ライフサイエンスコーパス: voltage sensitivity

1 ce on voltage indicating a lack of intrinsic voltage sensitivity.

2 vely, indicating that Cx36 exhibits very low voltage sensitivity.

3 ge-dependent manner but with relatively weak voltage sensitivity.

4 te that ABA stimulates ICl and modulates its voltage sensitivity.

5 l conductance without significantly changing voltage sensitivity.

6 g time constants yet did not influence their voltage sensitivity.

7 ane potential at a level determined by their voltage sensitivity.

8 ow high conductance channels with asymmetric voltage sensitivity.

9 urrents with a much increased calcium and/or voltage sensitivity.

10 nidentified also contribute to the slow gate voltage sensitivity.

11 n to more depolarized values and reduced its voltage sensitivity.

12 GEVIs for 2P brightness, response speed, and voltage sensitivity.

13 ganizing synaptic ribbons and setting CaV1.4 voltage sensitivity.

14 le AT1R expression could decrease BK channel voltage sensitivity.

15 tate, causing a dramatic decrease in channel voltage sensitivity.

16 Surprisingly, Trp substitution unmasks voltage sensitivity.

17 ven though they exhibited a complete loss of voltage sensitivity.

18 restin on its intracellular domain to confer voltage sensitivity.

19 annel isoforms that vary in their Ca(2+) and voltage sensitivities.

20 on (1P) illumination, RVF5 demonstrates high voltage sensitivity (28% DeltaF/F per 100 mV) and improv

21 amily channels, despite large differences in voltage sensitivity, activation rates, and activation th

22 a reduction in turnover number and a loss of voltage sensitivity, although there were no alterations

23 gating phenotype, a hyperpolarizing shift in voltage sensitivities and faster gating kinetics.

24 ubunit, which imprints unique kinetics, Ca2+/voltage sensitivities and pharmacology to the channel.

25 tinct effects on Kv channels: an increase in voltage sensitivity and a concomitant decrease in curren

26 Tubulin strikingly increases VDAC voltage sensitivity and at physiological salt conditions

27 ith the exception of markedly reduced Ca(2+)/voltage sensitivity and faster activation kinetics.

28 P2Y receptors are capable of modulating the voltage sensitivity and inactivation gating of an endoge

29 e two voltage-sensing domains (VSD2) encodes voltage sensitivity and inhibition by luminal Ca(2+) and

30 tassium-selective channels but with variable voltage sensitivity and pH regulation.

31 annel activity is correlated with diminished voltage sensitivity and slowed activation kinetics of th

32 The voltage sensitivity and strong dependence of the flecain

33 xpression near 70% without affecting channel voltage sensitivity, and deletion of 1007YNMLCFGIY1015 m

34 current amplitude, hyperpolarizing shift in voltage sensitivity, and slowing of deactivation in resp

35 Voltage sensitivity apparently depends in part on the ab

36 ed with native calmodulin, and the decreased voltage sensitivity are only observed when the mutant is

37 This gave values for the voltage sensitivity at the cell's resting potential, the

38 urrent was due to an increase in the channel voltage sensitivity by approximately 20 mV and was rever

39 in which the N-terminus determines the KAT1 voltage sensitivity by contributing to the electric fiel

40 , and supports mechanistic interpretation of voltage sensitivity by fractional amino acid contributio

41 h systematic chemical substitution modulates voltage sensitivity, estimate (DeltaGPeT + w) values fro

42 f 14 pS, flickery kinetics and showed little voltage sensitivity except at extreme positive potential

43 Surprisingly, the voltage sensitivity, expressed as a slope of the logarit

44 Voltage-gated ion channels derive their voltage sensitivity from the movement of specific charge

45 We discuss their mechanisms of voltage sensitivity, from reorientation, electrochromic,

46 QuasAr2, which show improved brightness and voltage sensitivity, have microsecond response times and

47 measured redox potentials, and validate the voltage sensitivities in patch-clamped HEK cells for 10

48 of designer channels, which accounts for low-voltage sensitivity in all known temperature-gated ion c

49 d reduces both CaV1.2 channel expression and voltage sensitivity in arterial myocytes.

50 ng cells, high photostability, and excellent voltage sensitivity in neurons.

51 Voltage sensitivity in PHA-1 mutants stems from the disr

52 reen (ICG), which has FDA approval, exhibits voltage sensitivity in various tissues, thus raising hop

53 Voltage sensitivity is conferred by charged residues loc

54 The voltage sensitivity is conferred through four voltage-se

55 Prestin's voltage sensitivity is influenced by intracellular chlor

56 Voltage sensitivity is not influenced by divalent cation

57 into these components revealed two different voltage-sensitivity mechanisms for ICG.

58 ix, but neither motion produced the observed voltage sensitivity, nor did either model result in a ca

59 ve detection of local electric fields with a voltage sensitivity of a few microvolts, a spatial resol

60 electrode damage or perhaps the asymmetrical voltage sensitivity of a heterotypic gap junction.

61 the re-entrant loop in coupling calcium and voltage sensitivity of ANO1 and hence in regulating ANO1

62 ith the reciprocal relationship based on the voltage sensitivity of approximately 20 nm/mV for 50-mic

63 However, the voltage sensitivity of bipolar channels correlates with

64 l potential but no change in the kinetics or voltage sensitivity of channel activation.

65 Surprisingly, the voltage sensitivity of closing kinetics changed with cal

66 depolarization, a value consistent with the voltage sensitivity of DHPR-mediated VICaR in skeletal m

67 bal SR Ca(2+) release over the full range of voltage sensitivity of EC coupling.

68 utamate uptake by EAAT2, we predict that the voltage sensitivity of exchange is caused by the voltage

69 The macroscopic voltage sensitivity of homotypic Cx46 conformed to the t

70 The voltage sensitivity of hSlo was right-shifted by approxi

71 ysical association, 8-bromo-cAMP shifted the voltage sensitivity of I(h) less than that of HCN4 chann

72 suggests that elevation of I(Kr) by reducing voltage sensitivity of inactivation, not via slowing of

73 The voltage sensitivity of inhibitors was also examined.

74 brane hyperpolarization, thus increasing the voltage sensitivity of internal alkalization.

75 The implication is that the voltage sensitivity of K(+) channels is not solely encod

76 BDM (5 mM) shifted the range of voltage sensitivity of membrane capacitance and cell len

77 most recent concepts regarding the intrinsic voltage sensitivity of muscarinic receptors and the cons

78 tiated by a specific interaction between the voltage sensitivity of NMDA receptors and voltage-gated

79 acteristics, including inward rectification, voltage sensitivity of open probability, sensitivity of

80 stitution at this locus reduced the apparent voltage sensitivity of open- and closed-state fast inact

81 rast, we find that CPZ and TNP influence the voltage sensitivity of prestin via membrane bending, dem

82 as auxiliary gamma subunits that elevate the voltage sensitivity of recombinant and prostate adenocar

83 The high photostability and voltage sensitivity of RVF5 is recapitulated under 2P il

84 ression with the beta4 subunit increased the voltage sensitivity of the alpha2, alpha3 and slow alpha

85 The lack of voltage sensitivity of the blocking protein suggests tha

86 unclear whether this is due to an increased voltage sensitivity of the Cav1.3 voltage-sensing domain

87 of these different loop substitutions on the voltage sensitivity of the channel and compared these ex

88 The voltage sensitivity of the channels was also reduced dur

89 low as 50 microM, and both the amplitude and voltage sensitivity of the current depended upon Zn2+ co

90 The lack of voltage sensitivity of the discharge of membrane noise i

91 han a factor of four better than the nominal voltage sensitivity of the dyes under "one-photon" fluor

92 Comparison of the kinetic properties and the voltage sensitivity of the isolated components of evoked

93 C-terminal deletions altered the voltage sensitivity of the KAT1 channel with greater del

94 adaic acid (1 microM, 30-60 min) shifted the voltage sensitivity of the membrane capacitance in the h

95 The second pathway shifts the voltage sensitivity of the OHC electromotile mechanism a

96 observation that sugar transport alters the voltage sensitivity of the OHC motor mechanism.

97 r, the deletions paradoxically increased the voltage sensitivity of the R176S mutant channel, but not

98 ior of KACh channels is due to the intrinsic voltage sensitivity of the receptor that activates KACh

99 at they resembled those of Cx46, reduced the voltage sensitivity of the steady-state junctional condu

100 iophysical mechanism responsible for the SHG voltage sensitivity of the styryl dye FM 4-64 in pyramid

101 ulation of inner segment conductances or the voltage sensitivity of the synaptic Ca(2+) current, sugg

102 We find that voltage sensitivity of the tubulin-VDAC blockage practic

103 The voltage sensitivity of these channels arises from the mo

104 is condition of -45 +/- 5 mV at 60 mmHg, the voltage sensitivity of wall [Ca2+] and diameter were 7.5

105 Like ABA, OA and CA shifted the voltage-sensitivities of the Ca2+ current and [Ca2+]i in

106 s in its single channel conductance, lack of voltage-sensitivity of activation, inward rectification,

107 indicated that in L529I, NS1643 reduces the voltage-sensitivity of S4 movement.

108 cells, promoting Ca2+ entry by shifting the voltage-sensitivity of the channels.

109 We find a dependence of voltage sensitivity on excitation wavelength that is con

110 ce, and there is a significant dependence of voltage sensitivity on the structure of the nonchromopho

111 is common to most K2P channels and that this voltage sensitivity originates from the movement of thre

112 bunit modification of Kv1.5 inactivation and voltage sensitivity require phosphorylation by protein k

113 as a sodium "background" current with little voltage sensitivity, revealed by NMDG replacement for so

114 contain high threshold Kv2.1 channels whose voltage sensitivity shifts upon declustering; nor are th

115 stituted voltage indicators exhibit improved voltage sensitivity should be broadly applicable to othe

116 The unique combination of weak voltage sensitivity, small unitary conductance, and perm

117 evertheless conserve both the charge and its voltage sensitivity suggest a primary action upon the Ry

118 reduced channel activity and alterations in voltage sensitivity that are best explained by a physica

119 bit a unique, agonist-dependent mechanism of voltage-sensitivity that modulates downstream receptor s

120 re, we demonstrate the possibility to confer voltage sensitivity to cytosolic enzymes.

121 he rhodamine aryl ring, exhibits the highest voltage sensitivity to date for red-shifted PeT-based vo

122 A number of studies link voltage sensitivity to interactions of S4 charges with m

123 ur transmembrane segments (S1-S4) and confer voltage sensitivity to many ion channels.

124 ecialized transmembrane segments that confer voltage sensitivity to many proteins such as ion channel

125 e membrane-bound protein modules that confer voltage sensitivity to membrane proteins.

126 raversing the channel from the inside confer voltage sensitivity to the Hui1 off-rate via Arg23, indi

127 oop linking the S3 helix and the S4 helix in voltage sensitivity, we have constructed a set of mutant

128 cal to the 130 pS channel in conductance and voltage sensitivity were activated in the absence of opi

129 e mice, the Ca(V)1.1 channel conductance and voltage sensitivity were increased by splice-shifting ol

130 s the voltage of half-maximum activation and voltage sensitivity, were altered, indicating that Cav1.

131 t alter Ca(2+) sparks but reduced BK channel voltage sensitivity, which decreased channel apparent Ca

132 y, though, such substitution also results in voltage sensitivity with greater activity at hyperpolari

133 The channel displays an unusual voltage sensitivity, with an abrupt increase in open-sta