ライフサイエンスコーパス: voltage gated Na channel

1 uter vestibule and selectivity region of the voltage-gated Na channel.

2 titive antagonists of batrachotoxin (BTX) in voltage-gated Na+ channels.

3 ), have played crucial roles in the study of voltage-gated Na+ channels.

4 its clinically important action by blocking voltage-gated Na+ channels.

5 ackbone location of S5 and S6 helices of the voltage-gated Na(+) channel.

6 N4A gene, encoding the human skeletal muscle voltage-gated Na(+) channel.

7 nels in a manner that resembles the block of voltage-gated Na(+) channels.

8 removal of Ca(2+), but not by a blockade of voltage-gated Na(+) channels.

9 gnificant homology with the beta2 subunit of voltage-gated Na(+) channels.

10 inhibit Na(+) flux by occluding the pore of voltage-gated Na(+) channels.

11 e best known for their inhibitory effects on voltage-gated Na(+) channels.

12 val and partially protected by a blockade of voltage-gated Na(+) channels.

13 of repriming (recovery from inactivation) of voltage-gated Na(+) channels.

14 similarity between bacterial and eukaryotic voltage-gated Na(+) channels.

15 otential and graded potential models lacking voltage-gated Na(+) channels.

16 mbrane excitability, and the localization of voltage-gated Na(+) channels.

17 ion channels in the heart, including cardiac voltage-gated Na(+) channels.

18 lar to voltage-gated Ca(2+) channels than to voltage-gated Na(+) channels.

19 The AII processes showed clustering of voltage-gated Na+ channel 1.1 (Na(v)1.1) as well as AIS

20 ting that ipRGC-to-DAC transmission requires voltage-gated Na(+) channels; (2) this transmission is p

21 ion of pyrethroids with the alpha subunit of voltage-gated Na+ channels, a radioactive photosensitive

22 hannel complexes unexpectedly identified the voltage-gated Na(+) channel accessory subunit Navbeta1.

23 ound, we modified only the properties of the voltage-gated Na(+) channel according to our patch-clamp

24 gulate TEP and JI Epistasis assays show that voltage-gated Na(+) channels act downstream of H2O2 to m

25 More broadly, voltage-gated Na channels adopt this same modulatory pri

26 Mutations in segment IVS6 of voltage-gated Na(+) channels affect fast-inactivation, s

27 ecombinant brain, skeletal muscle, and heart voltage-gated Na+ channel alpha subunits differ in their

28 The voltage-gated Na+ channel alpha-subunit consists of four

29 Two mutant human skeletal muscle voltage-gated Na+ channel alpha-subunits (hSkM1), with m

30 Na(V)1.5 is a cardiac voltage-gated Na(+) channel alphasubunit and is encoded

31 esterone had little or no effect on a cloned voltage-gated Na+ channel, an inward rectifier K+ channe

32 Our report demonstrates that a specific voltage-gated Na(+) channel and its associated impairmen

33 Batrachotoxin (BTX) alters the gating of voltage-gated Na(+) channels and causes these channels t

34 270-kD and participates in the clustering of voltage-gated Na(+) channels and cell-adhesion molecules

35 BTX targets voltage-gated Na(+) channels and enables them to open pe

36 Mechanistically, 4 inhibited voltage-gated Na(+) channels and N-type Ca(2+) channels

37 Mechanistically, 4a inhibited voltage-gated Na(+) channels and N-type Ca(2+) channels

38 rns the identification of different types of voltage-gated Na(+) channels and of muscarinic and purin

39 We examined the kinetic properties of voltage-gated Na(+) channels and their contribution to t

40 VTD causes persistent opening of the voltage-gated Na+ channel and reduces its single-channel

41 day 7 (P7), almost all node-like clusters of voltage-gated Na+ channels and ankyrinG are adjacent to

42 suggest the following: node-like clusters of voltage-gated Na+ channels and ankyrinG form adjacent to

43 nitric oxide production), Na+ influx through voltage-gated Na+ channels and axonal AMPA receptors, re

44 ernal QX and local anaesthetic pore block of voltage-gated Na+ channels and provide insight into unde

45 arbamazepine, and lamotrigine block neuronal voltage-gated Na(+) channels, and their binding sites to

46 epends strongly, although not completely, on voltage-gated Na+ channels, and the spatial extent of fe

47 Voltage-gated Na(+) channels are composed of pore-formin

48 Voltage-gated Na(+) channels are critical components in

49 Voltage-gated Na(+) channels are critical determinants o

50 Voltage-gated Na(+) channels are the primary targets of

51 Voltage-gated Na(+) channels are the workhorses of spike

52 Voltage-gated Na(+)-channels are transmembrane proteins

53 Voltage-gated Na+ channels are a primary target for loca

54 Voltage-gated Na+ channels are essential for the normal

55 Voltage-gated Na+ channels are major targets of G protei

56 Voltage-gated Na+ channels are the molecular targets of

57 This study examined the loss of voltage-gated Na+ channels as well as acetylcholine rece

58 (Nfasc186) is required for the clustering of voltage gated Na+ channels at the node, whilst the 155 k

59 This evidence for loss of voltage-gated Na+ channels at the motor end plate in bot

60 rity was not caused solely by a reduction in voltage-gated Na(+) channel availability.

61 mechanism was not via Na+ influx through the voltage-gated Na+ channels because the release was not a

62 Voltage-gated Na(+) channel beta1 subunits are multifunc

63 We conclude that voltage-gated Na(+) channel beta1 subunits signal via mu

64 The voltage-gated Na+ channel blocker tetrodotoxin (TTX) abo

65 that FHFs not only are potent modulators of voltage-gated Na+ channels but also affect Ca2+ channels

66 s; FGF11-14) are intracellular modulators of voltage-gated Na+ channels, but their cellular distribut

67 Opening of voltage-gated Na+ channels by application of 50 microM v

68 Expression of mRNA encoding several voltage-gated Na+ channels by the E11.5 gut was detected

69 s of the myelin-deficient rat, which contain voltage-gated Na(+) channel clusters but lack paranodal

70 rated function of a molecular aggregate (the voltage-gated Na(+) channel complex) that includes the b

71 (85%), suggesting that influx of Na+ through voltage-gated Na+ channels contributed to baseline [Na+]

72 with previous suggestions, the activation of voltage-gated Na(+) channels contributes to axonal damag

73 al communication; and (3) Na+ influx through voltage-gated Na+ channels could be important to fuel th

74 failure is associated with decreased cardiac voltage-gated Na+ channel current (encoded by SCN5A), an

75 Voltage-gated Na(+) channels display rapid activation ga

76 lly identified by its sequence similarity to voltage-gated Na(+) channels, encodes a functional volta

77 h less is known about developmental roles of voltage-gated Na+ channels, essential mediators of elect

78 a gene that encodes an auxiliary protein of voltage-gated Na(+) channels, fibroblast growth factor 1

79 Here we report the crystal structure of a voltage-gated Na(+) channel from Arcobacter butzleri (Na

80 Local anesthetic antiarrhythmic drugs block voltage-gated Na(+) channels from the cytoplasmic side.

81 nomic studies have revealed that animal-type voltage-gated Na(+) channels had evolved in choanoflagel

82 in (TTX, 1 microM), a selective inhibitor of voltage-gated Na(+) channels, had an effect on mechanica

83 hese oscillations required the activation of voltage-gated Na(+) channels, had the same frequency as

84 Here we introduce roNaV2, an engineered voltage-gated Na(+) channel harboring a selenocysteine i

85 sense mutations of the human skeletal muscle voltage-gated Na channel (hSkM1) underlie a variety of d

86 proliferated and coexpressed PDGFRalpha and voltage-gated Na(+) channels (I(Na)).

87 The principal voltage-gated Na channel in heart, Nav1.5, is directly a

88 Ankyrin-G associates with the principal voltage-gated Na channel in the heart, and loss of this

89 Voltage-gated Na channels in many neurons, including sev

90 Voltage-gated Na channels in several classes of neurons,

91 Na(V)1.1 is the primary voltage-gated Na(+) channel in several classes of GABAer

92 Voltage-gated Na(+) channels in the brain are composed o

93 temperature increases the ion influx through voltage-gated Na(+) channels in the cold sensory nerve e

94 Batrachotoxin (BTX) stabilizes the voltage-gated Na(+) channels in their open conformation,

95 the first time the molecular identity of the voltage-gated Na+ channel in freshly dispersed smooth mu

96 The function of BNC1 as a non-voltage-gated Na+ channel in human brain suggests it may

97 Kv3.1b colocalizes with voltage-gated Na+ channels in a subset of nodes in the s

98 Local anesthetics (LAs) block voltage-gated Na+ channels in excitable cells, whereas b

99 udy the role of Na+-dependent exchangers and voltage-gated Na+ channels in the maintenance of membran

100 Most voltage-gated Na(+) channels inactivate almost completel

101 Voltage-gated Na(+) channels initiate action potentials

102 Voltage-gated Na(+) channels initiate and propagate acti

103 The rat brain voltage-gated Na+ channel is composed of three glycoprot

104 The inner pore of the voltage-gated Na+ channel is predicted by the structure

105 etter understand why sensory neurons express voltage-gated Na+ channel isoforms that are different fr

106 hat residue with lysine (normally present in voltage-gated Na(+) channels) makes the channel more sel

107 Inhibition of voltage-gated Na+ channels may contribute to the presyna

108 lar linker between domains III and IV of the voltage-gated Na channel mediates fast inactivation.

109 Association of beta1B with voltage-gated Na+ channels Na(v)1.1 or Na(v)1.3 is not d

110 In P21 wild-type (WT) rats, the voltage-gated Na+ channels Na(v)1.2, Na(v)1.6, and Na(v)

111 Activity of voltage-gated Na channels (Na(v)) is modified by alterna

112 nslational regulation of the primary cardiac voltage-gated Na(+) channel (Na(v)1.5) by Ca(2+)/calmodu

113 We report that voltage-gated Na+ channels (Na(V)) from rat muscle (mu1)

114 Pancreatic alpha-cells express voltage-gated Na(+) channels (NaChs), which support the

115 he two-pore channel protein family, as a new voltage-gated Na(+) channel (NaV) that generates ulAPs,

116 Thus, influx of Na(+) via voltage-gated Na(+) channels (NaV ) has emerged as an im

117 Voltage-gated Na(+) channels (Nav ) modulate neuronal ex

118 Depolarization leads to the opening of voltage-gated Na(+) channels (Nav) and subsequently volt

119 Voltage-gated Na(+) channels (Nav) are essential for myo

120 by de novo gain-of-function mutations in the voltage-gated Na channel Nav1.6.

121 th mutations in the SCN5A gene, encoding the voltage-gated Na(+) channel NaV1.5.

122 (house mice, rats, humans) by activating the voltage-gated Na(+) channel Nav1.7, but has no effect on

123 nction mutations in the human SCN11A-encoded voltage-gated Na(+) channel NaV1.9 cause severe pain dis

124 the mouse gene encoding the skeletal muscle voltage-gated Na+ channel NaV1.4.

125 on after SCI of protein, but not mRNA, for a voltage-gated Na(+) channel, Nav1.8, that is expressed a

126 Neurotransmitter release depends on voltage-gated Na(+) channels (Navs) to propagate an acti

127 duct of action potential generation: (1) the voltage-gated Na(+) channels necessary for action potent

128 Voltage-gated Na channels of cerebellar Purkinje neurons

129 n can be classified as beta group toxins for voltage-gated Na+ channels of central neurons.

130 sant drugs acting via use-dependent block of voltage-gated Na(+) channels on GABAergic inhibitory mic

131 Voltage-gated Na(+) channels play an essential role in e

132 Thus, voltage-gated Na+ channels play cell-autonomous and non

133 ion in ventricular expression of the cardiac voltage-gated Na+ channel pore-forming alpha-subunit (Na

134 Crystal structures of bacterial voltage-gated Na(+) channels predict that the side chain

135 In these neurons, the tetrodotoxin-sensitive voltage-gated Na(+) channels responsible for action pote

136 The beta subunits of voltage-gated Na channels (Scnxb) regulate the gating of

137 rotons are potent physiological modifiers of voltage-gated Na(+) channels, shifting the voltage range

138 that requires opening of CaV(2.3) channels, voltage-gated Na channels, small conductance Ca-activate

139 Neurons have high densities of voltage-gated Na(+) channels that are restricted to axon

140 te that mossy fiber boutons have specialized voltage-gated Na(+) channels that critically impact upon

141 nel alpha-subunit, have been shown to encode voltage-gated Na+ channels that reopen during prolonged

142 y of several crystal structures of bacterial voltage-gated Na(+) channels, the structure of eukaryoti

143 t alter the expression of different nodal of voltage-gated Na+ channels; the absence of paranodes res

144 blocked by glutamate receptor antagonists, a voltage-gated Na(+) channel toxin, extracellular Ca(2+)

145 Voltage-gated Na+ channels undergo two types of inactiva

146 In metazoans, the coordinate activities of voltage-gated Na(+) channels underlie cellular excitabil

147 Voltage-gated Na(+) channels underlie rapid conduction i

148 t only by the properties of the pore-forming voltage-gated Na(+) channel (VGSC) alpha subunit, but al

149 Voltage-gated Na(+) channel (VGSC) beta1 subunits regula

150 Voltage-gated Na(+) channel (VGSC) beta1 subunits, encod

151 Here we identified a voltage-gated Na(+) channel (VGSC) that was essential fo

152 Voltage-gated Na(+) channels (VGSC) have been implicated

153 t only by the properties of the pore-forming voltage-gated Na+ channel (VGSC) alpha subunit, but also

154 ion of the PC-3M cells (24 or 48 h) with the voltage-gated Na+ channel (VGSC) blocker tetrodotoxin (T

155 Voltage-gated Na(+) channels (VGSCs) are responsible for

156 We have shown previously that voltage-gated Na(+) channels (VGSCs) are up-regulated in

157 Functional expression of voltage-gated Na(+) channels (VGSCs) has been demonstrat

158 nt (TTX-R) Na(+) current (I(Na)) mediated by voltage-gated Na(+) channels (VGSCs).

159 raction of symmetrical lidocaine dimers with voltage-gated Na+ channels (VGSCs) was examined using a

160 Mammalian voltage-gated Na(+) channels were less sensitive to pyre

161 tial waveforms and gating of less sialylated voltage-gated Na+ channels were altered consistently in

162 the transmembrane segment S6 in domain IV of voltage-gated Na+ channels, whereas the putative BTX rec

163 interaction between the Sig1R and the Nav1.5 voltage-gated Na(+) channel, which has also been implica

164 ert potent use-dependent blocking effects on voltage-gated Na(+) channels, which are thought to under