known as voltage-gated K(+) channel 4, Kv4) channels.

32 KCNB1 (formerly Kv2.1), a voltage-gated K(+) channel abundantly expressed in the c

33 Voltage-gated K+ channels activating close to resting me

34 These results suggest that, among voltage-gated K(+) channels, activation in Kv1.5 is uniq

35 utant line showed an almost complete loss of voltage gated K(+) channel activity and Vm depolarizatio

36 transmembrane potential (Vm) depolarization, voltage gated K(+) channel activity, cytosolic calcium [

37 transmembrane potential (Vm) depolarization, voltage gated K(+) channel activity, cytosolic calcium [

38 active oxygen species-mediated inhibition of voltage-gated K+ channel activity and leads to prolongat

39 le of p90RSK activation in the modulation of voltage-gated K+ channel activity determining cardiac re

40 ether-a-go-go-related gene, which encodes a voltage-gated K(+) channel alpha subunit.

41 hERG encodes the voltage-gated K(+) channel alpha-subunits that form the

42 (E1) beta-subunits assemble with KCNQ1 (Q1) voltage-gated K(+) channel alpha-subunits to form IKslow

43 The Kvbeta subunits of voltage-gated K+ channels alter the functional expressio

44 e architecture of the functional core of the voltage-gated (K+) channels and their relatives.

45 to eliminate the contribution of a class of voltage-gated K(+) channels and assessed its effects on

46 to interpret KCNE beta-subunit modulation of voltage-gated K(+) channels and the inherited mutations

47 In voltage-gated K(+) channels and the prokaryotic KcsA cha

48 We also review the role of voltage-gated K(+) channels and transient receptor poten

49 to multiple sites on the surface of the drk1 voltage-gated K+ channel and modifies channel gating.

50 on at more depolarized potentials than other voltage-gated K+ channels and fast kinetics.

51 Hanatoxin inhibits voltage-gated K+ channels and grammotoxin inhibits volta

52 e formation of the ion selectivity filter in voltage-gated K+ channels and is thought to interact wit

53 t domain, homologous to the S1-S6 regions of voltage-gated K+ channels, and a carboxy-terminal 120 am

54 ange of alpha subunits, the beta subunits of voltage-gated K channels are likely to have a much broad

55 Kv3 voltage-gated K(+) channels are important in shaping neu

56 Voltage-gated K(+) channels are multimeric proteins, con

57 KV11.1 voltage-gated K(+) channels are noted for unusually slow

58 els are inhibited by alcohol, and most other voltage-gated K(+) channels are refractory to drug actio

59 Mammalian voltage-gated K+ channels are assemblies of pore-forming

60 Voltage-gated K+ channels are complexes of membrane-boun

61 Voltage-gated K+ channels are dynamic macromolecular mac

62 Diverse voltage-gated K+ channels are produced by tetramerizatio

63 Voltage-gated K+ channels are protein complexes composed

64 In addition, voltage-gated K+ channels are required for G1/S-phase tr

65 Voltage-gated K+ channels are tetrameric, but how the fo

66 to adult-onset neurodegeneration and suggest voltage-gated K+ channels as candidates for additional n

67 ive for rapid N-type inactivating domains of voltage-gated K(+) channels, associated with negatively

68 ovary cells, which do not express endogenous voltage-gated K+ channels, became substantially more sen

69 body (MNTB) as a model system for examining voltage-gated K(+) channels, because of their known func

70 HCN channels have a structure similar to voltage-gated K(+) channels but have a much larger putat

71 Charybdotoxin (CTX), blocks homotetrameric, voltage-gated K(+) channels by binding near the outer en

72 beta subunits form complexes with Kv1 family voltage-gated K(+) channels by binding to a part of the

73 -1) cells was the vigorous activation of the voltage-gated K+ channel by UV irradiation.

74 Mutations in the Kv3.3 voltage-gated K(+) channel cause spinocerebellar ataxia

75 to the discovery of a new class of neuronal voltage-gated K(+) channels characterized by positively

76 rst report of the functional expression of a voltage-gated K channel clone expressed in kidney.

77 In contrast to voltage-gated K+ channels, complete deletion of the S3-S

78 nthetic maturation and surface expression of voltage-gated K+ channel complexes.

79 Voltage-gated K(+) channels composed of Kv7.2 and Kv7.3

80 I(Ks) voltage-gated K(+) channels contain four pore-forming KC

81 Voltage-gated K+ channels contain a central pore domain

82 Voltage-gated K+ channels containing Kv3 subunits play s

83 is issue of Neuron, Harnett et al. show that voltage-gated K+ channels control multiple layers of den

84 KNIR-1 treatment of cells expressing voltage-gated K(+) channels enabled the visualization of

85 Voltage-gated K+ channels exhibit a slow inactivation pr

86 tand the physiological significance of these voltage-gated K(+) channel expansions, we analyzed the f

87 ed the mechanism of the maurotoxin action on voltage-gated K(+) channels expressed in Xenopus oocytes

88 ode voltage clamp experiments on human Kv1.4 voltage-gated K+ channels expressed heterologously in Xe

89 physical profile to help identify the common voltage-gated K(+) channel families in a neuron.

90 We previously cloned a novel member of the voltage-gated K channel family from mouse brain (mBCNG-1

91 KCNQ (voltage-gated K(+) channel family 7 (Kv7)) channels cont

92 n addition to the molecular diversity of the voltage-gated K+ channel family.

93 activation kinetics when compared with other voltage-gated K+ channels, features that confer on Kv3 c

94 KvLm, the voltage-gated K(+) channel from Listeria monocytogenes,

95 rom the symposium on the structural basis of voltage-gated K(+) channel function, as well as the mech

96 In voltage-gated K(+) channels, gating is the result of the

97 The mouse voltage-gated K+ channel gene, Kv1.4, is expressed in br

98 Genetic mapping of the voltage-gated K channel genes has shown that similar mul

99 Mammalian voltage-gated K channel genes have been divided into fou

100 oning studies have found several families of voltage-gated K(+) channel genes expressed in the mammal

101 revealed the existence of a large family of voltage-gated K+ channel genes expressed in mammalian br

102 p that contains the KCNA1 gene and two other voltage-gated K+ channel genes, KCNA5 and KCNA6; 6) the

103 the delayed rectifiers Kv7.1 and Kv11.1, two voltage-gated K(+) channels, has been suggested, but the

104 or ensuring that KCNE peptides assemble with voltage-gated K(+) channels have yet to be elucidated.

105 Voltage-gated K+ channels have been shown to be required

106 While mutagenesis studies on voltage-gated K+ channels have begun to shed light on th

107 sis that KCNA genes (which encode K(V)alpha1 voltage-gated K(+) channels) have enhanced functional ex

108 ated channels and for modulation of the HERG voltage-gated K+ channel--important for visual and olfac

109 Kv1.5 is an important voltage-gated K(+) channel in the cardiovascular system

110 SMase C also inhibits voltage-gated K(+) channels in lymphocytes; inhibition o

111 a pivotal role for ROS-mediated oxidation of voltage-gated K(+) channels in sensorial decline during

112 and function of the K(V)alpha1 subfamily of voltage-gated K(+) channels in terminal arterioles from

113 .1) is a unique member of the superfamily of voltage-gated K(+) channels in that it displays a remark

114 nd calsenilin) act as auxiliary subunits for voltage-gated K(+) channels in the Kv4 family.

115 ha) subunits in the generation of functional voltage-gated K(+) channels in the mammalian heart.

116 due, in part, to the presence of endogenous voltage-gated K(+) channels in these cells.

117 antly to the complexity and heterogeneity of voltage-gated K+ channels in excitable cells.

118 Expression of voltage-gated K+ channels in these neurons was character

119 n extensive investigation of native Kv1.3, a voltage-gated K(+) channel, including transmembrane and

120 The Kv2.1 voltage-gated K(+) channel is found both freely diffusin

121 . elegans uses sensory thresholds and that a voltage-gated K(+) channel is specifically required for

122 One feature shared by all Shaker-type voltage-gated K(+) channels is a highly conserved domain

123 the various neuronal functions performed by voltage-gated K(+) channels is lacking.

124 membrane potentials, the conductance of some voltage-gated K(+) channels is reduced by C-type inactiv

125 of human ether-a-go-go-related gene (hERG) 1 voltage-gated K(+) channels is responsible for portions

126 The Kv2.1 voltage-gated K+ channel is widely expressed throughout

127 An array of rapidly inactivating voltage-gated K+ channels is distributed throughout the

128 The inner end of the pore in voltage-gated K+ channels is the site of conformational

129 Kv1.3, a voltage-gated K(+) channel, is a functional marker and a

130 The sigma receptor, which modulates voltage-gated K+ channels, is a novel protein with no ho

131 sign, which combines a transmembrane 6 (TM6) voltage-gated K(+) channel (K(V)) core with CTDs that em

132 Gating of voltage-gated K(+) channels (K(v) channels) depends on t

133 ells stably transfected with the Shaker-type voltage-gated K+ channel, K(V)1.3, has been used to inve

134 The voltage-gated K+ channel, K(V)2.1, is expressed in beta-

135 rehensive mutagenesis of the YG sites of the voltage-gated K+ channel, Kat1, is combined with phenoty

136 is an auxiliary subunit of the Kv4 family of voltage-gated K(+) channels known to enhance channel sur

137 Voltage gated K(+) channels (Kv) are a highly diverse gr

138 Voltage gated K+ channels (Kv) are a diverse group of ch

139 A delayed rectifier voltage-gated K(+) channel (Kv) represents the largest i

140 gene is homologous to genes of the family of voltage-gated K(+) channels (Kv type).

141 Voltage-gated K(+) channels (Kv) are responsible for rep

142 Voltage-gated K(+) channels (Kv) are tetramers whose ass

143 We now address this issue in voltage-gated K(+) channels (Kv) for the T1 domain, an N

144 ain (S3) on channel biogenesis and gating of voltage-gated K(+) channels (Kv) has been well establish

145 In voltage-gated K(+) channels (Kv), an intracellular gate

146 RT-PCR for voltage-gated K+ channel (KV) subunits revealed the expr

147 Activity of voltage-gated K+ channels (KV) in pulmonary arterial smo

148 nary vasoconstriction, in part by inhibiting voltage-gated K+ channels (Kv) in pulmonary artery smoot

149 For voltage-gated K+ channels (Kv), it is not clear at which

150 n in KCNA2 (c.881G>A, p.R294H), encoding the voltage-gated K(+) -channel, KV 1.2, in two unrelated fa

151 ors correlated with functional expression of voltage-gated K channels Kv1.1/1.2: Relatively higher ex

152 expressed significantly higher levels of the voltage-gated K(+) channel Kv1.3 and lower levels of the

153 f the GluR6 subunit of the kainate receptor, voltage-gated K(+) channel Kv1.4, and microtubule-associ

154 oss-of-function or a gain-of-function of the voltage-gated K+ channel Kv1.2, were described to cause

155 Sigma receptors modulated voltage-gated K+ channels (Kv1.4 or Kv1.5) in different

156 ng molecular model of the pore region of the voltage-gated K+ channel, Kv1.3.

157 We found the voltage-gated K+ channel Kv12.2 to be a potent regulator

158 e been shown to affect kinetic properties of voltage-gated K+ channel Kv1alpha subunits and increase

159 The voltage-gated K(+) channel Kv2.1 has been intimately lin

160 Here, we demonstrate that the voltage-gated K(+) channel Kv2.1, but not Kv4.2, targets

161 The voltage-gated K+ channel Kv2.1 is an abundant delayed re

162 gineered cysteines in the pore region of the voltage-gated K+ channel Kv2.1.

163 lar results were obtained in three different voltage-gated K+ channels: Kv2.1, a channel derived from

164 velopment, whereas transcript levels for the voltage-gated K+ channel Kv3.1, a delayed rectifier (KD)

165 ng a disrupted gene for the fast activating, voltage-gated K+ channel Kv3.1.

166 The permeation pathways of the voltage-gated K+ channels Kv3.1 and ShakerB delta 6-46 (

167 termini of members of the Shal subfamily of voltage-gated K(+) channel (Kv4) pore-forming (alpha) su

168 The voltage-gated K(+) channels Kv7.2 and Kv7.3 are located

169 The voltage-gated K(+) channels Kv7.2 and Kv7.3 exert strong

170 s consensus mechanism, recent studies of the voltage-gated K(+) channel KvAP suggest a strikingly dif

171 ectivity filters of the KcsA channel and the voltage-gated K(+) channel KvAP.

172 an associate with and functionally endow the voltage-gated K(+) channel KVS-1.

173 embrane domain protein that coassembles with voltage-gated K+ channel KVS-1 in the nervous system of

174 KCNQ1 encodes a voltage-gated K(+) channel located in both cardiomyocyte

175 Voltage-gated K(+) channels maintain salt and water bala

176 afferent fibres is mediated by inhibition of voltage-gated K+ channels (Maxi-K and M-current) and not

177 nel proteins, such as those forming selected voltage-gated K(+) channels, may also exhibit rapid turn

178 el, also bound calmodulin, whereas that of a voltage-gated K+ channel, mKv1.3, did not.

179 at share a subunit structure consisting of a voltage-gated K(+) channel motif coupled to a cytoplasmi

180 results show that a major diversification of voltage-gated K(+) channels occurred in ancestral paraho

181 subtypes indicate that BrMT inhibits certain voltage-gated K channels of the Kv1 subfamily.

182 er (P/C-type mechanism) is prevalent in many voltage-gated K(+) channels of the Kv1 subfamily.

183 Voltage-gated K(+) channels of the Kv3 subfamily have un

184 Voltage-gated K(+) channels of the Kv7 family underlie t

185 Voltage-gated K(+) channels of the Shaw family (also kno

186 The voltage-gated K+ channel of T-lymphocytes, Kv1.3, was he

187 arent defects in the regulation of Ca2+- and voltage-gated K+ channels or delayed rectifier K+ channe

188 Shaker-related or Kv1 voltage-gated K(+) channels play critical roles in regul

189 tructure and characterized the function of a voltage-gated K(+) channel pore in a lipid membrane.

190 intracellular domains, allowing us to dock a voltage-gated K(+) channel pore of known structure onto

191 A large number of voltage-gated K+ channel pore-forming (alpha) and access

192 lian Ether-a-go-go related gene (Erg) family voltage-gated K(+) channels possess an unusual gating ph

193 ucture, function, and molecular movements of voltage-gated K+ channel protein complexes.

194 K+ channel homologous to the pore domain of voltage-gated K+ channels, provides a starting point for

195 In some A-type voltage-gated K channels, rapid inactivation is achieved

196 The Kv7 (KCNQ) family of voltage-gated K(+) channels regulates cellular excitabil

197 molecular methods to determine how Kv3.4, a voltage-gated K(+) channel robustly expressed in dorsal

198 Expression of voltage-gated K channel, shaker-related subfamily, membe

199 Voltage-gated K+ channels share a common voltage sensor

200 HCN channels resemble voltage-gated K+ channels structurally, but much less is

201 Members of different voltage-gated K+ channel subfamilies usually do not form

202 e central core, which are promiscuous across voltage-gated K+ channel subfamilies.

203 udemans andcolleagues show that mutations in voltage-gated K+ channel subtype 1.1(Kv1.1) cause autoso

204 The expression of the voltage-gated K(+)-channel subunit Kv3.1b in the develop

205 lectrical abnormality, expression of cardiac voltage-gated K+ channel subunit genes was examined in v

206 ost-MI remodeled rat LV is distinct for each voltage-gated K+ channel subunit.

207 An immunocytochemical survey of voltage-gated K(+) channel subunits characteristic of ad

208 Voltage-gated K(+) channel subunits must reach the plasm

209 KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) are voltage-gated K(+) channel subunits that underlie the ne

210 KCNQ2) and Kv7.3 (KCNQ3) genes, encoding for voltage-gated K(+) channel subunits underlying the neuro

211 Moreover, mutagenesis of voltage-gated K+ channels suggests that hanatoxin and gr

212 A domain in the cytoplasmic NH2 terminus of voltage-gated K+ channels supervises the proper assembly

213 a-go-go-related gene encodes hERG, a cardiac voltage-gated K(+) channel that is abnormally expressed

214 channels (Kv3.1-Kv3.4) represent a family of voltage-gated K(+) channels that have fast-spiking prope

215 -go (Eag) family, named Eag2, that expresses voltage-gated K(+) channels that have significant activa

216 M-channels are voltage-gated K+ channels that regulate the excitability

217 e sharing significant sequence homology with voltage-gated K(+) channels, the gating of hyperpolariza

218 membrane topology closely resembles that of voltage-gated K(+) channels, the mechanism of their uniq

219 Unlike previously studied voltage-gated K+ channels, the bulk of charge movement i

220 Opposite to other voltage-gated K+ channels, the rate of HERG channel inac

221 om other venomous animals that interact with voltage-gated K(+) channels, there may be convergent fun

222 In voltage-gated K+ channels, this gate has been localized

223 n reaction, indicating that p90RSK regulates voltage-gated K+ channels through posttranslational modi

224 evolution of the Shaker and KCNQ families of voltage-gated K(+) channels to better understand how neu

225 nism for the subcellular sorting of specific voltage-gated K(+) channels to regions of the membrane r

226 brane shell of the pore domain in the Shaker voltage-gated K+ channel to localize potential protein-p

227 With prolonged or repetitive activation, voltage-gated K+ channels undergo a slow (C-type) inacti

228 Voltage-gated K(+) channels underlie the electrical exci

229 bunits are the principal constituents of the voltage-gated K+ channel underlying somatodendritic subt

230 Voltage-gated K(+) channels vary in sensitivity to block

231 usually associated with impaired function of voltage-gated K(+) channels (VGKCs) in neuromyotonia and

232 d Kv1.2 and Shab subfamily Kv2.1 subunits of voltage-gated K+ channels were determined in the retina

233 amic GABA release can be reduced by blocking voltage-gated K(+) channels, which increases the efficac

234 en similar mutations in inward-rectifier and voltage-gated K+ channels, which suggests that the pore

235 KCNE3 (MiRP2) forms heteromeric voltage-gated K(+) channels with the skeletal muscle-exp

236 and Kv3.2 K(+) channel proteins form similar voltage-gated K(+) channels with unusual properties, inc

237 ons can also be induced by the inhibition of voltage-gated K+ channels with 4-aminopyridine (4-AP), a

238 elective interaction of the beta-subunits of voltage-gated K+ channels with alpha-subunits observed i

239 gma receptors serve as auxiliary subunits to voltage-gated K+ channels with distinct functional inter

240 smembrane topology that is highly similar to voltage-gated K(+) channels, yet HCN channels open in re